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University of Rochester, Dept. Biochemistry & Biophysics
The Wedekind Lab
University of Rochester

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Scopus Author ID: 6701698887

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United States

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Employment (1)

University of Rochester: Rochester, New York, US

2002 to present | Professor (Biochemistry & Biophysics)
Employment
Source: Self-asserted source
Joseph Wedekind

Education and qualifications (2)

Stanford University: Stanford, California, US

1995-07 to 1999-06 | Post-Doctoral Fellow (Structural Biology)
Education
Source: Self-asserted source
Joseph Wedekind

University of Wisconsin Madison: Madison, WI, US

1990 to 1995 | Ph.D. (Biochemistry)
Education
Source: Self-asserted source
Joseph Wedekind

Professional activities (5)

American Society for Biochemistry and Molecular Biology: Rockville, US

Membership
Source: Self-asserted source
Joseph Wedekind

American Crystallographic Association: Buffalo, New York, US

Membership
Source: Self-asserted source
Joseph Wedekind

American Chemical Society: Washington D.C., District of Columbia, US

Membership
Source: Self-asserted source
Joseph Wedekind

American Association For The Advancement of Science: Washington D.C., District of Columbia, US

Membership
Source: Self-asserted source
Joseph Wedekind

University of Rochester: Rochester, US

2014 | Professor (Biochemistry & Biophysics )
Distinction
Source: Self-asserted source
Joseph Wedekind

Funding (8)

Cyclic Peptide Inhibitors of HIV-1 Proliferation

2017-09-30 to 2022-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.8557205
GRANT_NUMBER: R01AI150463
Source: Self-asserted source
Joseph Wedekind via DimensionsWizard

A shared macromolecular X-ray diffraction system in Rochester

2010-02-01 to 2011-01-31 | Grant
National Center for Advancing Translational Sciences (Rockville, US)
URL: https://app.dimensions.ai/details/grant/grant.2674973
GRANT_NUMBER: S10RR026501
Source: Self-asserted source
Joseph Wedekind via DimensionsWizard

Investigation of APOBEC3G/Vif Interactions by SAXS and X-ray Crystallography

2007-12-01 to 2014-06-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2631506
GRANT_NUMBER: R33AI076085
Source: Self-asserted source
Joseph Wedekind via DimensionsWizard

Training in HIV Replication and Pathogenesis

2001-07-01 to 2022-06-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2681967
GRANT_NUMBER: T32AI049815
Source: Self-asserted source
Joseph Wedekind via DimensionsWizard

Mechanisms of Action On Non-Coding RNA Molecules

2001-04-01 to 2025-08-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2517058
GRANT_NUMBER: R01GM063162
Source: Self-asserted source
Joseph Wedekind via DimensionsWizard

DETECTOR & GENERATOR FOR CRYSTALLOGRAPHY CORE FACILITY

2001-04-01 to 2003-03-31 | Grant
National Center for Advancing Translational Sciences (Rockville, US)
URL: https://app.dimensions.ai/details/grant/grant.2673613
GRANT_NUMBER: S10RR015934
Source: Self-asserted source
Joseph Wedekind via DimensionsWizard

Macromolecular Diffraction Resource: MacCHESS

1983-09-01 to 2013-06-30 | Grant
National Center for Advancing Translational Sciences (Rockville, US)
URL: https://app.dimensions.ai/details/grant/grant.2439850
GRANT_NUMBER: P41RR001646
Source: Self-asserted source
Joseph Wedekind via DimensionsWizard

A Synchroton Radiation Structural Biology Resource

1980-03-01 to 2015-02-28 | Grant
National Center for Advancing Translational Sciences (Rockville, US)
URL: https://app.dimensions.ai/details/grant/grant.2439831
GRANT_NUMBER: P41RR001209
Source: Self-asserted source
Joseph Wedekind via DimensionsWizard

Works (50 of 97)

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Page 1 of 2

Cyclic peptides targeting the SARS-CoV-2 programmed ribosomal frameshifting RNA from a multiplexed phage display library

ChemRxiv
2024 | Other
DOI: 10.26434/chemrxiv-2024-0hcs0
EID:

2-s2.0-85195431452

Part of ISSN: 25732293
Contributors: Iannuzzelli, J.A.; Bonn, R.; Hong, A.S.; Anitha, A.S.; Wedekind, J.E.; Fasan, R.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Cyclic peptides targeting the SARS-CoV-2 programmed ribosomal frameshifting RNA from a multiplexed phage display library

Chemical Science
2024 | Journal article
DOI: 10.1039/D4SC04026K
Contributors: Jacob A. Iannuzzelli; Rachel Bonn; Andrew S. Hong; Abhijith Saseendran Anitha; Jermaine L. Jenkins; Joseph E. Wedekind; Rudi Fasan
Source: check_circle
Crossref

Knotty is nice: Metabolite binding and RNA-mediated gene regulation by the preQ1 riboswitch family

Journal of Biological Chemistry
2024-12 | Journal article
DOI: 10.1016/j.jbc.2024.107951
Contributors: Daniil Kiliushik; Coleman Goenner; Matthew Law; Griffin M. Schroeder; Yoshita Srivastava; Jermaine L. Jenkins; Joseph E. Wedekind
Source: check_circle
Crossref

Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations

Nucleic Acids Research
2024-11-27 | Journal article
DOI: 10.1093/nar/gkae886
Contributors: Yoshita Srivastava; Olayinka Akinyemi; Tiana C Rohe; Elizabeth M Pritchett; Cameron D Baker; Akshara Sharma; Jermaine L Jenkins; David H Mathews; Joseph E Wedekind
Source: check_circle
Crossref

A riboswitch separated from its ribosome-binding site still regulates translation

Nucleic Acids Research
2023 | Journal article
DOI: 10.1093/nar/gkad056
EID:

2-s2.0-85150396912

Part of ISSN: 13624962 03051048
Contributors: Schroeder, G.M.; Akinyemi, O.; Malik, J.; Focht, C.M.; Pritchett, E.M.; Baker, C.D.; Mcsally, J.P.; Jenkins, J.L.; Mathews, D.H.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Full-Length NAD<sup>+</sup>-I Riboswitches Bind a Single Cofactor but Cannot Discriminate against Adenosine Triphosphate

Biochemistry
2023 | Journal article
DOI: 10.1021/acs.biochem.3c00391
EID:

2-s2.0-85178347736

Part of ISSN: 15204995 00062960
Contributors: Srivastava, Y.; Blau, M.E.; Jenkins, J.L.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Structure and function analysis of a type III preQ<sub>1</sub>-I riboswitch from Escherichia coli reveals direct metabolite sensing by the Shine-Dalgarno sequence

Journal of Biological Chemistry
2023 | Journal article
DOI: 10.1016/j.jbc.2023.105208
EID:

2-s2.0-85172863971

Part of ISSN: 1083351X 00219258
Contributors: Schroeder, G.M.; Kiliushik, D.; Jenkins, J.L.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
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RNA target highlights in CASP15: Evaluation of predicted models by structure providers.

Proteins
2023-07-19 | Journal article | Author
DOI: 10.1002/prot.26550
PMID: 37466021
Contributors: Rachael C. Kretsch; Ebbe Sloth Andersen; Janusz Bujnicki; Wah Chiu; Rhiju Das; Bingnan Luo; Benoit Masquida; Ewan McRae; Griffin Schroeder; Zhaoming Su et al.
Source: Self-asserted source
Joseph Wedekind
grade
Preferred source (of 2)‎

RNA in the Loop: Probing T-loop/T-loop Receptor Interactions as Mediators of Long-range RNA Contacts that Influence Gene Regulation.

Journal of molecular biology
2023-04-07 | Journal article
DOI: 10.1016/j.jmb.2023.168087
PMID: 37030650
Contributors: Wedekind JE
Source: Self-asserted source
Joseph Wedekind
grade
Preferred source (of 2)‎

Isothermal Titration Calorimetry Analysis of a Cooperative Riboswitch Using an Interdependent-Sites Binding Model.

