Personal information

Single-cell genomics, Machine Learning, Applied Mathematics, Optimal transport, Lineage Tracing, Spatial transcriptomics, Organoids, Disease modeling
Germany, Switzerland

Biography

I’m interested in understanding dynamical biological processes through the lens of single-cell genomics. To this end, I develop computational tools and apply them to solve biological questions that arise in processes including development, regeneration, and reprogramming. In my postdoc, I’m particularly interested in studying the development of the human brain in organoid model systems, integrating spatiotemporal data across molecular modalities to understand regulatory relationships. In the past, I co-developed CellRank, a framework to study cell fate decision-making using multi-view single-cell data, including gene expression and RNA velocity, as well as moslin, a method to integrate gene expression with lineage tracing data across time points, and moscot, a method for the spatiotemporal era of single-cell genomics.

Activities

Employment (3)

ETH Zurich: Zurich, CH

2023-05-01 to present | Postdoctoral Researcher (Department of Biosystems Science and Engineering)
Employment
Source: Self-asserted source
Marius Lange

Helmholtz Zentrum München: Munich, DE

2022-10-25 to 2023-04-30 | Postdoctoral Researcher (Computational Health Center)
Employment
Source: Self-asserted source
Marius Lange

Helmholtz Zentrum München: Munich, DE

2017-10-01 to 2022-10-24 | Doctoral Researcher (Computational Health Center)
Employment
Source: Self-asserted source
Marius Lange

Education and qualifications (3)

Technical University of Munich: Munich, DE

2017-10 to 2022-10 | PhD in Computational Biology (TUM School of Computation, Information and Technology)
Education
Source: Self-asserted source
Marius Lange

University of Oxford: Oxford, Oxfordshire, GB

2016-10-01 to 2017-09-15 | M.Sc. Applied Mathematics (Mathematics)
Education
Source: Self-asserted source
Marius Lange

University of Freiburg: Freiburg, Baden-Württemberg, DE

2013-10-01 to 2016-09-01 | B.Sc. Physics (Institute of Physics)
Education
Source: Self-asserted source
Marius Lange

Professional activities (5)

Munich Centre for Machine Learning (MCML): Munich, Bavaria, DE

2019-01-01 to 2023-04 | PhD Student
Membership
Source: Self-asserted source
Marius Lange

Graduate School of Quantitative Biosciences Munich (QBM): Munich, Bavaria, DE

2017-10-01 to 2022-10 | PhD Student
Membership
Source: Self-asserted source
Marius Lange

The Hebrew University of Jerusalem: Jerusalem, IL

2021-07 to 2021-10 | Visiting Research Fellow (School of Computer Science and Engineering, Lab of Mor Nitzan)
Invited position
Source: Self-asserted source
Marius Lange

Memorial Sloan-Kettering Cancer Center: NY, NY, US

2019-10-01 to 2019-12-19 | Visiting researcher (Pe'er Lab, Program for Computational and Systems Biology)
Invited position
Source: Self-asserted source
Marius Lange

University of Oxford: Oxford, Oxfordshire, GB

2017-11-04 | Distinction for the MSc in Mathematical Modelling and Scientific Computing (Mathematical Institute)
Distinction
Source: Self-asserted source
Marius Lange

Funding (4)

A framework for understanding brain organoid models of neurodevelopmental disorder

2023-08 to 2025-07 | Grant
EMBO (Heidelberg, DE)
Source: Self-asserted source
Marius Lange

Recovering cellular trajectories in health and disease

2019-10 to 2019-12 | Grant
Bayer-Stiftungen (Leverkusen, DE)
GRANT_NUMBER: NA
Source: Self-asserted source
Marius Lange

Inferring Single Cell Regulatory Networks and Dynamics

Inferring Single Cell Regulatory Networks and Dynamics

2017-10 to 2018-12 | Salary award
Graduate School of Quantitative Biosciences Munich (QBM) (Munich, DE)
Source: Self-asserted source
Marius Lange

