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University College London: London, London, GB

2018-09-01 to present | MD/PhD (UK Dementia Research Institute)
Employment
Source: Self-asserted source
Marc Aurel Busche

Works (26)

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease

PLOS Biology
2024-07-23 | Journal article | Author
DOI: 10.1371/journal.pbio.3002727
Part of ISSN: 1545-7885
Contributors: Rikesh M. Rajani; Robert Ellingford; Mariam Hellmuth; Samuel S. Harris; Orjona S. Taso; David Graykowski; Francesca Kar Wey Lam; Charles Arber; Emre Fertan; John S. H. Danial et al.
Source: Self-asserted source
Marc Aurel Busche

β-amyloid monomer scavenging by an anticalin protein prevents neuronal hyperactivity in mouse models of Alzheimer’s Disease

Nature Communications
2024-07-10 | Journal article
DOI: 10.1038/s41467-024-50153-y
Contributors: Benedikt Zott; Lea Nästle; Christine Grienberger; Felix Unger; Manuel M. Knauer; Christian Wolf; Aylin Keskin-Dargin; Anna Feuerbach; Marc Aurel Busche; Arne Skerra et al.
Source: check_circle
Crossref

PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.

Nature neuroscience
2024-02-29 | Journal article | Author
DOI: 10.1038/s41593-024-01589-4
PMID: 38424324
PMC: PMC11001582
Contributors: Carmelo Milioto; Mireia Carcolé Estrada; Ashling Giblin; Coneys R; Attrebi O; Mhoriam Ahmed; Harris SS; Lee BI; Yang M; Ellingford RA et al.
Source: Self-asserted source
Marc Aurel Busche

The β-Secretase Substrate Seizure 6–Like Protein (SEZ6L) Controls Motor Functions in Mice

Molecular Neurobiology
2022-02 | Journal article
DOI: 10.1007/s12035-021-02660-y
Part of ISSN: 0893-7648
Part of ISSN: 1559-1182
Source: Self-asserted source
Marc Aurel Busche

Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo

Alzheimer's Research & Therapy
2021-12 | Journal article
DOI: 10.1186/s13195-021-00860-1
Part of ISSN: 1758-9193
Source: Self-asserted source
Marc Aurel Busche
grade
Preferred source (of 2)‎

Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

Ageing Research Reviews
2021-08 | Journal article
DOI: 10.1016/j.arr.2021.101372
Contributors: Fernando Maestú; Willem de Haan; Marc Aurel Busche; Javier DeFelipe
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Synergy between amyloid-β and tau in Alzheimer’s disease

Nature Neuroscience
2020-10-10 | Journal article
DOI: 10.1038/s41593-020-0687-6
Contributors: Marc Aurel Busche; Bradley T. Hyman
Source: check_circle
Crossref

Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer’s Disease

Neuron
2020-06 | Journal article
DOI: 10.1016/j.neuron.2020.06.005
Part of ISSN: 0896-6273
Source: Self-asserted source
Marc Aurel Busche

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3

The EMBO Journal
2020-06-22 | Journal article
DOI: 10.15252/embj.2019103457
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Source: Self-asserted source
Marc Aurel Busche

Tau suppresses neuronal activity in vivo, even before tangles form.

Brain : a journal of neurology
2019-04 | Journal article
DOI: 10.1093/brain/awz060
PMID: 30946472
Contributors: Busche MA
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

Nature Neuroscience
2019-01 | Journal article
DOI: 10.1038/s41593-018-0289-8
Contributors: Marc Aurel Busche; Susanne Wegmann; Simon Dujardin; Caitlin Commins; Julia Schiantarelli; Naomi Klickstein; Tarun V. Kamath; George A. Carlson; Israel Nelken; Bradley T. Hyman
Source: check_circle
Crossref

In Vivo Two-Photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models.

Methods in molecular biology (Clifton, N.J.)
2018 | Journal article
DOI: 10.1007/978-1-4939-7704-8_23
PMID: 29512084
Contributors: Busche MA
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

Annual review of neuroscience
2018-07 | Journal article
DOI: 10.1146/annurev-neuro-080317-061725
PMID: 29986165
Contributors: Zott B; Busche MA; Sperling RA; Konnerth A
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

Pearls & Oy-sters: Ocular motor apraxia as essential differential diagnosis to supranuclear gaze palsy: Eyes up.

