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Employment (1)

Wayne State University School of Medicine: Detroit, MI, US

2020-06-01 to present | Associate Professor (Ophthalmology, Visual and Anatomical Sciences)
Employment
Source: Self-asserted source
Singh NK

Works (50 of 55)

Items per page:
Page 1 of 2

Nanotechnology in retinal diseases: From disease diagnosis to therapeutic applications

Biophysics Reviews
2024-12-01 | Journal article
Contributors: Geetika Kaur; Shivantika Bisen; Nikhlesh K. Singh
Source: check_circle
Crossref

A neutrophil elastase-generated mature form of IL-33 is a potent regulator of endothelial cell activation and proliferative retinopathy

Experimental & Molecular Medicine
2024-08-01 | Journal article
Contributors: Shivantika Bisen; Shailendra Kumar Verma; Chandra Sekhar Mukhopadhyay; Nikhlesh K. Singh
Source: check_circle
Crossref

Vascular cell-adhesion molecule 1 (VCAM-1) regulates JunB-mediated IL-8/CXCL1 expression and pathological neovascularization

Communications Biology
2023-05-13 | Journal article
Contributors: Geetika Kaur; Deepti Sharma; Shivantika Bisen; Chandra Sekhar Mukhopadhyay; Katherine Gurdziel; Nikhlesh K. Singh
Source: check_circle
Crossref

Long Non-Coding RNAs and Proliferative Retinal Diseases

Pharmaceutics
2023-05-10 | Journal article
Contributors: Anamika Sharma; Nikhlesh K. Singh
Source: check_circle
Crossref

IL-33 via PKCμ/PRKD1 Mediated α-Catenin Phosphorylation Regulates Endothelial Cell-Barrier Integrity and Ischemia-Induced Vascular Leakage

Cells
2023-02-23 | Journal article
Contributors: Deepti Sharma; Geetika Kaur; Shivantika Bisen; Anamika Sharma; Ahmed S. Ibrahim; Nikhlesh K. Singh
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Role of G-Proteins and GPCRs in Cardiovascular Pathologies

Bioengineering
2023-01-06 | Journal article
Contributors: Geetika Kaur; Shailendra Kumar Verma; Deepak Singh; Nikhlesh K. Singh
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

IL-33 enhances Jagged1 mediated NOTCH1 intracellular domain (NICD) deubiquitination and pathological angiogenesis in proliferative retinopathy

Communications Biology
2022-05-19 | Journal article
Contributors: Deepti Sharma; Shivantika Bisen; Geetika Kaur; Eric C. Van Buren; Gadiparthi N. Rao; Nikhlesh K. Singh
Source: check_circle
Crossref

Nano-Biomaterials for Retinal Regeneration

Nanomaterials
2021 | Journal article
EID:

2-s2.0-85110656856

Part of ISSN: 20794991
Contributors: Sharma, R.; Sharma, D.; Hazlett, L.D.; Singh, N.K.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis

Cell Death and Differentiation
2021 | Journal article
EID:

2-s2.0-85091369893

Part of ISSN: 14765403 13509047
Contributors: Boro, M.; Govatati, S.; Kumar, R.; Singh, N.K.; Pichavaram, P.; Traylor, J.G.; Orr, A.W.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

The Role of Inflammation in Retinal Neurodegeneration and Degenerative Diseases

International Journal of Molecular Sciences
2021-12 | Journal article | Author
Contributors: Geetika Kaur; Singh NK
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 3)‎

PKCθ-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization

Cell Death and Disease
2020 | Journal article
EID:

2-s2.0-85084389011

Part of ISSN: 20414889
Contributors: Kumar, R.; Mani, A.M.; Singh, N.K.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Cholesterol crystals promote endothelial cell and monocyte interactions via H <sub>2</sub> O <sub>2</sub> -mediated PP2A inhibition, NFκB activation and ICAM1 and VCAM1 expression

Redox Biology
2019 | Journal article
EID:

2-s2.0-85064456805

Part of ISSN: 22132317
Contributors: Pichavaram, P.; Mani, A.M.; Singh, N.K.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

Progress in Lipid Research
2019 | Journal article
EID:

2-s2.0-85057341269

Part of ISSN: 18732194 01637827
Contributors: Singh, N.K.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

NFATc1-E2F1-LMCD1-Mediated IL-33 Expression by Thrombin Is Required for Injury-Induced Neointima Formation

