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Scopus Author ID: 55234181700

Keywords

pharmacoresistant epilepsy, neuropharmacology

Countries

China

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Employment (2)

Zhejiang Chinese Medical University: Hangzhou, Zhejiang, CN

2020-12-01 to present | Associate investigator
Employment
Source: Self-asserted source
Cenglin Xu

Zhejiang University: Hangzhou, Zhejiang, CN

2016-11-01 to 2020-11-30 | assistant research fellow (School of basic medicine)
Employment
Source: Self-asserted source
Cenglin Xu

Education and qualifications (2)

Zhejiang University: Hangzhou, Zhejiang, CN

2011-09-01 to 2016-09-30 | Ph.D (School of basic medicine)
Education
Source: Self-asserted source
Cenglin Xu

Zhejiang University: Hangzhou, Zhejiang, CN

2007-09-01 to 2011-06-30 | Bachelor (College of Pharmaceutical Science)
Education
Source: Self-asserted source
Cenglin Xu

Works (50 of 69)

Items per page:
Page 1 of 2

A glutamatergic innervation from medial area of secondary visual cortex to lateral posterior thalamic nucleus facilitates nociceptive and neuropathic pain

Communications Biology
2025-03-11 | Journal article
DOI: 10.1038/s42003-025-07874-7
Contributors: Bei Tan; Xueqing Wu; Yila Ding; Cunrui Yuan; Yan Jin; Cenglin Xu; Tingting Hu; Jie Yu; Yu Du; Zhong Chen
Source: check_circle
Crossref

“CATCH ME IF YOU CAN”: Unlocking the Hidden Key in Obesity Intervention via the Vagus-Jejunum Axis

Neuroscience Bulletin
2025-03-01 | Journal article
DOI: 10.1007/s12264-025-01368-6
Contributors: Shuo Zhang; Lingyu Xu; Yila Ding; Cenglin Xu
Source: check_circle
Crossref

Revealing the complex role of CDKL5 in developmental epilepsy through a calcium channel related vision

Acta Epileptologica
2024-12 | Journal article
DOI: 10.1186/s42494-024-00162-7
Contributors: Mengqi Yan; Xiongfeng Guo; Cenglin Xu
Source: check_circle
Crossref

The bidirectional role of music effect in epilepsy: Friend or foe?

Epilepsia Open
2024-12 | Journal article
DOI: 10.1002/epi4.13064
Contributors: Shajing Gao; Yiwei Gong; Cenglin Xu; Zhong Chen
Source: check_circle
Crossref

“Catch me if you can” - locating the “Black Sheep” neurons after early-life seizures

Acta Epileptologica
2024-12 | Journal article
DOI: 10.1186/s42494-024-00174-3
Contributors: Yingying Tang; Xiongfeng Guo; Mengqi Yan; Cenglin Xu
Source: check_circle
Crossref

Caspase-1 inhibitor CZL80 protects against acute seizures via amplifying the inhibitory neural transmission

Neurochemistry International
2024-10 | Journal article
DOI: 10.1016/j.neuint.2024.105809
Contributors: Yingying Tang; Yao Liu; Yiwei Gong; Shuo Zhang; Sunliang Cui; Yi Wang; Zhong Chen; Cenglin Xu
Source: check_circle
Crossref

Raising New Hope for Controlling Seizures in Focal Cortical Dysplasia with Gene Therapy

Neuroscience Bulletin
2024-07 | Journal article
DOI: 10.1007/s12264-024-01212-3
Contributors: Yuanzhi Yang; Yang Zheng; Zhong Chen; Cenglin Xu
Source: check_circle
Crossref

Histamine H1 receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice

Nature Communications
2024-07-10 | Journal article
DOI: 10.1038/s41467-024-50042-4
Contributors: Li Cheng; Ling Xiao; Wenkai Lin; Minzhu Li; Jiaying Liu; Xiaoyun Qiu; Menghan Li; Yanrong Zheng; Cenglin Xu; Yi Wang et al.
Source: check_circle
Crossref

mTORC2: The “Ace in the Hole” for a Broader Control of Epileptic Seizures?

