Personal information

Other IDs

ResearcherID: V-2282-2019

Keywords

Molecular virology, RNA viruses, Reverse genetics, Virus-host interactions, Interspecies transmission, Primary cell cultures, SARS-CoV-2, Zoonoses

Countries

Germany

Activities

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Employment (4)

German Primate Center: Göttingen, DE

2023-05-01 to present | Head of Unit (Platform Infection Models)
Employment
Source: Self-asserted source
Nadine Krüger

German Primate Center: Göttingen, DE

2022-10-01 to 2023-04-30 | Veterinarian (Unit of Infection Models)
Employment
Source: Self-asserted source
Nadine Krüger

German Primate Center: Göttingen, DE

2020-04-01 to 2022-09-30 | Veterinarian (Infection Biology Unit)
Employment
Source: Self-asserted source
Nadine Krüger

Tierärztliche Hochschule Hannover: Hannover, Niedersachsen, DE

2014-06-01 to 2020-03-31 | Postdoc (Institute of Virology)
Employment
Source: Self-asserted source
Nadine Krüger

Education and qualifications (2)

University of Veterinary Medicine Hannover, Foundation: Hanover, DE

2019 | Venia legendi in Molecular Virology
Education
Source: Self-asserted source
Nadine Krüger

University of Veterinary Medicine Hannover, Foundation: Hanover, DE

2014 | PhD (Institute of Virologie)
Education
Source: Self-asserted source
Nadine Krüger

Professional activities (1)

University of Veterinary Medicine Hannover, Foundation: Hanover, DE

2015 | Förderpreis Tiermedizin, Kurt-Alten-Stiftung
Distinction
Source: Self-asserted source
Nadine Krüger

Funding (2)

ANI-CoV - Haustiere als potenzielle Vektoren für die Übertragung von SARS-CoV-2 - Teilvorhaben A, DPZ , Untersuchung der Empfänglichkeit von Haus- und Nutztieren

2020-06-01 to 2021-11-30 | Grant
Federal Ministry of Education and Research (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.9309700
GRANT_NUMBER: 01KI2074A
Source: Self-asserted source
Nadine Krüger via DimensionsWizard

Role of the surface glycoproteins of a bat-derived mumps virus concerning viral entry, replication, tropism, and virulence

2016-01-01 to 2020-09 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.5490392
GRANT_NUMBER: 310783470
Source: Self-asserted source
Nadine Krüger

Works (42)

Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity

ACS Pharmacology & Translational Science
2024 | Journal article
DOI: 10.1021/ACSPTSCI.3C00313
WOSUID: WOS:001161365500001
Contributors: Flury, Philipp; Breidenbach, Julian; Krueger, Nadine; Voget, Rabea; Schaekel, Laura; Si, Yaoyao; Krasniqi, Vesa; Calistri, Sara; Olfert, Matthias; Sylvester, Katharina et al.
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Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity (vol 7, pg 493, 2024)

ACS Pharmacology & Translational Science
2024 | Journal article
DOI: 10.1021/ACSPTSCI.4C00095
WOSUID: WOS:001181212500001
Contributors: Flury, Philipp; Breidenbach, Julian; Krueger, Nadine; Voget, Rabea; Schaekel, Laura; Si, Yaoyao; Krasniqi, Vesa; Calistri, Sara; Olfert, Matthias; Sylvester, Katharina et al.
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SARS-CoV-2 infection induces adaptive NK cell responses by spike protein-mediated induction of HLA-E expression.

Emerging microbes & infections
2024-06-27 | Journal article | Author
DOI: 10.1080/22221751.2024.2361019
PMID: 38804979
Contributors: Hasan MZ; Maren Claus; Nadine Krüger; Reusing S; Gall E; Bade-Döding C; Braun A; Watzl C; Markus Uhrberg; Lutz Walter
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Nadine Krüger

Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

Nature Communications
2024-03-14 | Journal article | Author
DOI: 10.1038/s41467-024-46443-0
Part of ISSN: 2041-1723
Contributors: Franziska Karola Kaiser; Mariana Gonzalez Hernandez; Nadine Krüger; Ellinor Englund; Wenjuan Du; Anna Mykytyn; Matthijs Raadsen; Mart M. Lamers; Francine Rodrigues Ianiski; Tatiana Shamorkina et al.
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Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein

