Personal information

Other IDs

Loop profile: 231256
Scopus Author ID: 7005811338

Keywords

Peroxisomes, Pexophagy, Cholesterol, Hypoxia-inducible factors, Lipid metabolism, Autophagy, ER stress, Cancer metabolism, ccRCC, clear cell renal cell carcinoma, hepatocellular carcinoma

Countries

Switzerland

Activities

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Employment (4)

ETH Zurich: Zurich, Zurich, CH

2007-01-01 to present | Senior Scientist (Oberassistent, Lecturer)/Group leader (Biology / Institute of Molecular Health Sciences)
Employment
Source: Self-asserted source
Werner Kovacs

Justus-Liebig-University: Giessen, DE

2005-11-15 to 2006-12-31 (Anatomy and Cell Biology)
Employment
Source: Self-asserted source
Werner Kovacs

San Diego State University: San Diego, CA, US

1999-04 to 2005-10 (Biology)
Employment
Source: Self-asserted source
Werner Kovacs

University of Vienna: Vienna, AT

1996-09 to 1999-03 (Medical Chemistry)
Employment
Source: Self-asserted source
Werner Kovacs

Education and qualifications (3)

ETH Zurich: Zurich, Zurich, CH

2019-02-01 to present | Venia Legendi (Habilitation) in Metabolism and Disease (Biology)
Qualification
Source: Self-asserted source
Werner Kovacs

Vienna University of Technology: Vienna, Niederösterreich, AT

1993-10-01 to 1997-06-27 | Dr. techn. (Ph.D.) (Biochemical Technology and Microbiology)
Education
Source: Self-asserted source
Werner Kovacs

Vienna University of Technology: Vienna, Niederösterreich, AT

1987-10-01 to 1993-06-07 | Dipl.-Ing. (Master degree) (Biochemical Technology and Microbiology)
Education
Source: Self-asserted source
Werner Kovacs

Professional activities (2)

Life Sciences Switzerland: Zurich, Zurich, CH

2018-01-01 to present
Membership
Source: Self-asserted source
Werner Kovacs

American Society for Cell Biology: Bethesda, MD, US

1996-01-01 to present
Membership
Source: Self-asserted source
Werner Kovacs

Funding (3)

Exploring the molecular mechanism of Hif-2-mediated pexophagy and the role of pexophagy in tumorigenesis

2017-01 to 2019-12 | Grant
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Bern, CH)
Source: Self-asserted source
Werner Kovacs

Trafficking of HDL and its lipids in mouse models

2010-10 to 2014-10 | Grant
Austrian Science Fund (Vienna, AT)
Part of GRANT_NUMBER:

P22838
Source: Self-asserted source
Werner Kovacs

Control of peroxisome abundance by hypoxia-inducible factors

2010-10 to 2014-04 | Grant
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Bern, CH)
GRANT_NUMBER:

31003A_132982
Source: Self-asserted source
Werner Kovacs

Works (49)

The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization

Cell Reports
2024-09-24 | Journal article
DOI: 10.1016/j.celrep.2024.114689
Part of ISSN: 2211-1247
Contributors: Devanarayanan Siva Sankar; Stephanie Kaeser-Pebernard; Christine Vionnet; Sebastian Favre; Lais de Oliveira Marchioro; Benjamin Pillet; Jianwen Zhou; Michael Stumpe; Werner Josef Kovacs; Dieter Kressler et al.
Source: Self-asserted source
Werner Kovacs

Travelling under pressure - hypoxia and shear stress in the metastatic journey

Clinical & Experimental Metastasis
2023-10 | Journal article
DOI: 10.1007/s10585-023-10224-8
Contributors: Ece Su Ildiz; Ana Gvozdenovic; Werner J Kovacs; Nicola Aceto
Source: check_circle
Crossref

The peroxisome: an up-and-coming organelle in immunometabolism

Trends in Cell Biology
2023-01 | Review
DOI: 10.1016/j.tcb.2022.06.001
Part of ISSN: 0962-8924
Contributors: Francesca Di cara; Stéphane Savary; Werner J. Kovacs; Peter Kim; Richard A. Rachubinski
Source: Self-asserted source
Werner Kovacs

A Functional SMAD2/3 Binding Site in the PEX11β Promoter Identifies a Role for TGFβ in Peroxisome Proliferation in Humans

