Personal information

Verified email domains

Organic Chemistry, Biochemistry, Serodiagnostics, Chemical Biology, Vaccines, Natural Products
Germany

Biography

I studied biomedical chemistry at the Johannes Gutenberg University in Mainz, Germany. During my diploma thesis, which was supervised by Prof. Horst Kunz, I worked on gold catalyzed glycosylations.
Afterwards, I carried out my PhD studies at the Max Planck Institute for Colloids and Interfaces and the Free University of Berlin in the Group of Prof. Peter H. Seeberger. For my work in carbohydrate chemistry and vaccine development I was honored with the 2014 Otto Hahn Medal.
Intrigued to learn more about infection biology and microorganisms I joined the lab of Pierre Stallforth at the Leibniz Institute for Natural Product Research and Infection Biology (Hans Knöll Institute/HKI) to investigate the relationship of bacteria and amoeba on a chemical and genetic level.
After learning much about antibiotics, I also wanted to become acquainted with medicinal and pharmaceutical chemistry to better understand the drug development process. Therefore, I moved to Kyoto University and became a JSPS fellow in the group of Prof. Motonari Uesugi developing small molecules for cell biology.
Afterwards I coordinated grant applications as a scientific consultant at the University Koblenz·Landau and became acquainted with science management.
In 2020 I rejoined the HKI as a senior scientist to conduct and manage a research project in biotechnology and anti-infectives. This exciting project aimed at finding and developing new natural products to combat infectious diseases or to protect crops from pests.
Since the end of 2023 I am a member of the HIPS in Saarbrücken investigating microbial communities for their biosynthetic potential and trying to develop new APIs for different diseases.

Activities

Employment (7)

The Helmholtz Institute for Pharmaceutical Research Saarland (HIPS): Saarbrücken, DE

2024 to present | Senior Scientist (ANTI-INFECTIVES FROM MICROBIOTA)
Employment
Source: Self-asserted source
Sebastian Götze

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie eV Hans-Knöll-Institut: Jena, Thüringen, DE

2020 to 2023 | Senior Scientist (Department of Paleobiotechnology)
Employment
Source: Self-asserted source
Sebastian Götze

Universität Koblenz-Landau: Landau, Rheinland-Pfalz, DE

2018 to 2019 | Research Consultant (Faculty 7: Natural and Environmental Sciences)
Employment
Source: Self-asserted source
Sebastian Götze

Kyoto University, Uesugi Laboratory: Kyoto, JP

2016 to 2017 | Research Associate (Institute for Integrated Cell-Material Sciences / Institute for Chemical Research)
Employment
Source: Self-asserted source
Sebastian Götze

Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI): Jena, Thüringen, DE

2014 to 2016 | PostDoc (Chemistry of Microbial Communication / Group of Dr. Pierre Stallforth)
Employment
Source: Self-asserted source
Sebastian Götze

Max Planck Institute of Colloids and Interfaces: Potsdam, Brandenburg, DE

2010 to 2014 | PhD student (Biomolecular Systems / Group of Prof. Peter H. Seeberger)
Employment
Source: Self-asserted source
Sebastian Götze

Johannes Gutenberg Universität Mainz: Mainz, Rheinland-Pfalz, DE

2009 to 2009 | Diploma student (Institute of Organic Chemistry / Group of Prof. Horst Kunz)
Employment
Source: Self-asserted source
Sebastian Götze

Education and qualifications (2)

Freie Universität Berlin: Berlin, Berlin, DE

2010 to 2014 | Dr. rer. nat. (Institute of Chemistry and Biochemistry)
Education
Source: Self-asserted source
Sebastian Götze

Johannes Gutenberg Universität Mainz: Mainz, Rheinland-Pfalz, DE

2005 to 2009 | Biomedical Chemistry (Diplom) (Institute of Organic Chemistry)
Education
Source: Self-asserted source
Sebastian Götze

Funding (7)

Medac Research Award 2020

2020 to 2020 | Award
medac GmbH (Wedel, DE)
Source: Self-asserted source
Sebastian Götze

Medac Research Award 2018

Source: Self-asserted source
Sebastian Götze

Chemical Biology of RNA G-Quadruplexes

2016-09 to 2017-03 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER:

16F16345

Source: Self-asserted source
Sebastian Götze

Medac Research Award 2016

2016 to 2016 | Award
medac GmbH (Wedel, DE)
Source: Self-asserted source
Sebastian Götze

Chemical Biology of RNA G-Quadruplexes

Salary award
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER:

P16345

Source: Self-asserted source
Sebastian Götze

ICS Madrid 2012

Grant
German Academic Exchange Service (Bonn, Nordrhein-Westfalen, DE)
Source: Self-asserted source
Sebastian Götze

