Personal information

Emails & domains

Verified email domains

Activities

Collapse all

Employment (7)

Lieber Institute for Brain Development: Baltimore, Maryland, US

2020-06 to present | Lead Investigator
Employment
Source: Self-asserted source
Shizhong Han

Johns Hopkins Medicine: Baltimore, Maryland, US

2017-08 to present | Associate Professor (Department of Psychiatry and Behavioral Sciences)
Employment
Source: Self-asserted source
Shizhong Han

The University of Iowa: Iowa City, IA, US

2017-07 to 2017-08 | Associate Professor (Psychiatry)
Employment
Source: Self-asserted source
Shizhong Han

The University of Iowa: Iowa City, IA, US

2012-11 to 2017-06 | Assistant Professor (Psychiatry)
Employment
Source: Self-asserted source
Shizhong Han

Yale University: New Haven, Connecticut, US

2009-10 to 2012-10 | Associate Research Scientist (Psychiatry)
Employment
Source: Self-asserted source
Shizhong Han

Yale University: New Haven, CT, US

2008-08 to 2009-09 | Postdoc (Psychiatry)
Employment
Source: Self-asserted source
Shizhong Han

Oklahoma Medical Research Foundation: Oklahoma City, OK, US

2006-09 to 2008-08 | Postdoc
Employment
Source: Self-asserted source
Shizhong Han

Education and qualifications (1)

Fudan University: Shanghai, Shanghai, CN

2001 to 2006 | PhD (Genetics)
Education
Source: Self-asserted source
Shizhong Han

Professional activities (1)

The University of Iowa: Iowa City, IA, US

2017-08 to present | Associate Professor (Psychiatry)
Invited position
Source: Self-asserted source
Shizhong Han

Works (50 of 64)

Items per page:
Page 1 of 2

Gene expression differences associated with alcohol use disorder in human brain

Molecular Psychiatry
2025-04 | Journal article
DOI: 10.1038/s41380-024-02777-1
Contributors: Caryn Willis; Julie D. White; Melyssa S. Minto; Bryan C. Quach; Shizhong Han; Ran Tao; Joo Heon Shin; Amy Deep-Soboslay; Thomas M. Hyde; R. Dayne Mayfield et al.
Source: check_circle
Crossref

Deep learning imputes DNA methylation states in single cells and enhances the detection of epigenetic alterations in schizophrenia

Cell Genomics
2025-03 | Journal article
DOI: 10.1016/j.xgen.2025.100774
Contributors: Jiyun Zhou; Chongyuan Luo; Hanqing Liu; Matthew G. Heffel; Richard E. Straub; Joel E. Kleinman; Thomas M. Hyde; Joseph R. Ecker; Daniel R. Weinberger; Shizhong Han
Source: check_circle
Crossref

Deep learning predicts DNA methylation regulatory variants in specific brain cell types and enhances fine mapping for brain disorders

Science Advances
2025-01-03 | Journal article
DOI: 10.1126/sciadv.adn1870
Contributors: Jiyun Zhou; Daniel R. Weinberger; Shizhong Han
Source: check_circle
Crossref

Classification of Schizophrenia, Bipolar Disorder and Major Depressive Disorder with Comorbid Traits and Deep Learning Algorithms

2024-03-07 | Preprint
DOI: 10.21203/rs.3.rs-4001384/v1
Contributors: Xiangning Chen; Yimei Liu; Joan Cue; Mira Han; Vishwajit Nimgaonkar; Daniel Weinberger; Shizhong Han; Zhongming Zhao; Jingchun Chen
Source: check_circle
Crossref

scMeFormer: a transformer-based deep learning model for imputing DNA methylation states in single cells enhances the detection of epigenetic alterations in schizophrenia

2024-01-25 | Preprint
DOI: 10.1101/2024.01.25.577200
Contributors: Jiyun Zhou; Chongyuan Luo; Hanqing Liu; Matthew G. Heffel; Richard E. Straub; Joel E. Kleinman; Thomas M. Hyde; Joseph R. Ecker; Daniel R. Weinberger; Shizhong Han
Source: check_circle
Crossref

Gene expression differences associated with alcohol use disorder in human brain

2024-01-22 | Preprint
DOI: 10.1101/2024.01.20.24301386
Contributors: Caryn Willis; Julie D. White; Melyssa S. Minto; Bryan C. Quach; Shizhong Han; Ran Tao; Joo Heon Shin; Amy Deep-Soboslay; Thomas M. Hyde; R. Dayne Mayfield et al.
Source: check_circle
Crossref

Deep learning predicts DNA methylation regulatory variants in specific brain cell types and enhances fine mapping for brain disorders

2024-01-21 | Preprint
DOI: 10.1101/2024.01.18.576319
Contributors: Jiyun Zhou; Daniel R. Weinberger; Shizhong Han
Source: check_circle
Crossref

Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex

2024-01-17 | Preprint
DOI: 10.1101/2024.01.17.23300238
Contributors: Julie D. White; Melyssa S. Minto; Caryn Willis; Bryan C. Quach; Shizhong Han; Ran Tao; Amy Deep-Soboslay; Lea Zillich; Shaunna L. Clark; Edwin J. C. G. van den Oord et al.
Source: check_circle
Crossref

Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci

2023-09-19 | Preprint
DOI: 10.1101/2023.09.18.23295431
Contributors: Megan Ulmer Carnes; Bryan C. Quach; Linran Zhou; Shizhong Han; Ran Tao; Meisha Mandal; Amy Deep-Soboslay; Jesse A. Marks; Grier P. Page; Brion S. Maher et al.
Source: check_circle
Crossref

Prioritization of potential causative genes for schizophrenia in placenta

Nature Communications
2023-05-15 | Journal article
DOI: 10.1038/s41467-023-38140-1
Contributors: Gianluca Ursini; Pasquale Di Carlo; Sreya Mukherjee; Qiang Chen; Shizhong Han; Jiyoung Kim; Maya Deyssenroth; Carmen J. Marsit; Jia Chen; Ke Hao et al.
Source: check_circle
Crossref

Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus

Molecular Psychiatry
2022-04 | Journal article
DOI: 10.1038/s41380-022-01453-6
Contributors: Kira A. Perzel Mandell; Nicholas J. Eagles; Amy Deep-Soboslay; Ran Tao; Shizhong Han; Richard Wilton; Alexander S. Szalay; Thomas M. Hyde; Joel E. Kleinman; Andrew E. Jaffe et al.
Source: check_circle
Crossref

Effect of selection bias on two sample summary data based Mendelian randomization.

Scientific reports
2021-04 | Journal article
DOI: 10.1038/s41598-021-87219-6
PMID: 33828182
PMC: PMC8027662
Contributors: Wang K; Han S
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Editorial: Machine Learning and Network-Driven Integrative Genomics.

Frontiers in genetics
2021-03 | Journal article
DOI: 10.3389/fgene.2021.660201
PMID: 33777114
PMC: PMC7990759
Contributors: Pirooznia M; Han S; Lee RS
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

A Machine Learning Approach to Predicting Autism Risk Genes: Validation of Known Genes and Discovery of New Candidates.

Frontiers in genetics
2020-09 | Journal article
DOI: 10.3389/fgene.2020.500064
PMID: 33133139
PMC: PMC7513695
Contributors: Lin Y; Afshar S; Rajadhyaksha AM; Potash JB; Han S
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Widespread methylation quantitative trait loci and their role in schizophrenia risk

2020-09 | Preprint
DOI: 10.1101/2020.09.24.311878
PPR: PPR218559
Contributors: Perzel Mandell KA; Eagles NJ; Wilton R; Price AJ; Semick SA; Collado-Torres L; Tao R; Han S; Szalay AS; Hyde TM et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Stochastic tissue window normalization of deep learning on computed tomography.

Journal of medical imaging (Bellingham, Wash.)
2019-10 | Journal article
DOI: 10.1117/1.jmi.6.4.044005
PMID: 31763353
PMC: PMC6863984
Contributors: Huo Y; Tang Y; Chen Y; Gao D; Han S; Bao S; De S; Terry JG; Carr JJ; Abramson RG et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study.

Depression and anxiety
2019-08 | Journal article
DOI: 10.1002/da.22912
PMID: 31385647
Contributors: Averill LA; Abdallah CG; Levey DF; Han S; Harpaz-Rotem I; Kranzler HR; Southwick SM; Krystal JH; Gelernter J; Pietrzak RH
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals.

Translational psychiatry
2019-01-31 | Journal article
DOI: 10.1038/s41398-019-0376-y
PMID: 30705257
PMC: PMC6355837
Source: Self-asserted source
Shizhong Han

A machine learning approach to predicting autism risk genes: Validation of known genes and discovery of new candidates

2018-11 | Preprint
DOI: 10.1101/463547
PPR: PPR61421
Contributors: Lin Y; Rajadhyaksha AM; Potash JB; Han S
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Integrating brain methylome with GWAS for psychiatric risk gene discovery

2018-10 | Preprint
DOI: 10.1101/440206
PPR: PPR58270
Contributors: Han S; Lin Y; Wang M; Goes FS; Tan K; Zandi P; Hyde T; Weinberger DR; Potash JB; Kleinman JE et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central
grade
Preferred source (of 2)‎

Genome-wide association study of seasonal affective disorder.

Translational psychiatry
2018-09 | Journal article
DOI: 10.1038/s41398-018-0246-z
PMID: 30217971
PMC: PMC6138666
Contributors: Ho KWD; Han S; Nielsen JV; Jancic D; Hing B; Fiedorowicz J; Weissman MM; Levinson DF; Potash JB
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort.

