Personal information

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Verified email domains

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Baxter lab

Other IDs

Scopus Author ID: 37017194300

Keywords

DNA replication, DNA topology, DNA topoisomerase

Activities

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Employment (1)

University of Sussex: Brighton, Brighton and Hove, GB

2010-09-01 to present | Principal Investigator (Genome Damage and Stability Centre)
Employment
Source: Self-asserted source
Jonathan Baxter

Education and qualifications (1)

Imperial College Faculty of Medicine: London, London, GB

1997-10-01 to 2002-07-01 | PhD (Clinical Sciences)
Education
Source: Self-asserted source
Jonathan Baxter

Funding (7)

Determining how EBV episome maintenance is regulated by TIMELESS function

2023-03-01 to 2026-02-28 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.13519639
GRANT_NUMBER: MR/X009432/1
Source: Self-asserted source
Jonathan Baxter via DimensionsWizard

Investigating the interplay between SMC complexes and Topoisomerase II

2018-09-30 to 2021-09-29 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
URL: https://app.dimensions.ai/details/grant/grant.7746082
GRANT_NUMBER: BB/S001425/1
Source: Self-asserted source
Jonathan Baxter via DimensionsWizard

Investigating how replication fork rotation causes chromosomal instability during S phase

Source: Self-asserted source
Jonathan Baxter via DimensionsWizard

Regulating replication fork rotation to maintain genome stability

2015-10-01 to 2018-09-01 | Grant
The Royal Society (London, GB)
URL: https://grants.uberresearch.com/501100000288/6417/Regulating-replication-fork-rotation-to-maintain-genome-stability
GRANT_NUMBER: 6417
Source: Self-asserted source
Jonathan Baxter via DimensionsWizard

How does Condensin mediate topological change during mitosis?

2012-08-31 to 2015-12-31 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
URL: https://grants.uberresearch.com/501100000268/B9308559-5FB1-421F-8099-DB8E7788CF24/How-does-Condensin-mediate-topological-change-during-mitosis
GRANT_NUMBER: BB/J018554/1
Source: Self-asserted source
Jonathan Baxter via DimensionsWizard

Understanding the mechanisms of termination of DNA replication in eukaryotes

Source: Self-asserted source
Jonathan Baxter via DimensionsWizard

Understanding the mechanisms of termination of DNA replication in eukaryotes

Salary award
Royal Society (London, GB)
Source: Self-asserted source
Jonathan Baxter

Works (21)

The fork protection complex generates DNA topological stress–induced DNA damage while ensuring full and faithful genome duplication

Proceedings of the National Academy of Sciences
2024-12-03 | Journal article
DOI: 10.1073/pnas.2413631121
Contributors: Andrea Keszthelyi; Sahar Mansoubi; Alex Whale; Jonathan Houseley; Jonathan Baxter
Source: check_circle
Crossref

Sister chromatid cohesion establishment during DNA replication termination

Science
2024-04-05 | Journal article
DOI: 10.1126/science.adf0224
Contributors: George Cameron; Dominika T. Gruszka; Rhian Gruar; Sherry Xie; Çağla Kaya; Kim A. Nasmyth; Jonathan Baxter; Madhusudhan Srinivasan; Hasan Yardimci
Source: check_circle
Crossref

The Fork Protection Complex protects long replicons from DNA damage at the cost of genome instability induced by DNA topological stress

2023-08-04 | Preprint
DOI: 10.1101/2023.08.04.551986
Contributors: Andrea Keszthelyi; Alex Whale; Jon Houseley; Jonathan Baxter
Source: check_circle
Crossref

Cryo-EM structure of the Smc5/6 holo-complex

Nucleic Acids Research
2022-09-09 | Journal article
DOI: 10.1093/nar/gkac692
Contributors: Stephen T Hallett; Isabella Campbell Harry; Pascale Schellenberger; Lihong Zhou; Nora B Cronin; Jonathan Baxter; Thomas J Etheridge; Johanne M Murray; Antony W Oliver
Source: check_circle
Crossref

Telomerase subunit Est2 marks internal sites that are prone to accumulate DNA damage

BMC Biology
2021-12 | Journal article
DOI: 10.1186/s12915-021-01167-1
Part of ISSN: 1741-7007
Source: Self-asserted source
Jonathan Baxter

Cryo-EM structure of the Smc5/6 holo-complex

2021-11-25 | Other
DOI: 10.1101/2021.11.25.470006
Contributors: Stephen T. Hallett; Isabella Campbell Harry; Pascale Schellenberger; Lihong Zhou; Nora B. Cronin; Jonathan Baxter; Thomas J. Etheridge; Johanne M. Murray; Antony W. Oliver
Source: check_circle
Crossref

Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress

Nucleic Acids Research
2020-12-02 | Journal article
DOI: 10.1093/nar/gkaa963
Contributors: Rose Westhorpe; Andrea Keszthelyi; Nicola E Minchell; David Jones; Jonathan Baxter
Source: check_circle
Crossref

Convergent genes shape budding yeast pericentromeres

Nature
2020-06-04 | Journal article
DOI: 10.1038/s41586-020-2244-6
Contributors: Flora Paldi; Bonnie Alver; Daniel Robertson; Stephanie A. Schalbetter; Alastair Kerr; David A. Kelly; Jonathan Baxter; Matthew J. Neale; Adele L. Marston
Source: check_circle
Crossref

Cohesin Causes Replicative DNA Damage by Trapping DNA Topological Stress

Molecular Cell
2020-05 | Journal article
DOI: 10.1016/j.molcel.2020.03.013
Contributors: Nicola Elizabeth Minchell; Andrea Keszthelyi; Jonathan Baxter
Source: check_circle
Crossref

Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress

2019-12-17 | Preprint
DOI: 10.1101/2019.12.17.877811
Contributors: Rose Westhorpe; Andrea Keszthelyi; Nicola E. Minchell; David Jones; Jonathan Baxter
Source: check_circle
Crossref

Checkpoint inhibition of origin firing prevents DNA topological stress.

Genes & development
2019-10 | Journal article
DOI: 10.1101/gad.328682.119
PMID: 31624083
Contributors: Morafraile EC; Hänni C; Allen G; Zeisner T; Clarke C; Johnson MC; Santos MM; Carroll L; Minchell NE; Baxter J et al.
Source: Self-asserted source
Jonathan Baxter via Europe PubMed Central

Principles of meiotic chromosome assembly revealed in S. cerevisiae

Nature Communications
2019-10-22 | Journal article
DOI: 10.1038/s41467-019-12629-0
Contributors: Stephanie A. Schalbetter; Geoffrey Fudenberg; Jonathan Baxter; Katherine S. Pollard; Matthew J. Neale
Source: check_circle
Crossref

Convergent genes shape budding yeast pericentromeres

2019-03-30 | Other
DOI: 10.1101/592782
Contributors: Flora Paldi; Bonnie Alver; Daniel Robertson; Stephanie A. Schalbetter; Alastair Kerr; David A. Kelly; Matthew J. Neale; Jonathan Baxter; Adele L. Marston
Source: check_circle
Crossref

Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes.

Molecular cell
2019-03-05 | Journal article
DOI: 10.1016/j.molcel.2019.01.040
PMID: 30850330
PMC: PMC6477153
Source: Self-asserted source
Jonathan Baxter

SMC complexes differentially compact mitotic chromosomes according to genomic context

Nature Cell Biology
2017-09-21 | Journal article
DOI: 10.1038/ncb3594
Contributors: Stephanie Andrea Schalbetter; Anton Goloborodko; Geoffrey Fudenberg; Jon-Matthew Belton; Catrina Miles; Miao Yu; Job Dekker; Leonid Mirny; Jonathan Baxter
Source: check_circle
Crossref

The Causes and Consequences of Topological Stress during DNA Replication

Genes
2016-12-21 | Journal article
DOI: 10.3390/genes7120134
Contributors: Andrea Keszthelyi; Nicola Minchell; Jonathan Baxter
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

"Breaking Up Is Hard to Do": The Formation and Resolution of Sister Chromatid Intertwines.

Journal of Molecular Biology
2014-09-04 | Journal article
DOI:

doi:10.1016/j.jmb.2014.08.022
Source: Self-asserted source
Jonathan Baxter

A model for chromosome condensation based on the interplay between condensin and topoisomerase II

Trends in Genetics
2012-03-28 | Journal article
Source: Self-asserted source
Jonathan Baxter

Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes.

Science
2011-03-11 | Journal article
Source: Self-asserted source
Jonathan Baxter

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability

Proceedings of the National Academy of Sciences USA
Journal article
DOI: 10.1073/pnas.1505356112
Source: Self-asserted source
Jonathan Baxter
grade
Preferred source (of 2)‎

Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast

Molecular Cell
Journal article
DOI:

doi: 10.1016/j.molcel.2008.04.019
Source: Self-asserted source
Jonathan Baxter

Peer review (10 reviews for 8 publications/grants)

Review activity for Cell. (1)
Review activity for Current opinion in cell biology. (1)
Review activity for Developmental cell. (1)
Review activity for EMBO journal. (1)
Review activity for Nature cell biology (1)
Review activity for Nature communications (2)
Review activity for Nature genetics. (1)
Review activity for Nucleic acids research. (2)
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