Personal information

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https://www.ed.ac.uk/profile/dr-owen-davies

Activities

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Employment (5)

University of Edinburgh: Edinburgh, GB

2024-09-01 to present | Professor of Structural Biology (Institute of Cell Biology)
Employment
Source: Self-asserted source
Owen Davies

University of Edinburgh: Edinburgh, GB

2021-02-15 to 2026-02-14 | Wellcome Senior Research Fellow (Institute of Cell Biology)
Employment
Source: Self-asserted source
Owen Davies

Newcastle University: Newcastle upon Tyne, Newcastle upon Tyne, GB

2013-09-01 to 2021-02-14 | University Research Fellow (Institute for Cell and Molecular Biosciences)
Employment
Source: Self-asserted source
Owen Davies

University of Cambridge: Cambridge, Cambridgeshire, GB

2010-01-01 to 2013-08-31 | Postdoctoral Research Associate (Department of Biochemistry)
Employment
Source: Self-asserted source
Owen Davies

University of Edinburgh: Edinburgh, Edinburgh, GB

2007-10-01 to 2010-12-31 | Royal Commission for 1851 Research Fellow (Institute for Stem Cell Research)
Employment
Source: Self-asserted source
Owen Davies

Education and qualifications (2)

University of Cambridge: Cambridge, Cambridgeshire, GB

2003-10 to 2007-07 | PhD (Department of Biochemistry)
Education
Source: Self-asserted source
Owen Davies

University of St Andrews: St. Andrews, Fife, GB

1998-09 to 2003-06 | BSc (Med. Sci.), BSc (Hons.) (School of Biology)
Education
Source: Self-asserted source
Owen Davies

Funding (7)

Molecular basis of chromosome synapsis and genetic exchange in mammalian meiosis

2021-02 to 2026-02 | Grant
Wellcome (London, GB)
GRANT_NUMBER:

219413/Z/19/Z
Source: Self-asserted source
Owen Davies

Cells to Molecules: Structural EM at Newcastle University

2018-04-30 to 2019-04-29 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
URL: https://app.dimensions.ai/details/grant/grant.7444238
GRANT_NUMBER: BB/R013942/1
Source: Self-asserted source
Owen Davies via DimensionsWizard

Biochemical and biophysical characterisation of the intact synaptonemal complex (SC) purified from meiotic cells

2018-03 to 2019-03 | Grant
Royal Society (London, GB)
GRANT_NUMBER:

RG170118
Source: Self-asserted source
Owen Davies

The molecular structure and function of the human synaptonemal complex in meiosis

2014-11 to 2019-11 | Grant
Wellcome Trust & Royal Society (London, GB)
GRANT_NUMBER:

104158/Z/14/Z
Source: Self-asserted source
Owen Davies

The functional architecture of the synaptonemal complex in meiosis

2013-09 to 2018-08 | Award
Newcastle University (Newcastle upon Tyne, GB)
Source: Self-asserted source
Owen Davies

Investigating the molecular assembly of the synaptonemal complex in meiosis

2010-09 to 2012-08 | Grant
Isaac Newton Trust (Cambridge, GB)
Source: Self-asserted source
Owen Davies

Uncovering the molecular mechanisms responsible for lineage commitment during early embryogenesis

2007-10 to 2010-10 | Award
Royal Commission for the Exhibition of 1851 (London, GB)
Source: Self-asserted source
Owen Davies

Works (50 of 54)

Items per page:
Page 1 of 2

Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin ortholog TpmCdc8

Journal of Biological Chemistry
2024-12 | Journal article
DOI: 10.1016/j.jbc.2024.107925
Contributors: Patrick Y.A. Reinke; Robin S. Heiringhoff; Theresia Reindl; Karen Baker; Manuel H. Taft; Alke Meents; Daniel P. Mulvihill; Owen R. Davies; Roman Fedorov; Michael Zahn et al.
Source: check_circle
Crossref

Addendum: BRCA2 stabilises RAD51 and DMC1 nucleoprotein filaments through a conserved interaction mode

Nature Communications
2024-11-18 | Journal article
DOI: 10.1038/s41467-024-54252-8
Contributors: James M. Dunce; Owen R. Davies
Source: check_circle
Crossref

BRCA2 stabilises RAD51 and DMC1 nucleoprotein filaments through a conserved interaction mode

