Personal information

Mycobacterium tuberculosis, Molecular diagnosis of infectious diseases, Antimicrobial resistance, Molecular Epidemiology, Microbial genomics, Foodborne AMR, Urban Microbiome
Hong Kong SAR China

Biography

Dr. Gilman SIU, Associate Professor of Department of Health Technology and Informatics, PolyU, was trained as a medical laboratory technologist during his undergraduate study in PolyU (BSc in Biomedical Science with 1st class honor) and obtained his PhD degree in HKU Microbiology in 2011. Dr. SIU has been working on microbial genomics for over 15 years. His major research areas include (i) advanced molecular testing for rapid diagnosis of infectious diseases, (ii) genetic mechanisms of antimicrobial resistance and virulence in highly infectious bacteria and viruses, such as Mycobacterium tuberculosis and HIV, and (iii) molecular epidemiology of emerging infectious agents, such as SARS-CoV-2.
He published over 60 peer-reviewed research articles related to emerging infectious diseases in high-impact journals, such as Lancet Respiratory Medicine and Clinical Chemistry. In the past two years, he has received the Faculty research and teaching award (individual) from PolyU based on his outstanding performance in both research and teaching activities. The total amount of competitive external grants (in the capacity of PI) has been over HK$40M in recent five years. Dr. SIU is also appointed as member of Medical Laboratory Technologist Board and as the Chairman of Examination and Education committee of the Board.
The rapid sequencing technique developed by Dr. SIU has played an important role in identifying and stopping transmission chains of COVID-19 in Hong Kong. His work has provided scientific support for the Government’s anti-pandemic measures. PolyU recently named Dr Siu as “Limin Endowed Young Scholar in Medical Laboratory Science” for his contribution to society through research excellence. In 2021, Dr Gilman Siu bestowed Outstanding Project Team on COVID-19 Research Awards by the Food and Health Bureau in recognition of his exceptional research efforts on COVID-19.

Activities

Employment (2)

The Hong Kong Polytechnic University: Hong Kong, HK

2019-07-01 to present | Associate Professor (Health Technology and Informatics)
Employment
Source: Self-asserted source
Kit Hang SIU

The Hong Kong Polytechnic University: Kowloon, HK

2013-09-01 to 2019-06-30 | Assistant Professor (Health Technology and Informatics)
Employment
Source: Self-asserted source
Kit Hang SIU

Education and qualifications (2)

University of Hong Kong: Hong Kong, HK, CN

2007-09-01 to 2010-08-31 | PhD (Microbiology)
Education
Source: Self-asserted source
Kit Hang SIU

Hong Kong Polytechnic University: Kowloon, HK, CN

2004-09-01 to 2006-05-31 | BSc (Hons) in Biomedical Science (1st Class Honor) (Health Technology and Informatics)
Education
Source: Self-asserted source
Kit Hang SIU

Professional activities (6)

PolyU Technology and Consultancy Company Limited: Hong Kong, HK

2021-07-01 to present | Limin Endowed Young Scholar in Medical Laboratory Science
Invited position
Source: Self-asserted source
Kit Hang SIU

Medical Laboratory Technologists Board : Hong Kong, HK

2022-07-01 to 2025-06-30 | Chairman (Education Committee)
Service
Source: Self-asserted source
Kit Hang SIU

The Hong Kong Polytechnic University: Hong Kong, HK

2022-07-03 | Faculty Award for Outstanding Performance/Achievement in Knowledge Transfer (Society) (Faculty of Health and Social Sciences)
Distinction
Source: Self-asserted source
Kit Hang SIU

The Hong Kong Polytechnic University: Hong Kong, HK

2022-04-12 | Outstanding Young Alumni Award in Scholarly Achievement (Faculty of Health and Social Sciences)
Distinction
Source: Self-asserted source
Kit Hang SIU

The Hong Kong Polytechnic University: Hong Kong, HK

2021-12-22 | Outstanding Young Alumni Award in Scholarly Achievement (Health Technology and Informatics)
Distinction
Source: Self-asserted source
Kit Hang SIU

