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Keywords

Flavivirus, Zika virus, Vaccine

Countries

China

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Employment (3)

Wuhan Institute Of Virology: Wuhan, CN

2019-12-17 to present | PI
Employment
Source: Self-asserted source
Chao Shan

University of Texas Medical Branch: TX, TX, US

2015-12-08 to 2019-12-15 | Postdoctoral Fellow (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Chao Shan

Novartis Institute for Tropical Diseases: Singapore, Singapore, SG

2013-04-13 to 2015-09-13 | Visiting Scientist (Disease Biology)
Employment
Source: Self-asserted source
Chao Shan

Education and qualifications (3)

University of Chinese Academy of Sciences: Beijing, CN

2010-09-01 to 2014-06-30 | Ph.D. /Biochemistry and Molecular Biology (Wuhan Institute of Virology, Chinese Academy of Sciences)
Education
Source: Self-asserted source
Chao Shan

Fujian Agriculture and Forestry University: Fuzhou, Fujian, CN

2007-09-01 to 2010-06-30 | M.S. /Microbiology ( College of Life Sciences)
Education
Source: Self-asserted source
Chao Shan

Qingdao Agricultural University: Qingdao, Shandong, CN

2003-09-01 to 2007-06-30 | B.S. /Biology (College of Life Sciences )
Education
Source: Self-asserted source
Chao Shan

Works (49)

AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity

Nature Communications
2024-11-06 | Journal article
DOI: 10.1038/s41467-024-54010-w
Contributors: Linliang Zhang; Hongyun Wang; Chao Han; Qi Dong; Jie Yan; Weiwei Guo; Chao Shan; Wen Zhao; Pu Chen; Rui Huang et al.
Source: check_circle
Crossref

Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic target

2024-01-18 | Preprint
DOI: 10.21203/rs.3.rs-3812840/v1
Contributors: Yun-Jia Ning; Cunhuan Zhang; Yuan-Qin Min; Heng Xue; Kunpeng Liu; Yichao Tian; Ziying Yang; Zihan Zhao; Hang Yang; Chao Shan et al.
Source: check_circle
Crossref

Japanese Encephalitis Vaccine Generates Cross-Reactive Memory T Cell Responses to Zika Virus in Humans

Journal of Tropical Medicine
2022-11-19 | Journal article
DOI: 10.1155/2022/8379286
Contributors: Ran Wang; Meng Zhang; Linlin Zhang; Mengjia Liu; Chao Shan; Jing An; Zhengde Xie; Maoshui Wang
Source: check_circle
Crossref

RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy

Nature Communications
2022-10-12 | Journal article
DOI: 10.1038/s41467-022-33805-9
Contributors: Jing Zhang; Bin Wang; Xiaoxiao Gao; Cheng Peng; Chao Shan; Silas F. Johnson; Richard C. Schwartz; Yong-Hui Zheng
Source: check_circle
Crossref

A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host

Proceedings of the National Academy of Sciences
2021-10-19 | Journal article
DOI: 10.1073/pnas.2113015118
Contributors: Xi Yu; Chao Shan; Yibin Zhu; Enhao Ma; Jinglin Wang; Penghua Wang; Pei-Yong Shi; Gong Cheng
Source: check_circle
Crossref

Reporter Virus Neutralization Test Evaluation for Dengue and Zika Virus Diagnosis in Flavivirus Endemic Area

Pathogens
2021-07-03 | Journal article
DOI: 10.3390/pathogens10070840
Contributors: Jannyce G. C. Nunes; Bruno T. D. Nunes; Chao Shan; Adriana F. Moraes; Tais R. Silva; Maria H. R. de Mendonça; Liliane L. das Chagas; Franco A. e Silva; Raimunda S. S. Azevedo; Eliana V. P. da Silva et al.
Source: check_circle
Crossref
grade
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Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells

PLOS Neglected Tropical Diseases
2021-03-03 | Journal article
DOI: 10.1371/journal.pntd.0009183
Contributors: Pei Xu; Gregory Gromowski; Junling Gao; Chao Shan; Tiffany J. Dunn; Xuping Xie; Hongjie Xia; Jing Zou; Beatriz H. Thames; Amulya Sajja et al.
Source: check_circle
Crossref

Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade

JCI Insight
2021-01-11 | Journal article
DOI: 10.1172/jci.insight.144619
Contributors: Sharmila Nair; Luciano Mazzoccoli; Arijita Jash; Jennifer Govero; Sachendra S. Bais; Tong Hu; Camila R. Fontes-Garfias; Chao Shan; Hideho Okada; Sujan Shresta et al.
Source: check_circle
Crossref

Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

Nature Communications
2020-11-13 | Journal article
DOI: 10.1038/s41467-020-19568-1
Contributors: Shuang Wang; Yun Peng; Rongjuan Wang; Shasha Jiao; Min Wang; Weijin Huang; Chao Shan; Wen Jiang; Zepeng Li; Chunying Gu et al.
Source: check_circle
Crossref

Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

Nature
2020-09-17 | Journal article
DOI: 10.1038/s41586-020-2457-8
Contributors: Maria I. Giraldo; Hongjie Xia; Leopoldo Aguilera-Aguirre; Adam Hage; Sarah van Tol; Chao Shan; Xuping Xie; Gail L. Sturdevant; Shelly J. Robertson; Kristin L. McNally et al.
Source: check_circle
Crossref

An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques

Nature Communications
2020-08-21 | Journal article
DOI: 10.1038/s41467-020-18077-5
Contributors: Liqiang Feng; Qian Wang; Chao Shan; Chenchen Yang; Ying Feng; Jia Wu; Xiaolin Liu; Yiwu Zhou; Rendi Jiang; Peiyu Hu et al.
Source: check_circle
Crossref

A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission

Proceedings of the National Academy of Sciences
2020-08-18 | Journal article
DOI: 10.1073/pnas.2005722117
Contributors: Chao Shan; Hongjie Xia; Sherry L. Haller; Sasha R. Azar; Yang Liu; Jianying Liu; Antonio E. Muruato; Rubing Chen; Shannan L. Rossi; Maki Wakamiya et al.
Source: check_circle
Crossref

Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection

Journal of Virology
2020-08-17 | Journal article
DOI: 10.1128/JVI.00048-20
Contributors: Anzhong Li; Miaoge Xue; Zayed Attia; Jingyou Yu; Mijia Lu; Chao Shan; Xueya Liang; Thomas Z. Gao; Pei-Yong Shi; Mark E. Peeples et al.
Source: check_circle
Crossref

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

Cell Research
2020-08-07 | Journal article
DOI: 10.1038/s41422-020-0364-z
Contributors: Chao Shan; Yan-Feng Yao; Xing-Lou Yang; Yi-Wu Zhou; Ge Gao; Yun Peng; Lian Yang; Xue Hu; Jin Xiong; Ren-Di Jiang et al.
Source: check_circle
Crossref

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

Nature
2020-08-06 | Journal article
DOI: 10.1038/s41586-020-2381-y
Contributors: Rui Shi; Chao Shan; Xiaomin Duan; Zhihai Chen; Peipei Liu; Jinwen Song; Tao Song; Xiaoshan Bi; Chao Han; Lianao Wu et al.
Source: check_circle
Crossref

Maternal vaccination and protective immunity against Zika virus vertical transmission

Nature Communications
2019-12-12 | Journal article
DOI: 10.1038/s41467-019-13589-1
Contributors: Chao Shan; Xuping Xie; Huanle Luo; Antonio E. Muruato; Yang Liu; Maki Wakamiya; Jun-Ho La; Jin Mo Chung; Scott C. Weaver; Tian Wang et al.
Source: check_circle
Crossref

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

npj Vaccines
2019-11-28 | Journal article
DOI: 10.1038/s41541-019-0143-3
Contributors: Guangyu Li; Awadalkareem Adam; Huanle Luo; Chao Shan; Zengguo Cao; Camila R. Fontes-Garfias; Vanessa V. Sarathy; Cody Teleki; Evandro R. Winkelmann; Yuejin Liang et al.
Source: check_circle
Crossref

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

PLOS Pathogens
2019-09-19 | Journal article
DOI: 10.1371/journal.ppat.1007996
Contributors: Xin-Ni Lim; Glenn Randall; Chao Shan; Jan K. Marzinek; Hongping Dong; Thiam Seng Ng; Justin S. G. Ooi; Guntur Fibriansah; Jiaqi Wang; Chandra S. Verma et al.
Source: check_circle
Crossref

Erratum for Chen et al., “Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate”

mBio
2019-04-30 | Journal article
DOI: 10.1128/mBio.00433-19
Contributors: Qi Chen; Jin Wu; Qing Ye; Feng Ma; Qian Zhu; Yan Wu; Chao Shan; Xuping Xie; Dapei Li; Xiaoyan Zhan et al.
Source: check_circle
Crossref

Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

eLife
2018-12-04 | Journal article
DOI: 10.7554/eLife.39023
Contributors: Ruben Soto-Acosta; Xuping Xie; Chao Shan; Coleman K Baker; Pei-Yong Shi; Shannan L Rossi; Mariano A Garcia-Blanco; Shelton Bradrick
Source: check_circle
Crossref

