Personal information

DNA replication, DNA Interstrand cross-link repair, DNA Protein cross-link repair, Fanconi Anemia, CMG Helicase, Ubiquitin proteasome system, Non-homologous end joining, Genome Instability
United States

Activities

Employment (5)

Howard Hughes Medical Institute - Harvard Medical School: Boston, MA, US

2013-09-01 to present | Investigator
Employment
Source: Self-asserted source
Johannes Walter

Harvard Medical School: Boston, MA, US

2010-09-01 to present | Professor (Department of Biological Chemistry and Molecular Pharmacology)
Employment
Source: Self-asserted source
Johannes Walter

Harvard Medical School: Boston, MA, US

2005-09-01 to 2010-08-31 | Associate Professor (Department of Biological Chemistry and Molecular Pharmacology)
Employment
Source: Self-asserted source
Johannes Walter

Harvard Medical School: Boston, MA, US

1999-09-01 to 2005-08-31 | Assistant Professor (Department of Biological Chemistry and Molecular Pharmacology)
Employment
Source: Self-asserted source
Johannes Walter

University of California San Diego: La Jolla, CA, US

1995-09-01 to 1999-08-31 | Postdoctoral Researcher
Employment
Source: Self-asserted source
Johannes Walter

Education and qualifications (2)

Yale University: New Haven, CT, US

1989-09-01 to 1995-08-31 | Ph.D. Molecular Biophysics and Biochemistry
Education
Source: Self-asserted source
Johannes Walter

University of California Berkeley: Berkeley, CA, US

1985-09-01 to 1989-05-01 | B.A. Biochemistry
Education
Source: Self-asserted source
Johannes Walter

Funding (1)

The Interplay of Transcription, Replication, and Repair

2023-01-01 to 2027-12-31 | Grant
American Cancer Society (Atlanta, US)
GRANT_NUMBER:

RP-22-185-06-COUN

Source: check_circle
American Cancer Society - ProposalCentral

Works (50 of 114)

Items per page:
Page 1 of 3

EndoMAP.v1, a Structural Protein Complex Landscape of Human Endosomes

2025-02-09 | Preprint
Contributors: Miguel A. Gonzalez-Lozano; Ernst W. Schmid; Enya Miguel Whelan; Yizhi Jiang; Joao A. Paulo; Johannes C. Walter; J. Wade Harper
Source: check_circle
Crossref

STK19 positions TFIIH for cell-free transcription-coupled DNA repair

Cell
2024-12 | Journal article
Contributors: Tycho E.T. Mevissen; Maximilian Kümmecke; Ernst W. Schmid; Lucas Farnung; Johannes C. Walter
Source: check_circle
Crossref

TTF2 promotes replisome eviction from stalled forks in mitosis

2024-11-30 | Preprint
Contributors: Geylani Can; Maksym Shyian; Archana Krishnamoorthy; Yang Lim; R. Alex Wu; Manal S. Zaher; Markus Raschle; Johannes C. Walter; David S. Pellman
Source: check_circle
Crossref

STK19 positions TFIIH for cell-free transcription-coupled DNA repair

2024-07-23 | Preprint
Contributors: Tycho E.T. Mevissen; Maximilian Kümmecke; Ernst W. Schmid; Lucas Farnung; Johannes C. Walter
Source: check_circle
Crossref

In silicoscreening identifies SHPRH as a novel nucleosome acidic patch interactor

2024-06-27 | Preprint
Contributors: Allison M. James; Ernst W. Schmid; Johannes C. Walter; Lucas Farnung
Source: check_circle
Crossref

Predictomes: A classifier-curated database of AlphaFold-modeled protein-protein interactions

2024-04-12 | Preprint
Contributors: Ernst W. Schmid; Johannes C. Walter
Source: check_circle
Crossref

Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining

Nature Communications
2024-02-10 | Journal article
Contributors: Benjamin M. Stinson; Sean M. Carney; Johannes C. Walter; Joseph J. Loparo
Source: check_circle
Crossref

In silico protein interaction screening uncovers DONSON's role in replication initiation.

Science (New York, N.Y.)
2023-09-22 | Journal article | Author
Contributors: Yang Lim; Lukas Tamayo-Orrego; Ernst Schmid; Zygimante Tarnauskaite; Kochenova OV; Gruar R; Muramatsu S; Luke Lynch; Schlie AV; paula carroll et al.
Source: Self-asserted source
Johannes Walter

TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away.

