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ResearchGate Profile
The University of Manchester profile page

Other IDs

Scopus Author ID: 36132011500

Keywords

Host-pathogen interactions, circadian behaviour, glia, Parasitism, cell biology

Countries

United Kingdom

Activities

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Employment (11)

The University of Manchester: Manchester, GB

Employment
Source: check_circle
University of Manchester - PURE

University of Manchester: Manchester, GB

2023-11-01 to present | Principal Investigator / Group Leader (Division, Division of Immunology, Immunity to Infection and Respiratory Medicine, Lydia Becker Institute of Immunology and Inflammation, Geoffrey Jefferson Centre for Brain Research)
Employment
Source: Self-asserted source
Juan F. Quintana

University of Edinburgh: Edinburgh, Edinburgh, GB

2013-03-01 to present | Postgraduate Research Assistant (Institute for Immunology and Infection Research)
Employment
Source: Self-asserted source
Juan F. Quintana

University of Glasgow: Glasgow, Glasgow, GB

2021-02-01 to 2026-01-31 | LKAS Leadership fellow (IBAHCM)
Employment
Source: Self-asserted source
Juan F. Quintana

University of Glasgow: Glasgow, Glasgow, GB

2021-02-01 to 2026-01-31 | Sir Henry Wellcome Fellow / Lord Kelvin Adam Smith Leadership Fellow (Wellcome Centre for Integrative Parasitology / Institute of Biodiversity, Animal health, and Comparative Medicine)
Employment
Source: Self-asserted source
Juan F. Quintana

University of Glasgow: Glasgow, Glasgow, GB

2021-02-01 to 2025-01-31 | Sir Henry Wellcome fellow (Wellcome Centre for Integrative Parasitology)
Employment
Source: Self-asserted source
Juan F. Quintana

University of Glasgow: Glasgow, GB

2019-10-01 to 2023-10-31 | Research Fellow (Wellcome Centre for Integrative Parasitology)
Employment
Source: Self-asserted source
Juan F. Quintana

University of Dundee: Dundee, Dundee, GB

2017-10-02 to 2019-10-01 | Postdoctoral Research Associate (The Wellcome Trust Centre for Anti-Infective Research)
Employment
Source: Self-asserted source
Juan F. Quintana

Centro de Investigaciones Biológicas: Madrid, Madrid, ES

2012-07-01 to 2012-11-30 | Postgraduate Research Assistant (Chemical and Physical Biology)
Employment
Source: Self-asserted source
Juan F. Quintana

Centro de Investigaciones Biológicas: Madrid, Madrid, ES

2010-09-01 to 2011-08-30 | • Scholarship from the program Bancaja-CIBER of Rare Diseases (CIBERER) (Cellular and Molecular Medicine)
Employment
Source: Self-asserted source
Juan F. Quintana

Universidad de Zaragoza: Zaragoza, Aragón, ES

2009-03-01 to 2010-08-30 | Postgraduate Research Assistant (Departamento de Bioquimica y Biologia molecular y celular)
Employment
Source: Self-asserted source
Juan F. Quintana

Education and qualifications (3)

University of Edinburgh: Edinburgh, Edinburgh, GB

2014-09-01 to 2017-09-30 | PhD (Institute for Infection and Immunology Research (IIIR))
Education
Source: Self-asserted source
Juan F. Quintana

Universidad de Zaragoza: Zaragoza, Aragón, ES

2009-03-01 to 2010-08-30 | MSc (with distinction) Biochemistry and Molecular Biology (Departamento de Bioquimica y Biologia molecular y celular)
Education
Source: Self-asserted source
Juan F. Quintana

Universidad de Carabobo: Valencia, Carabobo, VE

2002-09-01 to 2007-12-16 | BSc (Hons) Biology (Biologia)
Education
Source: Self-asserted source
Juan F. Quintana

Funding (4)

LKAS leadership fellowship

2021-02 to 2026-01 | Award
University of Glasgow (Glasgow, GB)
Source: Self-asserted source
Juan F. Quintana

Molecular basis of the pathogen-induced disruption of host circadian outputs

2021-02 to 2026-01 | Grant
Wellcome Trust (London, GB)
Source: Self-asserted source
Juan F. Quintana

