Personal information

Emails & domains

Verified email addresses

Verified email domains

Websites & social links

King's College London profile page

Other IDs

Scopus Author ID: 55767389000
Loop profile: 1012414
SciProfiles: 2749199
Loop profile: 727236

Keywords

RNA viruses, Flavivirus, TRIM proteins, PTMs,

Countries

United Kingdom, Italy

Biography

My research focuses on the intricate interactions between viruses and host cells that dictate the outcomes of infection, using flaviviruses like HCV, Zika and Dengue as models. I investigate initial antiviral defenses and the strategies these viruses employ to evade them, enabling replication and pathogenesis. Additionally, I study how viruses exploit critical cellular systems, such as the proteasome and cytoskeleton, to create favourable environments for their replication.
By integrating functional screens, proteomics, transcriptomics, and advanced molecular virology techniques, my work seeks to uncover novel mechanisms of viral manipulation. These insights aim to inform innovative antiviral strategies while advancing translational research in host-pathogen biology.

Activities

Collapse all

Employment (5)

University College London: London, London, GB

2023-09-01 to present | Research Fellow (Div Infection and immunity)
Employment
Source: Self-asserted source
Hashim Ali

University of Cambridge: Cambridge, GB

2021-10-01 to 2023-08-31 | Research Associate (Pathology)
Employment
Source: Self-asserted source
Hashim Ali

King's College London: London, GB

2021-09-30
Employment
Source: check_circle
King's College London

King's College London: London, London, GB

2019-03-01 to 2021-09-30 | Research Associate (School of Cardiovascular Medicine & Sciences)
Employment
Source: Self-asserted source
Hashim Ali

International Centre for Genetic Engineering and Biotechnology: Trieste, Friuli-Venezia Giulia, IT

2015 to 2019-02-28 | Post Doctoral Research Scientist (Molecular Medicine)
Employment
Source: Self-asserted source
Hashim Ali

Education and qualifications (3)

International Centre for Genetic Engineering and Biotechnology: Trieste, Friuli-Venezia Giulia, IT

2011-01-01 to 2015-08-15 | PhD (Molecular Medicine Laboratory)
Education
Source: Self-asserted source
Hashim Ali

Jamia Hamdard: New Delhi, Delhi, IN

2005 to 2007 | M.Sc Biotechnology (Department of Biotechnology)
Education
Source: Self-asserted source
Hashim Ali

Jamia Millia Islamia Faculty of Natural Sciences: New Delhi, Delhi, IN

2002-07-01 to 2005-07-01 | B.Sc Biotechnology (Department of Biosciences)
Education
Source: Self-asserted source
Hashim Ali

Professional activities (2)

Microbiology Society: London, GB

2021 to 2023 | Full (Virology Division, University of Cambridge)
Membership
Source: Self-asserted source
Hashim Ali

British Society for Cell Biology: Oxford, GB

2021 to 2022 (Virology Division, University Of Cambridge)
Membership
Source: Self-asserted source
Hashim Ali

Funding (1)

Characterization of molecular the mechanism involved in the extracellular release of the HIV-1 Tat protein

Award
ICGEB (Trieste, IT)
Source: Self-asserted source
Hashim Ali

Works (27)

Development and Application of MLB Human Astrovirus Reverse Genetics Clones and Replicons

Bio-Protocol
2025 | Journal article
DOI: 10.21769/BIOPROTOC.5201
WOSUID: WOS:001436394700006
Contributors: Ali, Hashim; Noyvert, David; Lulla, Valeria
Source: check_circle
Web of Science Researcher Profile Sync

The astrovirus N-terminal nonstructural protein anchors replication complexes to the perinuclear ER membranes

BioRxiv
2024 | Journal article
DOI: 10.1101/2024.01.09.574783
WOSUID: PPRN:87004549
Contributors: Ali, Hashim; Noyvert, David; Hankinson, Jack; Lindsey, Gemma; Lulla, Valeria
Source: check_circle
Web of Science Researcher Profile Sync

Development and Application of MLB Human Astrovirus Reverse Genetics Clones and Replicons

Bio-Protocol
2024-12-21 | Journal article
DOI: 10.17863/CAM.114459
Contributors: Hashim Ali; Valeria Lulla; David Noyvert
Source: Self-asserted source
Hashim Ali

The astrovirus N-terminal nonstructural protein anchors replication complexes to the perinuclear ER membranes

PLOS Pathogens
2024-07-15 | Journal article
DOI: 10.1371/journal.ppat.1011959
Part of ISSN: 1553-7374
Contributors: Hashim Ali; David Noyvert; Jacqueline Hankinson; Gemma Lindsey; Aleksei Lulla; Valeria Lulla
Source: Self-asserted source
Hashim Ali

SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet procoagulant activity

Frontiers in Cardiovascular Medicine
2023 | Journal article
DOI: 10.3389/FCVM.2022.1013262
WOSUID: WOS:000914844500001
Contributors: Cappelletto, Ambra; Allan, Harriet E.; Crescente, Marilena; Schneider, Edoardo; Bussani, Rossana; Ali, Hashim; Secco, Ilaria; Vodret, Simone; Simeone, Roberto; Mascaretti, Luca et al.
Source: check_circle
Web of Science Researcher Profile Sync

