Personal information

endo-lysosomes, organelle dysfunction, Parkinson's disease, Alzheimer's disease, neurodegeneration, drug discovery, target validation
United Kingdom

Activities

Employment (3)

Univerity of Oxford Nuffield Department of Medicine: Oxford, Oxfordshire, GB

2021-04-01 to present | Organelle Biology Team Leader (Nuffield Department of Medicine/CMD)
Employment
Source: Self-asserted source
Margarida Ruas

University of Oxford: Oxford, Oxfordshire, GB

2002-10-01 to 2021-03-31 (Pharmacology)
Employment
Source: Self-asserted source
Margarida Ruas

University of Cambridge: Cambridge, Cambridgeshire, GB

1999-10-01 to 2002-08-31 | Post-Doc (Gurdon Institute)
Employment
Source: Self-asserted source
Margarida Ruas

Education and qualifications (2)

Imperial College London: London, London, GB

1995-05 to 1999-08 | PhD (ICRF, Lincoln's Inn Fields Institute)
Education
Source: Self-asserted source
Margarida Ruas

University of Lisbon: Lisbon, Lisboa, PT

1987-09 to 1993-06 | BA/M (Biochemistry)
Qualification
Source: Self-asserted source
Margarida Ruas

Funding (1)

Todd-Bird Junior Research Fellowship

2006 to 2009 | Award
New College, University of Oxford (Oxford, GB)
Source: Self-asserted source
Margarida Ruas

Works (38)

Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain

Physiological Genomics
2018 | Journal article
EID:

2-s2.0-85056639777

Contributors: He, H.; Holl, K.; Debehnke, S.; Yeo, C.T.; Hansen, P.; Gebre, A.K.; Leone-Kabler, S.; Ruas, M.; Parks, J.S.; Parrington, J. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Plcζ is the physiological trigger of the Ca<sup>2+</sup> oscillations that induce embryogenesis in mammals but conception can occur in its absence

Development (Cambridge)
2017 | Journal article
EID:

2-s2.0-85027552543

Contributors: Hachem, A.; Godwin, J.; Ruas, M.; Lee, H.C.; Buitrago, M.F.; Ardestani, G.; Bassett, A.; Fox, S.; Navarrete, F.; De Sutter, P. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Synthesis of the Ca<sup>2+</sup>-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in -adrenoceptor signaling

Journal of Biological Chemistry
2017 | Journal article
EID:

2-s2.0-85027407916

Contributors: Lin, W.K.; Bolton, E.L.; Cortopassi, W.A.; Wang, Y.; O’Brien, F.; Maciejewska, M.; Jacobson, M.P.; Garnham, C.; Ruas, M.; Parrington, J. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Ebolavirus glycoprotein directs fusion through NPC1<sup>+</sup> endolysosomes

Journal of Virology
2016 | Journal article
EID:

2-s2.0-84953897258

Contributors: Simmons, J.A.; D'Souza, R.S.; Ruas, M.; Galione, A.; Casanova, J.E.; White, J.M.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Expression of Ca<sup>2+</sup>-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

EMBO Journal
2015 | Journal article
EID:

2-s2.0-84933674860

Contributors: Ruas, M.; Davis, L.C.; Chen, C.-C.; Morgan, A.J.; Chuang, K.-T.; Walseth, T.F.; Grimm, C.; Garnham, C.; Powell, T.; Platt, N. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Nicotinic acid adenine dinucleotide phosphate (NAADP) and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic β cells

Journal of Biological Chemistry
2015 | Journal article
EID:

2-s2.0-84940553934

Contributors: Arredouani, A.; Ruas, M.; Collins, S.C.; Parkesh, R.; Clough, F.; Pillinger, T.; Coltart, G.; Rietdorf, K.; Royle, A.; Johnson, P. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Reply to "TPC1 knockout knocks out TPC1"

Molecular and Cellular Biology
2015 | Journal article
EID:

2-s2.0-84929190277

Contributors: Ruas, M.; Galione, A.; Parrington, J.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

TPC: The NAADP discovery channel?

Biochemical Society Transactions
2015 | Journal article
EID:

2-s2.0-84934982329

Contributors: Morgan, A.J.; Davis, L.C.; Ruas, M.; Galione, A.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Two-pore channel 2 activity is required for slow muscle cell-generated Ca<sup>2+</sup> signaling during myogenesis in intact Zebrafish

International Journal of Developmental Biology
2015 | Journal article
EID:

2-s2.0-84947933450

Contributors: Kelu, J.J.; Chan, H.L.; Webb, S.E.; Cheng, A.H.H.; Ruas, M.; Parrington, J.; Galione, A.; Miller, A.L.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Two-pore channels (TPC2s) and nicotinic acid adenine dinucleotide phosphate (NAADP) at lysosomal-sarcoplasmic reticular junctions contribute to acute and chronic β-adrenoceptor signaling in the heart

Journal of Biological Chemistry
2015 | Journal article
EID:

2-s2.0-84947960769

Contributors: Capel, R.A.; Bolton, E.L.; Lin, W.K.; Aston, D.; Wang, Y.; Liu, W.; Wang, X.; Burton, R.-A.B.; Bloor-Young, D.; Shade, K.-T. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Identification of a novel gene for diabetic traits in rats, mice, and humans

Genetics
2014 | Journal article
EID:

2-s2.0-84907982004

Contributors: Tsaih, S.-W.; Holl, K.; Jia, S.; Kaldunski, M.; Tschannen, M.; He, H.; Andrae, J.W.; Li, S.-H.; Stoddard, A.; Wiederhold, A. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Measurement of luminal ph of acidic stores as a readout for naadp action

Cold Spring Harbor Protocols
2014 | Journal article
EID:

2-s2.0-84923852841

Contributors: Galione, A.; Chuang, K.-T.; Funnell, T.M.; Davis, L.C.; Morgan, A.J.; Ruas, M.; Parrington, J.; Churchill, G.C.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Preparation and use of sea urchin egg homogenates for studying NAADP-mediated Ca<sup>2+</sup> release

Cold Spring Harbor Protocols
2014 | Journal article
EID:

2-s2.0-84923918212

Contributors: Galione, A.; Chuang, K.-T.; Funnell, T.M.; Davis, L.C.; Morgan, A.J.; Ruas, M.; Parrington, J.; Churchill, G.C.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Synthesis of [<sup>32</sup>P]NAADP for the radioreceptor binding assay

Cold Spring Harbor Protocols
2014 | Journal article
EID:

2-s2.0-84923911276

Contributors: Galione, A.; Chuang, K.-T.; Funnell, T.M.; Davis, L.C.; Morgan, A.J.; Ruas, M.; Parrington, J.; Churchill, G.C.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Synthesis of caged NAADP

Cold Spring Harbor Protocols
2014 | Journal article
EID:

2-s2.0-84923862535

Contributors: Galione, A.; Chuang, K.-T.; Funnell, T.M.; Davis, L.C.; Morgan, A.J.; Ruas, M.; Parrington, J.; Churchill, G.C.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Synthesis of NAADP-AM as a Membrane-Permeant NAADP analog

Cold Spring Harbor Protocols
2014 | Journal article
EID:

2-s2.0-84923885096

Contributors: Galione, A.; Chuang, K.-T.; Funnell, T.M.; Davis, L.C.; Morgan, A.J.; Ruas, M.; Parrington, J.; Churchill, G.C.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2

Molecular and Cellular Biology
2014 | Journal article
EID:

2-s2.0-84907814142

Contributors: Ruas, M.; Chuang, K.-T.; Davis, L.C.; Al-Douri, A.; Tynan, P.W.; Tunn, R.; Teboul, L.; Galione, A.; Parrington, J.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2 -dependent ca<sup>2+</sup>signaling

Proceedings of the National Academy of Sciences of the United States of America
2014 | Journal article
EID:

2-s2.0-84914696686

Contributors: Faviaa, A.; Desiderib, M.; Gambaraa, G.; D'Alessioa, A.; Ruas, M.; Esposito, B.; Bufalo, D.D.; Parrington, J.; Ziparoa, E.; Palombia, F. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg

Journal of Biological Chemistry
2012 | Journal article
EID:

2-s2.0-84856075676

Contributors: Walseth, T.F.; Lin-Moshier, Y.; Jain, P.; Ruas, M.; Parrington, J.; Galione, A.; Marchant, J.S.; Slama, J.T.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes

Human Reproduction
2011 | Journal article
EID:

2-s2.0-81055146957

Contributors: Kashir, J.; Jones, C.; Lee, H.C.; Rietdorf, K.; Nikiforaki, D.; Durrans, C.; Ruas, M.; Tee, S.T.; Heindryckx, B.; Galione, A. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Two-pore channels form homo- and heterodimers

Journal of Biological Chemistry
2011 | Journal article
EID:

2-s2.0-80054828843

Contributors: Rietdorf, K.; Funnell, T.M.; Ruas, M.; Heinemann, J.; Parrington, J.; Galione, A.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

NAADP as an intracellular messenger regulating lysosomal calcium-release channels

Biochemical Society Transactions
2010 | Journal article
EID:

2-s2.0-78649721315

Contributors: Galione, A.; Morgan, A.J.; Arredouani, A.; Davis, L.C.; Rietdorf, K.; Ruas, M.; Parrington, J.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca<sup>2+</sup> Signaling and Endolysosomal Trafficking

Current Biology
2010 | Journal article
EID:

2-s2.0-77951205549

Contributors: Ruas, M.; Rietdorf, K.; Arredouani, A.; Davis, L.C.; Lloyd-Evans, E.; Koegel, H.; Funnell, T.M.; Morgan, A.J.; Ward, J.A.; Watanabe, K. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

TPC2 is a novel NAADP-sensitive Ca<sup>2+</sup> release channel, operating as a dual sensor of luminal pH and Ca<sup>2+</sup>

Journal of Biological Chemistry
2010 | Journal article
EID:

2-s2.0-78049396024

Contributors: Pitt, S.J.; Funnell, T.M.; Sitsapesan, M.; Venturi, E.; Rietdorf, K.; Ruas, M.; Ganesan, A.; Gosain, R.; Churchill, G.C.; Zhu, M.X. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

TPC2 proteins mediate Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)- and agonist-evoked contractions of smooth muscle

Journal of Biological Chemistry
2010 | Journal article
EID:

2-s2.0-77955291039

Contributors: Durlu-Kandilci, N.T.; Ruas, M.; Chuang, K.-T.; Brading, A.; Parrington, J.; Galione, A.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

NAADP mobilizes calcium from acidic organelles through two-pore channels

Nature
2009 | Journal article
EID:

2-s2.0-67349287016

Contributors: Calcraft, P.J.; Ruas, M.; Pan, Z.; Cheng, X.; Arredouani, A.; Hao, X.; Tang, J.; Rietdorf, K.; Teboul, L.; Chuang, K.-T. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Reduced amounts and abnormal forms of phospholipase C zeta (PLCζ) in spermatozoa from infertile men

Human Reproduction
2009 | Journal article
EID:

2-s2.0-70349443589

Contributors: Heytens, E.; Parrington, J.; Coward, K.; Young, C.; Lambrecht, S.; Yoon, S.-Y.; Fissore, R.A.; Hamer, R.; Deane, C.M.; Ruas, M. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Ca<sup>2+</sup> Signaling Occurs via Second Messenger Release from Intraorganelle Synthesis Sites

Current Biology
2008 | Journal article
EID:

2-s2.0-54149104220

Contributors: Davis, L.C.; Morgan, A.J.; Ruas, M.; Wong, J.L.; Graeff, R.M.; Poustka, A.J.; Lee, H.C.; Wessel, G.M.; Parrington, J.; Galione, A.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

A CDKN2A mutation in familial melanoma that abrogates binding of p16 <sup>INK4a</sup> to CDK4 but not CDK6

Cancer Research
2007 | Journal article
EID:

2-s2.0-35148825975

Contributors: Jones, R.; Ruas, M.; Gregory, F.; Moulin, S.; Delia, D.; Manoukian, S.; Rowe, J.; Brookes, S.; Peters, G.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

CDK4 and CDK6 delay senescence by kinase-dependent and p16 <sup>INK4a</sup>-independent mechanisms

Molecular and Cellular Biology
2007 | Journal article
EID:

2-s2.0-34250215990

Contributors: Ruas, M.; Gregory, F.; Jones, R.; Poolman, R.; Starborg, M.; Rowe, J.; Brookes, S.; Peters, G.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Methods in cyclic ADP-ribose and NAADP research

Calcium Signaling, Second Edition
2005 | Book
EID:

2-s2.0-85056068647

Contributors: Morgan, A.J.; Churchill, G.C.; Masgrau, R.; Ruas, M.; Davis, L.C.; Billington, R.A.; Patel, S.; Yamasaki, M.; Thomas, J.M.; Genazzani, A.A. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

NAADP receptors

Cell Calcium
2005 | Journal article
EID:

2-s2.0-24644442248

Contributors: Galione, A.; Ruas, M.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer

Cell
2003 | Journal article
EID:

2-s2.0-10744233204

Contributors: Hughes-Davies, L.; Huntsman, D.; Ruas, M.; Fuks, F.; Bye, J.; Chin, S.-F.; Milner, J.; Brown, L.A.; Hsu, F.; Gilks, B. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

EMBO Journal
2002 | Journal article
EID:

2-s2.0-18444380541

Contributors: Brookes, S.; Rowe, J.; Ruas, M.; Llanos, S.; Clark, P.A.; Lomax, M.; James, M.C.; Vatcheva, R.; Bates, S.; Vousden, K.H. et al.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Functional evaluation of tumour-specific variants of p16(INK4a)/CDKN2A: Correlation with protein structure information

Oncogene
1999 | Journal article
EID:

2-s2.0-0033598382

Contributors: Ruas, M.; Brookes, S.; McDonald, N.Q.; Peters, G.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Features of replicative senescence induced by direct addition of antennapedia-p16(INK4A) fusion protein to human diploid fibroblasts

FEBS Letters
1998 | Journal article
EID:

2-s2.0-0032496373

Contributors: Kato, D.; Miyazawa, K.; Ruas, M.; Starborg, M.; Wada, I.; Oka, T.; Sakai, T.; Peters, G.; Hara, E.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

The p16(INK4a)/CDKN2A tumor suppressor and its relatives

Biochimica et Biophysica Acta - Reviews on Cancer
1998 | Journal article
EID:

2-s2.0-0032517341

Contributors: Ruas, M.; Peters, G.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier

Isolation and prevalidation of an Escherichia coli tester strain for the use in mechanistic and metabolic studies of genotoxins

Mutation Research/Environmental Mutagenesis and Related Subjects
1994 | Journal article
EID:

2-s2.0-0028082743

Contributors: Kranendonk, M.; Ruas, M.; Laires, A.; Rueff, J.
Source: Self-asserted source
Margarida Ruas via Scopus - Elsevier