Journal of affective disorders
2018-09 | Journal article
DOI: 10.1016/j.jad.2018.09.003
PMID: 30219690
PMC: PMC6186181
Contributors: Heinzman JT; Hoth KF; Cho MH; Sakornsakolpat P; Regan EA; Make BJ; Kinney GL; Wamboldt FS; Holm KE; Bormann N et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Identifying noncoding risk variants using disease-relevant gene regulatory networks.

Nature communications
2018-02 | Journal article
DOI: 10.1038/s41467-018-03133-y
PMID: 29453388
PMC: PMC5816022
Contributors: Gao L; Uzun Y; Gao P; He B; Ma X; Wang J; Han S; Tan K
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Investigation of differential HDAC4 methylation patterns in eating disorders.

Psychiatric genetics
2018-02 | Journal article
DOI: 10.1097/ypg.0000000000000189
PMID: 29256967
PMC: PMC5741469
Contributors: Subramanian S; Braun PR; Han S; Potash JB
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Beyond genome-wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder.

Addiction biology
2018-01 | Journal article
DOI: 10.1111/adb.12591
PMID: 29316088
PMC: PMC6037617
Contributors: Salvatore JE; Han S; Farris SP; Mignogna KM; Miles MF; Agrawal A
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.

JAMA psychiatry
2017-12 | Journal article
DOI: 10.1001/jamapsychiatry.2017.3275
PMID: 29071344
PMC: PMC6331050
Contributors: Zhou H; Polimanti R; Yang BZ; Wang Q; Han S; Sherva R; Nuñez YZ; Zhao H; Farrer LA; Kranzler HR et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.

Depression and anxiety
2017-11 | Journal article
DOI: 10.1002/da.22698
PMID: 29172227
PMC: PMC5794529
Contributors: Mota NP; Han S; Harpaz-Rotem I; Maruff P; Krystal JH; Southwick SM; Gelernter J; Pietrzak RH
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.

JAMA psychiatry
2017-11-01 | Journal article
DOI: 10.1001/jamapsychiatry.2017.2269
PMID: 28813562
PMC: PMC5710224
Source: Self-asserted source
Shizhong Han

Attachment style moderates effects of <i>FKBP5</i> polymorphisms and childhood abuse on post-traumatic stress symptoms: Results from the National Health and Resilience in Veterans Study.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
2017-10 | Journal article
DOI: 10.1080/15622975.2017.1376114
PMID: 28891785
Contributors: Tamman AJF; Sippel LM; Han S; Neria Y; Krystal JH; Southwick SM; Gelernter J; Pietrzak RH
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.

The Journal of clinical psychiatry
2017-09 | Journal article
DOI: 10.4088/jcp.17l11646
PMID: 29099554
Contributors: Watkins LE; Han S; Krystal JH; Southwick SM; Gelernter J; Pietrzak RH
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

COMBAT: A Combined Association Test for Genes Using Summary Statistics.

Genetics
2017-09 | Journal article
DOI: 10.1534/genetics.117.300257
PMID: 28878002
PMC: PMC5676236
Contributors: Wang M; Huang J; Liu Y; Ma L; Potash JB; Han S
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Genetic association test based on principal component analysis.

Statistical applications in genetics and molecular biology
2017-07 | Journal article
DOI: 10.1515/sagmb-2016-0061
PMID: 28672760
Contributors: Chen Z; Han S; Wang K
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.

Journal of psychiatric research
2017-07 | Journal article
DOI: 10.1016/j.jpsychires.2017.07.008
PMID: 28715704
PMC: PMC5605420
Contributors: Sippel LM; Han S; Watkins LE; Harpaz-Rotem I; Southwick SM; Krystal JH; Olff M; Sherva R; Farrer LA; Kranzler HR et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Enhancing VTA Ca<sub>v</sub>1.3 L-type Ca<sup>2+</sup> channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens.

Molecular psychiatry
2017-02 | Journal article
DOI: 10.1038/mp.2017.9
PMID: 28194001
PMC: PMC5555837
Contributors: Martínez-Rivera A; Hao J; Tropea TF; Giordano TP; Kosovsky M; Rice RC; Lee A; Huganir RL; Striessnig J; Addy NA et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Sex-specific linkage scans in opioid dependence.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
2016-10 | Journal article
DOI: 10.1002/ajmg.b.32507
PMID: 27762075
PMC: PMC5695218
Contributors: Yang BZ; Han S; Kranzler HR; Palmer AA; Gelernter J
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

GLITTER: a web-based application for gene link inspection through tissue-specific coexpression.

Scientific reports
2016-09 | Journal article
DOI: 10.1038/srep33460
PMID: 27623690
PMC: PMC5022062
Contributors: Liu X; Yu P; Cheng C; Potash JB; Han S
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study.