Arteriosclerosis, Thrombosis, and Vascular Biology
2019 | Journal article
EID:

2-s2.0-85066512595

Part of ISSN: 15244636 10795642
Contributors: Govatati, S.; Pichavaram, P.; Janjanam, J.; Zhang, B.; Singh, N.K.; Mani, A.M.; Traylor, J.G.; Orr, A.W.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Response by Raghavan et al to Letter Regarding Article, "protein Kinase Cθ via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6C<sup>hi</sup> Cells Contributes to Atherosclerosis"

Circulation
2019 | Journal article
EID:

2-s2.0-85065881997

Part of ISSN: 15244539 00097322
Contributors: Raghavan, S.; Singh, N.K.; Gali, S.; Mani, A.M.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Cholesterol crystals increase vascular permeability by inactivating SHP2 and disrupting adherens junctions

Free Radical Biology and Medicine
2018 | Journal article
EID:

2-s2.0-85047394822

Part of ISSN: 18734596 08915849
Contributors: Mani, A.M.; Chattopadhyay, R.; Singh, N.K.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

LIM and cysteine-rich domains 1 is required for thrombininduced smooth muscle cell proliferation and promotes atherogenesis

Journal of Biological Chemistry
2018 | Journal article
EID:

2-s2.0-85042908257

Part of ISSN: 1083351X 00219258
Contributors: Janjanam, J.; Zhang, B.; Mani, A.M.; Singh, N.K.; Traylor, J.G.; Orr, A.W.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Protease-activated receptor 1 inhibits cholesterol efflux and promotes atherogenesis via cullin 3–mediated degradation of the ABCA1 transporter

Journal of Biological Chemistry
2018 | Journal article
EID:

2-s2.0-85049522328

Part of ISSN: 1083351X 00219258
Contributors: Raghavan, S.; Singh, N.K.; Mani, A.M.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Protein Kinase Cθ Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6C<sup>hi</sup> Cells Contributes to Atherosclerosis

Circulation
2018 | Journal article
EID:

2-s2.0-85058886609

Part of ISSN: 15244539 00097322
Contributors: Raghavan, S.; Singh, N.K.; Gali, S.; Mani, A.M.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Resolvin D1 blocks H <sub>2</sub> O <sub>2</sub> -mediated inhibitory crosstalk between SHP2 and PP2A and suppresses endothelial-monocyte interactions

Free Radical Biology and Medicine
2018 | Journal article
EID:

2-s2.0-85041630733

Part of ISSN: 18734596 08915849
Contributors: Chattopadhyay, R.; Mani, A.M.; Singh, N.K.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking

Journal of Biological Chemistry
2017 | Journal article
EID:

2-s2.0-85029225737

Part of ISSN: 1083351X 00219258
Contributors: Kotla, S.; Singh, N.K.; Kirchhofer, D.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

P115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation

Journal of Biological Chemistry
2017 | Journal article
EID:

2-s2.0-85028438786

Part of ISSN: 1083351X 00219258
Contributors: Singh, N.K.; Janjanam, J.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

ROS via BTK-p300-STAT1-PPARγ signaling activation mediates cholesterol crystals-induced CD36 expression and foam cell formation

Redox Biology
2017 | Journal article
EID:

2-s2.0-85007346992

Part of ISSN: 22132317
Contributors: Kotla, S.; Singh, N.K.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

A new role for cofilin in retinal neovascularization

Journal of Cell Science
2016 | Journal article
EID:

2-s2.0-84961231085

Part of ISSN: 14779137 00219533
Contributors: Kumar, R.; Janjanam, J.; Singh, N.K.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Proline-rich tyrosine kinase 2 via enhancing signal transducer and activator of transcription 3-dependent cJun expression mediates retinal neovascularization

Scientific Reports
2016 | Journal article
EID:

2-s2.0-84971294349

Part of ISSN: 20452322
Contributors: Kumar, R.; Singh, N.K.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction

Journal of Lipid Research
2015 | Journal article
EID:

2-s2.0-84924603360

Part of ISSN: 15397262 00222275
Contributors: Chattopadhyay, R.; Tinnikov, A.; Dyukova, E.; Singh, N.K.; Kotla, S.; Mobley, J.A.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling

EBioMedicine
2015 | Journal article
EID:

2-s2.0-84958859701

Part of ISSN: 23523964
Contributors: Singh, N.K.; Kotla, S.; Kumar, R.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice

Nature Communications
2015 | Journal article
EID:

2-s2.0-84933073691

Part of ISSN: 20411723
Contributors: Singh, N.K.; Kotla, S.; Dyukova, E.; Traylor Jr., J.G.; Orr, A.W.; Chernoff, J.; Marion, T.N.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation

Free Radical Biology and Medicine
2014 | Journal article
EID:

2-s2.0-84907224934

Part of ISSN: 18734596 08915849
Contributors: Kotla, S.; Singh, N.K.; Traylor, J.G.; Wayne Orr, A.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-Hydroxyeicosatetraenoic acid partly via Protein Kinase C <sub>e</sub>-mediated Zona Occludens-1 Phosphorylation at Threonine 770/772

Journal of Biological Chemistry
2014 | Journal article
EID:

2-s2.0-84893663062

Part of ISSN: 1083351X 00219258
Contributors: Chattopadhyay, R.; Dyukova, E.; Singh, N.K.; Ohba, M.; Mobley, J.A.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Both Kdr and Flt1 play a vital role in hypoxia-induced Src-PLD1-PKCγ- cPLA<sub>2</sub> activation and retinal neovascularization

Blood
2013 | Journal article
EID:

2-s2.0-84876548894

Part of ISSN: 15280020 00064971
Contributors: Singh, N.K.; Hansen III, D.E.; Kundumani-Sridharan, V.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration

Journal of Biological Chemistry
2013 | Journal article
EID:

2-s2.0-84886680226

Part of ISSN: 00219258 1083351X
Contributors: Gadepalli, R.; Kotla, S.; Heckle, M.R.; Verma, S.K.; Singh, N.K.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Nuclear factor of activated T cells c1 mediates p21-activated kinase 1 activation in the modulation of chemokine-induced human aortic smooth muscle cell F-actin stress fiber formation, migration, and proliferation and injury-induced vascular wall remodeling

Journal of Biological Chemistry
2013 | Journal article
EID:

2-s2.0-84881230457

Part of ISSN: 1083351X 00219258
Contributors: Kundumani-Sridharan, V.; Singh, N.K.; Kumar, S.; Gadepalli, R.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis

Science Signaling
2013 | Journal article
EID:

2-s2.0-84885805852

Part of ISSN: 19450877 19379145
Contributors: Kotla, S.; Singh, N.K.; Heckle, M.R.; Tigyi, G.J.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Novel interactions between NFATc1 (nuclear factor of activated T cells c1) and STAT-3 (signal transducer and activator of transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation

Journal of Biological Chemistry
2012 | Journal article
EID:

2-s2.0-84863308707

Part of ISSN: 00219258 1083351X
Contributors: Kundumani-Sridharan, V.; Van Quyen, D.; Subramani, J.; Singh, N.K.; Chin, Y.E.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Novel role of proline-rich nonreceptor tyrosine kinase 2 in vascular wall remodeling after balloon injury

Arteriosclerosis, Thrombosis, and Vascular Biology
2012 | Journal article
EID:

2-s2.0-84871867527

Part of ISSN: 10795642 15244636
Contributors: Gadepalli, R.; Singh, N.K.; Kundumani-Sridharan, V.; Heckle, M.R.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling

Journal of Biological Chemistry
2012 | Journal article
EID:

2-s2.0-84867828110

Part of ISSN: 1083351X 00219258
Contributors: Singh, N.K.; Kundumani-Sridharan, V.; Kumar, S.; Verma, S.K.; Kotla, S.; Mukai, H.; Heckle, M.R.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation

Blood
2011 | Journal article
EID:

2-s2.0-81555214613

Part of ISSN: 15280020 00064971
Contributors: Singh, N.K.; Kundumani-Sridharan, V.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall remodeling

Journal of Biological Chemistry
2011 | Journal article
EID:

2-s2.0-79959370637

Part of ISSN: 00219258 1083351X
Contributors: Singh, N.K.; Wang, D.; Kundumani-Sridharan, V.; Van Quyen, D.; Niu, J.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Activation of cytosolic phospholipase A2 downstream of the Src-phospholipase D1 (PLD1)-Protein kinase C γ (PKCγ) signaling axis is required for hypoxia-induced pathological retinal angiogenesis

