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matrix metalloproteinases, oxidative stress, heart disease, pharmacology, physiology

Biography

Richard (Rick) Schulz is a Professor in the Departments of Pediatrics and Pharmacology at the University of Alberta in Edmonton AB Canada. A member of the Mazankowski Alberta Heart Institute, the Women and Children's Health Research Institute, and the Cancer Research Institute of Northern Alberta, Rick is particularly interested in the impact of oxidative stress and matrix metalloproteinases (MMPs) in the heart and vasculature, in both health and disease. Rick’s translational research program is focused on therapies of ischemic heart disease, heart failure, septic shock and Chagas disease, through reducing the impact of oxidative stress and MMP activity. He serves on the editorial boards for several cardiovascular and pharmacology journals and is a member of many grants and personnel review panels. His research has been recognized with several awards, including his being made a fellow of the British Pharmacological Society

Activities

Employment (1)

University of Alberta: Edmonton, Alberta, CA

1992-07-01 to present | Professor (Pediatrics & Pharmacology/Mazankowski Alberta Heart Institute)
Employment
Source: Self-asserted source
Richard Schulz

Education and qualifications (2)

University of Alberta: Edmonton, AB, CA

1985-05-01 to 1989-05-15 | PhD Pharmacology
Education
Source: Self-asserted source
Richard Schulz

University of Calgary: Calgary, AB, CA

1977-09-01 to 1982-04-30 | BSc Chemistry
Education
Source: Self-asserted source
Richard Schulz

Funding (6)

CIHR Foundation Scheme - Established - Matrix Metalloproteinases in Cardiovascular Health and Disease: From Bench to Bedside

2015-07-01 to 2022-06-30 | Grant
Alberta Innovates (Edmonton, CA)
GRANT_NUMBER:

201500829

Source: Self-asserted source
Richard Schulz via DimensionsWizard

Matrix metalloproteinases in cardiovascular health and disease: from bench to bedside

2015-07-01 to 2022-06-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

21e6956a8fddcf3fd2631e36d99efc5f

Source: Self-asserted source
Richard Schulz via DimensionsWizard

Role of matrix metalloproteinase (MMP)-2 in regulating smooth muscle contraction

2011-04-01 to 2016-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
GRANT_NUMBER: 573377
Source: Self-asserted source
Richard Schulz via DimensionsWizard

Novel regulation and targets of matrix metalloproteinase-2 in the ischemic heart

2005-10-01 to 2015-06-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

eeabfc3ef962eba29882f510832507a8

Source: Self-asserted source
Richard Schulz via DimensionsWizard

Pathobiology of Matrix Metalloproteinases in the Heart

2005-07-01 to 2010-06-30 | Grant
Alberta Innovates (Edmonton, CA)
GRANT_NUMBER:

200400863

Source: Self-asserted source
Richard Schulz via DimensionsWizard

Matrix metalloproteinase-2 (MMP-2) in myocardial cell death from oxidative stress injury

2004-04-01 to 2014-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

5c6f4a86f39f3fec897d5170b27855fd

Source: Self-asserted source
Richard Schulz via DimensionsWizard

Works (50 of 157)

Items per page:
Page 1 of 4

The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury

Basic Research in Cardiology
2023-09-28 | Journal article
Contributors: Bridgette Hartley; Wesam Bassiouni; Richard Schulz; Olivier Julien
Source: check_circle
Crossref

Matrix metalloproteinase-2 proteolyzes mitofusin-2 and impairs mitochondrial function during myocardial ischemia–reperfusion injury

Basic Research in Cardiology
2023-07-26 | Journal article
Contributors: Wesam Bassiouni; Robert Valencia; Zabed Mahmud; John M. Seubert; Richard Schulz
Source: check_circle
Crossref

Matrix metalloproteinase‐2 mediates ribosomal RNA transcription by cleaving nucleolar histones

The FEBS Journal
2021-12 | Journal article
Contributors: Mohammad A. M. Ali; Javier A. Garcia‐Vilas; Christopher R. Cromwell; Basil P. Hubbard; Michael J. Hendzel; Richard Schulz
Source: check_circle
Crossref

Multifunctional intracellular matrix metalloproteinases: implications in disease

The FEBS Journal
2021-12 | Journal article
Contributors: Wesam Bassiouni; Mohammad A. M. Ali; Richard Schulz
Source: check_circle
Crossref