Works (12)

RegVelo: gene-regulatory-informed dynamics of single cells

2024-12-11 | Preprint
Contributors: Weixu Wang; Zhiyuan Hu; Philipp Weiler; Sarah Mayes; Marius Lange; Jingye Wang; Zhengyuan Xue; Tatjana Sauka-Spengler; Fabian J. Theis
Source: check_circle
Crossref

CellRank 2: unified fate mapping in multiview single-cell data

Nature Methods
2024-07 | Journal article
Contributors: Philipp Weiler; Marius Lange; Michal Klein; Dana Pe’er; Fabian Theis
Source: check_circle
Crossref

Unified fate mapping in multiview single-cell data

2023-07-20 | Preprint
Contributors: Philipp Weiler; Marius Lange; Michal Klein; Dana Pe’er; Fabian J. Theis
Source: check_circle
Crossref

Mapping cells through time and space with moscot

2023-05-11 | Preprint
Contributors: Dominik Klein; Giovanni Palla; Marius Lange; Michal Klein; Zoe Piran; Manuel Gander; Laetitia Meng-Papaxanthos; Michael Sterr; Aimée Bastidas-Ponce; Marta Tarquis-Medina et al.
Source: check_circle
Crossref

Mapping lineage-traced cells across time points with moslin

2023-04-17 | Preprint
Contributors: Marius Lange; Zoe Piran; Michal Klein; Bastiaan Spanjaard; Dominik Klein; Jan Philipp Junker; Fabian J. Theis; Mor Nitzan
Source: check_circle
Crossref

The scverse project provides a computational ecosystem for single-cell omics data analysis

Nature Biotechnology
2023-04-10 | Journal article | Author
Part of ISSN: 1087-0156
Part of ISSN: 1546-1696
Contributors: Isaac Virshup; Danila Bredikhin; Lukas Heumos; Giovanni Palla; Gregor Sturm; Adam Gayoso; Ilia Kats; Mikaela Koutrouli; Philipp Angerer; Volker Bergen et al.
Source: Self-asserted source
Marius Lange

CellRank for directed single-cell fate mapping

Nature Methods
2022-02 | Journal article
Contributors: Marius Lange; Volker Bergen; Michal Klein; Manu Setty; Bernhard Reuter; Mostafa Bakhti; Heiko Lickert; Meshal Ansari; Janine Schniering; Herbert B. Schiller et al.
Source: check_circle
Crossref
grade
Preferred source (of 4)‎

Generalizing RNA velocity to transient cell states through dynamical modeling

Nature Biotechnology
2020-12 | Journal article
Contributors: Volker Bergen; Marius Lange; Stefan Peidli; F. Alexander Wolf; Fabian J. Theis
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

Nature Communications
2020-07-16 | Journal article
Contributors: Maximilian Strunz; Lukas M. Simon; Meshal Ansari; Jaymin J. Kathiriya; Ilias Angelidis; Christoph H. Mayr; George Tsidiridis; Marius Lange; Laura F. Mattner; Min Yee et al.
Source: check_circle
Crossref

scSLAM-seq reveals core features of transcription dynamics in single cells

Nature
2019-07 | Journal article
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Marius Lange
grade
Preferred source (of 2)‎

Concepts and limitations for learning developmental trajectories from single cell genomics

Development
2019-06-15 | Journal article
Part of ISSN: 0950-1991
Part of ISSN: 1477-9129
Source: Self-asserted source
Marius Lange

On monotonic estimates of the norm of the minimizers of regularized quadratic functions in Krylov spaces

BIT Numerical Mathematics
2019-04-05 | Journal article
Source: Self-asserted source
Marius Lange
grade
Preferred source (of 2)‎

Peer review (5 reviews for 4 publications/grants)

Review activity for Bioinformatics (1)
Review activity for Genome biology. (2)
Review activity for Nature communications (1)
Review activity for Nature methods. (1)