Personal information

United States

Activities

Employment (1)

University of California San Diego: La Jolla, CA, US

Professor (Psychiatry)
Employment
Source: Self-asserted source
Lilia Iakoucheva

Funding (11)

Rescue of Cul3 haploinsufficiency phenotypes with CRISPR-mediated Cul3 activation

2022-08-01 to 2024-07-31 | Grant
National Institute of Mental Health (Bethesda, US)
GRANT_NUMBER: R21MH128827
Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

Cortical organoid models to study autism-associated 16p.11.2.CNV

2022-03-01 to 2023-02-28 | Grant
National Institute of Mental Health (Bethesda, US)
GRANT_NUMBER: R56MH128365
Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

Investigating neurodevelopmental toxicity of perfluoroalkyl acids and their derivatives in human brain organoids models

2022-02-07 to 2026-11-30 | Grant
National Institute of Environmental Health Sciences (Durham, US)
GRANT_NUMBER: R01ES033636
Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

Integrative functional genomic study of pathways impacted by recurrent autism CNV

Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

Evaluating the effect of splicing mutations on isoform networks in autism

Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

A computational framework for predicting the impact of mutations in autism

Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

Protein network of high risk copy number variants for psychiatric disorders

Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

Schizophrenia interactome mapping and global discovery of brain splice variants

Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

A systems biology approach to unravel theunderlying functional modules of ASD

2009-09-30 to 2012-08-31 | Grant
National Institute of Child Health and Human Development (Bethesda, US)
GRANT_NUMBER: R01HD065288
Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

Protein structural disorder and ubiquitination

2007-08-02 to 2010-07-31 | Grant
National Cancer Institute (Bethesda, US)
GRANT_NUMBER: R21CA113711
Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

Investigating Interactive Properties of Disordered Protein Regions

2005-02-01 to 2008-01-31 | Grant
National Science Foundation - Directorate for Biological Sciences (Arlington, US)
GRANT_NUMBER: 0444818
Source: Self-asserted source
Lilia Iakoucheva via DimensionsWizard

Works (50 of 70)

Items per page:
Page 1 of 2

Therapeutic strategies for autism: targeting three levels of the central dogma of molecular biology.

Translational psychiatry
2023-02-16 | Journal article | Author
Contributors: Derek Hong; Lilia Iakoucheva
Source: Self-asserted source
Lilia Iakoucheva

Multi-objective prioritization of genes for high-throughput functional assays towards improved clinical variant classification.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
2023-01-01 | Journal article
Contributors: Chen Y; Jain S; Zeiberg D; Iakoucheva LM; Mooney SD; Radivojac P; Pejaver V
Source: Self-asserted source
Lilia Iakoucheva

A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex.

Nature genetics
2022-06-02 | Journal article
Source: Self-asserted source
Lilia Iakoucheva

Correction: Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism (Molecular Psychiatry, (2021), 26, 12, (7560-7580), 10.1038/s41380-021-01243-6)

Molecular Psychiatry
2021 | Journal article
EID:

2-s2.0-85115624522

Part of ISSN: 14765578 13594184
Contributors: Urresti, J.; Zhang, P.; Moran-Losada, P.; Yu, N.-K.; Negraes, P.D.; Trujillo, C.A.; Antaki, D.; Amar, M.; Chau, K.; Pramod, A.B. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Prioritizing de novo autism risk variants with calibrated gene- and variant-scoring models

Human Genetics
2021 | Journal article
EID:

2-s2.0-85115256920

Part of ISSN: 14321203 03406717
Contributors: Jiang, Y.; Urresti, J.; Pagel, K.A.; Pramod, A.B.; Iakoucheva, L.M.; Radivojac, P.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism.

Molecular psychiatry
2021-08 | Journal article
Contributors: Urresti J; Zhang P; Moran-Losada P; Yu NK; Negraes PD; Trujillo CA; Antaki D; Amar M; Chau K; Pramod AB et al.
Source: Self-asserted source
Lilia Iakoucheva via Europe PubMed Central
grade
Preferred source (of 2)‎

Full-length isoform transcriptome of the developing human brain provides further insights into autism.