Hong Kong Government: Hong Kong, HK

2021-11-20 | Outstanding Project Team on COVID-19 Research Award (Food and Health Bureau)
Distinction
Source: Self-asserted source
Kit Hang SIU

Funding (2)

A portable nanopore sequencing-based assay for rapid diagnosis of bloodstream infection

2020-10-01 to 2023-03-31 | Grant
Innovation and Technology Commission (Hong Kong, CN)
GRANT_NUMBER: PRP/010/20FX
Source: Self-asserted source
Kit Hang SIU via DimensionsWizard

Portable Nanopore Sequencing For Rapid Diagnosis Of Drug Resistant Tuberculosis

2018-09-01 to 2020-05-31 | Grant
Innovation and Technology Commission (Hong Kong, CN)
GRANT_NUMBER: ITS/342/17
Source: Self-asserted source
Kit Hang SIU via DimensionsWizard

Works (37)

Scrofimicrobium appendicitidis sp. nov., isolated from a patient with ruptured appendicitis

International Journal of Systematic and Evolutionary Microbiology
2025-01-21 | Journal article
Contributors: Hiu-Yin Lao; Annette Y. P. Wong; Timothy Ting-Leung Ng; Ryan Yik-Lam Wong; Miranda Chong-Yee Yau; Jimmy Yiu-Wing Lam; Gilman Kit-Hang Siu
Source: check_circle
Crossref

Induction of amphotericin B resistance in susceptible Candida auris by extracellular vesicles

Emerging Microbes & Infections
2022-12-31 | Journal article
Contributors: Walton Chan; Franklin Wang-Ngai Chow; Chi-Ching Tsang; Xueyan Liu; Weiming Yao; Tony Tat-Yin Chan; Gilman Kit-Hang Siu; Alex Yat-Man Ho; Kristine Shik Luk; Susanna Kar-Pui Lau et al.
Source: check_circle
Crossref

Evaluation ofMycobacterium Tuberculosisenrichment in metagenomic samples using ONT adaptive sequencing and amplicon sequencing for identification and variant calling

2022-12-17 | Preprint
Contributors: Junhao Su; Wui Wang Lui; YanLam Lee; Zhenxian Zheng; Gilman Kit-Hang Siu; Timothy Ting-Leung Ng; Tong Zhang; Tommy Tsan-Yuk Lam; Hiu-Yin Lao; Wing-Cheong Yam et al.
Source: check_circle
Crossref

Probable Animal-to-Human Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant AY.127 Causing a Pet Shop-Related Coronavirus Disease 2019 (COVID-19) Outbreak in Hong Kong.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2022-08-01 | Journal article | Conceptualization, Data curation
Contributors: Kit Hang SIU
Source: Self-asserted source
Kit Hang SIU

Will a new clade of SARS-CoV-2 imported into the community spark a fourth wave of the COVID-19 outbreak in Hong Kong?

Emerging Microbes & Infections
2020-01 | Journal article
Contributors: Gilman Kit-Hang Siu; Lam-Kwong Lee; Kenneth Siu-Sing Leung; Jake Siu-Lun Leung; Timothy Ting-Leung Ng; Chloe Toi-Mei Chan; Kingsley King-Gee Tam; Hiu-Yin Lao; Alan Ka-Lun Wu; Miranda Chong-Yee Yau et al.
Source: check_circle
Crossref

Microbiological evaluation of different hand drying methods for removing bacteria from washed hands

Scientific Reports
2019-09-24 | Journal article
Contributors: Lorna K. P. Suen; Vanessa Y. T. Lung; Maureen V. Boost; Cypher H. Au-Yeung; Gilman K. H. Siu
Source: check_circle
Crossref

Molecular Characterization of HIV-1 Minority Subtypes in Hong Kong: A Recent Epidemic of CRF07_BC among the Men who have Sex with Men Population

Current HIV Research
2019-07-11 | Journal article
Contributors: Kenneth Siu-Sing Leung; Sabrina Wai-Chi To; Jonathan Hon-Kwan Chen; Gilman Kit-Hang Siu; Kenny Chi-Wai Chan; Wing-Cheong Yam
Source: check_circle
Crossref

Diagnostic evaluation of an in-house developed single-tube, duplex, nested IS6110 real-time PCR assay for rapid pulmonary tuberculosis diagnosis

