Personal information

Other IDs

Scopus Author ID: 57188648682
Scopus Author ID: 55276381100
Loop profile: 975974
SciProfiles: 2401912

Activities

Collapse all

Employment (4)

University of Minnesota, Twin Cities: Minneapolis, Minnesota, US

2024-12-16 to present | Associate Professor (BMBB)
Employment
Source: Self-asserted source
Ming Xu

University of Connecticut Health Center: Farmington, CT, US

2018-06-08 to present | Assistant Professor (Center on Aging)
Employment
Source: Self-asserted source
Ming Xu

Mayo Clinic: Rochester, Minnesota, US

2011-10-23 to 2018-06-07 | Postdoc (Kogod Center on Aging)
Employment
Source: Self-asserted source
Ming Xu

University of Kansas Medical Center: Kansas City, Kansas, US

2006-08-03 to 2011-10-20 | Graduate Student (Physical Therapy)
Employment
Source: Self-asserted source
Ming Xu

Education and qualifications (2)

University of Kansas Hospital: Kansas City, KS, US

2006-08-03 to 2011-08-26 | PhD (Physical Therapy)
Education
Source: Self-asserted source
Ming Xu

Fudan University: Shanghai, Shanghai, CN

2000-07-01 to 2004-06-30 | Bachelor (Biological Science)
Education
Source: Self-asserted source
Ming Xu

Funding (8)

Can Senolytics Improve the Aged Response to Viral Infection

2021-09-01 to 2023-05-31 | Grant
National Institute on Aging (Baltimore, US)
URL: https://app.dimensions.ai/details/grant/grant.9846540
GRANT_NUMBER: R21AG071292
Source: Self-asserted source
Ming Xu via DimensionsWizard

Targeting P21-Highly-Expressing Senescent Cells In Vivo for Improving Cognitive Function in the Alzheimers Diseases

2021-05-01 to 2023-04-30 | Grant
National Institute on Aging (Baltimore, US)
URL: https://app.dimensions.ai/details/grant/grant.9655676
GRANT_NUMBER: R03AG072374
Source: Self-asserted source
Ming Xu via DimensionsWizard

Reciprocal Modulation of the Microbiome and Cellular Senescence in Metabolic Dysfunction

2020-09-10 to 2025-05-31 | Grant
National Institute on Aging (Baltimore, US)
URL: https://app.dimensions.ai/details/grant/grant.9411963
GRANT_NUMBER: R01AG068860
Source: Self-asserted source
Ming Xu via DimensionsWizard

Targeting p21-positive Senescent Cells in vivo for Alleviating Metabolic and Physical Dysfunction

2020-04-01 to 2025-03-31 | Grant
National Institute on Aging (Baltimore, US)
URL: https://app.dimensions.ai/details/grant/grant.9019349
GRANT_NUMBER: R01AG066679
Source: Self-asserted source
Ming Xu via DimensionsWizard

Targeting p21high senescent cells to improve healthspan and lifespan

2019-10-01 to 2020-09-30 | Grant
American Federation for Aging Research (New York, US)
URL: https://app.dimensions.ai/details/grant/grant.100081692
GRANT_NUMBER:

A19204
Source: Self-asserted source
Ming Xu via DimensionsWizard

Role of Senolytics in Lower Urinary Tract Aging and Voiding Disorders

2019-04-15 to 2021-12-31 | Grant
National Institute on Aging (Baltimore, US)
URL: https://app.dimensions.ai/details/grant/grant.8473505
GRANT_NUMBER: R21AG063528
Source: Self-asserted source
Ming Xu via DimensionsWizard

Using senolytic drugs to alleviate age-related frailty and inflammation

2017-10-01 to 2019-09-30 | Grant
American Federation for Aging Research (New York, US)
URL: https://app.dimensions.ai/details/grant/grant.100054863
GRANT_NUMBER:

DIAMOND17148
Source: Self-asserted source
Ming Xu via DimensionsWizard

The role of cellular senescence in age-related tissue dysfunction and diseases

2014-12-31 to 2015-12-30 | Grant
American Federation for Aging Research (New York, US)
URL: https://app.dimensions.ai/details/grant/grant.100055111
GRANT_NUMBER:

PD14059
Source: Self-asserted source
Ming Xu via DimensionsWizard

Works (30)

Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics

Aging Cell
2025-02 | Journal article
DOI: 10.1111/acel.14399
Contributors: Iman M. Al‐Naggar; Maria Antony; Dylan Baker; Lichao Wang; Lucas Da Cunha Godoy; Chia‐Ling Kuo; Matthew O. Fraser; Phillip P. Smith; Ming Xu; George A. Kuchel
Source: check_circle
Crossref

TET2 contributes to gluconeogenesis and pathology of type 2 diabetes

2024-11-15 | Preprint
DOI: 10.7554/eLife.103663
Contributors: Xinchao Zhang; Hongchen Li; Shuyan Li; Ziyi Cui; Xinyu Zhao; Haijie Ma; Ming Xu; Yanping Xu
Source: check_circle
Crossref

TET2 contributes to gluconeogenesis and pathology of type 2 diabetes

2024-11-15 | Preprint
DOI: 10.7554/eLife.103663.1
Contributors: Xinchao Zhang; Hongchen Li; Shuyan Li; Ziyi Cui; Xinyu Zhao; Haijie Ma; Ming Xu; Yanping Xu
Source: check_circle
Crossref

HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes

2024-10-01 | Preprint
DOI: 10.1101/2024.09.29.615677
Contributors: Hongchen Li; Xinchao Zhang; Xiaoben Liang; Shuyan Li; Ziyi Cui; Xinyu Zhao; Kai Wang; Bingbing Zha; Haijie Ma; Ming Xu et al.
Source: check_circle
Crossref

Oscillatory Hypoxia Can Induce Senescence of Adipose-Derived Mesenchymal Stromal Cells Potentiating Invasive Transformation of Breast Epithelial Cells

Cancers
2024-02-28 | Journal article
DOI: 10.3390/cancers16050969
Contributors: Ashkan Novin; Khadija Wali; Aditya Pant; Shaofei Liu; Wenqiang Du; Yamin Liu; Lichao Wang; Ming Xu; Binsheng Wang; Yasir Suhail et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Unleashing CAR T cells to delay metabolic aging

Nature Aging
2024-02-15 | Journal article
DOI: 10.1038/s43587-024-00576-5
Contributors: Jenna M. Bartley; Ming Xu
Source: check_circle
Crossref

The heterogeneity of cellular senescence: insights at the single-cell level

Trends in Cell Biology
2023-01 | Journal article
DOI: 10.1016/j.tcb.2022.04.011
Contributors: Rachel L. Cohn; Nathan S. Gasek; George A. Kuchel; Ming Xu
Source: check_circle
Crossref

Role of Senescent Cells in Cutaneous Wound Healing

Biology
2022-11-29 | Journal article
DOI: 10.3390/biology11121731
Contributors: Allison M. Andrade; Mingda Sun; Nathan S. Gasek; Geneva R. Hargis; Roshanak Sharafieh; Ming Xu
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics

Aging Cell
2022-01 | Journal article
DOI: 10.1111/acel.13525
Contributors: Erica C. Lorenzo; Blake L. Torrance; Spencer R. Keilich; Iman Al‐Naggar; Andrew Harrison; Ming Xu; Jenna M. Bartley; Laura Haynes
Source: check_circle
Crossref

Strategies for targeting senescent cells in human disease

Nature Aging
2021-10-07 | Journal article
DOI: 10.1038/s43587-021-00121-8
Contributors: Nathan S. Gasek; George A. Kuchel; James L. Kirkland; Ming Xu
Source: check_circle
Crossref

Senolytics alleviate the degenerative disorders of temporomandibular joint in old age

Aging Cell
2021-07 | Journal article
DOI: 10.1111/acel.13394
Contributors: Yueying Zhou; Iman M. A. Al‐Naggar; Po‐Jung Chen; Nathan S. Gasek; Ke Wang; Shivam Mehta; George A. Kuchel; Sumit Yadav; Ming Xu
Source: check_circle
Crossref

Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

npj Regenerative Medicine
2021-06-11 | Journal article
DOI: 10.1038/s41536-021-00145-z
Contributors: Yueying Zhou; Xiaonan Xin; Lichao Wang; Binsheng Wang; Li Chen; Ousheng Liu; David W. Rowe; Ming Xu
Source: check_circle
Crossref

Transplanting cells from old but not young donors causes physical dysfunction in older recipients.