Nature Communications
2024-09-27 | Journal article
DOI: 10.1038/s41467-024-52699-3
Contributors: James M. Dunce; Owen R. Davies
Source: check_circle
Crossref

MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombination

Nature Communications
2024-08-02 | Journal article
DOI: 10.1038/s41467-024-50920-x
Contributors: Manickam Gurusaran; Jingjing Zhang; Kexin Zhang; Hiroki Shibuya; Owen R. Davies
Source: check_circle
Crossref

The crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion

Communications Biology
2024-01-30 | Journal article
DOI: 10.1038/s42003-024-05794-6
Contributors: Manickam Gurusaran; Benedikte S. Erlandsen; Owen R. Davies
Source: check_circle
Crossref

BRCA2 stabilises RAD51 and DMC1 nucleoprotein filaments through a conserved interaction mode

2023-11-21 | Preprint
DOI: 10.1101/2023.11.20.567968
Contributors: James M. Dunce; Owen R. Davies
Source: check_circle
Crossref

SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis

Science Advances
2023-10-20 | Journal article | Author
DOI: 10.1126/sciadv.adi1562
Part of ISSN: 2375-2548
Contributors: Katherine Kretovich Billmyre; Emily A. Kesler; Dai Tsuchiya; Timothy Corbin; Kyle Weaver; Andrea Moran; Zulin Yu; Lane Adams; Kym Delventhal; Michael Durnin et al.
Source: Self-asserted source
Owen Davies

MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombination

2023-07-04 | Preprint
DOI: 10.1101/2023.07.04.547728
Contributors: Manickam Gurusaran; Jingjing Zhang; Kexin Zhang; Hiroki Shibuya; Owen R. Davies
Source: check_circle
Crossref

Crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion

2023-06-07 | Preprint
DOI: 10.1101/2023.06.05.543797
Contributors: Manickam Gurusaran; Benedikte S. Erlandsen; Owen R. Davies
Source: check_circle
Crossref

A BubR1-independent pathway for CENP-E targeting to the outer corona of kinetochores

2023-05-10 | Preprint
DOI: 10.1101/2023.05.10.540161
Contributors: Thibault Legal; Calum Paterson; Agata Gluszek; Owen R. Davies; Julie P.I. Welburn
Source: check_circle
Crossref

The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

Journal of Cell Biology
2023-05-01 | Journal article
DOI: 10.1083/jcb.202204042
Contributors: Kirsten E.L. Garner; Anna Salter; Clinton K. Lau; Manickam Gurusaran; Cécile M. Villemant; Elizabeth P. Granger; Gavin McNee; Philip G. Woodman; Owen R. Davies; Brian E. Burke et al.
Source: check_circle
Crossref

Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3

Nature Structural & Molecular Biology
2023-02 | Journal article
DOI: 10.1038/s41594-022-00909-1
Contributors: James H. Crichton; James M. Dunce; Orla M. Dunne; Lucy J. Salmon; Paul S. Devenney; Jennifer Lawson; Ian R. Adams; Owen R. Davies
Source: check_circle
Crossref

Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip

Communications Biology
2022-09-07 | Journal article
DOI: 10.1038/s42003-022-03886-9
Contributors: James M. Dunce; Lucy J. Salmon; Owen R. Davies
Source: check_circle
Crossref

Parallel recruitment pathways contribute to synaptonemal complex assembly during mammalian meiosis

2022-04-14 | Preprint
DOI: 10.1101/2022.04.14.488335
Contributors: James H. Crichton; James M. Dunce; Willy M. Baarends; Owen R. Davies; Ian R. Adams
Source: check_circle
Crossref

The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

2022-04-13 | Preprint
DOI: 10.1101/2022.04.13.488131
Contributors: Kirsten E. L. Garner; Anna Salter; Clinton K. Lau; Manickam Gurusaran; Cécile Villemant; Elizabeth P. Granger; Gavin McNee; Philip G. Woodman; Owen R. Davies; Brian E. Burke et al.
Source: check_circle
Crossref

Structural maturation of SYCP1-mediated meiotic chromosome synapsis through conformational remodelling by molecular adapter SYCE3