SARS-CoV-2 Syncytium under the Radar: Molecular Insights of the Spike-Induced Syncytia and Potential Strategies to Limit SARS-CoV-2 Replication

Journal of Clinical Medicine
2023-09-20 | Journal article
DOI: 10.3390/jcm12186079
Contributors: Hashim Ali; Asma Naseem; Zaheenul Islam Siddiqui
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein

Molecular & Cellular Proteomics
2023-08 | Journal article
DOI: 10.1016/j.mcpro.2023.100600
Contributors: Sean A. Burnap; Ana Maria Ortega-Prieto; Jose M. Jimenez-Guardeño; Hashim Ali; Kaloyan Takov; Matthew Fish; Manu Shankar-Hari; Mauro Giacca; Michael H. Malim; Manuel Mayr
Source: check_circle
Crossref

Attenuation hotspots in neurotropic human astroviruses

PLOS Biology
2023-07-17 | Journal article
DOI: 10.1371/journal.pbio.3001815
Part of ISSN: 1545-7885
Contributors: Hashim Ali; Aleksei Lulla; Alex S. Nicholson; Jacqueline Hankinson; Elizabeth B. Wignall-Fleming; Rhian L. O’Connor; Diem-Lan Vu; Stephen C. Graham; Janet E. Deane; Susana Guix et al.
Source: Self-asserted source
Hashim Ali

Editorial: Decoding the genetics of viral evolution

Frontiers in Genetics
2022 | Journal article
DOI: 10.3389/FGENE.2022.978485
WOSUID: WOS:000879433800001
Contributors: Ali, Hashim; Rahman, Sheikh Abdul; Akhtar, Junaid; Haque, Syed Asfarul; Ali, Safdar
Source: check_circle
Web of Science Researcher Profile Sync

Anti-fungal drug anidulafungin inhibits SARS-CoV-2 Spike induced syncytia formation by targeting ACE2-Spike protein interaction

Frontiers of Genetics
2022-03-25 | Journal article | Author
DOI: 10.3389/fgene.2022.866474
SOURCE-WORK-ID:

d429d810-d543-4ba6-a776-be0b11d7ade0

EID:

2-s2.0-85128312516
Contributors: Shahzaib Ahamad; Hashim Ali; Ilaria Secco; MAURO GIACCA; Dinesh Gupta
Source: check_circle
King's College London

SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

Nature Communications
2021-12 | Journal article | Author
DOI: 10.1038/s41467-021-23494-1
SOURCE-WORK-ID:

8d565478-1e85-4136-b417-ba1f33437946

PMID: 34099652
PMID: 34099652
EID:

2-s2.0-85107529344

WOSUID:

000687325100034
Contributors: Clemens Gutmann; Kaloyan Takov; Sean A Burnap; Bhawana Singh; Hashim Ali; Konstantinos Theofilatos; Ella Reed; Maria Hasman; Adam Nabeebaccus; Matthew Fish et al.
Source: check_circle
King's College London

RNA interference therapeutics for cardiac regeneration

Current Opinion in Genetics and Development
2021-10 | Journal article | Author
DOI: 10.1016/j.gde.2021.05.007
SOURCE-WORK-ID:

ada754fb-c190-4d33-8523-e61714ccd719

EID:

2-s2.0-85108091197

PMID: 34098251
Contributors: Josef Huntington; Manendra Pachauri; Hashim Ali; MAURO GIACCA
Source: check_circle
King's College London

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

Nature
2021-06-03 | Journal article
DOI: 10.1038/s41586-021-03491-6
Contributors: Luca Braga; Hashim Ali; Ilaria Secco; Elena Chiavacci; Guilherme Neves; Daniel Goldhill; Rebecca Penn; Jose M. Jimenez-Guardeño; Ana M. Ortega-Prieto; Rossana Bussani et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Non-coding RNA therapeutics for cardiac regeneration

Cardiovascular Research
2021-02-22 | Journal article
DOI: 10.1093/cvr/cvaa071
Contributors: Luca Braga; Hashim Ali; Ilaria Secco; Mauro Giacca
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Innate immune signaling in cardiac homeostasis and cardiac injuries

Systems and Synthetic Immunology
2020 | Book chapter
Part of DOI: 10.1007/978-981-15-3350-1_7
EID:

2-s2.0-85088447829
Contributors: Naseem, A.; Ali, H.
Source: Self-asserted source
Hashim Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology

EBioMedicine
2020-11 | Journal article
DOI: 10.1016/j.ebiom.2020.103104
Contributors: Rossana Bussani; Edoardo Schneider; Lorena Zentilin; Chiara Collesi; Hashim Ali; Luca Braga; Maria Concetta Volpe; Andrea Colliva; Fabrizio Zanconati; Giorgio Berlot et al.
Source: check_circle
Crossref

Wiskott-Aldrich syndrome protein restricts cGAS/STING activation by dsDNA immune complexes