Aging cell
2020-01-23 | Journal article
DOI: 10.1111/acel.13106
PMID: 31971661
PMC: PMC7059132
Source: Self-asserted source
Ming Xu

Targeting senescent cells alleviates obesity-induced metabolic dysfunction.

Aging cell
2019-03-25 | Journal article
DOI: 10.1111/acel.12950
PMID: 30907060
PMC: PMC6516193
Source: Self-asserted source
Ming Xu

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Cell metabolism
2019-01-03 | Journal article
DOI: 10.1016/j.cmet.2018.12.008
PMID: 30612898
PMC: PMC6509403
Source: Self-asserted source
Ming Xu

Fisetin is a senotherapeutic that extends health and lifespan.

EBioMedicine
2018-09-29 | Journal article
DOI: 10.1016/j.ebiom.2018.09.015
PMID: 30279143
PMC: PMC6197652
Source: Self-asserted source
Ming Xu

Senolytics improve physical function and increase lifespan in old age

Nature Medicine
2018-08 | Journal article
DOI: 10.1038/s41591-018-0092-9
Contributors: Ming Xu; Tamar Pirtskhalava; Joshua N. Farr; Bettina M. Weigand; Allyson K. Palmer; Megan M. Weivoda; Christina L. Inman; Mikolaj B. Ogrodnik; Christine M. Hachfeld; Daniel G. Fraser et al.
Source: check_circle
Crossref

17α-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization

Journals of Gerontology - Series A Biological Sciences and Medical Sciences
2017 | Journal article
DOI: 10.1093/gerona/glv309
EID:

2-s2.0-85014718363
Contributors: Stout, M.B.; Steyn, F.J.; Jurczak, M.J.; Camporez, J.-P.G.; Zhu, Y.; Hawse, J.R.; Jurk, D.; Palmer, A.K.; Xu, M.; Pirtskhalava, T. et al.
Source: Self-asserted source
Ming Xu via Scopus - Elsevier

Targeting cellular senescence prevents age-related bone loss in mice

Nature Medicine
2017 | Journal article
DOI: 10.1038/nm.4385
EID:

2-s2.0-85029078668
Contributors: Farr, J.N.; Xu, M.; Weivoda, M.M.; Monroe, D.G.; Fraser, D.G.; Onken, J.L.; Negley, B.A.; Sfeir, J.G.; Ogrodnik, M.B.; Hachfeld, C.M. et al.
Source: Self-asserted source
Ming Xu via Scopus - Elsevier

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

Science Signaling
2016 | Journal article
DOI: 10.1126/scisignal.aaf3273
EID:

2-s2.0-84983471245
Contributors: Carpio, L.R.; Bradley, E.W.; McGee-Lawrence, M.E.; Weivoda, M.M.; Poston, D.D.; Dudakovic, A.; Xu, M.; Tchkonia, T.; Kirkland, J.L.; Van Wijnen, A.J. et al.
Source: Self-asserted source
Ming Xu via Scopus - Elsevier

Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction

Pharmacological Research
2016 | Journal article
DOI: 10.1016/j.phrs.2016.05.015
EID:

2-s2.0-84975840886
Contributors: Xu, M.; Tchkonia, T.; Kirkland, J.L.
Source: Self-asserted source
Ming Xu via Scopus - Elsevier

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
2016-08-10 | Journal article
DOI: 10.1093/gerona/glw154
Part of ISSN: 1079-5006
Contributors: Ming Xu; Elizabeth W. Bradley; Megan M. Weivoda; Soyun M. Hwang; Tamar Pirtskhalava; Teresa Decklever; Geoffry L. Curran; Mikolaj Ogrodnik; Diana Jurk; Kurt O. Johnson et al.
Source: Self-asserted source
Ming Xu via Crossref Metadata Search