2022-03-07 | Preprint
DOI: 10.1101/2022.03.06.483192
Contributors: James H. Crichton; James M. Dunce; Orla M. Dunne; Lucy J. Salmon; Paul S. Devenney; Jennifer Lawson; Ian R. Adams; Owen R. Davies
Source: check_circle
Crossref

Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12

Communications Biology
2021-12-08 | Journal article
DOI: 10.1038/s42003-021-02887-4
Contributors: Sumit Sandhu; Ieng F. Sou; Jill E. Hunter; Lucy Salmon; Caroline L. Wilson; Neil D. Perkins; Neil Hunter; Owen R. Davies; Urszula L. McClurg
Source: check_circle
Crossref

Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12

Nature Structural & Molecular Biology
2021-08-09 | Journal article
DOI: 10.1038/s41594-021-00636-z
Contributors: James M. Dunce; Lucy J. Salmon; Owen R. Davies
Source: check_circle
Crossref

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Nature Communications
2021-07-14 | Journal article
DOI: 10.1038/s41467-021-24554-2
Contributors: Christopher Thomas; Benjamin Wetherall; Mark D. Levasseur; Rebecca J. Harris; Scott T. Kerridge; Jonathan M. G. Higgins; Owen R. Davies; Suzanne Madgwick
Source: check_circle
Crossref

Structural basis for the coiled-coil architecture of human CtIP

Open Biology
2021-06 | Journal article
DOI: 10.1098/rsob.210060
Contributors: C. R. Morton; N. J. Rzechorzek; J. D. Maman; M. Kuramochi; H. Sekiguchi; R. Rambo; Y. C. Sasaki; O. R. Davies; L. Pellegrini
Source: check_circle
Crossref

Structural basis for the coiled-coil architecture of human CtIP

2021-03-05 | Preprint
DOI: 10.1101/2021.03.05.434060
Contributors: C. R. Morton; N. J. Rzechorzek; J. D. Maman; M. Kuramochi; H. Sekiguchi; R. Rambo; Y. C. Sasaki; O. R. Davies; L. Pellegrini
Source: check_circle
Crossref

SUMO is a pervasive regulator of meiosis

eLife
2021-01-27 | Journal article
DOI: 10.7554/eLife.57720
Contributors: Nikhil R Bhagwat; Shannon N Owens; Masaru Ito; Jay V Boinapalli; Philip Poa; Alexander Ditzel; Srujan Kopparapu; Meghan Mahalawat; Owen Richard Davies; Sean R Collins et al.
Source: check_circle
Crossref

A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies

eLife
2021-01-04 | Journal article
DOI: 10.7554/eLife.60175
Contributors: Manickam Gurusaran; Owen Richard Davies
Source: check_circle
Crossref

Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12

2020-12-31 | Preprint
DOI: 10.1101/2020.12.30.424799
Contributors: James M. Dunce; Lucy J. Salmon; Owen R. Davies
Source: check_circle
Crossref

Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

eLife
2020-12-16 | Journal article
DOI: 10.7554/eLife.65744
Contributors: Bernadette Carroll; Dorothea Maetzel; Oliver DK Maddocks; Gisela Otten; Matthew Ratcliff; Graham R Smith; Elaine A Dunlop; João F Passos; Owen Richard Davies; Rudolf Jaenisch et al.
Source: check_circle
Crossref

Helical ensembles outperform ideal helices in molecular replacement

Acta Crystallographica Section D Structural Biology
2020-10-01 | Journal article
DOI: 10.1107/S205979832001133X
Contributors: Filomeno Sánchez Rodríguez; Adam J. Simpkin; Owen R. Davies; Ronan M. Keegan; Daniel J. Rigden
Source: check_circle
Crossref

Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1 interactions that are disrupted in cases of human infertility

Science Advances
2020-09-04 | Journal article
DOI: 10.1126/sciadv.abb1660
Contributors: Fernando Sánchez-Sáez; Laura Gómez-H; Orla M. Dunne; Cristina Gallego-Páramo; Natalia Felipe-Medina; Manuel Sánchez-Martín; Elena Llano; Alberto M. Pendas; Owen R. Davies
Source: check_circle
Crossref

Helical ensembles out-perform ideal helices in Molecular Replacement

2020-06-17 | Preprint
DOI: 10.1101/2020.06.16.154690
Contributors: Filomeno Sánchez Rodríguez; Adam J. Simpkin; Owen R. Davies; Ronan M. Keegan; Daniel J. Rigden
Source: check_circle
Crossref

