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Loop profile: 482381

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China

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Employment (3)

School of Pharmaceutical Sciences : Guangzhou, CN

2016-03-01 to present (Southern Medical University)
Employment
Source: Self-asserted source
KUI CHENG

Tsinghua University: Beijing, Beijing, CN

2014-10-01 to 2016-01-31 | Assistant Investigator (Chemistry)
Employment
Source: Self-asserted source
KUI CHENG

University of Colorado Boulder: Boulder, CO, US

2011-07-01 to 2014-09-25 | Post Doc (Chemistry and Biochemistry)
Employment
Source: Self-asserted source
KUI CHENG

Education and qualifications (2)

Nanjing University: Nanjing, Jiangsu, CN

2008-09-01 to 2011-06-30 | PhD (School of Life Science)
Education
Source: Self-asserted source
KUI CHENG

University of Colorado Boulder: Boulder, CO, US

2009-10-19 to 2011-05-20 | Joint PhD (Chemistry and Biochemistry)
Education
Source: Self-asserted source
KUI CHENG

Works (29)

Oxymatrine, a novel TLR2 agonist, promotes megakaryopoiesis and thrombopoiesis through the STING/NF-κB pathway

Journal of Pharmaceutical Analysis
2025-01 | Journal article
DOI: 10.1016/j.jpha.2024.101054
Contributors: Chengyang Ni; Ling Zhou; Shuo Yang; Mei Ran; Jiesi Luo; Kui Cheng; Feihong Huang; Xiaoqin Tang; Xiang Xie; Dalian Qin et al.
Source: check_circle
Crossref

Synthesis of gem-difluorinated pentacyclic indenopyrazolopyrazolones via Rh(iii)-catalyzed cascade C–H functionalization/[3 + 2] dipolar cycloaddition

Organic Chemistry Frontiers
2024 | Journal article
DOI: 10.1039/D4QO00009A
Contributors: Fu-Xiaomin Liu; Weijie Chen; Ying Cai; Zhi Zhou; Wei Yi; Kui Cheng
Source: check_circle
Crossref

Pretheranostic agents with extraordinaryNIRF/photoacoustic imaging performanceand photothermal oncotherapy efficacy

Acta Pharmaceutica Sinica B
2024-12 | Journal article
DOI: 10.1016/j.apsb.2024.07.017
Contributors: Liu Shi; Zhenzhou Chen; Jiaxin Ou; En Liang; Zhipeng Chen; Qiuyue Fu; Lan Huang; Kui Cheng
Source: check_circle
Crossref

Ultrasensitive Chemiluminescence Probes Designed from Covalent Inhibitors for SRAS-CoV-2 Mpro Detection

Analytical Chemistry
2024-12-10 | Journal article
DOI: 10.1021/acs.analchem.4c04774
Contributors: Suping Xia; En Liang; Leisheng Xu; Liyi Tan; Xiaowen Guo; Kui Cheng
Source: check_circle
Crossref

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

Acta Pharmaceutica Sinica B
2024-02 | Journal article
DOI: 10.1016/j.apsb.2023.09.003
Contributors: Xiaopeng Peng; Zhihao Hu; Limei Zeng; Meizhu Zhang; Congcong Xu; Benyan Lu; Chengpeng Tao; Weiming Chen; Wen Hou; Kui Cheng et al.
Source: check_circle
Crossref

Assembly of fluorinated benzodiazepines via Rh(iii)-catalysed [5+2] annulation of N-benzo[d]imidazole indolines with 2,2-difluorovinyl tosylate

New Journal of Chemistry
2023 | Journal article
DOI: 10.1039/D3NJ01544K
Contributors: Fu-Xiaomin Liu; Weijie Chen; Lei Ma; Kui Cheng; Zhi Zhou; Wei Yi
Source: check_circle
Crossref

Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation

Acta Pharmaceutica Sinica B
2023-09 | Journal article
DOI: 10.1016/j.apsb.2023.05.034
Contributors: Junjie Yang; Yue Pan; Xiaoshan Zeng; Shuwen Liu; Zhipeng Chen; Kui Cheng
Source: check_circle
Crossref

