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Other IDs

ResearcherID: N-2304-2014
Loop profile: 605504
Scopus Author ID: 26026883900
ResearcherID: N-2304-2014
SciProfiles: 3374528

Keywords

Immunology, T cells, T cell memory, Tissue-resident memory T cells, Vaccines, Malaria, Infectious diseases, Preclinical models of infection

Countries

Australia

Activities

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Employment (2)

UNSW Sydney: Sydney, AU

2023-11-06 to present | Senior Research Fellow (Molecular Medicine)
Employment
Source: Self-asserted source
Daniel Fernández Ruiz

The University of Melbourne: Melbourne, VIC, AU

2008-11-17 to 2023-11-05 | Research Officer (Peter Doherty Institute)
Employment
Source: Self-asserted source
Daniel Fernández Ruiz

Education and qualifications (3)

Rheinische Friedrich Wilhelms Universitat Bonn: Bonn, Nordrhein-Westfalen, DE

2004 to 2008-08 | PhD
Education
Source: Self-asserted source
Daniel Fernández Ruiz

Universidad de Oviedo: Oviedo, Asturias, ES

2001 to 2003 | Bachelor in Biochemistry
Education
Source: Self-asserted source
Daniel Fernández Ruiz

Universidad de Oviedo: Oviedo, Asturias, ES

1997 to 2001 | Bachelor in Biology
Education
Source: Self-asserted source
Daniel Fernández Ruiz

Funding (5)

Adaptive immune cell mediated protection in the eye

2023-01 to 2023-12 | Award
University of Melbourne (VIC, VIC, AU)
Source: Self-asserted source
Daniel Fernández Ruiz

Harnessing tissue resident memory for efficient vaccines

2023-01 to 2023-12 | Grant
Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne (Melbourne, VIC, AU)
Source: Self-asserted source
Daniel Fernández Ruiz

Understanding the diverse biology of CD4+ T cell resident memory

2022-01-01 to 2025-12-31 | Grant
Australian Research Council (Canberra, AU)
URL: https://app.dimensions.ai/details/grant/grant.10008001
GRANT_NUMBER: DP220103545
Source: Self-asserted source
Daniel Fernández Ruiz via DimensionsWizard

Identifying key targets for novel, highly efficient malaria vaccines

2020-01 to 2020-12 | Grant
Cass Foundation (VIC, VIC, AU)
GRANT_NUMBER:

9188
Source: Self-asserted source
Daniel Fernández Ruiz

Protecting against malaria through liver resident memory T cells

2018-01 to 2021-12 | Grant
National Health and Medical Research Council (ACT, ACT, AU)
GRANT_NUMBER:

APP1139486
Source: Self-asserted source
Daniel Fernández Ruiz

Works (35)

Systemic inflammatory response syndrome triggered by blood-borne pathogens induces prolonged dendritic cell paralysis and immunosuppression

Cell Reports
2024-02-13 | Journal article
DOI: 10.1016/j.celrep.2024.113754
Part of ISSN: 2211-1247
Contributors: Mitra Ashayeripanah; Javier Vega-Ramos; Daniel Fernandez-Ruiz; Shirin Valikhani; Aaron T.L. Lun; Jason T. White; Louise J. Young; Atefeh Yaftiyan; Yifan Zhan; Linda Wakim et al.
Source: Self-asserted source
Daniel Fernández Ruiz

Human Nasal Epithelium Organoids for Assessing Neutralizing Antibodies to a Protective SARS-CoV-2 Virus-like Particle Vaccine

Organoids
2024-02-01 | Journal article
DOI: 10.3390/organoids3010002
Contributors: Julio Carrera Montoya; Simon Collett; Daniel Fernandez Ruiz; Linda Earnest; Melissa A. Edeling; Ashley Huey Yiing Yap; Chinn Yi Wong; James P. Cooney; Kathryn C. Davidson; Jason Roberts et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver T<sub>RM</sub> cells

Vaccine
2023 | Journal article
DOI: 10.1016/j.vaccine.2022.12.047
EID:

2-s2.0-85147204285

Part of ISSN: 18732518 0264410X
Contributors: Valencia-Hernandez, A.M.; Zillinger, T.; Ge, Z.; Tan, P.S.; Cozijnsen, A.; I. McFadden, G.; Lahoud, M.H.; Caminschi, I.; Barchet, W.; Heath, W.R. et al.
Source: Self-asserted source
Daniel Fernández Ruiz via Scopus - Elsevier

Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis

Immunity
2023 | Journal article
DOI: 10.1016/j.immuni.2023.01.031
EID:

2-s2.0-85149871270

Part of ISSN: 10974180 10747613
Contributors: Chora, Â.F.; Marques, S.; Gonçalves, J.L.; Lima, P.; Gomes da Costa, D.; Fernandez-Ruiz, D.; Marreiros, M.I.; Ruivo, P.; Carvalho, T.; Ribeiro, R.M. et al.
Source: Self-asserted source
Daniel Fernández Ruiz via Scopus - Elsevier

mRNA vaccine against malaria tailored for liver-resident memory T cells

Nature Immunology
2023-09 | Journal article | Author
DOI: 10.1038/s41590-023-01562-6
Part of ISSN: 1529-2908
Part of ISSN: 1529-2916
Contributors: Mitch Ganley; Lauren Holz; Jordan Minnell; Maria N. de Menezes; Olivia Burn; Kean Chan Yew Poa; Sarah Draper; Kieran English; Susanna T. S. Chan; Regan J. Anderson et al.
Source: Self-asserted source
Daniel Fernández Ruiz

Type I interferon production elicits differential CD4<sup>+</sup>T-cell responses in mice infected with Plasmodium berghei ANKA and P. chabaudi

International Immunology
2022 | Journal article
DOI: 10.1093/intimm/dxab090
EID:

2-s2.0-85123025482

Part of ISSN: 14602377 09538178
Contributors: Ntita, M.; Inoue, S.-I.; Jian, J.-Y.; Bayarsaikhan, G.; Kimura, K.; Kimura, D.; Miyakoda, M.; Nozaki, E.; Sakurai, T.; Fernandez-Ruiz, D. et al.
Source: Self-asserted source
Daniel Fernández Ruiz via Scopus - Elsevier

The Batman and Robin of liver-stage immunity to malaria

Trends in Parasitology
2022-01 | Journal article
DOI: 10.1016/j.pt.2021.11.002
Contributors: William R. Heath; Lauren E. Holz; Daniel Fernandez-Ruiz
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

CD49d marks Th1 and Tfh-like antigen-specific CD4<sup>+</sup>T cells during Plasmodium chabaudi infection

International Immunology
2021 | Journal article
DOI: 10.1093/intimm/dxab020
EID:

2-s2.0-85112134574

Part of ISSN: 14602377 09538178
Contributors: Jian, J.-Y.; Inoue, S.-I.; Bayarsaikhan, G.; Miyakoda, M.; Kimura, D.; Kimura, K.; Nozaki, E.; Sakurai, T.; Fernandez-Ruiz, D.; Heath, W.R. et al.
Source: Self-asserted source
Daniel Fernández Ruiz via Scopus - Elsevier

Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity

Cell Reports
2021 | Journal article
DOI: 10.1016/j.celrep.2021.109586
EID:

2-s2.0-85113408400

Part of ISSN: 22111247
Contributors: Pack, A.D.; Schwartzhoff, P.V.; Zacharias, Z.R.; Fernandez-Ruiz, D.; Heath, W.R.; Gurung, P.; Legge, K.L.; Janse, C.J.; Butler, N.S.
Source: Self-asserted source
Daniel Fernández Ruiz via Scopus - Elsevier

Plasmodium berghei Hsp90 contains a natural immunogenic I-A<sup>b</sup>-restricted antigen common to rodent and human Plasmodium species

Current Research in Immunology
2021 | Journal article
DOI: 10.1016/j.crimmu.2021.06.002
EID:

2-s2.0-85132258125

Part of ISSN: 25902555
Contributors: Enders, M.H.; Bayarsaikhan, G.; Ghilas, S.; Chua, Y.C.; May, R.; de Menezes, M.N.; Ge, Z.; Tan, P.S.; Cozijnsen, A.; Mollard, V. et al.
Source: Self-asserted source
Daniel Fernández Ruiz via Scopus - Elsevier

Elucidating the Motif for CpG Oligonucleotide Binding to the Dendritic Cell Receptor DEC-205 Leads to Improved Adjuvants for Liver-Resident Memory

The Journal of Immunology
2021-10-01 | Journal article
DOI: 10.4049/jimmunol.2001153
Contributors: Jessica Li; Fatma Panetta; Meredith O’Keeffe; Ingrid M Leal Rojas; Kristen J Radford; Jian-Guo Zhang; Daniel Fernandez-Ruiz; Gayle M Davey; Benjamin S Gully; Kirsteen M Tullett et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

CD8+ and CD4+ T Cells Infiltrate into the Brain during Plasmodium berghei ANKA Infection and Form Long-Term Resident Memory

The Journal of Immunology
2021-09-15 | Journal article
DOI: 10.4049/jimmunol.2000773
Contributors: Nazanin Ghazanfari; Julia L Gregory; Sapna Devi; Daniel Fernandez-Ruiz; Lynette Beattie; Scott N Mueller; William R Heath
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Harnessing liver-resident memory T cells for protection against malaria.

Expert review of vaccines
2021-02-07 | Journal article
DOI: 10.1080/14760584.2021.1881485
PMID: 33501877
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 2)‎

Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity.

