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Department of Infectious Disease, Imperial College London

Keywords

Bacterial pathogenicity, Innate Immunity, Neutrophils, Inhibitory receptors

Countries

United Kingdom, Netherlands

Activities

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Employment (4)

Imperial College London: London, London, GB

2019-01-01 to present | Lecturer in Innate Immunity (Department of Medicine)
Employment
Source: Self-asserted source
Alex McCarthy

Universitair Medisch Centrum Utrecht: Utrecht, Utrecht, NL

2016-10-01 to 2018-12-31 | Postdoctoral Research Fellow (Medical Microbiology)
Employment
Source: Self-asserted source
Alex McCarthy

University College London: London, London, GB

2013-01-09 to 2016-08-31 | Postdoctoral Research Fellow (School of Pharmacy)
Employment
Source: Self-asserted source
Alex McCarthy

St. George's University of London: London, GB

2009-02-01 to 2013-07-31 (Infection & Immunity)
Employment
Source: Self-asserted source
Alex McCarthy

Education and qualifications (2)

University of Leeds: Leeds, West Yorkshire, GB

2005-10-01 to 2009-04-30 | PhD (Faculty of Biological Sciences)
Qualification
Source: Self-asserted source
Alex McCarthy

University of Leeds: Leeds, West Yorkshire, GB

2002-10-01 to 2005-07-31 | BSc Human Genetics, 1st (School of Biology)
Qualification
Source: Self-asserted source
Alex McCarthy

Professional activities (3)

Microbiology Society: London, London, GB

Membership
Source: Self-asserted source
Alex McCarthy

European Society of Clinical Microbiology and Infectious Diseases: Basel, CH

Membership
Source: Self-asserted source
Alex McCarthy

British Society for Immunology: London, GB

Membership
Source: Self-asserted source
Alex McCarthy

Funding (4)

Inhibitory leukocyte immunoglobulin-like receptors (LILRs) in bacterial infection biology

2022-10-01 to 2030-09-30 | Grant
Wellcome Trust (London, UK, GB)
GRANT_NUMBER:

225315/Z/22/Z
Source: check_circle
WT Grant Tracker

Characterising the Physiological Role, Function and Structure of the Inhibitory LILRB3 Receptor on Neutrophils using a Novel Bacterial Ligand

2021-10 to 2024-09 | Grant
Biotechnology and Biological Sciences Research Council (London, GB)
GRANT_NUMBER:

BB/V006495/1
Source: Self-asserted source
Alex McCarthy

Exploiting LILR-Fc proteins for enhanced bacterial opsonisation, phagocytosis and killing

2020-03 to 2021-03 | Grant
Royal Society (London, GB)
GRANT_NUMBER:

RGS\R1\201044
Source: Self-asserted source
Alex McCarthy

Leukocyte immunoglobulin-like receptors (LILRs) on neutrophils

2016-10-03 to 2018-10-02 | Grant
European Commission (Brussels, BE)
URL: https://app.dimensions.ai/details/grant/grant.5493837
GRANT_NUMBER: 700862
Source: Self-asserted source
Alex McCarthy via DimensionsWizard

Works (37)

Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis

Nature Communications
2023-04-20 | Journal article | Author
DOI: 10.1038/s41467-023-37732-1
Part of ISSN: 2041-1723
Contributors: Erin A. Catton; Daniel A. Bonsor; Carolina Herrera; Margaretha Stålhammar-Carlemalm; Mykola Lyndin; Claire Turner; Jo Soden; Jos A. G. Van Strijp; Bernhard B. Singer; Nina van Sorge et al.
Source: Self-asserted source
Alex McCarthy

Analysis of Escherichia coli K1 Virulence Genes by Transposon-Directed Sequencing

Methods in Molecular Biology
2022 | Book chapter
DOI: 10.1007/978-1-0716-1720-5_11
Part of ISBN: 9781071617199
Part of ISBN: 9781071617205
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Alex McCarthy

Group B Streptococcus Surface Protein β: Structural Characterization of a Complement Factor H–Binding Motif and Its Contribution to Immune Evasion

The Journal of Immunology
2022-03-01 | Journal article
DOI: 10.4049/jimmunol.2101078
Contributors: Xin Xu; Alexander L Lewis Marffy; Andrew Keightley; Alex J McCarthy; Brian V Geisbrecht
Source: check_circle
Crossref

Bacterial protein domains with a novel Ig‐like fold target human CEACAM receptors

The EMBO Journal
2021-04 | Journal article
DOI: 10.15252/embj.2020106103
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Source: Self-asserted source
Alex McCarthy