A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies

2020-03-22 | Preprint
DOI: 10.1101/2020.03.21.001867
Contributors: Manickam Gurusaran; Owen R. Davies
Source: check_circle
Crossref

Extending the scope of coiled-coil crystal structure solution by AMPLE through improved ab initio modelling

Acta Crystallographica Section D Structural Biology
2020-03-01 | Journal article
DOI: 10.1107/S2059798320000443
Contributors: Jens M. H. Thomas; Ronan M. Keegan; Daniel J. Rigden; Owen R. Davies
Source: check_circle
Crossref

Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1 interactions that are disrupted in cases of human infertility

2020-02-04 | Preprint
DOI: 10.1101/2020.02.04.934372
Contributors: Fernando Sánchez-Sáez; Laura Gómez-H; Orla M. Dunne; Cristina Gallego-Páramo; Natalia Felipe-Medina; Manuel Sánchez-Martín; Elena Llano; Alberto M. Pendas; Owen R. Davies
Source: check_circle
Crossref

Delineation of the SUMO-Modified Proteome Reveals Regulatory Functions Throughout Meiosis

2019-11-12 | Other
DOI: 10.1101/828442
Contributors: Nikhil R Bhagwat; Shannon Owens; Masaru Ito; Jay Boinapalli; Philip Poa; Alexander Ditzel; Srujan Kopparapu; Meghan Mahalawat; Owen R Davies; Sean R Collins et al.
Source: check_circle
Crossref

Synchronous chromosome segregation in mouse oocytes is ensured by biphasic securin destruction and cyclin B1-Cdk1

2019-10-30 | Other
DOI: 10.1101/824763
Contributors: Christopher Thomas; Mark D. Levasseur; Rebecca J. Harris; Owen R. Davies; Suzanne Madgwick
Source: check_circle
Crossref

Molecular structure of human synaptonemal complex protein SYCE1

Chromosoma
2019-09-03 | Journal article
DOI: 10.1007/s00412-018-00688-z
Contributors: Orla M. Dunne; Owen R. Davies
Source: check_circle
Crossref

A molecular model for self-assembly of the synaptonemal complex protein SYCE3

Journal of Biological Chemistry
2019-06 | Journal article
DOI: 10.1074/jbc.RA119.008404
Contributors: Orla M. Dunne; Owen R. Davies
Source: check_circle
Crossref

Crossover recombination and synapsis are linked by adjacent regions within the N terminus of the Zip1 synaptonemal complex protein

PLOS Genetics
2019-06-20 | Journal article
DOI: 10.1371/journal.pgen.1008201
Contributors: Karen Voelkel-Meiman; Michael Lichten; Shun-Yun Cheng; Melanie Parziale; Savannah J. Morehouse; Arden Feil; Owen R. Davies; Arnaud de Muyt; Valérie Borde; Amy J. MacQueen
Source: check_circle
Crossref

Obtaining tertiary protein structures by the ab-initio interpretation of small angle X-ray scattering data

2019-03-08 | Other
DOI: 10.1101/572057
Contributors: Christopher Prior; Owen R Davies; Daniel Bruce; Ehmke Pohl
Source: check_circle
Crossref

Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1

Nature Communications
2018-12-17 | Journal article
DOI: 10.1038/s41467-018-07794-7
Contributors: James M. Dunce; Amy E. Milburn; Manickam Gurusaran; Irene da Cruz; Lee T. Sen; Ricardo Benavente; Owen R. Davies
Source: check_circle
Crossref

Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly

Nature Structural & Molecular Biology
2018-07-18 | Journal article
DOI: 10.1038/s41594-018-0078-9
Contributors: James M. Dunce; Orla M. Dunne; Matthew Ratcliff; Claudia Millán; Suzanne Madgwick; Isabel Usón; Owen R. Davies
Source: check_circle
Crossref

An Engineered Complement Factor H Construct for Treatment of C3 Glomerulopathy.