Cancer Cell Membrane-Coated Nanoparticle Co-loaded with Photosensitizer and Toll-like Receptor 7 Agonist for the Enhancement of Combined Tumor Immunotherapy

ACS Nano
2023-09-12 | Journal article
DOI: 10.1021/acsnano.3c02724
Contributors: Yanlin Chen; Siying Zhi; Jiaxin Ou; Junbin Gao; Lu Zheng; Meixin Huang; Shaohua Du; Liu Shi; Yingfeng Tu; Kui Cheng
Source: check_circle
Crossref

Thiol–Chromene “Click” Reaction-Activated Chemiluminescent Probe for Thiol Detection In Vitro and In Vivo

ACS Applied Materials & Interfaces
2023-07-26 | Journal article
DOI: 10.1021/acsami.3c05152
Contributors: Baoqu Wang; Xiaoxue Tian; Xing-Cong Li; Kui Cheng; Min Xu
Source: check_circle
Crossref

A highly selective and sensitive chemiluminescent probe for leucine aminopeptidase detection in vitro, in vivo and in human liver cancer tissue

Chemical Science
2022 | Journal article
DOI: 10.1039/D1SC06528A
Contributors: Baoqu Wang; Zhenzhou Chen; Xiaohong Cen; Yuqing Liang; Liyi Tan; En Liang; Lu Zheng; Yanjun Zheng; Zhikun Zhan; Kui Cheng
Source: check_circle
Crossref

Small molecule-based immunomodulators for cancer therapy

Acta Pharmaceutica Sinica B
2022-12 | Journal article
DOI: 10.1016/j.apsb.2022.11.007
Contributors: Yinrong Wu; Zichao Yang; Kui Cheng; Huichang Bi; Jianjun Chen
Source: check_circle
Crossref

Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy

Acta Pharmaceutica Sinica B
2022-09 | Journal article
DOI: 10.1016/j.apsb.2022.06.001
Contributors: Xiaohong Cen; Baoqu Wang; Yuqing Liang; Yanlin Chen; Yu Xiao; Shaohua Du; Kutty Selva Nandakumar; Hang Yin; Shuwen Liu; Kui Cheng
Source: check_circle
Crossref

Near-Infrared Fluorescent and Photoacoustic Dual-Mode Probe for Highly Sensitive and Selective Imaging of Cysteine In Vivo

Analytical Chemistry
2022-08-02 | Journal article
DOI: 10.1021/acs.analchem.2c01372
Contributors: Zhenzhou Chen; Baoqu Wang; Yuqing Liang; Liu Shi; Xiaohong Cen; Lu Zheng; En Liang; Lan Huang; Kui Cheng
Source: check_circle
Crossref

Optimization of CAR-T Cell-Based Therapies Using Small-Molecule-Based Safety Switches

Journal of Medicinal Chemistry
2021-07-22 | Journal article
DOI: 10.1021/acs.jmedchem.0c02054
Contributors: Yanjun Zheng; Kutty Selva Nandakumar; Kui Cheng
Source: check_circle
Crossref

Design, Synthesis, and Structure–Activity Relationship of N-Aryl-N′-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy

Journal of Medicinal Chemistry
2021-06-10 | Journal article
DOI: 10.1021/acs.jmedchem.0c02266
Contributors: Zhipeng Chen; Lina Zhang; Junjie Yang; Lu Zheng; Fanjie Hu; Siqin Duan; Kutty Selva Nandakumar; Shuwen Liu; Hang Yin; Kui Cheng
Source: check_circle
Crossref

Recent Research on Flavonoids and their Biomedical Applications

Current Medicinal Chemistry
2021-02 | Journal article
DOI: 10.2174/0929867327666200713184138
Contributors: Kangmei Wen; Xiaochuan Fang; Junli Yang; Yongfang Yao; Kutty Selva Nandakumar; Mohamed Labib Salem; Kui Cheng
Source: check_circle
Crossref

Design and pharmaceutical applications of proteolysis-targeting chimeric molecules

Biochemical Pharmacology
2020-12 | Journal article
DOI: 10.1016/j.bcp.2020.114211
Contributors: Yuqing Liang; Kutty Selva Nandakumar; Kui Cheng
Source: check_circle
Crossref

Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents

European Journal of Medicinal Chemistry
2019-10 | Journal article
DOI: 10.1016/j.ejmech.2019.06.059
Contributors: Jingjie Bi; Wenqing Wang; Junxi Du; Kun Chen; Kui Cheng
Source: check_circle
Crossref

Autophagy induced by STING, an unnoticed and primordial function of cGAS

Cellular & Molecular Immunology
2019-08-29 | Journal article
DOI: 10.1038/s41423-019-0240-2
Contributors: Junjie Yang; Xiaoshan Tang; Kutty Selva Nandakumar; Kui Cheng
Source: check_circle
Crossref

Synthesis of urea analogues bearing N-alkyl-N'-(thiophen-2-yl) scaffold and evaluation of their innate immune response to toll-like receptors

European Journal of Medicinal Chemistry
2019-05 | Journal article
DOI: 10.1016/j.ejmech.2019.02.067
Contributors: Zhipeng Chen; Xiaohong Cen; Junjie Yang; Zhiman Lin; Meihuan Liu; Kui Cheng
Source: check_circle
Crossref

Structure-based discovery of a specific TLR1–TLR2 small molecule agonist from the ZINC drug library database

Chemical Communications
2018 | Journal article
DOI: 10.1039/C8CC06618C
Contributors: Zhipeng Chen; Xiaohong Cen; Junjie Yang; Xiaoshan Tang; Kai Cui; Kui Cheng
Source: check_circle
Crossref

Ter‐cell, A New Target for Hepatocellular Carcinoma Therapy

ChemBioChem
2018-11-02 | Journal article
DOI: 10.1002/cbic.201800410
Contributors: Xiaohong Cen; Kui Cheng
Source: check_circle
Crossref

TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung

JCI Insight
2018-07-12 | Journal article
DOI: 10.1172/jci.insight.98850
Contributors: Swati Bhattacharyya; Wenxia Wang; Wenyi Qin; Kui Cheng; Sara Coulup; Sherry Chavez; Shuangshang Jiang; Kirtee Raparia; Lucia Maria V. De Almeida; Christian Stehlik et al.
Source: check_circle
Crossref

Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents

European Journal of Medicinal Chemistry
2018-06 | Journal article
DOI: 10.1016/j.ejmech.2018.05.033
Contributors: Yao Xu; Shujun Chen; Ying Cao; Pingzheng Zhou; Zhipeng Chen; Kui Cheng
Source: check_circle
Crossref

Targeting pattern-recognition receptors to discover new small molecule immune modulators

European Journal of Medicinal Chemistry
2018-01 | Journal article
DOI: 10.1016/j.ejmech.2017.12.026
Contributors: Gengzheng Zhu; Yao Xu; Xiaohong Cen; Kutty Selva Nandakumar; Shuwen Liu; Kui Cheng
Source: check_circle
Crossref

Development of Antibacterial Drugs by Targeting Toll-Like Receptors

Curr. Top. Med. Chem.
2017 | Journal article
Source: Self-asserted source
KUI CHENG

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists

Sci. Adv.
2015 | Journal article
Source: Self-asserted source
KUI CHENG

Discovery of Small Molecule Inhibitors of the TLR1-TLR2 Complex

Angew. Chem. Int. Edit.
2012 | Journal article
Source: Self-asserted source
KUI CHENG

Small Molecule Inhibitors of the TLR3/dsRNA Complex

J. Am. Chem. Soc.
2011 | Journal article
Source: Self-asserted source
KUI CHENG

Peer review (42 reviews for 13 publications/grants)

Review activity for ACS nano. (1)
Review activity for ACS omega. (3)
Review activity for Acta pharmaceutica sinica B. (8)
Review activity for Advanced functional materials. (1)
Review activity for Biochimica et biophysica acta CR. (1)
Review activity for Bioorganic & medicinal chemistry. (2)
Review activity for Chemistry & biodiversity. (2)
Review activity for ChemMedChem. (1)
Review activity for Coordination chemistry reviews (2)
Review activity for European journal of medicinal chemistry. (3)
Review activity for Journal of agricultural and food chemistry. (1)
Review activity for Journal of medicinal chemistry. (16)
Review activity for Nature reviews. (1)
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