Journal of Biological Chemistry
2011 | Journal article
EID:

2-s2.0-79959358969

Part of ISSN: 00219258 1083351X
Contributors: Zhang, Q.; Wang, D.; Singh, N.K.; Kundumani-Sridharan, V.; Gadiparthi, L.; Rao, Ch.M.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression

Blood
2010 | Journal article
EID:

2-s2.0-77950398950

Part of ISSN: 15280020 00064971
Contributors: Kundumani-Sridharan, V.; Niu, J.; Wang, D.; Van Quyen, D.; Zhang, Q.; Singh, N.K.; Subramani, J.; Karri, S.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis

Journal of Biological Chemistry
2010 | Journal article
EID:

2-s2.0-77952762498

Part of ISSN: 00219258 1083351X
Contributors: Singh, N.K.; Van Quyen, D.; Kundumani-Sridharan, V.; Brooks, P.C.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Effect of acidophilus casei dahi (probiotic curd) on faecal enzyme activities in DMH induced colon carcinogenesis

Milchwissenschaft
2010 | Journal article
EID:

2-s2.0-77954942957

Part of ISSN: 00263788
Contributors: Arvind; Sinha, P.R.; Singh, N.K.; Kumar, R.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Inhibition of 1,2-dimethylhydrazine induced colon genotoxicity in rats by the administration of probiotic curd

Molecular Biology Reports
2010 | Journal article
EID:

2-s2.0-77951886784

Part of ISSN: 03014851 15734978
Contributors: Kumar, A.; Singh, N.K.; Sinha, P.R.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Intervention of Acidophilus-casei dahi and Wheat bran against molecular alteration in colon carcinogenesis

Molecular Biology Reports
2010 | Journal article
EID:

2-s2.0-77949269002

Part of ISSN: 03014851 15734978
Contributors: Kumar, A.; Singh, N.K.; Sinha, P.R.; Kumar, R.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Alteration in oxidative stress and c-Myc protein by administration of Acidophilus-casei dahi on DMH induced colon carcinogenesis

Current Topics in Nutraceutical Research
2009 | Journal article
EID:

2-s2.0-81255190883

Part of ISSN: 15407535
Contributors: Sinha, A.P.R.; Singh, N.K.; Kumar, R.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Effect of Acidophilus - Casei dahi (Probiotic curd) on lipids in 1, 2 dimethylhydrazine induced intestinal cancer in rats

International Journal of Probiotics and Prebiotics
2009 | Journal article
EID:

2-s2.0-77958522752

Part of ISSN: 15551431
Contributors: Arvind; Sinha, P.R.; Singh, N.K.; Kumar, R.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Effect of Probiotic dahi (CURD) on cytogenetical profile during 1,2-dimethylhydrazine induced colon carcinogenesis in rats

International Journal of Probiotics and Prebiotics
2009 | Journal article
EID:

2-s2.0-62549117047

Part of ISSN: 15551431
Contributors: Kumar, R.; Sinha, P.R.; Yadav, B.R.; Arvind; Singh, N.K.; Tonk, R.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Inhibition of 1,2 dimethylhydrazine induced genotoxicity in rats by the administration of probiotic curd

International Journal of Probiotics and Prebiotics
2009 | Journal article
EID:

2-s2.0-77958616406

Part of ISSN: 15551431
Contributors: Arvind; Singh, N.K.; Sinha, P.R.
Source: Self-asserted source
Singh NK via Scopus - Elsevier

Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration

Journal of Biological Chemistry
2009 | Journal article
EID:

2-s2.0-71449108959

Part of ISSN: 00219258 1083351X
Contributors: Potula, H.S.K.; Wang, D.; Van Quyen, D.; Singh, N.K.; Kundumani-Sridharan, V.; Karpurapu, M.; Park, E.A.; Glasgow, W.C.; Rao, G.N.
Source: Self-asserted source
Singh NK via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (11 reviews for 7 publications/grants)

Review activity for Archives of biochemistry and biophysics. (5)
Review activity for Biochemical and biophysical research communications. (1)
Review activity for Biochimica et biophysica acta. (1)
Review activity for Cytokine. (1)
Review activity for Journal of translational medicine. (1)
Review activity for Military medical research. (1)
Review activity for PloS one. (1)