Genes on the Move: In Vitro Transduction of Antimicrobial Resistance Genes between Human and Canine Staphylococcal Pathogens

Microorganisms
2020-12-18 | Journal article
DOI: 10.3390/microorganisms8122031
Contributors: Sian Marie Frosini; Ross Bond; Alex J. McCarthy; Claudia Feudi; Stefan Schwarz; Jodi A. Lindsay; Anette Loeffler
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Leukocyte Immunoglobulin-Like Receptors (LILRs) on Human Neutrophils: Modulators of Infection and Immunity

Frontiers in Immunology
2020-05-13 | Journal article
DOI: 10.3389/fimmu.2020.00857
Part of ISSN: 1664-3224
Source: Self-asserted source
Alex McCarthy

The Orphan Immune Receptor LILRB3 Modulates Fc Receptor–Mediated Functions of Neutrophils

The Journal of Immunology
2020-02-15 | Journal article
DOI: 10.4049/jimmunol.1900852
Contributors: Yuxi Zhao; Esther van Woudenbergh; Jing Zhu; Albert J. R. Heck; Kok P. M. van Kessel; Carla J. C. de Haas; Piet C. Aerts; Jos A. G. van Strijp; Alex J. McCarthy
Source: check_circle
Crossref

Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic Infection with the Neonatal Pathogen Escherichia coli K1

Infection and immunity
2019 | Journal article
DOI: 10.1128/iai.00878-18
Source: Self-asserted source
Alex McCarthy

Genome-Wide Identification by Transposon Insertion Sequencing of Escherichia coli K1 Genes Essential for In Vitro Growth, Gastrointestinal Colonizing Capacity, and Survival in Serum

Journal of bacteriology
2018 | Journal article
DOI: 10.1128/JB.00698-17
Source: Self-asserted source
Alex McCarthy

Molecular basis determining species specificity for TLR2 inhibition by staphylococcal superantigen-like protein 3 (SSL3)

Veterinary research
2018 | Journal article
DOI: 10.1186/s13567-018-0609-8
Source: Self-asserted source
Alex McCarthy
grade
Preferred source (of 2)‎

Immune evasion by a staphylococcal inhibitor of myeloperoxidase

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
DOI: 10.1073/pnas.1707032114
Source: Self-asserted source
Alex McCarthy

Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection

Scientific reports
2017 | Journal article
DOI: 10.1038/s41598-017-00123-w
Source: Self-asserted source
Alex McCarthy

The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli

The Journal of infectious diseases
2016 | Journal article
DOI: 10.1093/infdis/jiw294
Source: Self-asserted source
Alex McCarthy

Pathoadaptive Mutations of Escherichia coli K1 in Experimental Neonatal Systemic Infection

PLOS ONE
2016-11-18 | Journal article
DOI: 10.1371/journal.pone.0166793
Part of ISSN: 1932-6203
Source: Self-asserted source
Alex McCarthy

Bioluminescent imaging reveals novel patterns of colonization and invasion in systemic Escherichia coli K1 experimental infection in the neonatal rat

Infection and immunity
2015 | Journal article
DOI: 10.1128/IAI.00953-15
Source: Self-asserted source
Alex McCarthy

The Genotoxin Colibactin Is a Determinant of Virulence in Escherichia coli K1 Experimental Neonatal Systemic Infection

Infection and immunity
2015 | Journal article
DOI: 10.1128/IAI.00716-15
Source: Self-asserted source
Alex McCarthy

Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo

Genome biology and evolution
2014 | Journal article
DOI: 10.1093/gbe/evu214
Source: Self-asserted source
Alex McCarthy
grade
Preferred source (of 2)‎

Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid

Cellular and molecular life sciences : CMLS
2014 | Journal article
DOI: 10.1007/s00018-014-1635-y
Source: Self-asserted source
Alex McCarthy

Non-invasive model of neuropathogenic Escherichia coli infection in the neonatal rat

Journal of visualized experiments : JoVE
2014 | Journal article
DOI: 10.3791/52018
Source: Self-asserted source
Alex McCarthy

Genomic insights into the rapid emergence and evolution of MDR in Staphylococcus pseudintermedius

Journal of Antimicrobial Chemotherapy
2014-12-18 | Journal article
DOI: 10.1093/jac/dku496
Part of ISSN: 0305-7453
Part of ISSN: 1460-2091
Source: Self-asserted source
Alex McCarthy

Staphylococcus aureus innate immune evasion is lineage-specific: a bioinfomatics study

