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A PDK-1 allosteric agonist improves spatial learning and memory in a βAPP/PS-1 transgenic mouse-high fat diet intervention model of Alzheimer's disease

Behavioural Brain Research
2023-02 | Journal article
DOI: 10.1016/j.bbr.2022.114183
Contributors: Henry Querfurth; Angela Slitt; Amy DiCamillo; Nathan Surles; Brenton DeBoef; Han-Kyu Lee
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A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro

PLOS ONE
2022-01-21 | Journal article
DOI: 10.1371/journal.pone.0261696
Contributors: Henry Querfurth; Jaya Padmanabhan; John Marshall; Keykavous Parang; Mengia S. Rioult-Pedotti; Rakesh Tiwari; Bumsup Kwon; Steve Reisinger; Han-Kyu Lee
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Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Molecular Neurodegeneration
2021-07-02 | Journal article
DOI: 10.1186/s13024-021-00428-5
Contributors: Henry Querfurth; Han-Kyu Lee
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