Tuberculosis
2018-09 | Journal article
Part of ISSN: 1472-9792
Contributors: Kenneth Siu-Sing Leung; Gilman Kit-Hang Siu; Kingsley King-Gee Tam; Pak-Leung Ho; Samson Sai-Yin Wong; Eunice Ka-Chun Leung; Shi Hui Yu; Oliver Chiu-Kit Ma; Wing-Cheong Yam
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search
grade
Preferred source (of 2)‎

MIRU-profiler: a rapid tool for determination of 24-loci MIRU-VNTR profiles from assembled genomes of Mycobacterium tuberculosis

PeerJ
2018-07-11 | Journal article
Part of ISSN: 2167-8359
Contributors: Rahim Rajwani; Sheeba Shehzad; Gilman Kit Hang Siu
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search

Comprehensive Evaluation of the MBT STAR-BL Module for Simultaneous Bacterial Identification and β-Lactamase-Mediated Resistance Detection in Gram-Negative Rods from Cultured Isolates and Positive Blood Cultures

Frontiers in Microbiology
2018-02 | Journal article
Part of ISSN: 1664-302X
Contributors: Annie W. T. Lee; Johnson K. S. Lam; Ricky K. W. Lam; Wan H. Ng; Ella N. L. Lee; Vicky T. Y. Lee; Po P. Sze; Rahim Rajwani; Kitty S. C. Fung; Wing K. To et al.
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search

Treatment Outcomes of Tuberculosis at Asella Teaching Hospital, Ethiopia: Ten Years’ Retrospective Aggregated Data

Frontiers in Medicine
2018-02 | Journal article
Part of ISSN: 2296-858X
Contributors: Ketema Tafess; Teresa Kisi Beyen; Adugna Abera; Geremew Tasew; Shimelis Mekit; Solomon Sisay; Legesse Tadesse; Gilman K. H. Siu
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search

Comparative Whole-Genomic Analysis of an Ancient L2 Lineage Mycobacterium tuberculosis Reveals a Novel Phylogenetic Clade and Common Genetic Determinants of Hypervirulent Strains

Frontiers in Cellular and Infection Microbiology
2018-01 | Journal article
Part of ISSN: 2235-2988
Contributors: Rahim Rajwani; Wing Cheong Yam; Ying Zhang; Yu Kang; Barry Kin Chung Wong; Kenneth Siu Sing Leung; Kingsley King Gee Tam; Ketema Tafess Tulu; Li Zhu; Gilman Kit Hang Siu
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Lancet Respiratory Medicine
2017 | Journal article
WOSUID:

WOS:000397257700022

Contributors: Dheda, Keertan; Gumbo, Tawanda; Maartens, Gary; Dooley, Kelly E.; McNerney, Ruth; Murray, Megan; Furin, Jennifer; Nardell, Edward A.; London, Leslie; Lessem, Erica et al.
Source: Self-asserted source
Kit Hang SIU via ResearcherID

Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing

Frontiers in Cellular and Infection Microbiology
2017-11 | Journal article
Part of ISSN: 2235-2988
Contributors: Kenneth Siu-Sing Leung; Gilman Kit-Hang Siu; Kingsley King-Gee Tam; Sabrina Wai-Chi To; Rahim Rajwani; Pak-Leung Ho; Samson Sai-Yin Wong; Wei W. Zhao; Oliver Chiu-Kit Ma; Wing-Cheong Yam
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search

Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realti m e MTB detection and RIF/INH resistance assay

Diagnostic Microbiology and Infectious Disease
2017-10 | Journal article
Part of ISSN: 0732-8893
Contributors: Kingsley King-Gee Tam; Kenneth Siu-Sing Leung; Sabrina Wai-Chi To; Gilman Kit-Hang Siu; Terrence Chi-Kong Lau; Victor Chi-Man Shek; Cindy Wing-Sze Tse; Samson Sai-Yin Wong; Pak-Leung Ho; Wing-Cheong Yam
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search

Development of an in-house real-time pcr to monitor the prevalence of macrolide-resistant Mycoplasma pneumoniae in Hong Kong