Cell reports
2021-08 | Journal article
Contributors: Chau KK; Zhang P; Urresti J; Amar M; Pramod AB; Chen J; Thomas A; Corominas R; Lin GN; Iakoucheva LM
Source: Self-asserted source
Lilia Iakoucheva via Europe PubMed Central
grade
Preferred source (of 2)‎

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling.

Molecular psychiatry
2021-03 | Journal article
Contributors: Amar M; Pramod AB; Yu NK; Herrera VM; Qiu LR; Moran-Losada P; Zhang P; Trujillo CA; Ellegood J; Urresti J et al.
Source: Self-asserted source
Lilia Iakoucheva via Europe PubMed Central
grade
Preferred source (of 2)‎

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

bioRxiv
2020 | Other
EID:

2-s2.0-85098899753

Part of ISSN: 26928205
Contributors: Amar, M.; Pramod, A.B.; Yu, N.-K.; Herrera, V.M.; Qiu, L.R.; Moran-Losada, P.; Zhang, P.; Trujillo, C.A.; Ellegood, J.; Urresti, J. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in Autism

bioRxiv
2020 | Other
EID:

2-s2.0-85098911140

Part of ISSN: 26928205
Contributors: Urresti, J.; Zhang, P.; Moran-Losada, P.; Yu, N.-K.; Negraes, P.D.; Trujillo, C.A.; Antaki, D.; Amar, M.; Chau, K.; Pramod, A.B. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Isoform transcriptome of developing human brain provides new insights into autism risk variants

bioRxiv
2020 | Other
EID:

2-s2.0-85098907187

Part of ISSN: 26928205
Contributors: Chau, K.; Zhang, P.; Urresti, J.; Amar, M.; Pramod, A.B.; Thomas, A.; Corominas, R.; Lin, G.N.; Iakoucheva, L.M.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Isoform Transcriptome of Developing Human Brain Provides New Insights into Autism Risk Variants

SSRN
2020 | Other
EID:

2-s2.0-85109874712

Part of ISSN: 15565068
Contributors: Chau, K.; Zhang, P.; Urresti, J.; Amar, M.; Pramod, A.B.; Thomas, A.; Corominas, R.; Lin, G.N.; Iakoucheva, L.M.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Inferring the molecular and phenotypic impact of amino acid variants with MutPred2.

Nature communications
2020-11 | Journal article
Contributors: Pejaver V; Urresti J; Lugo-Martinez J; Pagel KA; Lin GN; Nam HJ; Mort M; Cooper DN; Sebat J; Iakoucheva LM et al.
Source: Self-asserted source
Lilia Iakoucheva via Europe PubMed Central
grade
Preferred source (of 2)‎

Oligogenic effects of 16p11.2 copy number variation on craniofacial development

bioRxiv
2019 | Other
EID:

2-s2.0-85094263574

Part of ISSN: 26928205
Contributors: Qiu, Y.; Arbogast, T.; Lorenzo, S.M.; Li, H.; Tang, S.C.; Richardson, E.; Hong, O.; Cho, S.; Shanta, O.; Pang, T. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Oligogenic Effects of 16p11.2 Copy Number Variation on Craniofacial Development

SSRN
2019 | Other
EID:

2-s2.0-85113952678

Part of ISSN: 15565068
Contributors: Qiu, Y.; Arbogast, T.; Lorenzo, S.M.; Li, H.; Tang, S.C.; Richardson, E.; Hong, O.; Cho, S.; Shanta, O.; Pang, T. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Getting to the Cores of Autism.

Cell
2019-09 | Journal article
Contributors: Iakoucheva LM; Muotri AR; Sebat J
Source: Self-asserted source
Lilia Iakoucheva via Europe PubMed Central
grade
Preferred source (of 2)‎

Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development.