Cell reports
2023-02-18 | Journal article
Contributors: Mevissen TET; Prasad AV; Walter JC
Source: Self-asserted source
Johannes Walter

The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair

Molecular Cell
2023-01 | Journal article
Contributors: Denitsa Yaneva; Justin L. Sparks; Maximilian Donsbach; Shubo Zhao; Pedro Weickert; Rachel Bezalel-Buch; Julian Stingele; Johannes C. Walter
Source: check_circle
Crossref

Cooperative assembly of p97 complexes involved in replication termination.

Nature communications
2022-11-03 | Journal article | Author
Contributors: Kochenova OV; Sirisha Mukkavalli; malavika raman; Johannes Walter
Source: Self-asserted source
Johannes Walter
grade
Preferred source (of 2)‎

Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining

2022-10-26 | Preprint
Contributors: Benjamin M. Stinson; Sean M. Carney; Johannes C. Walter; Joseph J. Loparo
Source: check_circle
Crossref

Cell-free Trim-Away reveals the mechanism of antibody-mediated protein degradation by TRIM21

2022-07-24 | Preprint
Contributors: Tycho E.T. Mevissen; Anisa V. Prasad; Johannes C. Walter
Source: check_circle
Crossref

The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair

Nature Structural & Molecular Biology
2022-05 | Journal article
Contributors: Daniel R. Semlow; Victoria A. MacKrell; Johannes C. Walter
Source: check_circle
Crossref

CDC7-independent G1/S transition revealed by targeted protein degradation.

Nature
2022-05-04 | Journal article | Author
Contributors: Jan Suski; Nalin Ratnayeke; Marcin Braun; Tian Zhang; Vladislav Strmiska; Michowski W; Geylani Can; Simoneau A; Snioch K; Cup M et al.
Source: Self-asserted source
Johannes Walter

Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates.

Nucleic acids research
2021-12-01 | Journal article
Contributors: Zhou H; Zaher MS; Walter JC; Alan Brown
Source: Self-asserted source
Johannes Walter

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.

Nature cell biology
2021-06-09 | Journal article | Author
Contributors: van der Weegen Y; Klaas de Lint; van den Heuvel D; Nakazawa Y; Tycho E.T. Mevissen; van Schie JJM; San Martin Alonso M; Boer DEC; Román González-Prieto; Narayanan IV et al.
Source: Self-asserted source
Johannes Walter

Mechanisms of Vertebrate DNA Interstrand Cross-Link Repair.

Annual review of biochemistry
2021-04-21 | Journal article
Contributors: Semlow DR; Walter JC
Source: Self-asserted source
Johannes Walter

Single-strand DNA breaks cause replisome disassembly.

Molecular cell
2021-01-22 | Journal article
Contributors: Vrtis KB; Dewar JM; Gheorghe Chistol; Wu RA; Graham TGW; Walter JC
Source: Self-asserted source
Johannes Walter

The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome.

Trends in cell biology
2020-12 | Journal article
Contributors: Wu RA; Pellman DS; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Publisher Correction: The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

Nature Communications
2020-11-06 | Journal article
Contributors: Yana van der Weegen; Hadar Golan-Berman; Tycho E. T. Mevissen; Katja Apelt; Román González-Prieto; Joachim Goedhart; Elisheva E. Heilbrun; Alfred C. O. Vertegaal; Diana van den Heuvel; Johannes C. Walter et al.
Source: check_circle
Crossref

The DNA replication fork suppresses CMG unloading from chromatin before termination.

Genes & development
2020-09-17 | Journal article
Source: Self-asserted source
Johannes Walter

The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells.

Molecular cell
2020-06-23 | Journal article
Source: Self-asserted source
Johannes Walter

A new varietal of DNA interstrand crosslink repair.

Cell research
2020-04 | Journal article
Contributors: Amunugama R; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.

Nature communications
2020-04-30 | Journal article | Author
Contributors: Yana van der Weegen; Hadar Golan Berman; Tycho E.T. Mevissen; Apelt K; Román González-Prieto; Joachim Goedhart; Heilbrun EE; Alfred Vertegaal; van den Heuvel D; Johannes Walter et al.
Source: Self-asserted source
Johannes Walter
grade
Preferred source (of 3)‎

A Mechanism to Minimize Errors during Non-homologous End Joining.

Molecular cell
2019-12 | Journal article
Contributors: Stinson BM; Moreno AT; Walter JC; Loparo JJ
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements.

Molecular cell
2019-03 | Journal article
Contributors: Deng L; Wu RA; Sonneville R; Kochenova OV; Labib K; Pellman D; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

TRAIP is a master regulator of DNA interstrand crosslink repair.