Journal of the American Society of Nephrology : JASN
2018-03 | Journal article
DOI: 10.1681/asn.2017091006
PMID: 29588430
Contributors: Yang Y; Denton H; Davies OR; Smith-Jackson K; Kerr H; Herbert AP; Barlow PN; Pickering MC; Marchbank KJ
Source: Self-asserted source
Owen Davies via Europe PubMed Central

Single-molecule observation of DNA compaction by meiotic protein SYCP3

eLife
2017-03-13 | Journal article
DOI: 10.7554/eLife.22582
Contributors: Johanna L Syrjänen; Iddo Heller; Andrea Candelli; Owen R Davies; Erwin J G Peterman; Gijs J L Wuite; Luca Pellegrini
Source: check_circle
Crossref

C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility

Nature Communications
2016-10-31 | Journal article
DOI: 10.1038/ncomms13298
Contributors: Laura Gómez-H; Natalia Felipe-Medina; Manuel Sánchez-Martín; Owen R. Davies; Isabel Ramos; Ignacio García-Tuñón; Dirk G. de Rooij; Ihsan Dereli; Attila Tóth; José Luis Barbero et al.
Source: check_circle
Crossref

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.

eLife
2016-01 | Journal article
DOI: 10.7554/elife.11058
PMID: 26742086
PMC: PMC4764560
Contributors: Carroll B; Maetzel D; Maddocks OD; Otten G; Ratcliff M; Smith GR; Dunlop EA; Passos JF; Davies OR; Jaenisch R et al.
Source: Self-asserted source
Owen Davies via Europe PubMed Central

CtIP tetramer assembly is required for DNA-end resection and repair.

2015-02 | Journal article
DOI: 10.1038/nsmb.2937
PMID: 25558984
PMC: PMC4564947
Contributors: Davies OR; Forment JV; Sun M; Belotserkovskaya R; Coates J; Galanty Y; Demir M; Morton CR; Rzechorzek NJ; Jackson SP et al.
Source: Self-asserted source
Owen Davies via Europe PubMed Central
grade
Preferred source (of 2)‎

A molecular model for the role of SYCP3 in meiotic chromosome organisation.

2014 | Journal article
DOI: 10.7554/eLife.02963
PMID: 24950965
PMC: PMC4102245
Contributors: Syrjänen JL; Pellegrini L; Davies OR
Source: Self-asserted source
Owen Davies via Europe PubMed Central
grade
Preferred source (of 2)‎

Tcf15 primes pluripotent cells for differentiation.

2013-02 | Journal article
DOI:

10.1016/j.celrep.2013.01.017

PMID:

23395635

PMC:

PMC3607254
Contributors: Davies OR; Lin CY; Radzisheuskaya A; Zhou X; Taube J; Blin G; Waterhouse A; Smith AJ; Lowell S
Source: Self-asserted source
Owen Davies via Europe PubMed Central

Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly.

2012-07 | Journal article
DOI:

10.1098/rsob.120099

PMID:

22870393

PMC:

PMC3411106
Contributors: Davies OR; Maman JD; Pellegrini L
Source: Self-asserted source
Owen Davies via Europe PubMed Central

Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition.

2010-05 | Journal article
DOI:

10.1074/jbc.M109.082016

PMID:

20220147

PMC:

PMC2863239
Contributors: D'Arcy S; Davies OR; Blundell TL; Bolanos-Garcia VM
Source: Self-asserted source
Owen Davies via Europe PubMed Central

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ.

2008-01 | Journal article
DOI:

10.1038/sj.emboj.7601942

PMID:

18046455

PMC:

PMC2104711
Contributors: Li Y; Chirgadze DY; Bolanos-Garcia VM; Sibanda BL; Davies OR; Ahnesorg P; Jackson SP; Blundell TL
Source: Self-asserted source
Owen Davies via Europe PubMed Central

Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats.

2007-06 | Journal article
DOI:

10.1038/nsmb1251

PMID:

17515903

PMC:

PMC2096194
Contributors: Davies OR; Pellegrini L
Source: Self-asserted source
Owen Davies via Europe PubMed Central
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Page 1 of 2

Peer review (11 reviews for 7 publications/grants)

Review activity for EMBO journal. (3)
Review activity for EMBO reports. (1)
Review activity for Nature chemical biology. (1)
Review activity for Nature communications (3)
Review activity for Nature structural & molecular biology. (1)
Review activity for Review Commons (1)
Review activity for Science advances. (1)
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