JACS Au
2023 | Journal article
DOI: 10.1021/JACSAU.3C00163
WOSUID: WOS:001006210400001
Contributors: Budhadev, Darshita; Hooper, James; Rocha, Cheila; Nehlmeier, Inga; Kempf, Amy Madeleine; Hoffmann, Markus; Krueger, Nadine; Zhou, Dejian; Poehlmann, Stefan; Guo, Yuan
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Development of novel ligands against SARS‐CoV‐2 Mpro enzyme: an in silico and in vitro Study

Molecular Informatics
2023-09-06 | Journal article
DOI: 10.1002/minf.202300120
Part of ISSN: 1868-1743
Part of ISSN: 1868-1751
Contributors: Navid Kaboudi; Nadine Krüger; Maryam Hamzeh-Mivehroud
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Discovery of Polyphenolic Natural Products as SARS-CoV-2 M<sup>pro</sup> Inhibitors for COVID-19

Pharmaceuticals
2023-01 | Journal article | Author
DOI: 10.3390/ph16020190
Contributors: Nadine Krüger; Thales Kronenberger; Hang Xie; Cheila Rocha; Stefan Pöhlmann; Haixia Su; Yechun Xu; Stefan Laufer; Thanigaimalai Pillaiyar
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A Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein

ChemRxiv
2022 | Journal article
DOI: 10.26434/CHEMRXIV-2022-85DZ9
WOSUID: PPRN:22461826
Contributors: Budhadev, Darshita; Hooper, James; Rocha, Cheila; Nehlmeier, Inga; Kempf, Amy Madeleine; Hoffmann, Markus; Krueger, Nadine; Zhou, Dejian; Poehlmann, Stefan; Guo, Yuan
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Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19

Preprints.org
2022 | Journal article
DOI: 10.20944/PREPRINTS202211.0516.V1
WOSUID: PPRN:72850139
Contributors: Krueger, Nadine; Kronenberger, Thales; Xie, Hang; Rocha, Cheila; Poehlmann, Stefan; Su, Haixia; Xu, Yechun; Laufer, Stefan; Pillaiyar, Thanigaimalai
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Evidence for an ACE2-Independent Entry Pathway That Can Protect from Neutralization by an Antibody Used for COVID-19 Therapy

mBio
2022 | Journal article
DOI: 10.1128/MBIO.00364-22
WOSUID: WOS:000787807600013
Contributors: Hoffmann, Markus; Sidarovich, Anzhalika; Arora, Prerna; Krueger, Nadine; Nehlmeier, Inga; Kempf, Amy; Graichen, Luise; Winkler, Martin S.; Niemeyer, Daniela; Goffinet, Christine et al.
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Nafamostat-Mediated Inhibition of SARS-CoV-2 Ribosomal Frameshifting Is Insufficient to Impair Viral Replication in Vero Cells. Comment on Munshi et al. Identifying Inhibitors of-1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses. Viruses 2022, 14, 177

Viruses
2022 | Journal article
DOI: 10.3390/V14071526
WOSUID: WOS:000834451000001
Contributors: Jaeger, Niklas; Hoffmann, Markus; Poehlmann, Stefan; Krueger, Nadine
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SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies

Cell Host & Microbe
2022 | Journal article
DOI: 10.1016/J.CHOM.2022.04.017
WOSUID: WOS:000882920400010
Contributors: Arora, Prerna; Zhang, Lu; Krueger, Nadine; Rocha, Cheila; Sidarovich, Anzhalika; Schulz, Sebastian; Kempf, Amy; Graichen, Luise; Moldenhauer, Anna-Sophie; Cossmann, Anne et al.
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Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination

Journal of Medicinal Chemistry
2022 | Journal article
DOI: 10.1021/ACS.JMEDCHEM.2C00636
WOSUID: WOS:000821451600001
Contributors: Pillaiyar, Thanigaimalai; Flury, Philipp; Krueger, Nadine; Su, Haixia; Schaekel, Laura; Da Silva, Elany Barbosa; Eppler, Olga; Kronenberger, Thales; Nie, Tianqing; Luedtke, Stephanie et al.
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Host Cell Entry and Neutralization Sensitivity of SARS-CoV-2 Lineages B.1.620 and R.1

Viruses
2022-11 | Journal article | Author
DOI: 10.3390/v14112475
Contributors: Anzhalika Sidarovich; Nadine Krüger; Cheila Rocha; Luise Graichen; Amy Kempf; Inga Nehlmeier; Martin Lier; Anne Cossmann; Metodi V. Stankov; Sebastian R. Schulz et al.
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Investigations on SARS-CoV-2 Susceptibility of Domestic and Wild Animals Using Primary Cell Culture Models Derived from the Upper and Lower Respiratory Tract