Pathology
2017-02 | Journal article
Part of ISSN: 0031-3025
Contributors: Ho-Yin Lam; Thomas Hin-Ching Wong; Anthony Tsz-Chun Wong; Gilman Kit-Hang Siu; Wing-Cheong Yam; Bone Siu-Fai Tang
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search

GAAP: Genome-organization-framework-Assisted Assembly Pipeline for prokaryotic genomes

BMC Genomics
2017-01 | Journal article
Contributors: Lina Yuan; Yang Yu; Yanmin Zhu; Yulai Li; Changqing Li; Rujiao Li; Qin Ma; Gilman Kit-Hang Siu; Jun Yu; Taijiao Jiang et al.
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search
grade
Preferred source (of 2)‎

Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens

European Journal of Clinical Microbiology and Infectious Diseases
2015 | Journal article
EID:

2-s2.0-84940437751

Contributors: Chen, J.H.K.; She, K.K.K.; Kwong, T.-C.; Wong, O.-Y.; Siu, G.K.H.; Leung, C.-C.; Chang, K.-C.; Tam, C.-M.; Ho, P.-L.; Cheng, V.C.C. et al.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Performance of the VITEK MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid bacterial identification in two diagnostic centres in China

Journal of Medical Microbiology
2015 | Journal article
Source: Self-asserted source
Kit Hang SIU
grade
Preferred source (of 4)‎

Utilization of a Duplex HybProbe Real-Time PCR to Detect and Estimate IL-28B Polymorphisms Prevalence among HIV/HCV Co-infected Patients in Hong Kong

Journal of Medical Microbiology & Diagnosis
2015 | Journal article
Contributors: Sabrina Wai-Chi To; Gilman Kit-Hang Siu; Ka-Hing Wong Kenny Chi-Wai Chan; King-Tai Yuen Hon-Man Ng
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search
grade
Preferred source (of 2)‎

Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong

PLOS ONE
2015-10-02 | Journal article
Contributors: Gilman K. H. Siu; Jonathan H. K. Chen; T. K. Ng; Rodney A. Lee; Kitty S. C. Fung; Sabrina W. C. To; Barry K. C. Wong; Sherman Cheung; Ivan W. F. Wong; Marble M. P. Tam et al.
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search
grade
Preferred source (of 2)‎

An upstream truncation of the furA-katG operon confers high-level isoniazid resistance in a Mycobacterium tuberculosis clinical isolate with no known resistance-associated mutations

Antimicrobial Agents and Chemotherapy
2014 | Journal article
EID:

2-s2.0-84907279802

Contributors: Siu, G.K.H.; Yam, W.C.; Zhang, Y.; Kao, R.Y.T.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 3)‎

Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis

Tuberculosis
2014 | Journal article
EID:

2-s2.0-84906072275

Contributors: Lan, Y.; Lam, J.T.; Siu, G.K.H.; Yam, W.C.; Mason, A.J.; Lam, J.K.W.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems

Journal of Clinical Microbiology
2013 | Journal article
EID:

2-s2.0-84878496270

Contributors: Chen, J.H.K.; Ho, P.-L.; Kwan, G.S.W.; She, K.K.K.; Siu, G.K.H.; Cheng, V.C.C.; Yuen, K.-Y.; Yam, W.-C.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Evaluation of the lightcycler methicillin-resistant Staphylococcus aureus (MRSA) advanced test for detection of MRSA nasal colonization

Journal of Clinical Microbiology
2013 | Journal article
EID:

2-s2.0-84882786765

Contributors: Yam, W.C.; Siu, G.K.H.; Ho, P.L.; Ng, T.K.; Que, T.L.; Yip, K.T.; Fok, C.P.K.; Chen, J.H.K.; Cheng, V.C.C.; Yuen, K.Y.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Rapid identification of mycobacteria and rapid detection of drug resistance in mycobacterium tuberculosis in cultured isolates and in respiratory specimens

Methods in Molecular Biology
2013 | Book
EID:

2-s2.0-84870561676

Contributors: Yam, W.-C.; Siu, K.-H.G.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Epidemiology of Klebsiella oxytoca-associated diarrhea detected by simmons citrate agar supplemented with inositol, tryptophan, and bile salts