Otto Hahn Medal

Award
Max-Planck-Gesellschaft (München, Bayern, DE)
Source: Self-asserted source
Sebastian Götze

Works (39)

Structure Revision of Halisphingosine A via Total Synthesis and Bioactivity Studies

Angewandte Chemie International Edition
2024-12-20 | Journal article
Contributors: Maria Sauer; Andreas M. Kany; Sebastian Götze; Rolf Müller; Christine Beemelmanns
Source: check_circle
Crossref

Strukturrevision von Halisphingosin A durch Totalsynthese und Bioaktivitätsstudien

Angewandte Chemie
2024-12-20 | Journal article
Contributors: Maria Sauer; Andreas M. Kany; Sebastian Götze; Rolf Müller; Christine Beemelmanns
Source: check_circle
Crossref

KEANUMYCINS AND USES THEREOF IN MEDICINE AND PLANT PROTECTION

2024-11-28 | Patent | Investigation
Contributors: Sebastian Götze
Source: Self-asserted source
Sebastian Götze

Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis

Angewandte Chemie International Edition
2024-06-03 | Journal article
Contributors: Dávid Roman; Philippe Meisinger; Richard Guillonneau; Chia‐Chi Peng; Lukas K. Peltner; Paul M. Jordan; Veit Haensch; Sebastian Götze; Oliver Werz; Christian Hertweck et al.
Source: check_circle
Crossref

Strukturrevision einer weit verbreiteten marinen Sulfonolipidklasse basierend auf deren Isolierung und Totalsynthese

Angewandte Chemie
2024-06-03 | Journal article
Contributors: Dávid Roman; Philippe Meisinger; Richard Guillonneau; Chia‐Chi Peng; Lukas K. Peltner; Paul M. Jordan; Veit Haensch; Sebastian Götze; Oliver Werz; Christian Hertweck et al.
Source: check_circle
Crossref

Nonribosomal peptides protect Pseudomonas nunensis 4A2e from amoebal and nematodal predation

Chemical Science
2023 | Journal article
Contributors: Sebastian Pflanze; Ruchira Mukherji; Anan Ibrahim; Markus Günther; Sebastian Götze; Somak Chowdhury; Lisa Reimer; Lars Regestein; Pierre Stallforth
Source: check_circle
Crossref

Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block

Journal of the American Chemical Society
2023-02-01 | Journal article
Contributors: Sebastian Götze; Raghav Vij; Katja Burow; Nicola Thome; Lennart Urbat; Nicolas Schlosser; Sebastian Pflanze; Rita Müller; Veit G. Hänsch; Kevin Schlabach et al.
Source: check_circle
Crossref

Tyrosine bioconjugation with hypervalent iodine

Chemical Science
2022 | Journal article
Contributors: Nina Declas; John R. J. Maynard; Laure Menin; Natalia Gasilova; Sebastian Götze; Jakob L. Sprague; Pierre Stallforth; Stefan Matile; Jerome Waser
Source: check_circle
Crossref

Tyrosine Bioconjugation with Hypervalent Iodine

ChemRxiv
2022-08-11 | Preprint
Contributors: Sebastian Götze
Source: Self-asserted source
Sebastian Götze

Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A

Chemistry – A European Journal
2022-04-06 | Journal article
Contributors: Yuko Bando; Yu Hou; Lydia Seyfarth; Jannik Probst; Sebastian Götze; Marta Bogacz; Ute A. Hellmich; Pierre Stallforth; Maria Mittag; Hans‐Dieter Arndt
Source: check_circle
Crossref

Structure elucidation of bacterial nonribosomal lipopeptides

Organic & Biomolecular Chemistry
2020 | Journal article
Contributors: Sebastian Götze; Pierre Stallforth
Source: check_circle
Crossref

Structure, properties, and biological functions of nonribosomal lipopeptides from pseudomonads

Natural Product Reports
2020 | Journal article
Contributors: Sebastian Götze; Pierre Stallforth
Source: check_circle
Crossref

Discovery of a Small Molecule-Dependent Photolytic Peptide

Journal of the American Chemical Society
2020-01-03 | Journal article
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Source: Self-asserted source
Sebastian Götze
grade
Preferred source (of 2)‎

Microbe-focused glycan array screening platform

Proceedings of the National Academy of Sciences
2019 | Journal article
Source: Self-asserted source
Sebastian Götze

Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases

Chemical Science
2019 | Journal article
Contributors: Sebastian Götze; Johannes Arp; Gerald Lackner; Shuaibing Zhang; Hajo Kries; Martin Klapper; María García-Altares; Karsten Willing; Markus Günther; Pierre Stallforth
Source: check_circle
Crossref