Viruses
2022-04 | Journal article | Author
DOI: 10.3390/v14040828
Contributors: Iris Färber; Johannes Krüger; Cheila Rocha; Federico Armando; Maren von Köckritz-Blickwede; Stefan Pöhlmann; Armin Braun; Prof. Dr. Dr. h.c. Baumgärtner, PhD/Ohio State, Dipl ECVP, DACV (hon.); Sandra Runft; Nadine Krüger
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The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

Cell
2022-02 | Journal article
DOI: 10.1016/j.cell.2021.12.032
Part of ISSN: 0092-8674
Source: Self-asserted source
Nadine Krüger

Alternatives to animal models and their application in the discovery of species susceptibility to SARS-CoV-2 and other respiratory infectious pathogens: A review

Veterinary Pathology
2022-02-07 | Journal article
DOI: 10.1177/03009858211073678
Part of ISSN: 0300-9858
Part of ISSN: 1544-2217
Source: Self-asserted source
Nadine Krüger

B.1.617.2 enters and fuses lung cells with increased efficiency and evades antibodies induced by infection and vaccination

Cell Reports
2021 | Journal article
DOI: 10.1016/J.CELREP.2021.109825
WOSUID: WOS:000707017600023
Contributors: Arora, Prerna; Sidarovich, Anzhalika; Krueger, Nadine; Kempf, Amy; Nehlmeier, Inga; Graichen, Luise; Moldenhauer, Anna-Sophie; Winkler, Martin S.; Schulz, Sebastian; Jaeck, Hans-Martin et al.
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Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

EBioMedicine
2021 | Journal article
DOI: 10.1016/J.EBIOM.2021.103255
WOSUID: WOS:000634285400009
Contributors: Hoffmann, Markus; Hofmann-Winkler, Heike; Smith, Joan C.; Krueger, Nadine; Arora, Prerna; Sorensen, Lambert K.; Sogaard, Ole S.; Hasselstrom, Jorgen Bo; Winkler, Michael; Hempel, Tim et al.
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Increased lung cell entry of B.1.617.2 and evasion of antibodies induced by infection and BNT162b2 vaccination

BioRxiv
2021 | Journal article
DOI: 10.1101/2021.06.23.449568
WOSUID: PPRN:8864228
Contributors: Arora, P.; Kempf, A.; Nehlmeier, I.; Sidarovich, A.; Krueger, N.; Graichen, L.; Moldenhauer, Anna-Sophie; Winkler, M. S.; Schulz, S.; Jaeck, Hans-Martin et al.
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SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization

Cell Reports
2021 | Journal article
DOI: 10.1016/J.CELREP.2021.109017
WOSUID: WOS:000642161700014
Contributors: Hoffmann, Markus; Zhang, Lu; Krueger, Nadine; Graichen, Luise; Kleine-Weber, Hannah; Hofmann-Winkler, Heike; Kempf, Amy; Nessler, Stefan; Riggert, Joachim; Winkler, Martin Sebastian et al.
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SARS-CoV-2 variant B.1.617 is resistant to bamlanivimab and evades antibodies induced by infection and vaccination

Cell Reports
2021 | Journal article
DOI: 10.1016/J.CELREP.2021.109415
WOSUID: WOS:000675844000014
Contributors: Hoffmann, Markus; Hofmann-Winkler, Heike; Krueger, Nadine; Kempf, Amy; Nehlmeier, Inga; Graichen, Luise; Arora, Prerna; Sidarovich, Anzhalika; Moldenhauer, Anna-Sophie; Winkler, Martin S. et al.
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SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

Cell
2021 | Journal article
DOI: 10.1016/J.CELL.2021.03.036
WOSUID: WOS:000646027900015
Contributors: Hoffmann, Markus; Arora, Prerna; Gross, Rudiger; Seidel, Alina; Hornich, Bojan F.; Hahn, Alexander S.; Kruger, Nadine; Graichen, Luise; Hofmann-Winkler, Heike; Kempf, Amy et al.
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Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties

Chemical Science
2021 | Journal article
DOI: 10.1039/D1SC01494C
WOSUID: WOS:000689023500001
Contributors: Hempel, Tim; Elez, Katarina; Krueger, Nadine; Raich, Lluis; Shrimp, Jonathan H.; Danov, Olga; Jonigk, Danny; Braun, Armin; Shen, Min; Hall, Matthew D. et al.
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The Omicron variant is highly resistant against antibody-mediated neutralization-implications for control of the COVID-19 pandemic

