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gene expression, mRNA turnover, structural biology
United States

Activities

Employment (6)

NCI/NIH: Frederick, Maryland (MD), US

2019-08-04 to present | Principal Investigator (Center for Cancer Research)
Employment
Source: Self-asserted source
Eugene Valkov

Max Planck Institute for Developmental Biology: Tübingen, Baden-Württemberg, DE

2014-11 to present | Project Leader (Biochemistry)
Employment
Source: Self-asserted source
Eugene Valkov

MRC Laboratory of Molecular Biology: Cambridge, Cambridgeshire, GB

2011-09 to 2014-10 | Postdoctoral Career Development Fellow (Structural Studies)
Employment
Source: Self-asserted source
Eugene Valkov

University of Cambridge: Cambridge, Cambridgeshire, GB

2010-07 to 2011-08 | Postdoctoral Research Associate (Department of Biochemistry)
Employment
Source: Self-asserted source
Eugene Valkov

University of Queensland: Brisbane, QLD, AU

2008-03 to 2010-07 | Postdoctoral Research Associate (School of Chemistry and Molecular Biosciences)
Employment
Source: Self-asserted source
Eugene Valkov

Imperial College London: London, London, GB

2006-09 to 2008-02 | Research Assistant (Division of Medicine)
Employment
Source: Self-asserted source
Eugene Valkov

Education and qualifications (2)

University of Oxford: Oxford, Oxfordshire, GB

2002-09 to 2006-12 | Doctor of Philosophy (Department of Biochemistry)
Education
Source: Self-asserted source
Eugene Valkov

University of Portsmouth: Portsmouth, Hampshire, GB

1999-09 to 2002-07 | Bachelor of Molecular Biology with First Class Honours (School of Life Sciences)
Education
Source: Self-asserted source
Eugene Valkov

Works (50 of 53)

Items per page:
Page 1 of 2

Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution

Nature Structural & Molecular Biology
2024-05 | Journal article
Contributors: Young-suk Lee; Yevgen Levdansky; Yoonseok Jung; V. Narry Kim; Eugene Valkov
Source: check_circle
Crossref

Regulation by the RNA-binding protein Unkempt at its effector interface

Nature Communications
2024-04-11 | Journal article
Contributors: Kriti Shah; Shiyang He; David J. Turner; Joshua Corbo; Khadija Rebbani; Daniel Dominguez; Joseph M. Bateman; Sihem Cheloufi; Cátia Igreja; Eugene Valkov et al.
Source: check_circle
Crossref

A paradigm for regulation at the effector interface with RNA-binding proteins

2023-09-21 | Preprint
Contributors: Kriti Shah; Shiyang He; David J. Turner; Joshua Corbo; Khadija Rebbani; Joseph M. Bateman; Sihem Cheloufi; Cátia Igreja; Eugene Valkov; Jernej Murn
Source: check_circle
Crossref

Structure and assembly of the NOT10:11 module of the CCR4-NOT complex

Communications Biology
2023-07-17 | Journal article
Contributors: Yevgen Levdansky; Tobias Raisch; Justin C. Deme; Filip Pekovic; Hans Elmlund; Susan M. Lea; Eugene Valkov
Source: check_circle
Crossref

The nexus between RNA-binding proteins and their effectors

Nature Reviews Genetics
2023-05 | Journal article
Contributors: Shiyang He; Eugene Valkov; Sihem Cheloufi; Jernej Murn
Source: check_circle
Crossref

Regulation of the multisubunit CCR4-NOT deadenylase in the initiation of mRNA degradation

Current Opinion in Structural Biology
2022-12 | Journal article
Contributors: Tobias Raisch; Eugene Valkov
Source: check_circle
Crossref

DAP5 enables main ORF translation on mRNAs with structured and uORF-containing 5′ leaders

Nature Communications
2022-12-06 | Journal article
Contributors: Ramona Weber; Leon Kleemann; Insa Hirschberg; Min-Yi Chung; Eugene Valkov; Cátia Igreja
Source: check_circle
Crossref

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation

Nature Communications
2021-12-09 | Journal article
Contributors: Fabian Poetz; Joshua Corbo; Yevgen Levdansky; Alexander Spiegelhalter; Doris Lindner; Vera Magg; Svetlana Lebedeva; Jörg Schweiggert; Johanna Schott; Eugene Valkov et al.
Source: check_circle
Crossref

Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

iScience
2021-06 | Journal article
Contributors: Huaying Zhao; Di Wu; Ai Nguyen; Yan Li; Regina C. Adão; Eugene Valkov; George H. Patterson; Grzegorz Piszczek; Peter Schuck
Source: check_circle
Crossref

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome

RNA
2021-04-04 | Journal article
Contributors: Isioma I.I. Enwerem; Nathan D. Elrod; Chung-Te Chang; Ai Lin; Ping Ji; Jennifer A. Bohn; Yevgen Levdansky; Eric J. Wagner; Eugene Valkov; Aaron C. Goldstrohm
Source: check_circle
Crossref

Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

2021-02-09 | Preprint
Contributors: Huaying Zhao; Di Wu; Ai Nguyen; Yan Li; Regina C. Adão; Eugene Valkov; George H. Patterson; Grzegorz Piszczek; Peter Schuck
Source: check_circle
Crossref

DAP5 enables translation re-initiation on structured messenger RNAs

2021-01-21 | Preprint
Contributors: Ramona Weber; Leon Kleemann; Insa Hirschberg; Min-Yi Chung; Eugene Valkov; Cátia Igreja
Source: check_circle
Crossref

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome

2020-11-18 | Preprint
Contributors: Isioma I.I. Enwerem; Nathan D. Elrod; Chung-Te Chang; Ai Lin; Ping Ji; Jennifer A. Bohn; Yevgen Levdansky; Eric J. Wagner; Eugene Valkov; Aaron C. Goldstrohm
Source: check_circle
Crossref

4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay

Cell Reports
2020-10 | Journal article
Contributors: Ramona Weber; Min-Yi Chung; Csilla Keskeny; Ulrike Zinnall; Markus Landthaler; Eugene Valkov; Elisa Izaurralde; Cátia Igreja
Source: check_circle
Crossref

Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs

Nucleic Acids Research
2020-02-28 | Journal article
Contributors: René M Arvola; Chung-Te Chang; Joseph P Buytendorp; Yevgen Levdansky; Eugene Valkov; Peter L Freddolino; Aaron C Goldstrohm
Source: check_circle
Crossref

Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs

2019-10-13 | Other
Contributors: René M. Arvola; Chung-Te Chang; Joseph P. Buytendorp; Yevgen Levdansky; Eugene Valkov; Peter L. Freddolino; Aaron C. Goldstrohm
Source: check_circle
Crossref

A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay

Nucleic Acids Research
2019-09-26 | Journal article
Contributors: Chung-Te Chang; Sowndarya Muthukumar; Ramona Weber; Yevgen Levdansky; Ying Chen; Dipankar Bhandari; Catia Igreja; Lara Wohlbold; Eugene Valkov; Elisa Izaurralde
Source: check_circle
Crossref

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

Nature Communications
2019-07-18 | Journal article
Contributors: Tobias Raisch; Chung-Te Chang; Yevgen Levdansky; Sowndarya Muthukumar; Stefan Raunser; Eugene Valkov
Source: check_circle
Crossref

Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex

Journal of Structural Biology
2018-12 | Journal article
Contributors: Tobias Raisch; Felix Sandmeir; Oliver Weichenrieder; Eugene Valkov; Elisa Izaurralde
Source: check_circle
Crossref

Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast

Nucleic Acids Research
2018-07-27 | Journal article
Contributors: Stefan Grüner; Ramona Weber; Daniel Peter; Min-Yi Chung; Cátia Igreja; Eugene Valkov; Elisa Izaurralde
Source: check_circle
Crossref

Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester.

Journal of molecular biology
2018-03 | Journal article
Contributors: van Loo B; Schober M; Valkov E; Heberlein M; Bornberg-Bauer E; Faber K; Hyvönen M; Hollfelder F
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Mille viae in eukaryotic mRNA decapping.

Current opinion in structural biology
2017-12 | Journal article
Contributors: Valkov E; Jonas S; Weichenrieder O
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.

Genes & development
2017-06 | Journal article
Contributors: Peter D; Weber R; Sandmeir F; Wohlbold L; Helms S; Bawankar P; Valkov E; Igreja C; Izaurralde E
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.

Molecular cell
2016-11 | Journal article
Contributors: Grüner S; Peter D; Weber R; Wohlbold L; Chung MY; Weichenrieder O; Valkov E; Igreja C; Izaurralde E
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.

Nature structural & molecular biology
2016-06 | Journal article
Contributors: Valkov E; Muthukumar S; Chang CT; Jonas S; Weichenrieder O; Izaurralde E
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central
grade
Preferred source (of 2)‎

Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos.

The EMBO journal
2016-05 | Journal article
Contributors: Raisch T; Bhandari D; Sabath K; Helms S; Valkov E; Weichenrieder O; Izaurralde E
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase.

PloS one
2015 | Journal article
Contributors: Cork AJ; Ericsson DJ; Law RH; Casey LW; Valkov E; Bertozzi C; Stamp A; Jovcevski B; Aquilina JA; Whisstock JC et al.
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex.

Acta crystallographica. Section F, Structural biology communications
2015-10 | Journal article
Contributors: Valkov E; Stewart M
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design.

ChemMedChem
2015-07 | Journal article
Contributors: Holvey RS; Valkov E; Neal D; Stewart M; Abell C
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.

Structure (London, England : 1993)
2015-07 | Journal article
Contributors: Dimitrova L; Valkov E; Aibara S; Flemming D; McLaughlin SH; Hurt E; Stewart M
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.