Methods in molecular biology (Clifton, N.J.)
2023-01-01 | Journal article
DOI: 10.1007/978-1-0716-2687-0_5
PMID: 36227562
Contributors: Cavender CE; Griffin Schroeder; Mathews DH; Wedekind JE
Source: Self-asserted source
Joseph Wedekind
grade
Preferred source (of 2)‎

A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control

Nature Communications
2022 | Journal article
DOI: 10.1038/s41467-021-27790-8
EID:

2-s2.0-85122813907

Part of ISSN: 20411723
Contributors: Schroeder, G.M.; Cavender, C.E.; Blau, M.E.; Jenkins, J.L.; Mathews, D.H.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Affinity and structural analysis of the u1a rna recognition motif with engineered methionines to improve experimental phasing

Crystals
2021 | Journal article
DOI: 10.3390/cryst11030273
EID:

2-s2.0-85102949284

Part of ISSN: 20734352
Contributors: Srivastava, Y.; Bonn‐breach, R.; Chavali, S.S.; Lippa, G.M.; Jenkins, J.L.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 3)‎

Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells

Journal of Biological Chemistry
2021 | Journal article
DOI: 10.1016/j.jbc.2021.101390
EID:

2-s2.0-85120796116

Part of ISSN: 1083351X 00219258
Contributors: Chavali, S.S.; Mali, S.M.; Bonn, R.; Anitha, A.S.; Bennett, R.P.; Smith, H.C.; Fasan, R.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Analysis of a preQ<sub>1</sub>-I riboswitch in effector-free and bound states reveals a metabolite-programmed nucleobase-stacking spine that controls gene regulation

Nucleic Acids Research
2020 | Journal article
DOI: 10.1093/nar/gkaa546
EID:

2-s2.0-85089708530

Part of ISSN: 13624962 03051048
Contributors: Schroeder, G.M.; Dutta, D.; Cavender, C.E.; Jenkins, J.L.; Pritchett, E.M.; Baker, C.D.; Ashton, J.M.; Mathews, D.H.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Arginine Forks Are a Widespread Motif to Recognize Phosphate Backbones and Guanine Nucleobases in the RNA Major Groove

Journal of the American Chemical Society
2020 | Journal article
DOI: 10.1021/jacs.0c09689
EID:

2-s2.0-85096888600

Part of ISSN: 15205126 00027863
Contributors: Chavali, S.S.; Cavender, C.E.; Mathews, D.H.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors

Journal of Biological Chemistry
2020 | Journal article
DOI: 10.1074/jbc.RA120.015444
EID:

2-s2.0-85097570548

Part of ISSN: 1083351X 00219258
Contributors: Chavali, S.S.; Mali, S.M.; Jenkins, J.L.; Fasan, R.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Nucleobase mutants of a bacterial preQ<sub>1</sub>-II riboswitch that uncouple metabolite sensing from gene regulation

Journal of Biological Chemistry
2020 | Journal article
DOI: 10.1074/jbc.RA119.010755
EID:

2-s2.0-85080961723

Part of ISSN: 1083351X 00219258
Contributors: Dutta, D.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Face-time with TAR: Portraits of an HIV-1 RNA with diverse modes of effector recognition relevant for drug discovery

Journal of Biological Chemistry
2019 | Journal article
DOI: 10.1074/jbc.REV119.006860
EID:

2-s2.0-85067405671

Part of ISSN: 1083351X 00219258
Contributors: Chavali, S.S.; Bonn-Breach, R.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Observation of preQ<sub>1</sub>-II riboswitch dynamics using single-molecule FRET

RNA Biology
2019 | Journal article
DOI: 10.1080/15476286.2018.1536591
EID:

2-s2.0-85055732992

Part of ISSN: 15558584 15476286
Contributors: Warnasooriya, C.; Ling, C.; Belashov, I.A.; Salim, M.; Wedekind, J.E.; Ermolenko, D.N.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Structure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design

Acta Crystallographica Section D: Structural Biology
2019 | Journal article
DOI: 10.1107/S2059798319012890
EID:

2-s2.0-85074593579

Part of ISSN: 20597983
Contributors: Bonn-Breach, R.; Gu, Y.; Jenkins, J.; Fasan, R.; Wedekind, J.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Coupling Green Fluorescent Protein Expression with Chemical Modification to Probe Functionally Relevant Riboswitch Conformations in Live Bacteria

Biochemistry
2018 | Journal article
DOI: 10.1021/acs.biochem.8b00316
EID:

2-s2.0-85048887838

Part of ISSN: 15204995 00062960
Contributors: Dutta, D.; Belashov, I.A.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
grade
Preferred source (of 2)‎

Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription

Nucleic Acids Research
2018 | Journal article
DOI: 10.1093/nar/gky529
EID:

2-s2.0-85055519762

Part of ISSN: 13624962 03051048
Contributors: Belashov, I.A.; Crawford, D.W.; Cavender, C.E.; Dai, P.; Beardslee, P.C.; Mathews, D.H.; Pentelute, B.L.; McNaughton, B.R.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Metalloriboswitches: RNA-based inorganic ion sensors that regulate genes

Journal of Biological Chemistry
2017 | Journal article
DOI: 10.1074/jbc.R117.787713
EID:

2-s2.0-85020638395

Part of ISSN: 1083351X 00219258
Contributors: Wedekind, J.E.; Dutta, D.; Belashov, I.A.; Jenkins, J.L.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

The quick and the dead: A guide to fast phasing of small ribozyme and riboswitch crystal structures

Methods in Molecular Biology
2016 | Book chapter
DOI: 10.1007/978-1-4939-6433-8_17
EID:

2-s2.0-84988909564

Part of ISSN: 10643745
Contributors: Jenkins, J.L.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Gene Regulation Gets in Tune: How Riboswitch Tertiary-Structure Networks Adapt to Meet the Needs of Their Transcription Units

Journal of Molecular Biology
2015 | Journal article
DOI: 10.1016/j.jmb.2015.08.001
EID:

2-s2.0-84952863472

Part of ISSN: 10898638 00222836
Contributors: Dutta, D.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Metal ion binding and function in natural and artificial small RNA enzymes from a structural perspective

Structural and Catalytic Roles of Metal Ions in RNA
2015 | Book chapter
Part of DOI: 10.1039/978184973251200299
EID:

2-s2.0-85140277146

ISBN: 9783110436648 9783110442823
Contributors: Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Molecular mechanism for preQ<sub>1</sub>-II riboswitch function revealed by molecular dynamics

RNA
2015 | Journal article
DOI: 10.1261/rna.051367.115
EID:

2-s2.0-84944790300

Part of ISSN: 14699001 13558382
Contributors: Aytenfisu, A.H.; Liberman, J.A.; Wedekind, J.E.; Mathews, D.H.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Structural analysis of a class III preQ<sub>1</sub> riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
DOI: 10.1073/pnas.1503955112
EID:

2-s2.0-84936136220

Part of ISSN: 10916490 00278424
Contributors: Liberman, J.A.; Suddala, K.C.; Aytenfisu, A.; Chan, D.; Belashov, I.A.; Salim, M.; Mathews, D.H.; Spitale, R.C.; Walter, N.G.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Evidence for the role of active site residues in the hairpin ribozyme from molecular simulations along the reaction path

Journal of the American Chemical Society
2014 | Journal article
DOI: 10.1021/ja500180q
EID:

2-s2.0-84901921779

Part of ISSN: 15205126 00027863
Contributors: Heldenbrand, H.; Janowski, P.A.; Giambaşu, G.; Giese, T.J.; Wedekind, J.E.; York, D.M.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

ITC analysis of ligand binding to PreQ<sub>1</sub> riboswitches

Methods in Enzymology
2014 | Book chapter
DOI: 10.1016/B978-0-12-801122-5.00018-0
EID:

2-s2.0-84925445372

Part of ISSN: 15577988 00766879
Contributors: Liberman, J.A.; Bogue, J.T.; Jenkins, J.L.; Salim, M.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Metal dependence of ligand binding and heavy-atom derivatization of evolutionarily distinct PreQ<sub>1</sub> riboswitches

Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications
2014 | Book chapter
Part of DOI: 10.1007/978-3-642-54452-1_23
EID:

2-s2.0-85031126403

ISBN: 9783642544521 9783642544514
Contributors: Wedekind, J.E.; Liberman, J.A.; Jenkins, J.L.; Salim, M.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ<sub>1</sub> Riboswitches

RNA Technologies
2014 | Book chapter
DOI: 10.1007/978-3-642-54452-1_23
EID:

2-s2.0-85145072771

Part of ISSN: 21979758 21979731
Contributors: Wedekind, J.E.; Liberman, J.A.; Jenkins, J.L.; Salim, M.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Single transcriptional and translational preQ<sub>1</sub> riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure

Nucleic Acids Research
2013 | Journal article
DOI: 10.1093/nar/gkt798
EID:

2-s2.0-84890410887

Part of ISSN: 03051048 13624962
Contributors: Suddala, K.C.; Rinaldi, A.J.; Feng, J.; Mustoe, A.M.; Eichhorn, C.D.; Liberman, J.A.; Wedekind, J.E.; Al-Hashimi, H.M.; Brooks, C.L.; Walter, N.G.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Structural characterization of nitrosomonas europaea cytochrome c-552 variants with marked differences in electronic structure

ChemBioChem
2013 | Journal article
DOI: 10.1002/cbic.201300118
EID:

2-s2.0-84884701749

Part of ISSN: 14394227 14397633
Contributors: Can, M.; Krucinska, J.; Zoppellaro, G.; Andersen, N.H.; Wedekind, J.E.; Hersleth, H..-P.; Andersson, K.K.; Bren, K.L.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Structure of a class II preQ<sub>1</sub> riboswitch reveals ligand recognition by a new fold

Nature Chemical Biology
2013 | Journal article
DOI: 10.1038/nchembio.1231
EID:

2-s2.0-84879103214

Part of ISSN: 15524450 15524469
Contributors: Liberman, J.A.; Salim, M.; Krucinska, J.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Structure of phosphorylated SF1 bound to U2AF<sup>65</sup> in an essential splicing factor complex

Structure
2013 | Journal article
DOI: 10.1016/j.str.2012.10.020
EID:

2-s2.0-84873407795

Part of ISSN: 09692126 18784186
Contributors: Wang, W.; Maucuer, A.; Gupta, A.; Manceau, V.; Thickman, K.R.; Bauer, W.J.; Kennedy, S.D.; Wedekind, J.E.; Green, M.R.; Kielkopf, C.L.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

A transition-state interaction shifts nucleobase ionization toward neutrality to facilitate small ribozyme catalysis

Journal of the American Chemical Society
2012 | Journal article
DOI: 10.1021/ja3070528
EID:

2-s2.0-84867521047

Part of ISSN: 00027863 15205126
Contributors: Liberman, J.A.; Guo, M.; Jenkins, J.L.; Krucinska, J.; Chen, Y.; Carey, P.R.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Core-binding factor β Increases the affinity between human cullin 5 and HIV-1 Vif within an E3 ligase complex

Biochemistry
2012 | Journal article
DOI: 10.1021/bi301244z
EID:

2-s2.0-84868601127

Part of ISSN: 00062960 15204995
Contributors: Salter, J.D.; Lippa, G.M.; Belashov, I.A.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Crystallographic analysis of small ribozymes and riboswitches

Methods in Molecular Biology
2012 | Book
DOI: 10.1007/978-1-61779-545-9_11
EID:

2-s2.0-84858163283

ISBN: 9781617795442
Part of ISSN: 10643745
Contributors: Lippa, G.M.; Liberman, J.A.; Jenkins, J.L.; Krucinska, J.; Salim, M.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Molecular mechanism of preQ<sub>1</sub> riboswitch action: A molecular dynamics study

Journal of Physical Chemistry B
2012 | Journal article
DOI: 10.1021/jp309230v
EID:

2-s2.0-84867801144

Part of ISSN: 15205207 15206106
Contributors: Banáŝ, P.; Sklenovský, P.; Wedekind, J.E.; Ŝponer, J.; Otyepka, M.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Riboswitch structure in the ligand-free state