BioRxiv
2021 | Journal article
DOI: 10.1101/2021.12.12.472286
WOSUID: PPRN:11532451
Contributors: Hoffmann, M.; Krueger, N.; Schulz, S.; Cossmann, A.; Rocha, C.; Kempf, A.; Nehlmeier, I.; Graichen, L.; Moldenhauer, A.-s.; Winkler, M. S. et al.
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Therapeutic Application of Alpha-1 Antitrypsin in COVID-19

American Journal of Respiratory and Critical Care Medicine
2021 | Journal article
DOI: 10.1164/RCCM.202104-0833LE
WOSUID: WOS:000675524700019
Contributors: Krueger, Nadine; Hoffmann, Markus; Zuo, Wei; Lammert, Frank; Smola, Sigrun; Tov, Naveh; Alagem, Noga; Lepper, Philipp M.; Poehlmann, Stefan; Beisswenger, Christoph et al.
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The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection

International Journal of Molecular Sciences
2021-09 | Journal article | Author
DOI: 10.3390/ijms221910636
Contributors: Nadine Krüger; Cheila Rocha; Sandra Runft; Johannes Krüger; Iris Färber; Federico Armando; Eva Leitzen; Graham Brogden; Gisa Gerold; Stefan Pöhlmann et al.
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Multidisciplinary Digital Publishing Institute
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Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2

Nature
2020 | Journal article
DOI: 10.1038/S41586-020-2575-3
WOSUID: WOS:000570130100001
Contributors: Hoffmann, Markus; Moesbauer, Kirstin; Hofmann-Winkler, Heike; Kaul, Artur; Kleine-Weber, Hannah; Krueger, Nadine; Gassen, Nils C.; Mueller, Marcel A.; Drosten, Christian; Poehlmann, Stefan
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Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus

Emerging Microbes & Infections
2020 | Journal article
DOI: 10.1080/22221751.2020.1713705
WOSUID: WOS:000509325900001
Contributors: Kleine-Weber, Hannah; Schroeder, Simon; Krueger, Nadine; Prokscha, Alexander; Naim, Hassan Y.; Mueller, Marcel A.; Drosten, Christian; Poehlmann, Stefan; Hoffmann, Markus
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Cell
2020 | Journal article
DOI: 10.1016/J.CELL.2020.02.052
WOSUID: WOS:000526184900011
Contributors: Hoffmann, Markus; Kleine-Weber, Hannah; Schroeder, Simon; Krueger, Nadine; Herrler, Tanja; Erichsen, Sandra; Schiergens, Tobias S.; Herrler, Georg; Wu, Nai-Huei; Nitsche, Andreas et al.
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The Amino Acid at Position 8 of the Proteolytic Cleavage Site of the Mumps Virus Fusion Protein Affects Viral Proteolysis and Fusogenicity

Journal of Virology
2020 | Journal article
DOI: 10.1128/JVI.01732-20
WOSUID: WOS:000582729300013
Contributors: Huettl, Sarah; Hoffmann, Markus; Steinmetzer, Torsten; Sauder, Christian; Krueger, Nadine
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Fusogenicity of the Ghana Virus (Henipavirus: Ghanaian bat henipavirus) Fusion Protein is Controlled by the Cytoplasmic Domain of the Attachment Glycoprotein

Viruses
2019 | Journal article
DOI: 10.3390/V11090800
WOSUID: WOS:000487962400090
Contributors: Voigt, Kathleen; Hoffmann, Markus; Drexler, Jan Felix; Mueller, Marcel Alexander; Drosten, Christian; Herrler, Georg; Krueger, Nadine
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Inhibitors of signal peptide peptidase and subtilisin/kexin-isozyme 1 inhibit Ebola virus glycoprotein-driven cell entry by interfering with activity and cellular localization of endosomal cathepsins

Plos One
2019 | Journal article
DOI: 10.1371/JOURNAL.PONE.0214968
WOSUID: WOS:000464095000027
Contributors: Plegge, Teresa; Spiegel, Martin; Krueger, Nadine; Nehlmeier, Inga; Winkler, Michael; Hernandez, Mariana Gonzalez; Poehlmann, Stefan
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Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells

Journal of Virology
2019 | Journal article
DOI: 10.1128/JVI.01821-18
WOSUID: WOS:000456001300028
Contributors: Hoffmann, Markus; Nehlmeier, Inga; Brinkmann, Constantin; Kraehling, Verena; Behner, Laura; Moldenhauer, Anna-Sophie; Krueger, Nadine; Nehls, Julia; Schindler, Michael; Hoenen, Thomas et al.
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Entry, Replication, Immune Evasion, and Neurotoxicity of Synthetically Engineered Bat-Borne Mumps Virus