NEUROTryp: mouse and human brain organoids to model host-pathogen interactions

2021-02 to 2023-02 | Grant
National Centre for the Replacement Refinement and Reduction of Animals in Research (London, GB)
Source: Self-asserted source
Juan F. Quintana

Small RNAs and extracellular vesicles in filarial nematodes: from nematode development to diagnostics

2016-10 to 2016-11 | Award
American Society of Tropical Medicine and Hygiene (IL, IL, US)
Source: Self-asserted source
Juan F. Quintana

Works (34)

Interleukin-17 and fat: Timing is everything

Immunity
2025-01 | Journal article
DOI: 10.1016/j.immuni.2024.12.005
Contributors: Matthew C. Sinton; Olivia Shorthouse; Alice Costain; Juan F. Quintana
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Murine trypanosomiasis recapitulates transcriptomic features of acute kidney injury

2024-05-08 | Preprint
DOI: 10.1101/2024.05.08.593024
Contributors: John Ogunsola; Anneli Cooper; Juan F. Quintana; Annette MacLeod
Source: check_circle
Crossref

The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection

PLOS Biology
2023-11-20 | Journal article
DOI: 10.1371/journal.pbio.3002389
Contributors: Juan F. Quintana; Takeshi Tsubata; Matthew C. Sinton; Praveena Chandrasegaran; Lalit Kumar Dubey; John Ogunsola; Moumen Al Samman; Michael Haley; Gail McConnell; Nono-Raymond Kuispond Swar et al.
Source: check_circle
Crossref
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IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection

Nature Communications
2023-11-03 | Journal article | Author
DOI: 10.1038/s41467-023-42918-8
SOURCE-WORK-ID:

04d88f20-ebf0-4c32-94b2-d88c4847eb36

EID:

2-s2.0-85175713106

PMID: 37923768
Contributors: Matthew Sinton; Praveena R. G. Chandrasegaran; Paul Capewell; Anneli Cooper; Alex Girard; John Ogunsola; Georgia Perona-Wright; Dieudonné M Ngoyi; Nono Kuispond; Bruno Bucheton et al.
Source: check_circle
University of Manchester - PURE

γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection

Nature Communications
2023-08-29 | Journal article
DOI: 10.1038/s41467-023-40962-y
Contributors: Juan F. Quintana; Matthew C. Sinton; Praveena Chandrasegaran; Agatha Nabilla Lestari; Rhiannon Heslop; Bachar Cheaib; John Ogunsola; Dieudonne Mumba Ngoyi; Nono-Raymond Kuispond Swar; Anneli Cooper et al.
Source: check_circle
Crossref
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Preferred source (of 2)‎

Modelling host-Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids [version 2; peer review: 2 approved]

2023-07-28 | Journal article
DOI: 10.12688/f1000research.131507.2
Part of ISSN: 2046-1402
Funded by GRANT_NUMBER: 221640
Funded by GRANT_NUMBER: Institutional Strategic Support Fund
Funded by GRANT_NUMBER: NC/ECA0001/1
Contributors: Praveena Chandrasegaran; Agatha Nabilla Lestari; Matthew C. Sinton; Jay Gopalakrishnan; Juan F. Quintana; Chandrasegaran Praveena; Chandrasegaran Praveena; Chandrasegaran Praveena; Chandrasegaran Praveena; Chandrasegaran Praveena et al.
Source: check_circle
F1000
grade
Preferred source (of 3)‎

The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection

2023-05-11 | Preprint
DOI: 10.21203/rs.3.rs-2878504/v1
Contributors: Juan Quintana; Matthew Sinton; Praveena Chandrasegaran; Lalit Kumar Dubey; John Ogunsola; Moumen Samman; Michael Haley; Gail McConnell; Nono Kuispond Swar; Dieudonne Mumba Ngoyi et al.
Source: check_circle
Crossref

The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronicTrypanosoma bruceiinfection

2023-04-30 | Preprint
DOI: 10.1101/2023.04.30.538710
Contributors: Juan F. Quintana; Matthew C. Sinton; Praveena Chandrasegaran; Lalit Kumar Dubey; John Ogunsola; Moumen Al Samman; Michael Haley; Gail McConnell; Nono-Raymond Kuispond Swar; Dieudonne Mumba Ngoyi et al.
Source: check_circle
Crossref

