Personal information

Activities

Employment (1)

Universidade Federal de Santa Catarina: Florianopolis, SC, BR

2011-01-02 to present | Associate Professor (Pharmacology)
Employment
Source: Self-asserted source
Fernando Spiller

Education and qualifications (5)

Scripps Research Institute: La Jolla, CA, US

2014-11-17 to 2015-10-15 | Postdoctoral
Education
Source: Self-asserted source
Fernando Spiller

School of Medicine of Ribeirao Preto, University of Sao Paulo: Ribeirao Preto, SP, BR

2009-09-01 to 2011-01-01 | Postdoctoral (Department of Pharmacology)
Education
Source: Self-asserted source
Fernando Spiller

School of Medicine of Ribeirao Preto, University of Sao Paulo: Ribeirao Preto, SP, BR

2006-08-01 to 2009-08-01 | PhD (Pharmacology)
Education
Source: Self-asserted source
Fernando Spiller

University of Turin: Turin, Piemonte, IT

2007-11-01 to 2008-06-31 | PhD - visitor student (Department of Molecular Biotechnology and Health Sciences)
Education
Source: Self-asserted source
Fernando Spiller

School of Medicine of Ribeirao Preto, University of Sao Paulo: Ribeirao Preto, SP, BR

2004-09-01 to 2006-07-31 | Master (Department of Pharmacology)
Education
Source: Self-asserted source
Fernando Spiller

Funding (1)

Mecanismos envolvidos no aumento da mortalidade em doenças inflamatórias pelo uso profilático de antibióticos

2014-11-20 to 2017-11-30 | Grant
National Council for Scientific and Technological Development (Brasília, BR)
GRANT_NUMBER:

grant.CNPq_6f99e1e647

Source: Self-asserted source
Fernando Spiller
grade
Preferred source (of 2)‎

Works (31)

Cannabinoid CB2 receptor agonist reduces local and systemic inflammation associated with pneumonia-induced sepsis in mice

European Journal of Pharmacology
2023-11 | Journal article
Part of ISSN: 0014-2999
Contributors: Camila Fernandes Souza; Luana Bolsoni Borges; Filipe Rodolfo Moreira Borges Oliveira; Priscila Creppas de Souza Silva; Daniel Oliveira Patricio; Thiele Osvaldt Rosales; Nicoly Fernandes Souza; Fernando Spiller; Daniel Santos Mansur; Jamil Assreuy et al.
Source: Self-asserted source
Fernando Spiller

Chitosan/genipin modified electrode for voltammetric determination of interleukin-6 as a biomarker of sepsis

International Journal of Biological Macromolecules
2023-01 | Journal article
Part of ISSN: 0141-8130
Contributors: Franciele de Matos Morawski; Greicy Brisa Malaquias Dias; Kelline Alaide Pereira Sousa; Rodrigo Formiga; Fernando Spiller; Alexandre Luis Parize; André Báfica; Cristiane Luisa Jost
Source: Self-asserted source
Fernando Spiller

Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19.

British journal of pharmacology
2023-01-13 | Journal article
Contributors: Rodrigo de Oliveira Formiga; Amaral FC; Souza CF; Mendes DAGB; Wanderley CWS; Lorenzini CB; Santos AA; Antônia J; Faria LF; Natale CC et al.
Source: Self-asserted source
Fernando Spiller

Role of toll-like receptor 4 and sex in 6-hydroxydopamine–induced behavioral impairments and neurodegeneration in mice

Neurochemistry International
2021-12 | Journal article
Part of ISSN: 0197-0186
Contributors: Nauana Somensi; Samantha Cristiane Lopes; Gasparotto J; Rosângela Mayer Gonçalves; Camila Tiefensee Ribeiro; Daniel Oppermann Peixoto; Pedro Ozorio Brum; Cibele Martins Pinho; Jonathan Paulo Agnes; Lucas dos Santos da Silva et al.
Source: Self-asserted source
Fernando Spiller

Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation

The Journal of Pain
2021-08 | Journal article
Part of ISSN: 1526-5900
Contributors: Jonathan Paulo Agnes; Vitória Wibbelt dos Santos; Raquel Nascimento das Neves; Rosângela Mayer Gonçalves; Marina Delgobo; Carolina Saibro Girardi; Débora Denardin Lückemeyer; Marcella de Amorim Ferreira; Sérgio José Macedo Júnior; Samantha Cristiane Lopes et al.
Source: Self-asserted source
Fernando Spiller

Effect of p-cymene and rosmarinic acid on gastric ulcer healing – Involvement of multiple endogenous curative mechanisms

