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Employment (1)

Icahn School of Medicine at Mount Sinai: New York, NY, US

2018-10-01 to 2019-08-01 | Associate Researcher (Neurosurgery)
Employment
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James Vicari

Education and qualifications (2)

Icahn School of Medicine at Mount Sinai: New York, NY, US

2019-08-01 to present | PhD in Biomedical Science (Pharmacology and Therapeutic Discovery )
Education
Source: Self-asserted source
James Vicari

Icahn School of Medicine at Mount Sinai: New York, NY, US

2017-08-05 to 2019-06-20 | MS in Biomedical Science (Neuroscience / Neurosurgery)
Education
Source: Self-asserted source
James Vicari

Works (9)

A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19

2025-01-14 | Preprint
DOI: 10.1101/2025.01.10.25320348
Contributors: Georgios Voloudakis; Kyung Min Lee; James M. Vicari; Wen Zhang; Daisy Hoagland; Sanan Venkatesh; Jiantao Bian; Marios Anyfantakis; Zhenyi Wu; Samir Rahman et al.
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Alzheimer's disease transcriptional landscape in ex-vivo human microglia

2024-01-26 | Preprint
DOI: 10.21203/rs.3.rs-3851590/v1
Contributors: Panos Roussos; Roman Kosoy; John Fullard; Jaroslav Bendl; Steven Kleopoulos; Zhiping Shao; Stathis Argyriou; Deepika Mathur; James Vicari; Yixuan Ma et al.
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Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer’s Disease

2023-10-26 | Preprint
DOI: 10.1101/2023.10.25.23297558
Contributors: Donghoon Lee; James M. Vicari; Christian Porras; Collin Spencer; Milos Pjanic; Xinyi Wang; Seon Kinrot; Philipp Weiler; Roman Kosoy; Jaroslav Bendl et al.
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Multi-omic profiling of the developing human cerebral cortex at the single-cell level

Science Advances
2023-10-13 | Journal article
DOI: 10.1126/sciadv.adg3754
Contributors: Kaiyi Zhu; Jaroslav Bendl; Samir Rahman; James M. Vicari; Claire Coleman; Tereza Clarence; Ovaun Latouche; Nadejda M. Tsankova; Aiqun Li; Kristen J. Brennand et al.
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Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer’s Disease, healthspan and lifespan- Aging as a consequence of glycolysis

2023-06-13 | Preprint
DOI: 10.1101/2023.06.12.544352
Contributors: Rachel Litke; James Vicari; Bik Tzu Huang; Lila Shapiro; Kun-Hyung Roh; Aaron Silver; Pooja Talreja; Nicolle Palacios; Yonejung Yoon; Christopher Kellner et al.
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Crossref

Population-level variation in enhancer expression identifies disease mechanisms in the human brain

Nature Genetics
2022-10 | Journal article
DOI: 10.1038/s41588-022-01170-4
Contributors: Pengfei Dong; Gabriel E. Hoffman; Pasha Apontes; Jaroslav Bendl; Samir Rahman; Michael B. Fernando; Biao Zeng; James M. Vicari; Wen Zhang; Kiran Girdhar et al.
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The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease

Nature Neuroscience
2022-10 | Journal article
DOI: 10.1038/s41593-022-01166-7
Contributors: Jaroslav Bendl; Mads E. Hauberg; Kiran Girdhar; Eunju Im; James M. Vicari; Samir Rahman; Michael B. Fernando; Kayla G. Townsley; Pengfei Dong; Ruth Misir et al.
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Crossref

A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility

npj Genomic Medicine
2022-09-05 | Journal article
DOI: 10.1038/s41525-022-00324-x
Contributors: Georgios Voloudakis; James M. Vicari; Sanan Venkatesh; Gabriel E. Hoffman; Kristina Dobrindt; Wen Zhang; Noam D. Beckmann; Christina A. Higgins; Stathis Argyriou; Shan Jiang et al.
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Crossref

IL10RB as a key regulator of COVID-19 host susceptibility and severity

2021-06-02 | Other
DOI: 10.1101/2021.05.31.21254851
Contributors: Georgios Voloudakis; Gabriel Hoffman; Sanan Venkatesh; Kyung Min Lee; Kristina Dobrindt; James M. Vicari; Wen Zhang; Noam D. Beckmann; Shan Jiang; Daisy Hoagland et al.
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