Cell reports
2019-09 | Journal article
Contributors: Qiu Y; Arbogast T; Lorenzo SM; Li H; Tang SC; Richardson E; Hong O; Cho S; Shanta O; Pang T et al.
Source: Self-asserted source
Lilia Iakoucheva via Europe PubMed Central
grade
Preferred source (of 2)‎

Pathogenicity and functional impact of non-frameshifting insertion/deletion variation in the human genome.

PLoS computational biology
2019-06 | Journal article
Contributors: Pagel KA; Antaki D; Lian A; Mort M; Cooper DN; Sebat J; Iakoucheva LM; Mooney SD; Radivojac P
Source: Self-asserted source
Lilia Iakoucheva via Europe PubMed Central
grade
Preferred source (of 2)‎

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.

Science (New York, N.Y.)
2018-12 | Journal article
Contributors: Gandal MJ; Zhang P; Hadjimichael E; Walker RL; Chen C; Liu S; Won H; van Bakel H; Varghese M; Wang Y et al.
Source: Self-asserted source
Lilia Iakoucheva via Europe PubMed Central
grade
Preferred source (of 2)‎

Paternally inherited cis-regulatory structural variants are associated with autism.

Science (New York, N.Y.)
2018-04 | Journal article
Contributors: Brandler WM; Antaki D; Gujral M; Kleiber ML; Whitney J; Maile MS; Hong O; Chapman TR; Tan S; Tandon P et al.
Source: Self-asserted source
Lilia Iakoucheva via Europe PubMed Central
grade
Preferred source (of 2)‎

Comprehensive analyses of tissue-specific networks with implications to psychiatric diseases

Methods in Molecular Biology
2017 | Book
EID:

2-s2.0-85028598094

Contributors: Lin, G.N.; Corominas, R.; Nam, H.-J.; Urresti, J.; Iakoucheva, L.M.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

MutPred2: Inferring the molecular and phenotypic impact of amino acid variants

bioRxiv
2017 | Other
EID:

2-s2.0-85095653033

Part of ISSN: 26928205
Contributors: Pejaver, V.; Urresti, J.; Lugo-Martinez, J.; Pagel, K.A.; Lin, G.N.; Nam, H.-J.; Mort, M.; Cooper, D.N.; Sebat, J.; Iakoucheva, L.M. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Paternally inherited noncoding structural variants contribute to autism

bioRxiv
2017 | Other
EID:

2-s2.0-85095650168

Part of ISSN: 26928205
Contributors: Brandler, W.M.; Antaki, D.; Gujral, M.; Kleiber, M.L.; Maile, M.S.; Hong, O.; Chapman, T.R.; Tan, S.; Tandon, P.; Pang, T. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

When loss-of-function is loss of function: Assessing mutational signatures and impact of loss-of-function genetic variants

Bioinformatics
2017 | Journal article
EID:

2-s2.0-85024473573

Contributors: Pagel, K.A.; Pejaver, V.; Lin, G.N.; Nam, H.-J.; Mort, M.; Cooper, D.N.; Sebat, J.; Iakoucheva, L.M.; Mooney, S.D.; Radivojac, P.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Frequency and Complexity of de Novo Structural Mutation in Autism

American Journal of Human Genetics
2016 | Journal article
EID:

2-s2.0-84964800573

Contributors: Brandler, W.M.; Antaki, D.; Gujral, M.; Noor, A.; Rosanio, G.; Chapman, T.R.; Barrera, D.J.; Lin, G.N.; Malhotra, D.; Watts, A.C. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

Cell
2016 | Journal article
EID:

2-s2.0-84958182784

Contributors: Yang, X.; Coulombe-Huntington, J.; Kang, S.; Sheynkman, G.M.; Hao, T.; Richardson, A.; Sun, S.; Yang, F.; Shen, Y.A.; Murray, R.R. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Spatiotemporal 16p11.2 Protein Network Implicates Cortical Late Mid-Fetal Brain Development and KCTD13-Cul3-RhoA Pathway in Psychiatric Diseases

Neuron
2015 | Journal article
EID:

2-s2.0-84925451823

Contributors: Lin, G.N.; Corominas, R.; Lemmens, I.; Yang, X.; Tavernier, J.; Hill, D.E.; Vidal, M.; Sebat, J.; Iakoucheva, L.M.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

