Personal information

Keywords

biopharmaceutics, inhalation, pharmacokinetic, drug absorption

Countries

Sweden

Activities

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Employment (2)

AstraZeneca R and D Gothenburg: Gothenburg, SE

2014-11-01 to present | Senior Scientist in Biopharmaceutics (Pharmaceutical Technology & Development)
Employment
Source: Self-asserted source
Helena Thörn

Dfind Science & Engineering: Gothenburg, SE

2013-02-01 to 2014-10-31 | Consultant @ AstraZeneca R&D Molndal
Employment
Source: Self-asserted source
Helena Thörn

Education and qualifications (2)

Uppsala Universitet Farmaceutiska fakulteten: Uppsala, SE

2006-02-01 to 2012-02-24 | PhD in Biopharmaceutics (Department of Pharmacy)
Education
Source: Self-asserted source
Helena Thörn

Uppsala Universitet Farmaceutiska fakulteten: Uppsala, SE

2001-09-01 to 2006-01-31 | Master of Pharmacy, licensed pharmacist
Education
Source: Self-asserted source
Helena Thörn

Works (7)

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results.

2016-11 | Journal article
DOI: 10.1016/j.ejps.2016.10.036
PMID: 27816631
Contributors: Margolskee A; Darwich AS; Pepin X; Aarons L; Galetin A; Rostami-Hodjegan A; Carlert S; Hammarberg M; Hilgendorf C; Johansson P et al.
Source: Self-asserted source
Helena Thörn via Europe PubMed Central

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes.

2016-09 | Journal article
DOI: 10.1016/j.ejps.2016.09.037
PMID: 27693299
Contributors: Darwich AS; Margolskee A; Pepin X; Aarons L; Galetin A; Rostami-Hodjegan A; Carlert S; Hammarberg M; Hilgendorf C; Johansson P et al.
Source: Self-asserted source
Helena Thörn via Europe PubMed Central

In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models.

2016-06 | Journal article
DOI: 10.1021/acs.molpharmaceut.5b00861
PMID: 26926043
Contributors: Sjögren E; Thörn H; Tannergren C
Source: Self-asserted source
Helena Thörn via Europe PubMed Central

Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo.

2012-11 | Journal article
DOI: 10.1021/mp3000875
PMID: 23009633
Contributors: Thörn HA; Sjögren E; Dickinson PA; Lennernäs H
Source: Self-asserted source
Helena Thörn via Europe PubMed Central

Extensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery.

2012-09 | Journal article
DOI: 10.3109/00498254.2012.683497
PMID: 22559211
Contributors: Thörn HA; Yasin M; Dickinson PA; Lennernäs H
Source: Self-asserted source
Helena Thörn via Europe PubMed Central

Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans.

2011-06 | Journal article
DOI: 10.1016/j.ejps.2011.03.008
PMID: 21447389
Contributors: Thörn HA; Lundahl A; Schrickx JA; Dickinson PA; Lennernäs H
Source: Self-asserted source
Helena Thörn via Europe PubMed Central

Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions.

2009-11 | Journal article
DOI: 10.1124/dmd.109.028027
PMID: 19687151
Contributors: Thörn HA; Hedeland M; Bondesson U; Knutson L; Yasin M; Dickinson P; Lennernäs H
Source: Self-asserted source
Helena Thörn via Europe PubMed Central
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