Matrix Metalloproteinase-2 Inhibition in Acute Ischemia-Reperfusion Heart Injury—Cardioprotective Properties of Carvedilol

Pharmaceuticals
2021-12-07 | Journal article
Contributors: Monika Skrzypiec-Spring; Joanna Urbaniak; Agnieszka Sapa-Wojciechowska; Jadwiga Pietkiewicz; Alina Orda; Bożena Karolko; Regina Danielewicz; Iwona Bil-Lula; Mieczysław Woźniak; Richard Schulz et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Letter by Hwang et al Regarding Article, “Temporal Release of High-Sensitivity Cardiac Troponin T and I and Copeptin After Brief Induced Coronary Artery Balloon Occlusion in Humans”

Circulation
2021-08-31 | Journal article
Contributors: Peter Hwang; Richard Schulz; Peter Kavsak
Source: check_circle
Crossref

MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling

Cardiovascular Research
2021-01-01 | Journal article
Contributors: Brandon Y H Chan; Andrej Roczkowsky; Woo Jung Cho; Mathieu Poirier; Consolato Sergi; Vic Keschrumrus; Jared M Churko; Henk Granzier; Richard Schulz
Source: check_circle
Crossref

Junctophilin-2 is a target of matrix metalloproteinase-2 in myocardial ischemia–reperfusion injury

Basic Research in Cardiology
2019-11 | Journal article
Contributors: Brandon Y. H. Chan; Andrej Roczkowsky; Woo Jung Cho; Mathieu Poirier; Tim Y. T. Lee; Zabed Mahmud; Richard Schulz
Source: check_circle
Crossref

Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia–reperfusion injury

Cardiovascular Research
2019-08-20 | Journal article
Contributors: Andrej Roczkowsky; Brandon Y H Chan; Tim Y T Lee; Zabed Mahmud; Bridgette Hartley; Olivier Julien; Gareth Armanious; Howard S Young; Richard Schulz
Source: check_circle
Crossref

Prognostic Value of MMP-9 -1562 C/T Gene Polymorphism in Patients With Sepsis

Biomarker Insights
2019-01 | Journal article
Contributors: César Bermúdez-Mejía; Melissa F Torres-Cordón; Silvia Becerra-Bayona; Carolina María Páez; Clara Inés Vargas; María Eugenia Cárdenas; Sergio Eduardo Serrano; Ingrid Baquero; Ruth Martínez-Vega; Richard Schulz et al.
Source: check_circle
Crossref

DOXYCYCLINE ATTENUATES RENAL INJURY IN A SWINE MODEL OF NEONATAL HYPOXIA-REOXYGENATION

Shock
2015 | Journal article
WOSUID:

WOS:000346422700015

Contributors: Labossiere, Joseph R.; Pelletier, Jean-Sebastian; Thiesen, Aducio; Schulz, Richard; Bigam, David L.; Cheung, Po-Yin
Source: Self-asserted source
Richard Schulz via ResearcherID

Matrix metalloproteinases 2 and 9 as diagnostic tools in Chagas cardiomyopathy

International Journal of Cardiology
2014 | Journal article
WOSUID:

WOS:000343895000034

Contributors: Bautista-Lopez, Norma Leticia; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

MMP-2 is localized to the mitochondria-associated membrane of the heart

American Journal of Physiology-Heart and Circulatory Physiology
2014 | Journal article
WOSUID:

WOS:000332477900016

Contributors: Hughes, Bryan G.; Fan, Xiaohu; Cho, Woo Jung; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Mmp25 beta Facilitates Elongation of Sensory Neurons During Zebrafish Development

Genesis
2014 | Journal article
WOSUID:

WOS:000344323100001

Contributors: Crawford, Bryan D.; Po, Michelle D.; Saranyan, Pillai V.; Forsberg, Daniel; Schulz, Richard; Pilgrim, Dave B.
Source: Self-asserted source
Richard Schulz via ResearcherID

Myocardial matrix metalloproteinase-2: inside out and upside down

Journal of Molecular and Cellular Cardiology
2014 | Journal article
WOSUID:

WOS:000346460100007

Contributors: DeCoux, Ashley; Lindsey, Merry L.; Villarreal, Francisco; Garcia, Ricardo A.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Postresuscitation Administration of Doxycycline Preserves Cardiac Contractile Function in Hypoxia- Reoxygenation Injury of Newborn Piglets*