Bioactivity and Mode of Action of Bacterial Tetramic Acids

ACS Chemical Biology
2019-07-11 | Journal article
Part of ISSN: 1554-8929
Part of ISSN: 1554-8937
Source: Self-asserted source
Sebastian Götze

Synthesis, Liposomal Formulation, and Immunological Evaluation of a Minimalistic Carbohydrate-α-GalCer Vaccine Candidate

Journal of Medicinal Chemistry
2018-05-09 | Journal article
ARXIV:

https://doi.org/10.1021/acs.jmedchem.8b00312

Source: Self-asserted source
Sebastian Götze

Synergistic activity of cosecreted natural products from amoebae-associated bacteria

Proceedings of the National Academy of Sciences
2018-04-10 | Journal article
Contributors: Johannes Arp; Sebastian Götze; Ruchira Mukherji; Derek J. Mattern; María García-Altares; Martin Klapper; Debra A. Brock; Axel A. Brakhage; Joan E. Strassmann; David C. Queller et al.
Source: check_circle
Crossref

Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin

ACS Chemical Biology
2017-08-28 | Journal article
ARXIV:

http://dx.doi.org/10.1021/acschembio.7b00589

Source: Self-asserted source
Sebastian Götze

Lysinibacillus fusiformis M5 induces increased complexity in Bacillus subtilis 168 colony biofilms via hypoxanthine

Journal of Bacteriology
2017-06-05 | Journal article
Source: Self-asserted source
Sebastian Götze

Bacterial Alkaloids Prevent Amoebal Predation

Angewandte Chemie International Edition
2016-07-25 | Journal article
Contributors: Martin Klapper; Sebastian Götze; Robert Barnett; Karsten Willing; Pierre Stallforth
Source: check_circle
Crossref

Bacterial Alkaloids Prevent Amoebal Predation

Angewandte Chemie
2016-07-25 | Journal article
Contributors: Martin Klapper; Sebastian Götze; Robert Barnett; Karsten Willing; Pierre Stallforth
Source: check_circle
Crossref

Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides.

Chembiochem : a European journal of chemical biology
2015 | Journal article
WOSUID:

MEDLINE:25919894

Contributors: Hanashima, Shinya; Gotze, Sebastian; Liu, Yan; Ikeda, Akemi; Kojima-Aikawa, Kyoko; Taniguchi, Naoyuki; Varon Silva, Daniel; Feizi, Ten; Seeberger, Peter H; Yamaguchi, Yoshiki
Source: Self-asserted source
Sebastian Götze via ResearcherID

Investigation of the protective properties of glycosylphosphatidylinositol-based vaccine candidates in a Toxoplasma gondii mouse challenge model.

Glycobiology
2015 | Journal article
WOSUID:

MEDLINE:26044798

Contributors: Gotze, Sebastian; Reinhardt, Anika; Geissner, Andreas; Azzouz, Nahid; Tsai, Yu-Hsuan; Kurucz, Reka; Varon Silva, Daniel; Seeberger, Peter H
Source: Self-asserted source
Sebastian Götze via ResearcherID

The diagnostic targeting of a carbohydrate virulence factor from M.Tuberculosis.

Scientific reports
2015 | Journal article
WOSUID:

MEDLINE:25975873

Contributors: Chan, Conrad E; Gotze, Sebastian; Seah, Geok T; Seeberger, Peter H; Tukvadze, Nestan; Wenk, Markus R; Hanson, Brendon J; MacAry, Paul A
Source: Self-asserted source
Sebastian Götze via ResearcherID

Three Redundant Synthetases Secure Redox-Active Pigment Production in the Basidiomycete Paxillus involutus.

Chemistry & biology
2015 | Journal article
WOSUID:

MEDLINE:26496685

Contributors: Braesel, Jana; Gotze, Sebastian; Shah, Firoz; Heine, Daniel; Tauber, James; Hertweck, Christian; Tunlid, Anders; Stallforth, Pierre; Hoffmeister, Dirk
Source: Self-asserted source
Sebastian Götze via ResearcherID

Well-defined carbohydrate-based polymers in calcium carbonate crystallization: Influence of stereochemistry in the polymer side chain on polymorphism and morphology

European Polymer Journal
2015 | Journal article
WOSUID:

WOS:000359504800057

Contributors: Barz, Matthias; Goetze, Sebastian; Loges, Niklas; Schueler, Timo; Theato, Patrick; Tremel, Wolfgang; Zentel, Rudolf
Source: Self-asserted source
Sebastian Götze via ResearcherID