JCI Insight
2020-09-03 | Journal article
DOI: 10.1172/jci.insight.132857
Contributors: Giulia Maria Piperno; Asma Naseem; Giulia Silvestrelli; Roberto Amadio; Nicoletta Caronni; Karla Evelia Cervantes-Luevano; Nalan Liv; Judith Klumperman; Andrea Colliva; Hashim Ali et al.
Source: check_circle
Crossref

Gene Therapy for the Heart Lessons Learned and Future Perspectives

Circulation Research
2020-05-08 | Journal article
DOI: 10.1161/CIRCRESAHA.120.315855
Contributors: Antonio Cannatà; Hashim Ali; Gianfranco Sinagra; Mauro Giacca
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation

Nature Communications
2019 | Journal article
DOI: 10.1038/s41467-019-08810-0
EID:

2-s2.0-85062109278
Contributors: Ali, H.; Mano, M.; Braga, L.; Naseem, A.; Marini, B.; Vu, D.M.; Collesi, C.; Meroni, G.; Lusic, M.; Giacca, M.
Source: Self-asserted source
Hashim Ali via Scopus - Elsevier

Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation

Cell Reports
2019 | Journal article
DOI: 10.1016/j.celrep.2019.05.005
EID:

2-s2.0-85065912743
Contributors: Torrini, C.; Cubero, R.J.; Dirkx, E.; Braga, L.; Ali, H.; Prosdocimo, G.; Gutierrez, M.I.; Collesi, C.; Licastro, D.; Zentilin, L. et al.
Source: Self-asserted source
Hashim Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Deciphering the role of trehalose in hindering antithrombin polymerization

Bioscience Reports
2019 | Journal article
DOI: 10.1042/BSR20182259
EID:

2-s2.0-85064215977
Contributors: Naseem, A.; Khan, M.S.; Ali, H.; Ahmad, I.; Jairajpuri, M.A.
Source: Self-asserted source
Hashim Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs

Nature
2019 | Journal article
DOI: 10.1038/s41586-019-1191-6
EID:

2-s2.0-85065544756
Contributors: Gabisonia, K.; Prosdocimo, G.; Aquaro, G.D.; Carlucci, L.; Zentilin, L.; Secco, I.; Ali, H.; Braga, L.; Gorgodze, N.; Bernini, F. et al.
Source: Self-asserted source
Hashim Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Cardiac regeneration and remodelling of the cardiomyocyte cytoarchitecture

FEBS Journal
2019-01-01 | Journal article | Author
DOI: 10.1111/febs.15146
SOURCE-WORK-ID:

626bd233-76f8-4805-9e49-f48eafe3a9a5

EID:

2-s2.0-85076356145

PMID: 31743572
Contributors: Hashim Ali; Luca Braga; MAURO GIACCA
Source: check_circle
King's College London
grade
Preferred source (of 3)‎

Reversible Notch1 acetylation tunes proliferative signalling in cardiomyocytes

Cardiovascular Research
2018 | Journal article
DOI: 10.1093/cvr/cvx228
EID:

2-s2.0-85040612511
Contributors: Collesi, C.; Felician, G.; Secco, I.; Gutierrez, M.I.; Martelletti, E.; Ali, H.; Zentilin, L.; Myers, M.P.; Giacca, M.
Source: Self-asserted source
Hashim Ali via Scopus - Elsevier

Inhibition of Non Canonical HIV-1 Tat Secretion Through the Cellular Na<sup>+</sup>,K<sup>+</sup>-ATPase Blocks HIV-1 Infection

EBioMedicine
2017 | Journal article
DOI: 10.1016/j.ebiom.2017.06.011
EID:

2-s2.0-85021121932
Contributors: Agostini, S.; Ali, H.; Vardabasso, C.; Fittipaldi, A.; Tasciotti, E.; Cereseto, A.; Bugatti, A.; Rusnati, M.; Lusic, M.; Giacca, M.
Source: Self-asserted source
Hashim Ali via Scopus - Elsevier

Nuclear architecture dictates HIV-1 integration site selection

Nature
2015 | Journal article
DOI: 10.1038/nature14226
EID:

2-s2.0-84929337088
Contributors: Marini, B.; Kertesz-Farkas, A.; Ali, H.; Lucic, B.; Lisek, K.; Manganaro, L.; Pongor, S.; Luzzati, R.; Recchia, A.; Mavilio, F. et al.
Source: Self-asserted source
Hashim Ali via Scopus - Elsevier

Proximity to PML nuclear bodies regulates HIV-1 latency in CD4+ T cells

Cell Host and Microbe
2013 | Journal article
DOI: 10.1016/j.chom.2013.05.006
EID:

2-s2.0-84879105224
Contributors: Lusic, M.; Marini, B.; Ali, H.; Lucic, B.; Luzzati, R.; Giacca, M.
Source: Self-asserted source
Hashim Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Peer review (3 reviews for 3 publications/grants)

Review activity for Cells. (1)
Review activity for Life science alliance. (1)
Review activity for Viruses. (1)
How many people are using ORCID?