Frontiers in Cell and Developmental Biology
2020 | Journal article
DOI: 10.3389/fcell.2020.577637
EID:

2-s2.0-85095613695

Part of ISSN: 2296634X
Contributors: Azadi, A.S.; Carmichael, R.E.; Kovacs, W.J.; Koster, J.; Kors, S.; Waterham, H.R.; Schrader, M.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

A Single Metabolite which Modulates Lipid Metabolism Alters Hematopoietic Stem/Progenitor Cell Behavior and Promotes Lymphoid Reconstitution

Stem Cell Reports
2020 | Journal article
DOI: 10.1016/j.stemcr.2020.07.021
EID:

2-s2.0-85090033101

Part of ISSN: 22136711
Contributors: Giger, S.; Kovtonyuk, L.V.; Utz, S.G.; Ramosaj, M.; Kovacs, W.J.; Schmid, E.; Ioannidis, V.; Greter, M.; Manz, M.G.; Lutolf, M.P. et al.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits

Cell Stem Cell
2020 | Journal article
DOI: 10.1016/j.stem.2020.04.002
EID:

2-s2.0-85084825093

Part of ISSN: 18759777 19345909
Contributors: Bowers, M.; Liang, T.; Gonzalez-Bohorquez, D.; Zocher, S.; Jaeger, B.N.; Kovacs, W.J.; Röhrl, C.; Cramb, K.M.L.; Winterer, J.; Kruse, M. et al.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Functional Peroxisomes Are Essential for Efficient Cholesterol Sensing and Synthesis

Frontiers in Cell and Developmental Biology
2020 | Journal article
DOI: 10.3389/fcell.2020.560266
EID:

2-s2.0-85096374364

Part of ISSN: 2296634X
Contributors: Charles, K.N.; Shackelford, J.E.; Faust, P.L.; Fliesler, S.J.; Stangl, H.; Kovacs, W.J.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

High-throughput screening in multicellular spheroids for target discovery in the tumor microenvironment

Expert Opinion on Drug Discovery
2020 | Journal article
DOI: 10.1080/17460441.2020.1756769
EID:

2-s2.0-85084290649

Part of ISSN: 1746045X 17460441
Contributors: Calpe, B.; Kovacs, W.J.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Peroxisome-Deficiency and HIF-2α Signaling Are Negative Regulators of Ketohexokinase Expression

Frontiers in Cell and Developmental Biology
2020 | Journal article
DOI: 10.3389/fcell.2020.00566
EID:

2-s2.0-85088443662

Part of ISSN: 2296634X
Contributors: Eberhart, T.; Schönenberger, M.J.; Walter, K.M.; Charles, K.N.; Faust, P.L.; Kovacs, W.J.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors

Clinical Cancer Research
2019-11-15 | Journal article
DOI: 10.1158/1078-0432.ccr-19-0253
Part of ISSN: 1078-0432
Part of ISSN: 1557-3265
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly

Scientific Reports
2019-05-23 | Journal article
DOI: 10.1038/s41598-019-44112-7
Contributors: Lukas Frischknecht; Christian Britschgi; Patricia Galliker; Yann Christinat; Anton Vichalkovski; Matthias Gstaiger; Werner J. Kovacs; Wilhelm Krek
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Correction of gene model annotations improves isoform abundance estimates: the example of ketohexokinase (Khk)

F1000Research
2019-04-03 | Journal article
DOI: 10.12688/f1000research.17082.2
Contributors: Christophe D. Chabbert; Tanja Eberhart; Ilaria Guccini; Wilhelm Krek; Werner J. Kovacs
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Pexophagy in yeast and mammals: an update on mysteries

Histochemistry and cell biology
2018 | Journal article
DOI: 10.1007/s00418-018-1724-3
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 3)‎

Correction of gene model annotations improves isoform abundance estimates: the example of ketohexokinase (Khk) [version 1; referees: awaiting peer review]

2018-12-19 | Journal article
DOI: 10.12688/f1000research.17082.1
Part of ISSN: 2046-1402
Contributors: Christophe D. Chabbert; Tanja Eberhart; Ilaria Guccini; Wilhelm Krek; Werner J. Kovacs
Source: check_circle
F1000
grade
Preferred source (of 2)‎