PLoS pathogens
2021-02-02 | Journal article
DOI: 10.1371/journal.ppat.1009288
PMID: 33529242
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 2)‎

Development of Plasmodium-specific liver-resident memory CD8+ T cells after heat-killed sporozoite immunization in mice.

European journal of immunology
2021-01-23 | Journal article
DOI: 10.1002/eji.202048757
PMID: 33486759
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 2)‎

Resident Memory T Cells and Their Role within the Liver.

International journal of molecular sciences
2020-11-13 | Journal article
DOI: 10.3390/ijms21228565
PMID: 33202970
PMC: PMC7696659
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 2)‎

Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination.

Journal of immunology (Baltimore, Md. : 1950)
2020-08-24 | Journal article
DOI: 10.4049/jimmunol.2000549
PMID: 32839238
PMC: PMC7504891
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria.

Science immunology
2020-06-01 | Journal article
DOI: 10.1126/sciimmunol.aaz8035
PMID: 32591409
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver Trm Cell-Mediated Immunity against Malaria in Mice.

Cell host & microbe
2020-05-11 | Journal article
DOI: 10.1016/j.chom.2020.04.010
PMID: 32396839
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.

Immunity
2019-07-01 | Journal article
DOI: 10.1016/j.immuni.2019.06.002
PMID: 31272808
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 2)‎

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver.

Cell reports
2018-10-01 | Journal article
DOI: 10.1016/j.celrep.2018.08.094
PMID: 30282039
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

Optimal protection against Salmonella infection requires noncirculating memory.

Proceedings of the National Academy of Sciences of the United States of America
2018-09-25 | Journal article
DOI: 10.1073/pnas.1808339115
PMID: 30254173
PMC: PMC6187142
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection.

Journal of immunology (Baltimore, Md. : 1950)
2018-01-10 | Journal article
DOI: 10.4049/jimmunol.1700782
PMID: 29321276
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

Development of a Novel CD4+ TCR Transgenic Line that Reveals a Dominant Role for CD8+ DC and CD40-Signaling in the Generation of Helper and CTL Responses to Blood Stage Malaria

bioRxiv
2017 | Other
DOI: 10.1101/113837
EID:

2-s2.0-85095616995

Part of ISSN: 26928205
Contributors: Fernandez-Ruiz, D.; Lau, L.S.; Ghazanfari, N.; Jones, C.M.; Ng, W.Y.; Davey, G.M.; Berthold, D.; Holz, L.; Kato, Y.; Bayarsaikhan, G. et al.
Source: Self-asserted source
Daniel Fernández Ruiz via Scopus - Elsevier

Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria.

Journal of immunology (Baltimore, Md. : 1950)
2017-10-30 | Journal article
DOI: 10.4049/jimmunol.1700186
PMID: 29084838
PMC: PMC5713497
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.

Science immunology
2017-03-01 | Journal article
DOI: 10.1126/sciimmunol.aal2192
PMID: 28345074
PMC: PMC5365145
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

Protective immunity to liver-stage malaria.

Clinical & translational immunology
2016-10-21 | Journal article
DOI: 10.1038/cti.2016.60
PMID: 27867517
PMC: PMC5099428
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 4)‎

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

Immunity
2016-09-27 | Journal article
DOI: 10.1016/j.immuni.2016.08.011
PMID: 27692609
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 5)‎

Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation.

Genome biology
2016-05-12 | Journal article
DOI: 10.1186/s13059-016-0957-5
PMID: 27176874
PMC: PMC4866375
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 5)‎

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria.

PLoS pathogens
2014-05-22 | Journal article
DOI: 10.1371/journal.ppat.1004135
PMID: 24854165
PMC: PMC4031232
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells.

Nature immunology
2012-01-08 | Journal article
DOI: 10.1038/ni.2195
PMID: 22231517
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

Blood-stage Plasmodium berghei infection generates a potent, specific CD8+ T-cell response despite residence largely in cells lacking MHC I processing machinery.

The Journal of infectious diseases
2011-10-13 | Journal article
DOI: 10.1093/infdis/jir656
PMID: 21998471
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.

Journal of immunology (Baltimore, Md. : 1950)
2011-06-27 | Journal article
DOI: 10.4049/jimmunol.1001670
PMID: 21709155
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

Filaria-induced IL-10 suppresses murine cerebral malaria.

Microbes and infection
2010-04-24 | Journal article
DOI: 10.1016/j.micinf.2010.04.006
PMID: 20420933
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

Filarial infection induces protection against P. berghei liver stages in mice.

Microbes and infection
2008-11-19 | Journal article
DOI: 10.1016/j.micinf.2008.11.003
PMID: 19049828
Source: Self-asserted source
Daniel Fernández Ruiz
grade
Preferred source (of 3)‎

Peer review (4 reviews for 4 publications/grants)

Review activity for Heliyon. (1)
Review activity for Nature communications (1)
Review activity for PLoS biology. (1)
Review activity for PloS one. (1)
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