Neuroscience Bulletin
2024-05 | Journal article
DOI: 10.1007/s12264-024-01187-1
Contributors: Shuo Zhang; Xiongfeng Guo; Wei Huang; Cenglin Xu
Source: check_circle
Crossref

Novel Mechanism, Drug Target and Therapy in Epilepsy

Neuroscience Bulletin
2024-05 | Journal article
DOI: 10.1007/s12264-024-01215-0
Contributors: Cenglin Xu; Yi Wang; Zhong Chen
Source: check_circle
Crossref

Satellite glial cells in sensory ganglia play a wider role in chronic pain via multiple mechanisms

Neural Regeneration Research
2024-05 | Journal article
DOI: 10.4103/1673-5374.382986
Contributors: Xiaoyun Qiu; Yuanzhi Yang; Xiaoli Da; Yi Wang; Zhong Chen; Cenglin Xu
Source: check_circle
Crossref

Diverse nature of interictal oscillations: EEG-based biomarkers in epilepsy

Neurobiology of Disease
2023 | Journal article
DOI: 10.1016/j.nbd.2023.105999
EID:

2-s2.0-85146058251

Part of ISSN: 1095953X 09699961
Contributors: Lai, N.; Li, Z.; Xu, C.; Wang, Y.; Chen, Z.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

One Small Step for Neurotechnology, One Giant Leap for an In-Depth Understanding of the Brain

Neuroscience Bulletin
2023 | Journal article
DOI: 10.1007/s12264-023-01027-8
EID:

2-s2.0-85147113318

Part of ISSN: 19958218 16737067
Contributors: Qiu, X.; Sun, M.; Xu, C.; Tang, Y.; Chen, Z.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Shed a New Light on Spinal Cord Injury-induced Permanent Paralysis with the Brain-spine Interface

Neuroscience Bulletin
2023-12 | Journal article
DOI: 10.1007/s12264-023-01127-5
Contributors: Shuang Zou; Yang Zheng; Xuhong Jiang; Yu-Long Lan; Zhong Chen; Cenglin Xu
Source: check_circle
Crossref

The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology

Nature Communications
2023-11-30 | Journal article
DOI: 10.1038/s41467-023-43636-x
Contributors: Yu-Jun Wang; Gui-Ying Zan; Cenglin Xu; Xue-Ping Li; Xuelian Shu; Song-Yu Yao; Xiao-Shan Xu; Xiaoyun Qiu; Yexiang Chen; Kai Jin et al.
Source: check_circle
Crossref

Now We Can Tame the Wild West of Controlling Astrocytes for Treating Neocortical Epilepsy

Neuroscience Bulletin
2023-07 | Journal article
DOI: 10.1007/s12264-023-01048-3
Contributors: Yingying Tang; Shuo Zhang; Cenglin Xu
Source: check_circle
Crossref

Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits

Signal Transduction and Targeted Therapy
2023-06-07 | Journal article
DOI: 10.1038/s41392-023-01433-4
Contributors: Liying Chen; Yingwei Xu; Heming Cheng; Zhongxia Li; Nanxi Lai; Menghan Li; Yeping Ruan; Yang Zheng; Fan Fei; Cenglin Xu et al.
Source: check_circle
Crossref

Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia

Signal Transduction and Targeted Therapy
2023-05-17 | Journal article
DOI: 10.1038/s41392-023-01404-9
Contributors: Yang Zheng; Cenglin Xu; Jinyi Sun; Wenjie Ming; Sijie Dai; Yuying Shao; Xiaoyun Qiu; Menghan Li; Chunhong Shen; Jinghong Xu et al.
Source: check_circle
Crossref

Computerized application for epilepsy in China: Does the era of artificial intelligence comes?

Acta Neurologica Scandinavica
2022 | Journal article
DOI: 10.1111/ane.13711
EID:

2-s2.0-85138723355

Part of ISSN: 16000404 00016314
Contributors: Gong, Y.; Xu, C.; Wang, S.; Wang, Y.; Chen, Z.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Discovery of triazenyl triazoles as Na<sub>v</sub>1.1 channel blockers for treatment of epilepsy

Bioorganic and Medicinal Chemistry Letters
2022 | Journal article
DOI: 10.1016/j.bmcl.2022.128946
EID:

2-s2.0-85136516827

Part of ISSN: 14643405 0960894X
Contributors: Zhou, X.; Zeng, L.; Wang, Y.; Xu, C.; Chen, Z.; Cui, S.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain

Journal of Headache and Pain
2022 | Journal article
DOI: 10.1186/s10194-022-01475-z
EID:

2-s2.0-85136050764

Part of ISSN: 11292377 11292369
Contributors: Du, Y.; Xu, C.-L.; Yu, J.; Liu, K.; Lin, S.-D.; Hu, T.-T.; Qu, F.-H.; Guo, F.; Lou, G.-D.; Nishibori, M. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development

Cell Reports
2022 | Journal article
DOI: 10.1016/j.celrep.2022.111798
EID:

2-s2.0-85144587026

Part of ISSN: 22111247
Contributors: Lai, N.; Cheng, H.; Li, Z.; Wang, X.; Ruan, Y.; Qi, Y.; Yang, L.; Fei, F.; Dai, S.; Chen, L. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Nanoengineered on-demand drug delivery system improves efficacy of pharmacotherapy for epilepsy

Science Advances
2022 | Journal article
DOI: 10.1126/sciadv.abm3381
EID:

2-s2.0-85123058867

Part of ISSN: 23752548
Contributors: Wu, D.; Fei, F.; Zhang, Q.; Wang, X.; Gong, Y.; Chen, X.; Zheng, Y.; Tan, B.; Xu, C.; Xie, H. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Paradoxical effects of posterior intralaminar thalamic calretinin neurons on hippocampal seizure via distinct downstream circuits

iScience
2022 | Journal article
DOI: 10.1016/j.isci.2022.104218
EID:

2-s2.0-85129224774

Part of ISSN: 25890042
Contributors: Qi, Y.; Cheng, H.; Lou, Q.; Wang, X.; Lai, N.; Gao, C.; Wu, S.; Xu, C.; Ruan, Y.; Chen, Z. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Subicular Seizure-Tagged C-Fos Neurons Alleviate Cognitive Deficit in Epilepsy

SSRN
2022 | Other
EID:

2-s2.0-85143195357

Part of ISSN: 15565068
Contributors: Yang, L.; Zhang, Q.; Wu, X.; Qiu, X.; Fei, F.; Lai, N.; Zheng, Y.; Zhang, Q.; Zhang, M.; Wang, Y. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase

Nature Communications
2022-11-21 | Journal article
DOI: 10.1038/s41467-022-34662-2
Contributors: Junli Zhao; Jinyi Sun; Yang Zheng; Yanrong Zheng; Yuying Shao; Yulan Li; Fan Fei; Cenglin Xu; Xiuxiu Liu; Shuang Wang et al.
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Discrete subicular circuits control generalization of hippocampal seizures

Nature Communications
2022-08-25 | Journal article
DOI: 10.1038/s41467-022-32742-x
Contributors: Fan Fei; Xia Wang; Cenglin Xu; Jiaying Shi; Yiwei Gong; Heming Cheng; Nanxi Lai; Yeping Ruan; Yao Ding; Shuang Wang et al.
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New advances in pharmacoresistant epilepsy towards precise management-from prognosis to treatments

Pharmacology &amp; Therapeutics
2022-05 | Journal article
DOI: 10.1016/j.pharmthera.2021.108026
Part of ISSN: 0163-7258
Contributors: Cenglin Xu
Source: Self-asserted source
Cenglin Xu
grade
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Long‐term music adjuvant therapy enhances the efficacy of sub‐dose antiepileptic drugs in temporal lobe epilepsy

CNS Neuroscience & Therapeutics
2022-02 | Journal article
DOI: 10.1111/cns.13623
Contributors: Ceng‐Lin Xu; Jia‐Zhen Nao; Yu‐Jia Shen; Yi‐Wei Gong; Bei Tan; Shuo Zhang; Ke‐Xin Shen; Cui‐Rong Sun; Yi Wang; Zhong Chen
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Hierarchy Graph Convolution Network and Tree Classification for Epileptic Detection on Electroencephalography Signals

IEEE Transactions on Cognitive and Developmental Systems
2021 | Journal article
DOI: 10.1109/TCDS.2020.3012278
EID:

2-s2.0-85121711687

Part of ISSN: 23798939 23798920
Contributors: Zeng, D.; Huang, K.; Xu, C.; Shen, H.; Chen, Z.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Inhibition of hyperactivity of the dorsal raphe 5-HTergic neurons ameliorates hippocampal seizure

CNS Neuroscience and Therapeutics
2021 | Journal article
DOI: 10.1111/cns.13648
EID:

2-s2.0-85105145598

Part of ISSN: 17555949 17555930
Contributors: Cheng, H.; Qi, Y.; Lai, N.; Yang, L.; Xu, C.; Wang, S.; Guo, Y.; Chen, Z.; Wang, Y.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Secondary Epileptogenesis: Common to See, but Possible to Treat?