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

Cell reports
2017 | Journal article
DOI: 10.1016/j.celrep.2017.08.029
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Isolation of Peroxisomes from Mouse Brain Using a Continuous Nycodenz Gradient: A Comparison to the Isolation of Liver and Kidney Peroxisomes

Methods in molecular biology (Clifton, N.J.)
2017 | Journal article
DOI: 10.1007/978-1-4939-6937-1_2
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Autophagy
2016 | Journal article
DOI: 10.1080/15548627.2016.1147886
EID:

2-s2.0-85054826264

Part of ISSN: 15548635 15548627
Contributors: Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; Adams, C.M.; Adams, P.D.; Adeli, K. et al.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Autophagy
2016 | Journal article
DOI: 10.1080/15548627.2015.1100356
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

EPAS1/HIF-2α is a driver of mammalian pexophagy

Autophagy
2015 | Journal article
DOI: 10.1080/15548627.2015.1045180
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Hypoxia signaling pathways: modulators of oxygen-related organelles

Frontiers in cell and developmental biology
2015 | Journal article
DOI: 10.3389/fcell.2015.00042
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Cholesterol biosynthesis and ER stress in peroxisome deficiency

Biochimie
2014 | Journal article
DOI: 10.1016/j.biochi.2013.10.019
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver

Histochemistry and cell biology
2014 | Journal article
DOI: 10.1007/s00418-014-1251-9
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells

Journal of lipid research
2014 | Journal article
DOI: 10.1194/jlr.M043299
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy

Cell metabolism
2014 | Journal article
DOI: 10.1016/j.cmet.2014.09.017
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

High-density lipoprotein endocytosis in endothelial cells

World journal of biological chemistry
2013 | Journal article
DOI: 10.4331/wjbc.v4.i4.131
Source: Self-asserted source
Werner Kovacs

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Nature
2013 | Journal article
DOI: 10.1038/nature11689
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice

Biochimica et biophysica acta
2012 | Journal article
DOI: 10.1016/j.bbalip.2012.02.011
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Atherogenic diet leads to posttranslational down-regulation of murine hepatocyte SR-BI expression

Atherosclerosis
2009 | Journal article
DOI: 10.1016/j.atherosclerosis.2008.04.018
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress

The Journal of biological chemistry
2009 | Journal article
DOI: 10.1074/jbc.M809064200
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Peroxisomes in human and mouse testis: Differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis (Biology of Reproduction (2007) 77, (1060-1072) DOI: 10.1095/biolreprod.107. 061242)

Biology of Reproduction
2008 | Journal article
DOI: 10.1095/biolreprod.108.067579
EID:

2-s2.0-38549099044

Part of ISSN: 00063363
Contributors: Nenicu, A.; Lüers, G.H.; Kovacs, W.; Otte, D.M.; Zimmer, A.; Bergmann, M.; Baumgart-Vogt, E.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Differential expression of peroxisomal matrix and membrane proteins during postnatal development of mouse brain

The Journal of comparative neurology
2007 | Journal article
DOI: 10.1002/cne.21448
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes

Histochemistry and cell biology
2007 | Journal article
DOI: 10.1007/s00418-006-0254-6
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Peroxisomes in human and mouse testis: Diferential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis

Biol. Reprod.
2007 | Journal article
DOI: 10.1095/biolreprod.107.061242
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model

Molecular and cellular biology
2004 | Journal article
DOI: 10.1128/MCB.24.1.1-13.2004
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement

Histochemistry and cell biology
2004 | Journal article
DOI: 10.1007/s00418-004-0689-6
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Cholesterol biosynthesis and regulation: Role of peroxisomes

Advances in Experimental Medicine and Biology
2003 | Book
DOI: 10.1007/978-1-4419-9072-3_41
EID:

2-s2.0-1542329066

Part of ISSN: 00652598
Contributors: Kovacs, W.J.; Krisans, S.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Central role of peroxisomes in isoprenoid biosynthesis

Progress in lipid research
2002 | Journal article
DOI: 10.1016/s0163-7827(02)00002-4
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma cells and HepG2 human hepatoblastoma cells

Histochemistry and Cell Biology
2001 | Journal article
DOI: 10.1007/s004180100278
EID:

2-s2.0-0034913236

Part of ISSN: 09486143
Contributors: Kovacs, W.; Walter, I.; Stangl, H.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Localization of mRNAs encoding peroxisomal proteins in cell culture by non-radioactive in situ hybridization. Comparison of rat and human hepatoma cells and their responses to two divergent hypolipidemic drugs

Histochemistry and Cell Biology
2001 | Journal article
DOI: 10.1007/s004180100277
EID:

2-s2.0-0034916855

Part of ISSN: 09486143
Contributors: Kovacs, W.; Stangl, H.; Völkl, A.; Schad, A.; Fahimi, H.D.; Baumgart, E.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Purification of brain peroxisomes and localization of 3-hydroxy-3-methylglutaryl coenzyme A reductase

European journal of biochemistry
2001 | Journal article
DOI: 10.1046/j.0014-2956.2001.02409.x
Source: Self-asserted source
Werner Kovacs
grade
Preferred source (of 2)‎

Identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes: AA-CoA thiolase, HMG-CoA synthase, MPPD, and FPP synthase

Journal of Lipid Research
2000 | Journal article
EID:

2-s2.0-0034524328

Part of ISSN: 00222275
Contributors: Olivier, L.M.; Kovacs, W.; Masuda, K.; Keller, G.-A.; Krisans, S.K.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Biogeography and phenotypic variation in Trichoderma sect. Longibrachiatum and associated Hypocrea species

Mycological research
1997 | Journal article
DOI: 10.1017/s0953756296002845
Source: Self-asserted source
Werner Kovacs

[Pleiotrophic peroxisome induction by hypolipidemic agents in primates and rodents]

Wiener klinische Wochenschrift
1996 | Journal article
Source: Self-asserted source
Werner Kovacs

Cellulase formation by species of Trichoderma sect. Longibrachiatum and of Hypocrea spp. with anamorphs referable to Trichoderma sect. Longibrachiatum

Fungal genetics and biology : FG & B
1996 | Journal article
DOI: 10.1006/fgbi.1996.0025
Source: Self-asserted source
Werner Kovacs

Molecular evidence that the asexual industrial fungus Trichoderma reesei is a clonal derivative of the ascomycete Hypocrea jecorina

Proceedings of the National Academy of Sciences of the United States of America
1996 | Journal article
DOI: 10.1073/pnas.93.15.7755
Source: Self-asserted source
Werner Kovacs

Pleiotropic proliferation of peroxisomes of primates and rodents by hypolipidemic agents,PLEIOTROPHISCHE PEROXISOMENINDUKTION VON HYPOLIPIDAMIKA BEI PRIMATEN UND NAGETIEREN

Wiener Klinische Wochenschrift
1996 | Journal article
EID:

2-s2.0-0029683597

Part of ISSN: 00435325
Contributors: Stangl, H.; Kovacs, W.; Kopeky, E.; Nagl, G.; Kremser, K.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

A hepatic model system for hypolipidemic agents

Journal of Experimental and Clinical Cancer Research
1995 | Journal article
EID:

2-s2.0-0028917585

Part of ISSN: 03929078
Contributors: Kovacs, W.; Kopecky, E.; Nagl, G.; Stangl, H.; Bock, P.; Kaiser, E.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Differential Induction of Peroxisomal Enzymes by Hypolipidaemics in Human (HepG2) and Rat (MH1C1) Hepatoma Cell Lines<sup>1</sup>)

Clinical Chemistry and Laboratory Medicine
1995 | Journal article
DOI: 10.1515/cclm.1995.33.11.775
EID:

2-s2.0-84945733539

Part of ISSN: 14374331 14346621
Contributors: Stangl, H.; Kovacs, W.; Bock, P.; Kremser, K.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Peroxisomal disorders - Oxygen and free radicals,PEROXISOMALE ERKRANKUNGEN - SAUERSTOFF UND FREIE RADIKALE

Wiener Klinische Wochenschrift
1995 | Journal article
EID:

2-s2.0-0028847249

Part of ISSN: 00435325
Contributors: Kremser, K.; Kovacs, W.; Stangl, H.
Source: Self-asserted source
Werner Kovacs via Scopus - Elsevier

Peer review (16 reviews for 5 publications/grants)

Review activity for Cell biology and toxicology. (1)
Review activity for Cellular and molecular life sciences (1)
Review activity for EMBO reports. (1)
Review activity for Experimental cell research. (3)
Review activity for Histochemistry and cell biology. (10)
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