Wiley Interdisciplinary Reviews: RNA
2012 | Journal article
DOI: 10.1002/wrna.114
EID:

2-s2.0-84865243362

Part of ISSN: 17577004 17577012
Contributors: Liberman, J.A.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Base ionization and ligand binding: How small ribozymes and riboswitches gain a foothold in a protein world

Current Opinion in Structural Biology
2011 | Journal article
DOI: 10.1016/j.sbi.2011.03.016
EID:

2-s2.0-79958042263

Part of ISSN: 0959440X 1879033X
Contributors: Liberman, J.A.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Comparison of a PreQ<sub>1</sub> riboswitch aptamer in metabolite-bound and free states with implications for gene regulation

Journal of Biological Chemistry
2011 | Journal article
DOI: 10.1074/jbc.M111.230375
EID:

2-s2.0-79960114180

Part of ISSN: 00219258 1083351X
Contributors: Jenkins, J.L.; Krucinska, J.; McCarty, R.M.; Bandarian, V.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Metal ion binding and function in natural and artificial small RNA enzymes from a structural perspective.

Metal ions in life sciences
2011 | Journal article
EID:

2-s2.0-79958034144

Part of ISSN: 15590836
Contributors: Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Direct Raman measurement of an elevated base pK<sub>a</sub> in the active site of a small ribozyme in a pre-catalytic conformation

AIP Conference Proceedings
2010 | Conference paper
DOI: 10.1063/1.3482715
EID:

2-s2.0-78649911801

Part of ISBN: 9780735408180
Part of ISSN: 0094243X 15517616
Contributors: Guo, M.; Spitale, R.C.; Volpini, R.; Krucinska, J.; Cristalli, G.; Carey, P.R.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

The Apo Riboswitch as a Molecular Hydra

Structure
2010 | Journal article
DOI: 10.1016/j.str.2010.06.003
EID:

2-s2.0-77954649566

Part of ISSN: 09692126
Contributors: Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

A hydrodynamic analysis of APOBEC3G reveals a monomer-dimer-tetramer self-association that has implications for anti-HIV function

Biochemistry
2009 | Journal article
DOI: 10.1021/bi901642c
EID:

2-s2.0-70449560591

Part of ISSN: 00062960
Contributors: Salter, J.D.; Krucinska, J.; Raina, J.; Smith, H.C.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Direct Raman measurement of an elevated base pK<sub>a</sub> in the active site of a small ribozyme in a precatalytic conformation

Journal of the American Chemical Society
2009 | Journal article
DOI: 10.1021/ja9060883
EID:

2-s2.0-70349095576

Part of ISSN: 00027863
Contributors: Guo, M.; Spitale, R.C.; Volpini, R.; Krucinska, J.; Cristalli, G.; Carey, P.R.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Exploring ribozyme conformational changes with X-ray crystallography

Methods
2009 | Journal article
DOI: 10.1016/j.ymeth.2009.06.003
EID:

2-s2.0-70349301373

Part of ISSN: 10462023 10959130
Contributors: Spitale, R.C.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier

Identification of an imino group indispensable for cleavage by a small ribozyme

Journal of the American Chemical Society
2009 | Journal article
DOI: 10.1021/ja900450h
EID:

2-s2.0-69949179163

Part of ISSN: 00027863
Contributors: Spitale, R.C.; Volpini, R.; Heller, M.G.; Krucinska, J.; Cristalli, G.; Wedekind, J.E.
Source: Self-asserted source
Joseph Wedekind via Scopus - Elsevier
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Peer review (14 reviews for 10 publications/grants)

Review activity for Biochemistry. (1)
Review activity for Cell reports. (2)
Review activity for Current opinion in structural biology. (1)
Review activity for Journal of Molecular Biology. (1)
Review activity for Journal of the American Chemical Society. (1)
Review activity for Nature (1)
Review activity for Nature chemical biology. (2)
Review activity for Nature communications (3)
Review activity for Nature methods. (1)
Review activity for PLOS genetics. (1)
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