A proteome-scale map of the human interactome network

Cell
2014 | Journal article
EID:

2-s2.0-84911474471

Contributors: Rolland, T.; TaÅŸan, M.; Charloteaux, B.; Pevzner, S.J.; Zhong, Q.; Sahni, N.; Yi, S.; Lemmens, I.; Fontanillo, C.; Mosca, R. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Pathological unfoldomics of uncontrolled chaos: Intrinsically disordered proteins and human diseases

Chemical Reviews
2014 | Journal article
EID:

2-s2.0-84903957093

Contributors: Uversky, V.N.; Davé, V.; Iakoucheva, L.M.; Malaney, P.; Metallo, S.J.; Pathak, R.R.; Joerger, A.C.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Predicted disorder-to-order transition mutations in IκBα disrupt function

Physical Chemistry Chemical Physics
2014 | Journal article
EID:

2-s2.0-84896364623

Contributors: Dembinski, H.; Wismer, K.; Balasubramaniam, D.; Gonzalez, H.A.; Alverdi, V.; Iakoucheva, L.M.; Komives, E.A.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism

Nature Communications
2014 | Journal article
EID:

2-s2.0-84898612068

Contributors: Corominas, R.; Yang, X.; Lin, G.N.; Kang, S.; Shen, Y.; Ghamsari, L.; Broly, M.; Rodriguez, M.; Tam, S.; Trigg, S.A. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Disease mutations in disordered regions - Exception to the rule?

Molecular BioSystems
2012 | Journal article
EID:

2-s2.0-82655179908

Contributors: Vacic, V.; Iakoucheva, L.M.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Disease-Associated Mutations Disrupt Functionally Important Regions of Intrinsic Protein Disorder

PLoS Computational Biology
2012 | Journal article
EID:

2-s2.0-84868115657

Contributors: Vacic, V.; Markwick, P.R.L.; Oldfield, C.J.; Zhao, X.; Haynes, C.; Uversky, V.N.; Iakoucheva, L.M.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Erratum: A protein domain-based interactome network for C. elegans early embryogenesis (Cell (2008) 134 (534-545))

Cell
2012 | Journal article
EID:

2-s2.0-84871601296

Contributors: Boxem, M.; Maliga, Z.; Klitgord, N.; Li, N.; Lemmens, I.; Mana, M.; De Lichtervelde, L.; Mul, J.D.; Van De Peut, D.; Devos, M. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Whole-genome sequencing in autism identifies hot spots for de novo germline mutation

Cell
2012 | Journal article
EID:

2-s2.0-84871595000

Contributors: Michaelson, J.J.; Shi, Y.; Gujral, M.; Zheng, H.; Malhotra, D.; Jin, X.; Jian, M.; Liu, G.; Greer, D.; Bhandari, A. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

Nature
2011 | Journal article
EID:

2-s2.0-79953057217

Contributors: Vacic, V.; McCarthy, S.; Malhotra, D.; Murray, F.; Chou, H.-H.; Peoples, A.; Makarov, V.; Yoon, S.; Bhandari, A.; Corominas, R. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia (Nature (2011) 471 (499-501))

Nature
2011 | Journal article
EID:

2-s2.0-79957958345

Contributors: Vacic, V.; McCarthy, S.; Malhotra, D.; Murray, F.; Chou, H.-H.; Peoples, A.; Makarov, V.; Yoon, S.; Bhandari, A.; Corominas, R. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Mapping copy number variation by population-scale genome sequencing

Nature
2011 | Journal article
EID:

2-s2.0-84975804424

Contributors: Mills, R.E.; Walter, K.; Stewart, C.; Handsaker, R.E.; Chen, K.; Alkan, C.; Abyzov, A.; Yoon, S.C.; Ye, K.; Cheetham, R.K. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Graphlet kernels for prediction of functional residues in protein structures

Journal of Computational Biology
2010 | Journal article
EID:

2-s2.0-77149167608

Contributors: Vacic, V.; Iakoucheva, L.M.; Lonardi, S.; Radivojac, P.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Identification, analysis, and prediction of protein ubiquitination sites

Proteins: Structure, Function and Bioinformatics
2010 | Journal article
EID:

2-s2.0-77449103113

Contributors: Radivojac, P.; Vacic, V.; Haynes, C.; Cocklin, R.R.; Mohan, A.; Heyen, J.W.; Goebl, M.G.; Iakoucheva, L.M.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Loss of post-translational modification sites in disease

Pacific Symposium on Biocomputing 2010, PSB 2010
2010 | Conference paper
EID:

2-s2.0-84873053429

Contributors: Li, S.; Iakoucheva, L.M.; Mooney, S.D.; Radivojac, P.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Loss of post-translational modification sites in disease.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
2010-01 | Journal article
Contributors: Li S; Iakoucheva LM; Mooney SD; Radivojac P
Source: Self-asserted source
Lilia Iakoucheva via Europe PubMed Central

Microduplications of 16p11.2 are associated with schizophrenia

Nature Genetics
2009 | Journal article
EID:

2-s2.0-70350626873

Contributors: McCarthy, S.E.; Makarov, V.; Kirov, G.; Addington, A.M.; McClellan, J.; Yoon, S.; Perkins, D.O.; Dickel, D.E.; Kusenda, M.; Krastoshevsky, O. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Prioritizing disease genes and understanding disease pathways

Biological Data Mining in Protein Interaction Networks
2009 | Book
EID:

2-s2.0-84901566414

Contributors: Zhao, X.; Iakoucheva, L.M.; Zhang, M.Q.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Unfoldomics of human diseases: Linking protein intrinsic disorder with diseases

BMC Genomics
2009 | Journal article
EID:

2-s2.0-67650369989

Contributors: Uversky, V.N.; Oldfield, C.J.; Midic, U.; Xie, H.; Xue, B.; Vucetic, S.; Iakoucheva, L.M.; Obradovic, Z.; Keith, A.K.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

A Protein Domain-Based Interactome Network for C. elegans Early Embryogenesis

Cell
2008 | Journal article
EID:

2-s2.0-48649096489

Contributors: Boxem, M.; Maliga, Z.; Klitgord, N.; Li, N.; Lemmens, I.; Mana, M.; de Lichtervelde, L.; Mul, J.D.; van de Peut, D.; Devos, M. et al.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

RNA association or phosphorylation of the RS domain prevents aggregation of RS domain-containing proteins

Biochimica et Biophysica Acta - General Subjects
2008 | Journal article
EID:

2-s2.0-38549104033

Contributors: Nikolakaki, E.; Drosou, V.; Sanidas, I.; Peidis, P.; Papamarcaki, T.; Iakoucheva, L.M.; Giannakouros, T.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions

Journal of Proteome Research
2007 | Journal article
EID:

2-s2.0-33847768609

Contributors: Xie, H.; Vucetic, S.; Iakoucheva, L.M.; Oldfield, C.J.; Dunker, A.K.; Uversky, V.N.; Obradovic, Z.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Functional anthology of intrinsic disorder. 2. cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions

Journal of Proteome Research
2007 | Journal article
EID:

2-s2.0-34249282661

Contributors: Vucetic, S.; Xie, H.; Iakoucheva, L.M.; Oldfield, C.J.; Dunker, A.K.; Obradovic, Z.; Uversky, V.N.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier

Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins

Journal of Proteome Research
2007 | Journal article
EID:

2-s2.0-33847783298

Contributors: Xie, H.; Vucetic, S.; Iakoucheva, L.M.; Oldfield, C.J.; Dunker, A.K.; Obradovic, Z.; Uversky, V.N.
Source: Self-asserted source
Lilia Iakoucheva via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (14 reviews for 6 publications/grants)

Review activity for American journal of human genetics. (1)
Review activity for JoVE. (1)
Review activity for Molecular psychiatry. (3)
Review activity for Nature (1)
Review activity for Nature neuroscience. (4)
Review activity for PLoS computational biology. (4)