Nature
2019-03 | Journal article
Contributors: Wu RA; Semlow DR; Kamimae-Lanning AN; Kochenova OV; Chistol G; Hodskinson MR; Amunugama R; Sparks JL; Wang M; Deng L et al.
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts.

Molecular cell
2018-12 | Journal article
Contributors: Larsen NB; Gao AO; Sparks JL; Gallina I; Wu RA; Mann M; Räschle M; Walter JC; Duxin JP
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair.

Cell
2018-12 | Journal article
Contributors: Sparks JL; Chistol G; Gao AO; Räschle M; Larsen NB; Mann M; Duxin JP; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

A single XLF dimer bridges DNA ends during nonhomologous end joining.

Nature structural & molecular biology
2018-09 | Journal article
Contributors: Graham TGW; Carney SM; Walter JC; Loparo JJ
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Mechanism of replication-coupled DNA-protein crosslink proteolysis by SPRTN and the proteasome

2018-08 | Other
OTHER-ID:

PPR46264

Contributors: Gao A; Larsen NB; Sparks JL; Gallina I; Mann M; Räschle M; Walter JC; Duxin JP
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Cell reports
2018-06 | Journal article
Contributors: Amunugama R; Willcox S; Wu RA; Abdullah UB; El-Sagheer AH; Brown T; McHugh PJ; Griffith JD; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Extracts for Analysis of DNA Replication in a Nucleus-Free System.

Cold Spring Harbor protocols
2018-05 | Journal article
Contributors: Sparks J; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Ensemble and Single-Molecule Analysis of Non-Homologous End Joining in Frog Egg Extracts.

Methods in enzymology
2017-05 | Journal article
Contributors: Graham TGW; Walter JC; Loparo JJ
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Mechanisms of DNA replication termination.

Nature reviews. Molecular cell biology
2017-05 | Journal article
Contributors: Dewar JM; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

CRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination.

Genes & development
2017-02 | Journal article
Contributors: Dewar JM; Low E; Mann M; Räschle M; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase.

Cell
2016-09 | Journal article
Contributors: Semlow DR; Zhang J; Budzowska M; Drohat AC; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Two-Stage Synapsis of DNA Ends during Non-homologous End Joining.

Molecular cell
2016-03 | Journal article
Contributors: Graham TG; Walter JC; Loparo JJ
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Assays to Study Mitotic Centrosome and Spindle Pole Assembly and Regulation.

Methods in molecular biology (Clifton, N.J.)
2016-01 | Journal article
Contributors: Joukov V; Walter JC; De Nicolo A
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

What is the DNA repair defect underlying Fanconi anemia?

Current opinion in cell biology
2015-11 | Journal article
Contributors: Duxin JP; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

The mechanism of DNA replication termination in vertebrates.

Nature
2015-08 | Journal article
Contributors: Dewar JM; Budzowska M; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Regulation of the Rev1-pol ζ complex during bypass of a DNA interstrand cross-link.

The EMBO journal
2015-06 | Journal article
Contributors: Budzowska M; Graham TG; Sobeck A; Waga S; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.

Science (New York, N.Y.)
2015-04 | Journal article
Contributors: Räschle M; Smeenk G; Hansen RK; Temu T; Oka Y; Hein MY; Nagaraj N; Long DT; Walter JC; Hofmann K et al.
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing.

Cell
2015-04 | Journal article
Contributors: Chistol G; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

DNA interstrand cross-link repair requires replication-fork convergence.

Nature structural & molecular biology
2015-02 | Journal article
Contributors: Zhang J; Dewar JM; Budzowska M; Motnenko A; Cohn MA; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Repair of a DNA-protein crosslink by replication-coupled proteolysis.

Cell
2014-10 | Journal article
Contributors: Duxin JP; Dewar JM; Yardimci H; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

BRCA1 promotes unloading of the CMG helicase from a stalled DNA replication fork.

Molecular cell
2014-09 | Journal article
Contributors: Long DT; Joukov V; Budzowska M; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly.

Molecular cell
2014-07 | Journal article
Contributors: Joukov V; Walter JC; De Nicolo A
Source: Self-asserted source
Johannes Walter via Europe PubMed Central

Thymine DNA glycosylase is a CRL4Cdt2 substrate.

The Journal of biological chemistry
2014-06 | Journal article
Contributors: Slenn TJ; Morris B; Havens CG; Freeman RM; Takahashi TS; Walter JC
Source: Self-asserted source
Johannes Walter via Europe PubMed Central
Items per page:
Page 1 of 3

Peer review (2 reviews for 2 publications/grants)

Review activity for EMBO journal. (1)
Review activity for Nature communications (1)