Using a Virion Assembly-Defective Dengue Virus as a Vaccine Approach

Journal of Virology
2018-11 | Journal article
DOI: 10.1128/JVI.01002-18
Contributors: Chao Shan; Xuping Xie; Jing Zou; Roland Züst; Bo Zhang; Rebecca Ambrose; Jason Mackenzie; Katja Fink; Pei-Yong Shi; Julie K. Pfeiffer
Source: check_circle
Crossref

Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate

mBio
2018-11-07 | Journal article
DOI: 10.1128/mBio.01683-18
Contributors: Qi Chen; Jin Wu; Qing Ye; Feng Ma; Qian Zhu; Yan Wu; Chao Shan; Xuping Xie; Dapei Li; Xiaoyan Zhan et al.
Source: check_circle
Crossref

A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

Nature Communications
2018-08-03 | Journal article
DOI: 10.1038/s41467-018-05276-4
Contributors: Anzhong Li; Jingyou Yu; Mijia Lu; Yuanmei Ma; Zayed Attia; Chao Shan; Miaoge Xue; Xueya Liang; Kelsey Craig; Nirajkumar Makadiya et al.
Source: check_circle
Crossref

A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

EBioMedicine
2017 | Journal article
Source: Self-asserted source
Chao Shan

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

Nature Medicine
2017 | Journal article
Source: Self-asserted source
Chao Shan

A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients

EBioMedicine
2017 | Journal article
Source: Self-asserted source
Chao Shan

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

Nature Communications
2017 | Journal article
Source: Self-asserted source
Chao Shan

Correction: Zika virus has oncolytic activity against glioblastoma stem cells

The Journal of experimental medicine
2017 | Journal article
Source: Self-asserted source
Chao Shan

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

PLoS pathogens
2017 | Journal article
Source: Self-asserted source
Chao Shan

Evaluation of a Novel Reporter Virus Neutralization Test for the Serological Diagnosis of Zika and Dengue Virus Infection

Journal of clinical microbiology
2017 | Journal article
Source: Self-asserted source
Chao Shan

Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

Nature
2017 | Journal article
Source: Self-asserted source
Chao Shan

Functional Analysis of Glycosylation of Zika Virus Envelope Protein

Cell Reports
2017 | Journal article
Source: Self-asserted source
Chao Shan

Reverse Genetics of Zika Virus

Reverse Genetics of RNA Viruses: Methods and Protocols
2017 | Journal article
Source: Self-asserted source
Chao Shan

Understanding Zika virus stability and developing a chimeric vaccine through functional analysis

MBio
2017 | Journal article
Source: Self-asserted source
Chao Shan

Vaccine mediated protection against zika virus-induced congenital disease

Cell
2017 | Journal article
Source: Self-asserted source
Chao Shan

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Antiviral Research
2017 | Journal article
Source: Self-asserted source
Chao Shan

Zika virus has oncolytic activity against glioblastoma stem cells

Journal of Experimental Medicine
2017 | Journal article
Source: Self-asserted source
Chao Shan

An infectious cDNA clone of Zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors

Cell host & microbe
2016 | Journal article
Source: Self-asserted source
Chao Shan

Generation of a recombinant West Nile virus stably expressing the Gaussia luciferase for neutralization assay

Virus research
2016 | Journal article
Source: Self-asserted source
Chao Shan

Restriction of zika virus by host innate immunity

Cell host & microbe
2016 | Journal article
Source: Self-asserted source
Chao Shan

Zika virus replicons for drug discovery

EBioMedicine
2016 | Journal article
Source: Self-asserted source
Chao Shan

Zika virus: diagnosis, therapeutics, and vaccine

ACS infectious diseases
2016 | Journal article
Source: Self-asserted source
Chao Shan

Development of a stable Gaussia luciferase enterovirus 71 reporter virus

Journal of virological methods
2015 | Journal article
Source: Self-asserted source
Chao Shan

Discovery of dengue virus NS4B inhibitors

Journal of virology
2015 | Journal article
Source: Self-asserted source
Chao Shan

Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A

Journal of General Virology
2014 | Journal article
Source: Self-asserted source
Chao Shan

The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication

PLoS neglected tropical diseases
2014 | Journal article
Source: Self-asserted source
Chao Shan

Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation

Journal of virology
2013 | Journal article
Source: Self-asserted source
Chao Shan

Development and characterization of West Nile virus replicon expressing secreted Gaussia luciferase

Virologica Sinica
2013 | Journal article
Source: Self-asserted source
Chao Shan

Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase

Journal of virology
2012 | Journal article
Source: Self-asserted source
Chao Shan

Peer review (1 review for 1 publication/grant)

Review activity for Biosafety and health. (1)
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