Cell Reports
2018 | Journal article
DOI: 10.1016/J.CELREP.2018.09.018
WOSUID: WOS:000446691400006
Contributors: Krueger, Nadine; Sauder, Christian; Huetl, Sarah; Papies, Jan; Voigt, Kathleen; Herrler, Georg; Hardes, Kornelia; Steinmetzer, Torsten; Orvell, Claes; Drexler, Jan Felix et al.
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The Sialic Acid Binding Activity of Human Parainfluenza Virus 3 and Mumps Virus Glycoproteins Enhances the Adherence of Group B Streptococci to HEp-2 Cells

Frontiers in Cellular and Infection Microbiology
2018 | Journal article
DOI: 10.3389/FCIMB.2018.00280
WOSUID: WOS:000441934100001
Contributors: Tong, Jie; Fu, Yuguang; Meng, Fandan; Krueger, Nadine; Valentin-Weigand, Peter; Herrler, Georg
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Recombinant mumps viruses expressing the batMuV fusion glycoprotein are highly fusion active and neurovirulent

Journal of General Virology
2016 | Journal article
DOI: 10.1099/JGV.0.000596
WOSUID: WOS:000388677600005
Contributors: Krueger, Nadine; Sauder, Christian; Hoffmann, Markus; Orvell, Claes; Drexler, Jan Felix; Rubin, Steven; Herrler, Georg
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The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells

Plos One
2016 | Journal article
DOI: 10.1371/JOURNAL.PONE.0152134
WOSUID: WOS:000373116500037
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Functional Properties and Genetic Relatedness of the Fusion and Hemagglutinin-Neuraminidase Proteins of a Mumps Virus-Like Bat Virus

Journal of Virology
2015 | Journal article
DOI: 10.1128/JVI.03693-14
WOSUID: WOS:000352218400042
Contributors: Krueger, Nadine; Hoffmann, Markus; Drexler, Jan Felix; Mueller, Marcel Alexander; Corman, Victor Max; Sauder, Christian; Rubin, Steven; He, Biao; Orvell, Claes; Drosten, Christian et al.
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Attachment Protein G of an African Bat Henipavirus Is Differentially Restricted in Chiropteran and Nonchiropteran Cells

Journal of Virology
2014 | Journal article
DOI: 10.1128/JVI.01561-14
WOSUID: WOS:000342688000031
Contributors: Krueger, Nadine; Hoffmann, Markus; Drexler, Jan Felix; Mueller, Marcel Alexander; Corman, Victor Max; Drosten, Christian; Herrler, Georg
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Characterization of African bat henipavirus GH-M74a glycoproteins

Journal of General Virology
2014 | Journal article
DOI: 10.1099/VIR.0.060632-0
WOSUID: WOS:000338177500003
Contributors: Weis, Michael; Behner, Laura; Hoffmann, Markus; Krueger, Nadine; Herrler, Georg; Drosten, Christian; Drexler, Jan Felix; Dietzel, Erik; Maisner, Andrea
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Surface Glycoproteins of an African Henipavirus Induce Syncytium Formation in a Cell Line Derived from an African Fruit Bat, <i>Hypsignathus monstrosus</i>

Journal of Virology
2013 | Journal article
DOI: 10.1128/JVI.02458-13
WOSUID: WOS:000327443300073
Contributors: Krueger, Nadine; Hoffmann, Markus; Weis, Michael; Drexler, Jan Felix; Mueller, Marcel Alexander; Winter, Christine; Corman, Victor Max; Guetzkow, Tim; Drosten, Christian; Maisner, Andrea et al.
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Peer review (57 reviews for 16 publications/grants)

Review activity for Antibodies. (1)
Review activity for Drug development and industrial pharmacy. (1)
Review activity for Immunology. (1)
Review activity for Journal of applied toxicology. (2)
Review activity for Methods and protocols. (1)
Review activity for Microorganisms. (2)
Review activity for Open forum infectious diseases. (2)
Review activity for Pathogens. (2)
Review activity for Proceedings of the National Academy of Sciences of the United States of America. (3)
Review activity for Saudi pharmaceutical journal. (1)
Review activity for Vaccines. (5)
Review activity for Veterinary research communications. (1)
Review activity for Veterinary research communications. (1)
Review activity for Virologica sinica. (2)
Review activity for Viruses. (31)
Review activity for Zoonoses. (1)
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