Phytomedicine
2021-06 | Journal article
Part of ISSN: 0944-7113
Contributors: Rodrigo de Oliveira Formiga; Edvaldo Balbino Alves Júnior; Roseane Carvalho Vasconcelos; Aurigena Antunes Araújo; Thaís Gomes de Carvalho; Raimundo Fernandes de Araújo Junior; Gerlane Bernardo Coelho Guerra; Giciane Carvalho Vieira; Kardilandia Mendes de Oliveira; Margareth de Fátima Formiga Melo Diniz et al.
Source: Self-asserted source
Fernando Spiller

p-Cymene and Rosmarinic Acid Ameliorate TNBS-Induced Intestinal Inflammation Upkeeping ZO-1 and MUC-2: Role of Antioxidant System and Immunomodulation

International Journal of Molecular Sciences
2020-08-15 | Journal article | Author
Part of ISSN: 1422-0067
Contributors: Rodrigo de Oliveira Formiga; Edvaldo Balbino Alves Júnior; Roseane Carvalho Vasconcelos; Gerlane Coelho Bernardo Guerra; Aurigena Araújo; Thais Carvalho; Vinícius Barreto Garcia; Araujo jr, R F; Francisco Allysson Assis Ferreira Gadelha; Giciane Carvalho Vieira et al.
Source: Self-asserted source
Fernando Spiller
grade
Preferred source (of 2)‎

Targeting nitric oxide as a key modulator of sepsis, arthritis and pain

2019-08 | Journal article
Part of ISSN: 1089-8603
Source: Self-asserted source
Fernando Spiller

Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens.

Journal of immunology (Baltimore, Md. : 1950)
2018-02 | Journal article
Contributors: Spiller F; Nycholat CM; Kikuchi C; Paulson JC; Macauley MS
Source: Self-asserted source
Fernando Spiller via Europe PubMed Central

Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis.

Frontiers in immunology
2017 | Journal article
Contributors: Soares FS; Amaral FC; Silva NLC; Valente MR; Santos LKR; Yamashiro LH; Scheffer MC; Castanheira FVES; Ferreira RG; Gehrke L et al.
Source: Self-asserted source
Fernando Spiller via Europe PubMed Central

Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice.

International journal of experimental pathology
2017-12 | Journal article
Contributors: Ferreira FBD; Dos Santos C; Bruxel MA; Nunes EA; Spiller F; Rafacho A
Source: Self-asserted source
Fernando Spiller via Europe PubMed Central

MyD88-, but not Nod1- And/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

PLoS ONE
2014 | Journal article
EID:

2-s2.0-84905457851

Contributors: Sônego, F.; Castanheira, F.V.S.; Czaikoski, P.G.; Kanashiro, A.; Souto, F.O.; França, R.O.; Nascimento, D.C.; Freitas, A.; Spiller, F.; Cunha, L.D. et al.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Decreased levels of alpha-1-acid glycoprotein are related to the mortality of septic patients in the emergency department

Clinics
2013 | Journal article
EID:

2-s2.0-84884278793

Contributors: Barroso-Sousa, R.; Lobo, R.R.; Mendonça, P.R.; Memória, R.R.; Spiller, F.; Cunha, F.Q.; Pazin-Filho, A.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis

Shock
2013 | Journal article
EID:

2-s2.0-84875364770

Contributors: Czaikoski, P.G.; Nascimento, D.C.; Sônego, F.; De Freitas, A.; Turato, W.M.; De Carvalho, M.A.; Santos, R.S.; De Oliveira, G.P.; Dos Santos Samary, C.; Tefe-Silva, C. et al.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Histamine H2 receptor signaling in the pathogenesis of sepsis: Studies in a murine diabetes model

Journal of Immunology
2013 | Journal article
EID:

2-s2.0-84880690488

Contributors: Carlos, D.; Spiller, F.; Souto, F.O.; Trevelin, S.C.; Borges, V.F.; De Freitas, A.; Alves-Filho, J.C.; Silva, J.S.; Ryffel, B.; Cunha, F.Q.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Possible mechanisms of neutrophil activation in Behçet's disease

International Immunopharmacology
2013 | Journal article
EID:

2-s2.0-84890117400

Contributors: Neves, F.S.; Spiller, F.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

α1-acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice

Diabetes
2012 | Journal article
EID:

2-s2.0-84861884688

Contributors: Spiller, F.; Carlos, D.; Souto, F.O.; De Freitas, A.; Soares, F.S.; Vieira, S.M.; Paula, F.J.A.; Alves-Filho, J.C.; Cunha, F.Q.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Divergent role of heme oxygenase inhibition in the pathogenesis of sepsis

Shock
2011 | Journal article
EID:

2-s2.0-79957891183

Contributors: Freitas, A.; Alves-Filho, J.C.; Trevelin, S.C.; Spiller, F.; Suavinha, M.M.; Nascimento, D.C.; Pestana, C.R.; Dal-Secco, D.; Sônego, F.; Czaikoski, P.G. et al.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Inhibition of guanylyl cyclase restores neutrophil migration and maintains bactericidal activity increasing survival in sepsis

Shock
2011 | Journal article
EID:

2-s2.0-78650773030

Contributors: Paula-Neto, H.A.; Alves-Filho, J.C.; Souto, F.O.; Spiller, F.; Amêndola, R.S.; Freitas, A.; Cunha, F.Q.; Barja-Fidalgo, C.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice

American Journal of Respiratory and Critical Care Medicine
2011 | Journal article
EID:

2-s2.0-79953320619

Contributors: Spiller, F.; Costa, C.; Souto, F.O.; Vinchi, F.; Mestriner, F.L.A.C.; Laure, H.J.; Alves-Filho, J.C.; Freitas, A.; Rosa, J.C.; Ferreira, S.H. et al.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Sildenafil improves the beneficial hemodynamic effects exerted by atorvastatin during acute pulmonary thromboembolism

European Journal of Pharmacology
2011 | Journal article
EID:

2-s2.0-80755189986

Contributors: Neto-Neves, E.M.; Dias-Junior, C.A.; Uzuelli, J.A.; Pereira, R.P.; Spiller, F.; Czaikoski, P.G.; Tanus-Santos, J.E.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Chronic treatment with quercetin does not inhibit angiotensin-converting Enzyme in Vivo or in Vitro

Basic and Clinical Pharmacology and Toxicology
2010 | Journal article
EID:

2-s2.0-77956800515

Contributors: Neto-Neves, E.M.; Montenegro, M.F.; Dias-Junior, C.A.; Spiller, F.; Kanashiro, A.; Tanus-Santos, J.E.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Hydrogen sulfide improves neutrophil migration and survival in sepsis via K<sup>+</sup><inf>ATP</inf>channel activation

American Journal of Respiratory and Critical Care Medicine
2010 | Journal article
EID:

2-s2.0-77956628056

Contributors: Spiller, F.; Orrico, M.I.L.; Nascimento, D.C.; Czaikoski, P.G.; Souto, F.O.; Alves-Filho, J.C.; Freitas, A.; Carlos, D.; Montenegro, M.F.; Neto, A.F. et al.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Neutrophil paralysis in sepsis

Shock
2010 | Journal article
EID:

2-s2.0-77955985078

Contributors: Alves-Filho, J.C.; Spiller, F.; Cunha, F.Q.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis

Proceedings of the National Academy of Sciences of the United States of America
2009 | Journal article
EID:

2-s2.0-62649121369

Contributors: Alves-Filho, J.C.; Freitas, A.; Souto, F.O.; Spiller, F.; Paula-Neto, H.; Silva, J.S.; Gazzinelli, R.T.; Teixeira, M.M.; Ferreira, S.H.; Cunha, F.Q.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation

Journal of Pharmacy and Pharmacology
2008 | Journal article
EID:

2-s2.0-41849147899

Contributors: Spiller, F.; Alves, M.K.; Vieira, S.M.; Carvalho, T.A.; Leite, C.E.; Lunardelli, A.; Poloni, J.A.; Cunha, F.Q.; De Oliveira, J.R.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

The role of neutrophils in severe sepsis

Shock
2008 | Journal article
EID:

2-s2.0-54049136026

Contributors: Alves-Filho, J.C.; De Freitas, A.; Spiller, F.; Souto, F.O.; Cunha, F.Q.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism

Proceedings of the National Academy of Sciences of the United States of America
2007 | Journal article
EID:

2-s2.0-37649013172

Contributors: Mestriner, F.L.A.C.; Spiller, F.; Laure, H.J.; Souto, F.O.; Tavares-Murta, B.M.; Rosa, J.C.; Basile-Filho, A.; Ferreira, S.H.; Greene, L.J.; Cunha, F.Q.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide

American Journal of Respiratory and Critical Care Medicine
2007 | Journal article
EID:

2-s2.0-33847638979

Contributors: Rios-Santos, F.; Alves-Filho, J.C.; Souto, F.O.; Spiller, F.; Freitas, A.; Lotufo, C.M.C.; Soares, M.B.P.; Dos Santos, R.R.; Teixeira, M.M.; Cunha, F.D.Q.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice

British Journal of Pharmacology
2007 | Journal article
EID:

2-s2.0-34848852751

Contributors: Torres-Duẽas, D.; Celes, M.R.N.; Freitas, A.; Alves-Filho, J.C.; Spiller, F.; Dal-Secco, D.; Dalto, V.F.; Rossi, M.A.; Ferreira, S.H.; Cunha, F.Q.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier

Increased resistance of glioma cell lines to extracellular ATP cytotoxicity

Journal of Neuro-Oncology
2005 | Journal article
EID:

2-s2.0-20144366139

Contributors: Morrone, F.B.; Horn, A.P.; Stella, J.; Spiller, F.; Sarkis, J.J.F.; Salbego, C.G.; Lenz, G.; Battastini, A.M.O.
Source: Self-asserted source
Fernando Spiller via Scopus - Elsevier