Acta crystallographica. Section F, Structural biology communications
2015-07 | Journal article
Contributors: Aibara S; Valkov E; Lamers MH; Dimitrova L; Hurt E; Stewart M
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface.

Nucleic acids research
2015-02 | Journal article
Contributors: Aibara S; Valkov E; Lamers M; Stewart M
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in Toll-like receptor and interferon signaling.

Protein expression and purification
2015-02 | Journal article
Contributors: Ullah MO; Valkov E; Ve T; Williams S; Mas C; Mansell A; Kobe B
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA.

Nucleic acids research
2015-02 | Journal article
Contributors: Aibara S; Katahira J; Valkov E; Stewart M
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.

The EMBO journal
2014-07 | Journal article
Contributors: Wolf J; Valkov E; Allen MD; Meineke B; Gordiyenko Y; McLaughlin SH; Olsen TM; Robinson CV; Bycroft M; Stewart M et al.
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export.

Nucleic acids research
2014-06 | Journal article
Contributors: Jani D; Valkov E; Stewart M
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB.

The Journal of biological chemistry
2014-01 | Journal article
Contributors: Alaidarous M; Ve T; Casey LW; Valkov E; Ericsson DJ; Ullah MO; Schembri MA; Mansell A; Sweet MJ; Kobe B
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers.

Nucleic Acids Research
2014-01 | Journal article
Contributors: Kuhlmann SI; Valkov E; Stewart M
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB.

Acta crystallographica. Section F, Structural biology and crystallization communications
2013-10 | Journal article
Contributors: Alaidarous M; Ve T; Ullah MO; Valkov E; Mansell A; Schembri MA; Sweet MJ; Kobe B
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

De novo GTP biosynthesis is critical for virulence of the fungal pathogen Cryptococcus neoformans.

PLoS pathogens
2012 | Journal article
Contributors: Morrow CA; Valkov E; Stamp A; Chow EW; Lee IR; Wronski A; Williams SJ; Hill JM; Djordjevic JT; Kappler U et al.
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Targeting protein-protein interactions and fragment-based drug discovery.

Topics in current chemistry
2012 | Journal article
Contributors: Valkov E; Sharpe T; Marsh M; Greive S; Hyvönen M
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Structural basis for the assembly and disassembly of mRNA nuclear export complexes.

Biochimica et biophysica acta
2012-06 | Journal article
Contributors: Valkov E; Dean JC; Jani D; Kuhlmann SI; Stewart M
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins.

PloS one
2011 | Journal article
Contributors: Swarbrick JD; Shaw DJ; Chhabra S; Ghai R; Valkov E; Norwood SJ; Seaman MN; Collins BM
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM.

Acta crystallographica. Section F, Structural biology and crystallization communications
2011-12 | Journal article
Contributors: Ve T; Williams SJ; Stamp A; Valkov E; Dodds PN; Anderson PA; Kobe B
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

A molecular mechanism for bacterial susceptibility to zinc.

PLoS pathogens
2011-11 | Journal article
Contributors: McDevitt CA; Ogunniyi AD; Valkov E; Lawrence MC; Kobe B; McEwan AG; Paton JC
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection.

Proceedings of the National Academy of Sciences of the United States of America
2011-09 | Journal article
Contributors: Valkov E; Stamp A; Dimaio F; Baker D; Verstak B; Roversi P; Kellie S; Sweet MJ; Mansell A; Gay NJ et al.
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Improved molecular replacement by density- and energy-guided protein structure optimization.

Nature
2011-05 | Journal article
Contributors: DiMaio F; Terwilliger TC; Read RJ; Wlodawer A; Oberdorfer G; Wagner U; Valkov E; Alon A; Fass D; Axelrod HL et al.
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation.

Cell host & microbe
2011-03 | Journal article
Contributors: Bernoux M; Ve T; Williams S; Warren C; Hatters D; Valkov E; Zhang X; Ellis JG; Kobe B; Dodds PN
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6.

Acta crystallographica. Section F, Structural biology and crystallization communications
2011-02 | Journal article
Contributors: Ve T; Williams S; Valkov E; Ellis JG; Dodds PN; Kobe B
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central

Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus.

Acta crystallographica. Section F, Structural biology and crystallization communications
2010-09 | Journal article
Contributors: Morrow CA; Stamp A; Valkov E; Kobe B; Fraser JA
Source: Self-asserted source
Eugene Valkov via Europe PubMed Central
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Peer review (20 reviews for 11 publications/grants)

Review activity for Cell biochemistry and biophysics. (1)
Review activity for Cell reports. (1)
Review activity for Cells. (1)
Review activity for Communications biology. (1)
Review activity for Current opinion in structural biology. (3)
Review activity for eLife (1)
Review activity for Genome biology. (2)
Review activity for Nature cell biology (1)
Review activity for Nature communications (7)
Review activity for PLOS genetics. (1)
Review activity for Trends in biochemical sciences. (1)