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
2013 | Journal article
DOI: 10.1016/j.meegid.2013.06.012
Source: Self-asserted source
Alex McCarthy
grade
Preferred source (of 2)‎

Whole-genome comparison of meticillin-resistantStaphylococcus aureusCC22 SCCmecIV from people and their in-contact pets

Veterinary Dermatology
2013-10 | Journal article
DOI: 10.1111/vde.12062
Part of ISSN: 0959-4493
Source: Self-asserted source
Alex McCarthy

Are all meticillin-resistant Staphylococcus aureus (MRSA) equal in all hosts? Epidemiological and genetic comparison between animal and human MRSA

Veterinary dermatology
2012 | Journal article
DOI: 10.1111/j.1365-3164.2012.01072.x
Source: Self-asserted source
Alex McCarthy

Comparative host specificity of human- and pig- associated Staphylococcus aureus clonal lineages

PloS one
2012 | Journal article
DOI: 10.1371/journal.pone.0049344
Source: Self-asserted source
Alex McCarthy

Detection of mobile-genetic-element variation between colonizing and infecting hospital-associated methicillin-resistant Staphylococcus aureus isolates

Journal of clinical microbiology
2012 | Journal article
DOI: 10.1128/JCM.05938-11
Source: Self-asserted source
Alex McCarthy

Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 clone with distinct genomic and cell adhesion properties

mBio
2012 | Journal article
DOI: 10.1128/mBio.00027-12
Source: Self-asserted source
Alex McCarthy

Shuffling of mobile genetic elements (MGEs) in successful healthcare-associated MRSA (HA-MRSA)

Mobile genetic elements
2012 | Journal article
DOI: 10.4161/mge.22085
Source: Self-asserted source
Alex McCarthy
grade
Preferred source (of 2)‎

Staphylococcus aureus CC398 clade associated with human-to-human transmission

Applied and environmental microbiology
2012 | Journal article
DOI: 10.1128/AEM.02398-12
Source: Self-asserted source
Alex McCarthy

Staphylococcus aureus temperate bacteriophage: carriage and horizontal gene transfer is lineage associated

Frontiers in cellular and infection microbiology
2012 | Journal article
DOI: 10.3389/fcimb.2012.00006
Source: Self-asserted source
Alex McCarthy
grade
Preferred source (of 2)‎

Survival of Staphylococcus aureus ST398 in the human nose after artificial inoculation

PloS one
2012 | Journal article
DOI: 10.1371/journal.pone.0048896
Source: Self-asserted source
Alex McCarthy
grade
Preferred source (of 2)‎

The distribution of plasmids that carry virulence and resistance genes in Staphylococcus aureus is lineage associated

BMC microbiology
2012 | Journal article
DOI: 10.1186/1471-2180-12-104
Source: Self-asserted source
Alex McCarthy
grade
Preferred source (of 2)‎

The distribution of mobile genetic elements (MGEs) in MRSA CC398 is associated with both host and country

Genome biology and evolution
2011 | Journal article
DOI: 10.1093/gbe/evr092
Source: Self-asserted source
Alex McCarthy
grade
Preferred source (of 2)‎

Variation in European harbour seal immune response genes and susceptibility to phocine distemper virus (PDV)

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
2011 | Journal article
DOI: 10.1016/j.meegid.2011.06.002
Source: Self-asserted source
Alex McCarthy
grade
Preferred source (of 2)‎

Novel polymorphisms in ovine immune response genes and their association with abortion

Animal Genetics
2011-10 | Journal article
DOI: 10.1111/j.1365-2052.2011.02180.x
Part of ISSN: 0268-9146
Source: Self-asserted source
Alex McCarthy

Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions

BMC microbiology
2010 | Journal article
DOI: 10.1186/1471-2180-10-173
Source: Self-asserted source
Alex McCarthy

Reassessing conflicting evolutionary histories of the Paramyxoviridae and the origins of respiroviruses with Bayesian multigene phylogenies

Infection, Genetics and Evolution
2010-01 | Journal article
DOI: 10.1016/j.meegid.2009.11.002
Part of ISSN: 1567-1348
Source: Self-asserted source
Alex McCarthy

Pathogen evolution and disease emergence in carnivores

Proceedings. Biological sciences
2007 | Journal article
DOI: 10.1098/rspb.2007.0884
Source: Self-asserted source
Alex McCarthy

Peer review (3 reviews for 3 publications/grants)

Review activity for Communications biology. (1)
Review activity for Microbiology. (1)
Review activity for Structure. (1)
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