Modelling host-Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids

F1000Research
2023-04-24 | Journal article
DOI: 10.12688/f1000research.131507.1
Contributors: Praveena Chandrasegaran; Agatha Nabilla Lestari; Matthew C. Sinton; Jay Gopalakrishnan; Juan F. Quintana
Source: check_circle
Crossref

Spatially-resolved single cell transcriptomics reveal a critical role for γδ T cells in the control of skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection

2023-03-14 | Preprint
DOI: 10.21203/rs.3.rs-2647707/v1
Contributors: Juan Quintana; Matthew Sinton; Praveena Chandrasegaran; Agatha Lestari; Rhiannon Heslop; Bachar Cheaib; John Ogunsola; Dieudonne Mumba Ngoyi; Nono Kuispond Swar; Anneli Cooper et al.
Source: check_circle
Crossref

Spatially-resolved single cell transcriptomics reveal a critical role for γδ T cells in the control of skin inflammation and subcutaneous adipose wasting during chronicTrypanosoma bruceiinfection

2023-03-02 | Preprint
DOI: 10.1101/2023.03.01.530674
Contributors: Juan F. Quintana; Matthew C. Sinton; Praveena Chandrasegaran; Agatha Nabilla Lestari; Rhiannon Heslop; Bachar Cheaib; John Ogunsola; Dieudonne Mumba Ngoyi; Nono-Raymond Kuispond Swar; Anneli Cooper et al.
Source: check_circle
Crossref

Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection

Nature Communications
2022-09-30 | Journal article
DOI: 10.1038/s41467-022-33542-z
Contributors: Juan F. Quintana; Praveena Chandrasegaran; Matthew C. Sinton; Emma M. Briggs; Thomas D. Otto; Rhiannon Heslop; Calum Bentley-Abbot; Colin Loney; Luis de Lecea; Neil A. Mabbott et al.
Source: check_circle
Crossref
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Preferred source (of 2)‎

Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection

2022-04-19 | Preprint
DOI: 10.21203/rs.3.rs-1526092/v1
Contributors: Juan Quintana; Praveena Chandrasegaran; Matthew Sinton; Emma Briggs; Thomas Otto; Rhiannon Heslop; Calum Bentley-Abbot; Colin Loney; Luis de Lecea; Neil Mabbott et al.
Source: check_circle
Crossref

Application of light-sheet mesoscopy to image host-pathogen interactions in intact organs

2022-04-05 | Preprint
DOI: 10.1101/2022.04.04.486945
Contributors: Eliana Battistella; Juan F. Quintana; Gail McConnell
Source: check_circle
Crossref

Microfluidic system for near-patient extraction and detection of miR-122 microRNA biomarker for drug-induced liver injury diagnostics

Biomicrofluidics
2022-03 | Journal article
DOI: 10.1063/5.0085078
Contributors: Maïwenn Kersaudy-Kerhoas; Antonio Liga; Appan Roychoudhury; Marilena Stamouli; Rhiannon Grant; Damaso Sanchez Carrera; Holger Schulze; Witold Mielczarek; Wilna Oosthuyzen; Juan F. Quintana et al.
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Crossref

Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia-plasma cell crosstalk in the mouse brain during chronic Trypanosoma brucei infection

2022-03-27 | Preprint
DOI: 10.1101/2022.03.25.485502
Contributors: Juan F. Quintana; Praveena Chandrasegaran; Matthew C. Sinton; Emma Briggs; Thomas D. Otto; Rhiannon Heslop; Calum Bentley-Abbot; Colin Loney; Luis de Lecea; Neil A. Mabbott et al.
Source: check_circle
Crossref

Expression in Escherichia coli, purification and kinetic characterization of LAPLm, a Leishmania major M17-aminopeptidase

Protein Expression and Purification
2021-07 | Journal article
DOI: 10.1016/j.pep.2021.105877
Contributors: Mirtha Elisa Aguado; Maikel González-Matos; Maikel Izquierdo; Juan Quintana; Mark C. Field; Jorge González-Bacerio
Source: check_circle
Crossref

Evolving Differentiation in African Trypanosomes

Trends in Parasitology
2020-12 | Journal article
DOI: 10.1016/j.pt.2020.11.003
Part of ISSN: 1471-4922
Source: Self-asserted source
Juan F. Quintana