Neurology
2018-03 | Journal article
DOI: 10.1212/wnl.0000000000005069
PMID: 29507134
Contributors: Schweyer K; Busche MA; Hammes J; Zwergal A; Buhmann C; van Eimeren T; Höglinger GU
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

BACE inhibition-dependent repair of Alzheimer's pathophysiology.

Proceedings of the National Academy of Sciences of the United States of America
2017-07 | Journal article
DOI: 10.1073/pnas.1708106114
PMID: 28739891
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

Impairments of neural circuit function in Alzheimer's disease.

2016-08 | Journal article
DOI: 10.1098/rstb.2015.0429
PMID: 27377723
Contributors: Busche MA; Konnerth A
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

[Connections between sleep and Alzheimer's disease : Insomnia, amnesia and amyloid].

2016-06 | Journal article
PMID: 27251738
Contributors: Busche MA; Kekuš M; Förstl H
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

[Mechanisms of Alzheimer's disease : Neuronal hyperactivity and hypoactivity as new therapeutic targets].

2016-01 | Journal article
PMID: 26781314
Contributors: Busche MA; Staufenbiel M; Willem M; Haass C; Förstl H
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models.

2015-12 | Journal article
DOI: 10.1038/nn.4163
PMID: 26551546
Contributors: Busche MA; Grienberger C; Keskin AD; Song B; Neumann U; Staufenbiel M; Förstl H; Konnerth A
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

Trends of patient referral to a memory clinic and towards earlier diagnosis from 1985-2009.

2015-12 | Journal article
DOI: 10.1017/S104161021500157X
PMID: 26424328
Contributors: Grimmer T; Beringer S; Kehl V; Alexopoulos P; Busche A; Förstl H; Goldhardt O; Natale B; Ortner M; Peters H et al.
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

Rescue of long-range circuit dysfunction in Alzheimer's disease models.

2015-11 | Journal article
DOI: 10.1038/nn.4137
PMID: 26457554
Contributors: Busche MA; Kekuš M; Adelsberger H; Noda T; Förstl H; Nelken I; Konnerth A
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

2015-10 | Journal article
DOI: 10.1038/nature14864
PMID: 26322584
Contributors: Willem M; Tahirovic S; Busche MA; Ovsepian SV; Chafai M; Kootar S; Hornburg D; Evans LD; Moore S; Daria A et al.
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

Neuronal hyperactivity--A key defect in Alzheimer's disease?

2015-06 | Journal article
DOI: 10.1002/bies.201500004
PMID: 25773221
Contributors: Busche MA; Konnerth A
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease.

2012-05 | Journal article
DOI: 10.1073/pnas.1206171109
PMID: 22592800
PMC: PMC3365221
Contributors: Busche MA; Chen X; Henning HA; Reichwald J; Staufenbiel M; Sakmann B; Konnerth A
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.

2008-09 | Journal article
DOI: 10.1126/science.1162844
PMID: 18802001
Contributors: Busche MA; Eichhoff G; Adelsberger H; Abramowski D; Wiederhold KH; Haass C; Staufenbiel M; Konnerth A; Garaschuk O
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

In vivo calcium imaging of the aging and diseased brain.

2008-03 | Journal article
DOI: 10.1007/s00259-007-0709-6
PMID: 18193219
Contributors: Eichhoff G; Busche MA; Garaschuk O
Source: Self-asserted source
Marc Aurel Busche via Europe PubMed Central

Peer review (22 reviews for 10 publications/grants)

Review activity for Alzheimer's research & therapy (2)
Review activity for Communications biology. (1)
Review activity for ENeuro. (1)
Review activity for Nature aging. (1)
Review activity for Nature communications (8)
Review activity for Nature medicine. (1)
Review activity for Nature neuroscience. (3)
Review activity for Neuron. (3)
Review activity for PLoS biology. (1)
Review activity for The journal of neuroscience : (1)
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