Cellular senescence in type 2 diabetes: A therapeutic opportunity

Diabetes
2015 | Journal article
DOI: 10.2337/db14-1820
EID:

2-s2.0-84962079683
Contributors: Palmer, A.K.; Tchkonia, T.; LeBrasseur, N.K.; Chini, E.N.; Xu, M.; Kirkland, J.L.
Source: Self-asserted source
Ming Xu via Scopus - Elsevier

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
DOI: 10.1073/pnas.1515386112
EID:

2-s2.0-84966397603
Contributors: Xu, M.; Tchkonia, T.; Ding, H.; Ogrodnik, M.; Lubbers, E.R.; Pirtskhalava, T.; White, T.A.; Johnson, K.O.; Stout, M.B.; Mezera, V. et al.
Source: Self-asserted source
Ming Xu via Scopus - Elsevier

Targeting senescent cells enhances adipogenesis and metabolic function in old age

eLife
2015 | Journal article
DOI: 10.7554/eLife.12997
EID:

2-s2.0-84988603034
Contributors: Xu, M.; Palmer, A.K.; Ding, H.; Weivoda, M.M.; Pirtskhalava, T.; White, T.A.; Sepe, A.; Johnson, K.O.; Stout, M.B.; Giorgadze, N. et al.
Source: Self-asserted source
Ming Xu via Scopus - Elsevier

Beta-cell injury in Ncb5or-null mice is exacerbated by consumption of a high-fat diet

European Journal of Lipid Science and Technology
2011 | Journal article
DOI: 10.1002/ejlt.201100309
Part of ISSN: 1438-7697
Contributors: Ying Guo; Ming Xu; Bin Deng; Jennifer R. Frontera; Karen L. Kover; Daniel Aires; Helin Ding; Susan E. Carlson; John Turk; WenFang Wang et al.
Source: Self-asserted source
Ming Xu via Crossref Metadata Search

Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
2011-11 | Journal article
DOI: 10.1016/j.bbadis.2011.07.016
Part of ISSN: 0925-4439
Contributors: WenFang Wang; Ying Guo; Ming Xu; Han-Hung Huang; Lesya Novikova; Kevin Larade; Zhi-Gang Jiang; Terri C. Thayer; Jennifer R. Frontera; Daniel Aires et al.
Source: Self-asserted source
Ming Xu via Crossref Metadata Search

Ncb5or Deficiency Increases Fatty Acid Catabolism and Oxidative Stress

Journal of Biological Chemistry
2011-02-07 | Journal article
DOI: 10.1074/jbc.m110.196543
Part of ISSN: 0021-9258
Contributors: Ming Xu; WenFang Wang; Jennifer R. Frontera; Melanie C. Neely; Jianghua Lu; Daniel Aires; Fong-Fu Hsu; John Turk; Russell H. Swerdlow; Susan E. Carlson et al.
Source: Self-asserted source
Ming Xu via Crossref Metadata Search

Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1

The FASEB Journal
2007-10 | Journal article
DOI: 10.1096/fj.06-6914com
Part of ISSN: 0892-6638
Contributors: Zhihong Zhang; Bing Liao; Ming Xu; Ying Jin
Source: Self-asserted source
Ming Xu via Crossref Metadata Search

Inferring population history from fine-scale spatial genetic analysis in Oryza rufipogon (Poaceae)

Molecular Ecology
2006-03-08 | Journal article
DOI: 10.1111/j.1365-294x.2006.02870.x
Part of ISSN: 0962-1083
Contributors: XIAN XU; BAO-RONG LU; YOLANDA H. CHEN; MING XU; JUN RONG; PINGYANG YE; JIAKUAN CHEN; ZHIPING SONG
Source: Self-asserted source
Ming Xu via Crossref Metadata Search

Peer review (12 reviews for 5 publications/grants)

Review activity for Cell metabolism. (2)
Review activity for Nature aging. (6)
Review activity for Nature biomedical engineering. (1)
Review activity for Nature communications (1)
Review activity for Nature metabolism. (2)
How many people are using ORCID?