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

eLife
2020-08-07 | Journal article
DOI: 10.7554/elife.56416
Part of ISSN: 2050-084X
Source: Self-asserted source
Juan F. Quintana

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei

PLOS Neglected Tropical Diseases
2020-07-09 | Journal article
DOI: 10.1371/journal.pntd.0008458
Contributors: Juan F. Quintana; Timothy G. Geary; Juan Bueren-Calabuig; Fabio Zuccotto; Harry P. de Koning; David Horn; Mark C. Field
Source: check_circle
Crossref

To the skin and beyond: the immune response to African trypanosomes as they enter and exit the vertebrate host

Frontiers in Immunology
2020-05-18 | Journal article
Source: Self-asserted source
Juan F. Quintana

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance inTrypanosoma brucei

2020-02-23 | Preprint
DOI: 10.1101/2020.02.22.960963
Contributors: Juan F. Quintana; Juan Bueren-Calabuig; Fabio Zuccotto; Harry P. de Koning; David Horn; Mark C. Field
Source: check_circle
Crossref

Comparative analysis of small RNAs released by the filarial nematode Litomosoides sigmodontis in vitro and in vivo

PLOS Neglected Tropical Diseases
2019-11-26 | Journal article
DOI: 10.1371/journal.pntd.0007811
Contributors: Juan F. Quintana; Sasisekhar Bennuru; Sujai Kumar; Alasdair Ivens; Franklin W. N. Chow; Anna M. Hoy; Alison Fulton; Paul Dickinson; Coralie Martin; Matthew Taylor et al.
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Crossref

Adaptation and Therapeutic Exploitation of the Plasma Membrane of African Trypanosomes

Genes
2018-07-20 | Journal article
DOI: 10.3390/genes9070368
Source: Self-asserted source
Juan F. Quintana
grade
Preferred source (of 3)‎

Small RNAs and extracellular vesicles in filarial nematodes: from nematode development to diagnostics

Parasite Immunology
2016-10-17 | Journal article
Source: Self-asserted source
Juan F. Quintana

MicroRNAs: new players in IBD

Gut
2015 | Journal article
DOI:

doi: 10.1136/gutjnl-2014-307891
Source: Self-asserted source
Juan F. Quintana

The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster

PLoS BIOLOGY
2015 | Journal article
Source: Self-asserted source
Juan F. Quintana

Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni

Journal of Extracellular Vesicles
2015-10-05 | Journal article
Source: Self-asserted source
Juan F. Quintana

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity

Nature communications
2014 | Journal article
DOI:

doi:10.1038/ncomms6488
Source: Self-asserted source
Juan F. Quintana

Parasite-derived MicroRNAs in host serum as novel biomarkers of helminth infection

PLoS neglected tropical diseases
2014 | Journal article
DOI:

DOI: 10.1371/journal.pntd.0002701
Source: Self-asserted source
Juan F. Quintana
grade
Preferred source (of 2)‎

Structural Analysis and Mutant Growth Properties Reveal Distinctive Enzymatic and Cellular Roles for the Three Major L-Alanine Transaminases of Escherichia coli

PLoS ONE
2014 | Journal article
Source: Self-asserted source
Juan F. Quintana

Efecto del tratamiento con praziquantel sobre la actividad de la fosfatasa alcalina, fosfatasa acida, superoxido dismutasa en extractos crudos y productos de excreción-secreción de gusanos de Schistosoma mansoni.

BIOMOLP. VEINTE AÑOS DE INVESTIGACIÓN PARASITOLÓGICA
2013 | Journal article
Source: Self-asserted source
Juan F. Quintana

Course of Infection with the Emergent Pathogen Brucella microti in Immunocompromised Mice

Infection and immunity
2011 | Journal article
DOI:

doi: 10.1128/IAI.05542-11
Source: Self-asserted source
Juan F. Quintana

The new species Brucella microti replicates in macrophages and causes death in murine models of infection

Journal of Infectious Diseases
2010 | Journal article
DOI:

doi: 10.1086/653084
Source: Self-asserted source
Juan F. Quintana

Peer review (9 reviews for 3 publications/grants)

Review activity for Genome medicine. (1)
Review activity for Nature communications (7)
Review activity for Tropical animal health and production. (1)
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