Critical Care Medicine
2014 | Journal article
WOSUID:

WOS:000332839700001

Contributors: LaBossiere, Joseph R.; Pelletier, Jean-Sebastian; Ali, Mohammad A.; Thiesen, Aducio; Schulz, Richard; Bigam, David L.; Cheung, Po-Yin
Source: Self-asserted source
Richard Schulz via ResearcherID

Remodeling of Aorta Extracellular Matrix as a Result of Transient High Oxygen Exposure in Newborn Rats: Implication for Arterial Rigidity and Hypertension Risk

Plos One
2014 | Journal article
WOSUID:

WOS:000335309100007

Contributors: Huyard, Fanny; Yzydorczyk, Catherine; Castro, Michele M.; Cloutier, Anik; Bertagnolli, Mariane; Sartelet, Herve; Germain, Nathalie; Comte, Blandine; Schulz, Richard; DeBlois, Denis et al.
Source: Self-asserted source
Richard Schulz via ResearcherID

Smoothelin-B is not a target of matrix metalloproteinase (MMP)-2 in the vasculature of endotoxemic rats

Canadian Journal of Physiology and Pharmacology
2014 | Journal article
WOSUID:

WOS:000343099500011

Contributors: de Souza, Priscila; de Castro, Michele Mazzaron; Goobie, Gillian; da Silva-Santos, Jose Eduardo; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Targeting MMP-2 to treat ischemic heart injury

Basic Research in Cardiology
2014 | Journal article
WOSUID:

WOS:000338996100001

Contributors: Hughes, Bryan G.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study

Bmc Cardiovascular Disorders
2014 | Journal article
WOSUID:

WOS:000342027300001

Contributors: Ezekowitz, Justin A.; Becher, Harald; Belenkie, Israel; Clark, Alexander M.; Duff, Henry J.; Friedrich, Matthias G.; Haykowsky, Mark J.; Howlett, Jonathan G.; Kassiri, Zamaneh; Kaul, Padma et al.
Source: Self-asserted source
Richard Schulz via ResearcherID

Activation of intracellular matrix metalloproteinase-2 by reactive oxygen nitrogen species: Consequences and therapeutic strategies in the heart

Archives of Biochemistry and Biophysics
2013 | Journal article
WOSUID:

WOS:000327917800010

Contributors: Jacob-Ferreira, Anna L.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Doxycycline Reduces Cardiac Matrix Metalloproteinase-2 Activity but Does not Ameliorate Myocardial Dysfunction During Reperfusion in Coronary Artery Bypass Patients Undergoing Cardiopulmonary Bypass

Critical Care Medicine
2013 | Journal article
WOSUID:

WOS:000326291600037

Contributors: Schulze, Costas J.; Castro, Michele M.; Kandasamy, Arulmozhi D.; Cena, Jonathan; Bryden, Courtney; Wang, Shoa H.; Koshal, Arvind; Tsuyuki, Ross T.; Finegan, Barry A.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Hydrogen peroxide-induced necrotic cell death in cardiomyocytes is independent of matrix metalloproteinase-2

Toxicology in Vitro
2013 | Journal article
WOSUID:

WOS:000324847800011

Contributors: Ali, Mohammad A. M.; Kandasamy, Arulmozhi D.; Fan, Xiaohu; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2

Biochemical Pharmacology
2013 | Journal article
WOSUID:

WOS:000323297100003

Contributors: Castro, M. M.; Fuah, J.; Ali, M.; Sung, M.; Schulz, J.; Kondo, M. Y.; Fan, X.; Holt, A.; Schulz, R.
Source: Self-asserted source
Richard Schulz via ResearcherID

Intracellular proteases and sarcomere disassembly in neonatal cardiomyocytes

Faseb Journal
2013 | Journal article
WOSUID:

WOS:000319860505288

Contributors: Fan, Frank; Ali, Mohammad A. M.; Lopez, Waleska; Kondo, Marcia Y.; Hughes, Bryan G.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Matrix metalloproteinase inhibition attenuates right ventricular dysfunction and improves responses to dobutamine during acute pulmonary thromboembolism

Journal of Cellular and Molecular Medicine
2013 | Journal article
WOSUID:

WOS:000328817900008

Contributors: Neto-Neves, Evandro M.; Sousa-Santos, Ozelia; Ferraz, Karina C.; Rizzi, Elen; Ceron, Carla S.; Romano, Minna M. D.; Gali, Luis G.; Maciel, Benedito C.; Schulz, Richard; Gerlach, Raquel F. et al.
Source: Self-asserted source
Richard Schulz via ResearcherID

Matrix metalloproteinases 2 and 9 as diagnostic markers in the progression to Chagas cardiomyopathy

American Heart Journal
2013 | Journal article
WOSUID:

WOS:000317184300018

Contributors: Bautista-Lopez, Norma Leticia; Morillo, Carlos A.; Lopez-Jaramillo, Patricio; Quiroz, Roberto; Luengas, Carlos; Silva, Sandra Y.; Galipeau, Jacques; Lalu, Manoj Mathew; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Nuclear MMP-2: presence and activity in cardiac myocytes

Faseb Journal
2013 | Journal article
WOSUID:

WOS:000319883502559

Contributors: Kondo, Marcia Yuri; Castro, Michele Mazzaron; Fan, Frank; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Phosphorylation Status of 72 kDa MMP-2 Determines Its Structure and Activity in Response to Peroxynitrite

Plos One
2013 | Journal article
WOSUID:

WOS:000323815200019

Contributors: Jacob-Ferreira, Anna Laura; Kondo, Marcia Yuri; Baral, Pravas Kumar; James, Michael N. G.; Holt, Andrew; Fan, Xiaohu; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Role of MMP-2 activation in oncostatin-M induced cardiomyocyte dedifferentiation

Faseb Journal
2013 | Journal article
WOSUID:

WOS:000319860503251

Contributors: Fan, Frank; Ali, Mohammad A. M.; Hughes, Bryan G.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

An inside-out story: matrix metalloproteinase-2 and myocardial oxidative stress injury

Canadian Journal of Physiology and Pharmacology
2012 | Journal article
WOSUID:

WOS:000304531700027

Contributors: Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity

Biochemical and Biophysical Research Communications
2012 | Journal article
WOSUID:

WOS:000307087700001

Contributors: Ali, M. A. M.; Stepanko, A.; Fan, X. H.; Holt, A.; Schulz, R.
Source: Self-asserted source
Richard Schulz via ResearcherID

Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2

Febs Journal
2012 | Journal article
WOSUID:

WOS:000305279500016

Contributors: Cadete, V. J. J.; Sawicka, J.; Jaswal, J. S.; Lopaschuk, G. D.; Schulz, R.; Szczesna-Cordary, D.; Sawicki, G.
Source: Self-asserted source
Richard Schulz via ResearcherID

Matrix Metalloproteinase-2 Proteolysis of Calponin-1 Contributes to Vascular Hypocontractility in Endotoxemic Rats

Arteriosclerosis, Thrombosis, and Vascular Biology
2012 | Journal article
Contributors: Castro, Michele M.; Cena, Jonathan; Cho, Woo Jung; Walsh, Michael P.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Matrix metalloproteinase-2: an emerging biomarker for reperfusion injury following percutaneous coronary intervention

Heart
2012 | Journal article
WOSUID:

WOS:000297687800001

Contributors: Fan, Xiaohu; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Mechanisms of cytosolic targeting of matrix metalloproteinase-2

Journal of Cellular Physiology
2012 | Journal article
WOSUID:

WOS:000305509900006

Contributors: Ali, M. A. M.; Chow, A. K.; Kandasamy, A. D.; Fan, X. H.; West, L. J.; Crawford, B. D.; Simmen, T.; Schulz, R.
Source: Self-asserted source
Richard Schulz via ResearcherID

Phosphorylation status of matrix metalloproteinase 2 in myocardial ischaemia-reperfusion injury

Heart
2012 | Journal article
WOSUID:

WOS:000302872000012

Contributors: Sariahmetoglu, M.; Skrzypiec-Spring, M.; Youssef, N.; Jacob-Ferreira, A. L. B.; Sawicka, J.; Holmes, C.; Sawicki, G.; Schulz, R.
Source: Self-asserted source
Richard Schulz via ResearcherID

Cardiac Sarcomeric Proteins: Novel Intracellular Targets of Matrix Metalloproteinase-2 in Heart Disease