Frontiers in Neurology
2021 | Journal article
DOI: 10.3389/fneur.2021.747372
EID:

2-s2.0-85121579370

Part of ISSN: 16642295
Contributors: Shen, Y.; Gong, Y.; Ruan, Y.; Chen, Z.; Xu, C.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Thermo-sensitive micelles extend therapeutic potential for febrile seizures

Signal Transduction and Targeted Therapy
2021 | Journal article
DOI: 10.1038/s41392-021-00638-9
EID:

2-s2.0-85112701319

Part of ISSN: 20593635 20959907
Contributors: Wu, D.; Tang, Y.; Li, W.; You, Y.; Shi, J.; Xu, C.; Du, Y.; Chen, Z.; Wang, Y.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Subicular Caspase‐1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy

Annals of Neurology
2021-09 | Journal article
DOI: 10.1002/ana.26173
Part of ISSN: 0364-5134
Part of ISSN: 1531-8249
Contributors: Cenglin Xu
Source: Self-asserted source
Cenglin Xu
grade
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Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

Nature Communications
2021-02-18 | Journal article
DOI: 10.1038/s41467-021-21476-x
Contributors: Li Cheng; Cenglin Xu; Lu Wang; Dadao An; Lei Jiang; Yanrong Zheng; Yixin Xu; Yi Wang; Yujing Wang; Kuo Zhang et al.
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A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain

Nature Nanotechnology
2020 | Journal article
DOI: 10.1038/s41565-020-0634-4
EID:

2-s2.0-85079435264

Part of ISSN: 17483395 17483387
Contributors: Liu, J.; Li, F.; Wang, Y.; Pan, L.; Lin, P.; Zhang, B.; Zheng, Y.; Xu, Y.; Liao, H.; Ko, G. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Decoding Circadian Rhythm and Epileptic Activities: Clues From Animal Studies

Frontiers in Neurology
2020 | Journal article
DOI: 10.3389/fneur.2020.00751
EID:

2-s2.0-85089347674

Part of ISSN: 16642295
Contributors: Xu, C.; Yu, J.; Ruan, Y.; Wang, Y.; Chen, Z.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Direct Septum-Hippocampus Cholinergic Circuit Attenuates Seizure Through Driving Somatostatin Inhibition

Biological Psychiatry
2020 | Journal article
DOI: 10.1016/j.biopsych.2019.11.014
EID:

2-s2.0-85078339026

Part of ISSN: 18732402 00063223
Contributors: Wang, Y.; Wang, Y.; Xu, C.; Wang, S.; Tan, N.; Chen, C.; Chen, L.; Wu, X.; Fei, F.; Cheng, H. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window

Neurotherapeutics
2020 | Journal article
DOI: 10.1007/s13311-019-00815-3
EID:

2-s2.0-85076234890

Part of ISSN: 18787479 19337213
Contributors: Zhao, J.; Zheng, Y.; Liu, K.; Chen, J.; Lai, N.; Fei, F.; Shi, J.; Xu, C.; Wang, S.; Nishibori, M. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Low-frequency Stimulation at the Subiculum is Anti-convulsant and Anti-drug-resistant in a Mouse Model of Lamotrigine-resistant Temporal Lobe Epilepsy

Neuroscience Bulletin
2020 | Journal article
DOI: 10.1007/s12264-020-00482-x
EID:

2-s2.0-85081336404

Part of ISSN: 19958218 16737067
Contributors: Ruan, Y.; Xu, C.; Lan, J.; Nao, J.; Zhang, S.; Fan, F.; Wang, Y.; Chen, Z.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures

Cell Reports
2020 | Journal article
DOI: 10.1016/j.celrep.2020.108346
EID:

2-s2.0-85095459844

Part of ISSN: 22111247
Contributors: Wan, Y.; Feng, B.; You, Y.; Yu, J.; Xu, C.; Dai, H.; Trapp, B.D.; Shi, P.; Chen, Z.; Hu, W.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Pharmaco-genetic inhibition of pyramidal neurons retards hippocampal kindling-induced epileptogenesis

CNS Neuroscience and Therapeutics
2020 | Journal article
DOI: 10.1111/cns.13434
EID:

2-s2.0-85087218294

Part of ISSN: 17555949 17555930
Contributors: Chen, L.-Y.; Liang, J.; Fei, F.; Ruan, Y.-P.; Cheng, H.-M.; Wang, Y.; Chen, Z.; Xu, C.-L.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Structure-based discovery of CZL80, a caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility

British Journal of Pharmacology
2020 | Journal article
DOI: 10.1111/bph.15076
EID:

2-s2.0-85085681999

Part of ISSN: 14765381 00071188
Contributors: Tang, Y.; Feng, B.; Wang, Y.; Sun, H.; You, Y.; Yu, J.; Chen, B.; Xu, C.; Ruan, Y.; Cui, S. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Parabrachial nucleus circuit governs neuropathic pain-like behavior

Nature Communications
2020-11-25 | Journal article
DOI: 10.1038/s41467-020-19767-w
Contributors: Li Sun; Rui Liu; Fang Guo; Man-qing Wen; Xiao-lin Ma; Kai-yuan Li; Hao Sun; Ceng-lin Xu; Yuan-yuan Li; Meng-yin Wu et al.
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A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy

Nature Communications
2020-02-17 | Journal article
DOI: 10.1038/s41467-020-14648-8
Contributors: Bin Chen; Cenglin Xu; Yi Wang; Wenkai Lin; Ying Wang; Liying Chen; Heming Cheng; Lingyu Xu; Tingting Hu; Junli Zhao et al.
Source: check_circle
Crossref
grade
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Alterations in the hippocampal-thalamic pathway underlying secondarily generalized tonic–clonic seizures in mesial temporal lobe epilepsy: A diffusion tensor imaging study

Epilepsia
2019 | Journal article
DOI: 10.1111/epi.14614
EID:

2-s2.0-85057287537

Part of ISSN: 15281167 00139580
Contributors: Chen, C.; Li, H.; Ding, F.; Yang, L.; Huang, P.; Wang, S.; Jin, B.; Xu, C.; Wang, Y.; Ding, M. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy

Annals of Neurology
2019-10 | Journal article
DOI: 10.1002/ana.25554
Part of ISSN: 0364-5134
Part of ISSN: 1531-8249
Contributors: Cenglin Xu
Source: Self-asserted source
Cenglin Xu
grade
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Correction to: Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures (Neuroscience Bulletin, (2014), 30, 6, (913-922), 10.1007/s12264-014-1482-8)

Neuroscience Bulletin
2018 | Journal article
DOI: 10.1007/s12264-017-0197-z
EID:

2-s2.0-85035084175

Part of ISSN: 19958218 16737067
Contributors: Dai, Y.-J.; Xu, Z.-H.; Feng, B.; Xu, C.-L.; Zhao, H.-W.; Wu, D.-C.; Hu, W.-W.; Chen, Z.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Pharmaco-genetic therapeutics targeting parvalbumin neurons attenuate temporal lobe epilepsy

Neurobiology of Disease
2018 | Journal article
DOI: 10.1016/j.nbd.2018.06.006
EID:

2-s2.0-85048420749

Part of ISSN: 1095953X 09699961
Contributors: Wang, Y.; Liang, J.; Chen, L.; Shen, Y.; Zhao, J.; Xu, C.; Wu, X.; Cheng, H.; Ying, X.; Guo, Y. et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier

Corrigendum to “Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures” (EBioMedicine (2017) 17 (206–215)(S2352396417300658)(10.1016/j.ebiom.2017.02.006))

EBioMedicine
2017 | Journal article
DOI: 10.1016/j.ebiom.2017.11.007
EID:

2-s2.0-85034020331

Part of ISSN: 23523964
Contributors: Wu, D.; Feng, B.; Dai, Y.; Wu, X.; Chen, B.; Xu, C.; Tang, Y.; Wang, K.; Zhang, S.; ShuangWang et al.
Source: Self-asserted source
Cenglin Xu via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (12 reviews for 7 publications/grants)

Review activity for Acta epileptologica. (1)
Review activity for Advanced science. (1)
Review activity for Clinical complementary medicine and pharmacology. (3)
Review activity for Computer methods and programs in biomedicine. (1)
Review activity for Neurobiology of disease. (2)
Review activity for Neurochemistry international. (2)
Review activity for STAR protocols. (2)
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