A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation

Journal of Controlled Release
2014 | Journal article
WOSUID:

WOS:000330121200005

Contributors: Maglinao, Maha; Eriksson, Magdalena; Schlegel, Mark K.; Zimmermann, Stephanie; Johannssen, Timo; Goetze, Sebastian; Seeberger, Peter H.; Lepenies, Bernd
Source: Self-asserted source
Sebastian Götze via ResearcherID

Diagnosis of Toxoplasmosis Using a Synthetic Glycosylphosphatidylinositol Glycan

Angewandte Chemie-International Edition
2014 | Journal article
WOSUID:

WOS:000345833100007

Contributors: Goetze, Sebastian; Azzouz, Nahid; Tsai, Yu-Hsuan; Gross, Uwe; Reinhardt, Anika; Anish, Chakkumkal; Seeberger, Peter H.; Silva, Daniel Varon
Source: Self-asserted source
Sebastian Götze via ResearcherID

Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites

Proceedings of the National Academy of Sciences of the United States of America
2014 | Journal article
WOSUID:

WOS:000336687900071

Contributors: Nonaka, Motohiro; Bao, Xingfeng; Matsumura, Fumiko; Goetze, Sebastian; Kandasamy, Jeyakumar; Kononov, Andrew; Broide, David H.; Nakayama, Jun; Seeberger, Peter H.; Fukuda, Minoru
Source: Self-asserted source
Sebastian Götze via ResearcherID

Toxoplasmose-Diagnose mithilfe eines synthetisch hergestellten Glycosylphosphatidylinositol-Glycans

Angewandte Chemie
2014 | Journal article
Source: Self-asserted source
Sebastian Götze

Synthesis of Parasite Related Carbohydrates and their Use as Probes for Glycobiology

Freie Universität Berlin
2014-03-31 | Dissertation or Thesis
Source: Self-asserted source
Sebastian Götze

Synthesis of diverse glycosylphosphatidylinositol glycans from toxoplasma gondii and their application as vaccines and diagnostics

2014-01-30 | Patent
PAT:

WO2014016317A1

Source: Self-asserted source
Sebastian Götze

A general and convergent synthesis of diverse glycosylphosphatidylinositol glycolipids

Chemical Science
2013 | Journal article
WOSUID:

WOS:000311971500056

Contributors: Tsai, Yu-Hsuan; Goetze, Sebastian; Vilotijevic, Ivan; Grube, Maurice; Silva, Daniel Varon; Seeberger, Peter H.
Source: Self-asserted source
Sebastian Götze via ResearcherID

Chemical Synthesis of GPI Anchors and GPI-Anchored Molecules

Modern Synthetic Methods in Carbohydrate Chemistry
2013 | Book chapter
Source: Self-asserted source
Sebastian Götze

Synthesis of Carbohydrate-Functionalised Sequence-Defined Oligo(amidoamine)s by Photochemical ThiolEne Coupling in a Continuous Flow Reactor

Chemistry-a European Journal
2013 | Journal article
WOSUID:

WOS:000315142300021

Contributors: Wojcik, Felix; O'Brien, Alexander G.; Goetze, Sebastian; Seeberger, Peter H.; Hartmann, Laura
Source: Self-asserted source
Sebastian Götze via ResearcherID

A General Method for Synthesis of GPI Anchors Illustrated by the Total Synthesis of the Low-Molecular-Weight Antigen from Toxoplasma gondii

Angewandte Chemie-International Edition
2011 | Journal article
WOSUID:

WOS:000296207100036

Contributors: Tsai, Yu-Hsuan; Goetze, Sebastian; Azzouz, Nahid; Hahm, Heung Sik; Seeberger, Peter H.; Silva, Daniel Varon
Source: Self-asserted source
Sebastian Götze via ResearcherID

Eine allgemeine Methode zur Herstellung von GPI-Membranankern am Beispiel der Totalsynthese des “Low-molecular-weight-Antigens” von Toxoplasma gondii

Angewandte Chemie
2011 | Journal article
Source: Self-asserted source
Sebastian Götze

Gold Catalysis in Glycosylation Reactions

Synlett
2009 | Journal article
WOSUID:

WOS:000273536500025

Contributors: Goetze, Sebastian; Fitzner, Roland; Kunz, Horst
Source: Self-asserted source
Sebastian Götze via ResearcherID

Peer review (19 reviews for 6 publications/grants)

Review activity for ACS chemical biology. (2)
Review activity for Angewandte Chemie. (10)
Review activity for ChemBioChem. (1)
Review activity for Nucleic acids research. (3)
Review activity for PloS one. (1)
Review activity for Trends in microbiology (2)