Trends in Cardiovascular Medicine
2011 | Journal article
WOSUID:

WOS:000305435800003

Contributors: Ali, M. A. M.; Fan, X. H.; Schulz, R.
Source: Self-asserted source
Richard Schulz via ResearcherID

Intracellular MMP-2: Role in Normal and Diseased Hearts

Molecular Defects in Cardiovascular Disease
2011 | Book
WOSUID:

WOS:000294660600002

Contributors: Youssef, Nermeen; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Matrix metalloproteinase (MMP)-2 proteolysis of calponin contributes to vascular hypocontractility in endotoxemic rats

Faseb Journal
2011 | Journal article
WOSUID:

WOS:000310708405590

Contributors: de Castro, Michele Mazzaron; Cena, Jonathan; Walsh, Michael P.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Matrix metalloproteinase inhibitor properties of tetracyclines: Therapeutic potential in cardiovascular diseases

Pharmacological Research
2011 | Journal article
WOSUID:

WOS:000296756000002

Contributors: Castro, Michele M.; Kandasamy, Arulmozhi D.; Youssef, Nermeen; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Peroxynitrite-induced changes in 72kDa matrix metalloproteinase-2 activity are further regulated by its phosphorylation status

Faseb Journal
2011 | Journal article
WOSUID:

WOS:000310708401290

Contributors: Ferreira, Anna Laura Bechara Jacob; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Smoothelin-B: a potential target of matrix metalloproteinase (MMP)-2 in the vasculature of endotoxemic rats

Faseb Journal
2011 | Journal article
WOSUID:

WOS:000310708401540

Contributors: de Castro, Michele Mazzaron; Goobie, Gillian; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Antioxidant treatment protects diabetic rats from cardiac dysfunction by preserving contractile protein targets of oxidative stress

Journal of Nutritional Biochemistry
2010 | Journal article
WOSUID:

WOS:000281710700006

Contributors: Aydemir-Koksoy, Aslihan; Bilginoglu, Ayca; Sariahmetoglu, Meltem; Schulz, Richard; Turan, Belma
Source: Self-asserted source
Richard Schulz via ResearcherID

Cardiac function is not significantly diminished in hearts isolated from young caveolin-1 knockout mice

American Journal of Physiology-Heart and Circulatory Physiology
2010 | Journal article
WOSUID:

WOS:000283857300024

Contributors: Chow, Ava K.; Daniel, Edwin E.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Caveolin-1 exists and may function in cardiomyocytes

Canadian Journal of Physiology and Pharmacology
2010 | Journal article
WOSUID:

WOS:000275273800010

Contributors: Cho, Woo Jung; Chow, Ava K.; Schulz, Richard; Daniel, Edwin E.
Source: Self-asserted source
Richard Schulz via ResearcherID

Inhibition of matrix metalloproteinase activity in vivo protects against vascular hyporeactivity in endotoxemia

American Journal of Physiology-Heart and Circulatory Physiology
2010 | Journal article
WOSUID:

WOS:000272831600007

Contributors: Cena, Jonathan J.; Lalu, Manoj M.; Cho, Woo Jung; Chow, Ava K.; Bagdan, Mariel L.; Daniel, Edwin E.; Castro, Michele M.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix

Cardiovascular Research
2010 | Journal article
WOSUID:

WOS:000273493900005

Contributors: Kandasamy, Arulmozhi D.; Chow, Ava K.; Ali, Mohammad A. M.; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Titin is a Target of Matrix Metalloproteinase-2 Implications in Myocardial Ischemia/Reperfusion Injury

Circulation
2010 | Journal article
WOSUID:

WOS:000284213200014

Contributors: Ali, Mohammad A. M.; Cho, Woo Jung; Hudson, Bryan; Kassiri, Zamaneh; Granzier, Henk; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID

Activation and modulation of 72 kDa matrix metalloproteinase-2 by peroxynitrite and glutathione

Biochemical Pharmacology
2009 | Journal article
WOSUID:

WOS:000263812300007

Contributors: Viappiani, Serena; Nicolescu, Adrian C.; Holt, Andrew; Sawicki, Grzegorz; Crawford, Bryan D.; Leon, Hernando; van Mulligen, Tyler; Schulz, Richard
Source: Self-asserted source
Richard Schulz via ResearcherID
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