Psychoneuroendocrinology
2016-04 | Journal article
DOI: 10.1016/j.psyneuen.2016.04.001
PMID: 27078785
Contributors: Watkins LE; Han S; Harpaz-Rotem I; Mota NP; Southwick SM; Krystal JH; Gelernter J; Pietrzak RH
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics.

Genetics
2016-01 | Journal article
DOI: 10.1534/genetics.115.185009
PMID: 26773050
PMC: PMC4788129
Contributors: Huang J; Wang K; Wei P; Liu X; Liu X; Tan K; Boerwinkle E; Potash JB; Han S
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Association of the HTR2A gene with alcohol and heroin abuse.

Human genetics
2013-11 | Journal article
DOI: 10.1007/s00439-013-1388-y
PMID: 24178752
PMC: PMC4085799
Contributors: Cao J; Liu X; Han S; Zhang CK; Liu Z; Li D
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

Genetic epidemiology
2013-11 | Journal article
DOI: 10.1002/gepi.21760
PMID: 24186853
PMC: PMC3947535
Contributors: Stephens SH; Hartz SM; Hoft NR; Saccone NL; Corley RC; Hewitt JK; Hopfer CJ; Breslau N; Coon H; Chen X et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Eating disorder predisposition is associated with ESRRA and HDAC4 mutations.

The Journal of clinical investigation
2013-11 | Journal article
DOI: 10.1172/jci71400
PMID: 24216484
PMC: PMC3809805
Contributors: Cui H; Moore J; Ashimi SS; Mason BL; Drawbridge JN; Han S; Hing B; Matthews A; McAdams CJ; Darbro BW et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence.

American journal of human genetics
2013-11 | Journal article
DOI: 10.1016/j.ajhg.2013.10.021
PMID: 24268660
PMC: PMC3853414
Contributors: Han S; Yang BZ; Kranzler HR; Liu X; Zhao H; Farrer LA; Boerwinkle E; Potash JB; Gelernter J
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Variant callers for next-generation sequencing data: a comparison study.

PloS one
2013-09 | Journal article
DOI: 10.1371/journal.pone.0075619
PMID: 24086590
PMC: PMC3785481
Contributors: Liu X; Han S; Wang Z; Gelernter J; Yang BZ
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.

PLoS genetics
2013-02 | Journal article
DOI: 10.1371/journal.pgen.1003222
PMID: 23441136
PMC: PMC3575474
Contributors: Molineros JE; Maiti AK; Sun C; Looger LL; Han S; Kim-Howard X; Glenn S; Adler A; Kelly JA; Niewold TB et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans.

Human genetics
2012-12 | Journal article
DOI: 10.1007/s00439-012-1255-2
PMID: 23239122
PMC: PMC3751162
Contributors: Han S; Gelernter J; Kranzler HR; Yang BZ
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.

Archives of general psychiatry
2012-08 | Journal article
DOI: 10.1001/archgenpsychiatry.2012.124
PMID: 22868939
PMC: PMC3482121
Contributors: Hartz SM; Short SE; Saccone NL; Culverhouse R; Chen L; Schwantes-An TH; Coon H; Han Y; Stephens SH; Sun J et al.
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.

Biological psychiatry
2012-04 | Journal article
DOI: 10.1016/j.biopsych.2012.02.038
PMID: 22520967
PMC: PMC3699339
Contributors: Han S; Yang BZ; Kranzler HR; Oslin D; Anton R; Farrer LA; Gelernter J
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
2012-02 | Journal article
DOI: 10.1002/ajmg.b.32037
PMID: 22354695
PMC: PMC3920832
Contributors: Yang BZ; Han S; Kranzler HR; Farrer LA; Elston RC; Gelernter J
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

A genomewide linkage scan of cocaine dependence and major depressive episode in two populations.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
2011-08 | Journal article
DOI: 10.1038/npp.2011.122
PMID: 21849985
PMC: PMC3194068
Contributors: Yang BZ; Han S; Kranzler HR; Farrer LA; Gelernter J
Source: Self-asserted source
Shizhong Han via Europe PubMed Central

Association of CHRNA4 polymorphisms with smoking behavior in two populations.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
2011-03 | Journal article
DOI: 10.1002/ajmg.b.31177
PMID: 21445957
PMC: PMC3742073
Contributors: Han S; Yang BZ; Kranzler HR; Oslin D; Anton R; Gelernter J
Source: Self-asserted source
Shizhong Han via Europe PubMed Central
Items per page:
Page 1 of 2

Peer review (3 reviews for 3 publications/grants)

Review activity for Molecular psychiatry. (1)
Review activity for Nature machine intelligence. (1)
Review activity for PLOS genetics. (1)
How many people are using ORCID?