Journal of Clinical Microbiology
2012 | Journal article
EID:

2-s2.0-84859992625

Contributors: Cheng, V.C.C.; Yam, W.-C.; Tsang, L.-L.; Yau, M.C.Y.; Siu, G.K.H.; Wong, S.C.Y.; Chan, J.F.W.; To, K.K.W.; Tse, H.; Hung, I.F.N. et al.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in mycobacterium tuberculosis

PLoS ONE
2012 | Journal article
EID:

2-s2.0-84857429292

Contributors: Lee, A.S.G.; Ong, D.C.T.; Wong, J.C.L.; Siu, G.K.H.; Yam, W.-C.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates from Shanghai, China

Diagnostic Microbiology and Infectious Disease
2012 | Journal article
EID:

2-s2.0-84862228470

Contributors: Zhu, C.; Zhang, Y.; Shen, Y.; Siu, G.K.H.; Wu, W.; Qian, X.; Deng, G.; Xu, Y.; Lau, R.; Fan, X. et al.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic α-helical peptides

The Journal of Biological Chemistry
2012-10-05 | Journal article
Source: Self-asserted source
Kit Hang SIU
grade
Preferred source (of 2)‎

Clostridium difficile isolates with increased sporulation: Emergence of PCR ribotype 002 in Hong Kong

European Journal of Clinical Microbiology and Infectious Diseases
2011 | Journal article
EID:

2-s2.0-80054757852

Contributors: Cheng, V.C.C.; Yam, W.C.; Lam, O.T.C.; Tsang, J.L.Y.; Tse, E.Y.F.; Siu, G.K.H.; Chan, J.F.W.; Tse, H.; To, K.K.W.; Tai, J.W.M. et al.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Direct detection of isoniazid-resistant Mycobacterium tuberculosis in respiratory specimens by multiplex allele-specific polymerase chain reaction

Diagnostic Microbiology and Infectious Disease
2011 | Journal article
EID:

2-s2.0-78649958683

Contributors: Siu, G.K.H.; Tam, Y.H.; Ho, P.L.; Lee, A.S.G.; Que, T.L.; Tse, C.W.S.; Yip, K.T.; Lam, J.T.H.; Cheng, V.C.C.; Yuen, K.Y. et al.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Mutations outside the rifampicin resistance-determining region associated with rifampicin resistance in Mycobacterium tuberculosis

Journal of Antimicrobial Chemotherapy
2011 | Journal article
EID:

2-s2.0-79952807087

Contributors: Siu, G.K.H.; Zhang, Y.; Lau, T.C.K.; Lau, R.W.T.; Ho, P.-L.; Yew, W.-W.; Tsui, S.K.W.; Cheng, V.C.C.; Yuen, K.-Y.; Yam, W.-C.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Rapid detection of rifampicin- and isoniazid-resistant mycobacterium tuberculosis by high-resolution melting analysis

Journal of Clinical Microbiology
2010 | Journal article
EID:

2-s2.0-77950494237

Contributors: Ong, D.C.T.; Yam, W.-C.; Siu, G.K.H.; Lee, A.S.G.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Rapid diagnosis of multidrug-resistant smear-positive pulmonary tuberculosis

International Journal of Antimicrobial Agents
2010 | Journal article
EID:

2-s2.0-72449212198

Contributors: Lau, R.W.T.; Ho, P.-L.; Kao, R.Y.T.; Siu, G.K.H.; Cheng, V.C.C.; Yuen, K.-Y.; Yam, W.-C.
Source: Self-asserted source
Kit Hang SIU via Scopus - Elsevier
grade
Preferred source (of 2)‎

Characterisation of methicillin-resistant Staphylococcus aureus isolates from dogs and their owners

Clinical Microbiology and Infection
2007 | Journal article
Source: Self-asserted source
Kit Hang SIU
grade
Preferred source (of 2)‎

Molecular characterization of multi-drug resistance mechanisms in mycobacterium tuberculosis

Dissertation or Thesis
Contributors: Kit-hang Siu
Source: Self-asserted source
Kit Hang SIU via Crossref Metadata Search
grade
Preferred source (of 2)‎