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Page 1 of 4

On how to feed critically ill children in intensive care: A slowly shifting paradigm

Clinical Nutrition
2025-03 | Journal article
DOI: 10.1016/j.clnu.2025.02.003
Contributors: Jan Gunst; Ilse Vanhorebeek; Sascha CAT. Verbruggen; Karolijn Dulfer; Koen FM. Joosten; Greet Van den Berghe
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Crossref

Predicting adverse long-term neurocognitive outcomes after pediatric intensive care unit admission

Computer Methods and Programs in Biomedicine
2024-06 | Journal article
DOI: 10.1016/j.cmpb.2024.108166
Contributors: Felipe Kenji Nakano; Karolijn Dulfer; Ilse Vanhorebeek; Pieter J. Wouters; Sascha C. Verbruggen; Koen F. Joosten; Fabian Güiza Grandas; Celine Vens; Greet Van den Berghe
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Plasma and red blood cell concentrations of zinc, copper, selenium and magnesium in the first week of paediatric critical illness

Clinical Nutrition
2024-02 | Journal article
DOI: 10.1016/j.clnu.2024.01.004
Contributors: K. Veldscholte; M. Al Fify; A. Catchpole; D. Talwar; J. Wadsworth; I. Vanhorebeek; M.P. Casaer; G. Van den Berghe; K.F.M. Joosten; K. Gerasimidis et al.
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Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness

Clinical Epigenetics
2024-02-23 | Journal article
DOI: 10.1186/s13148-024-01640-y
Contributors: Grégoire Coppens; Ilse Vanhorebeek; Fabian Güiza; Inge Derese; Pieter J. Wouters; Arno Téblick; Karolijn Dulfer; Koen F. Joosten; Sascha C. Verbruggen; Greet Van den Berghe
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Assessment of aberrant DNA methylation two years after paediatric critical illness: a pre-planned secondary analysis of the international PEPaNIC trial

Epigenetics
2023-12-31 | Journal article
DOI: 10.1080/15592294.2022.2146966
Contributors: Grégoire Coppens; Ilse Vanhorebeek; Ines Verlinden; Inge Derese; Pieter J Wouters; Koen F. Joosten; Sascha C. Verbruggen; Fabian Güiza; Greet Van den Berghe
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Early weight measures and long-term neuropsychological outcome of critically ill neonates and infants: a secondary analysis of the PEPaNIC trial.

European journal of pediatrics
2023-11 | Journal article
DOI: 10.1007/s00431-023-05298-1
PMID: 37950792
Contributors: Dijkhuizen EI; Dulfer K; de Munck S; van Haren NEM; de Jonge RCJ; Vanhorebeek I; Wouters PJ; Van den Berghe G; Verbruggen SCAT; Joosten KFM
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Our Scientific Journey through the Ups and Downs of Blood Glucose Control in the ICU.

American journal of respiratory and critical care medicine
2023-11 | Journal article
DOI: 10.1164/rccm.202309-1696so
PMID: 37991900
Contributors: Van den Berghe G; Vanhorebeek I; Langouche L; Gunst J
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central
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Gastrointestinal biomarkers and their association with feeding in the first five days of pediatric critical illness.

Journal of pediatric gastroenterology and nutrition
2023-09 | Journal article
DOI: 10.1097/mpg.0000000000003950
PMID: 37728917
PMC: PMC10642702
Contributors: Veldscholte K; Hulst JM; Eveleens RD; de Jonge RCJ; de Koning BAE; van den Berg SAA; van der Wal R; Ruijter GJG; Rizopoulos D; Vanhorebeek I et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?

Skeletal muscle
2023-08 | Journal article
DOI: 10.1186/s13395-023-00320-4
PMID: 37537627
PMC: PMC10401744
Contributors: Vankrunkelsven W; Thiessen S; Derde S; Vervoort E; Derese I; Pintelon I; Matheussen H; Jans A; Goossens C; Langouche L et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time

Clinical Epigenetics
2023-07-19 | Journal article
DOI: 10.1186/s13148-023-01530-9
Contributors: Ilse Vanhorebeek; Grégoire Coppens; Fabian Güiza; Inge Derese; Pieter J. Wouters; Koen F. Joosten; Sascha C. Verbruggen; Greet Van den Berghe
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Nutrition and autophagy deficiency in critical illness.

Current opinion in critical care
2023-06 | Journal article
DOI: 10.1097/mcc.0000000000001056
PMID: 37306474
PMC: PMC10328539
Contributors: Vanhorebeek I; Casaer M; Gunst J
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies.

Critical care (London, England)
2023-06 | Journal article
DOI: 10.1186/s13054-023-04514-6
PMID: 37365667
PMC: PMC10294527
Contributors: Gunst J; De Bruyn A; Jacobs A; Langouche L; Derese I; Dulfer K; Güiza F; Garcia Guerra G; Wouters PJ; Joosten KF et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

The epigenetic legacy of ICU feeding and its consequences.

Current opinion in critical care
2023-02 | Journal article
DOI: 10.1097/mcc.0000000000001021
PMID: 36794929
PMC: PMC9994844
Contributors: Vanhorebeek I; Van den Berghe G
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Long-term impact of paediatric critical illness on the difference between epigenetic and chronological age in relation to physical growth.

Clinical epigenetics
2023-01 | Journal article
DOI: 10.1186/s13148-023-01424-w
PMID: 36639798
PMC: PMC9840263
Contributors: Verlinden I; Coppens G; Vanhorebeek I; Güiza F; Derese I; Wouters PJ; Joosten KF; Verbruggen SC; Van den Berghe G
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Skeletal Muscle Myokine Expression in Critical Illness, Association With Outcome and Impact of Therapeutic Interventions

Journal of the Endocrine Society
2023-01-06 | Journal article
DOI: 10.1210/jendso/bvad001
Contributors: Ilse Vanhorebeek; Jan Gunst; Michaël P Casaer; Inge Derese; Sarah Derde; Lies Pauwels; Johan Segers; Greet Hermans; Rik Gosselink; Greet Van den Berghe
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Early hypophosphatemia in critically ill children and the effect of parenteral nutrition: A secondary analysis of the PEPaNIC RCT

Clinical Nutrition
2022-11 | Journal article
DOI: 10.1016/j.clnu.2022.09.001
Contributors: K. Veldscholte; M.A.N. Veen; R.D. Eveleens; R.C.J. de Jonge; I. Vanhorebeek; J. Gunst; M.P. Casaer; P.J. Wouters; Gonzalo Garcia Guerra; G. Van den Berghe et al.
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DNA methylation alterations in muscle of critically ill patients

Journal of Cachexia, Sarcopenia and Muscle
2022-06 | Journal article
DOI: 10.1002/jcsm.12970
Contributors: Lisa Van Dyck; Fabian Güiza; Inge Derese; Lies Pauwels; Michaël P. Casaer; Greet Hermans; Pieter J. Wouters; Greet Van den Berghe; Ilse Vanhorebeek
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Development and validation of clinical prediction models for acute kidney injury recovery at hospital discharge in critically ill adults.

Journal of clinical monitoring and computing
2022-05 | Journal article
DOI: 10.1007/s10877-022-00865-7
PMID: 35532860
Contributors: Huang CY; Güiza F; De Vlieger G; Wouters P; Gunst J; Casaer M; Vanhorebeek I; Derese I; Van den Berghe G; Meyfroidt G
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Impact of critical illness and withholding of early parenteral nutrition in the pediatric intensive care unit on long-term physical performance of children: a 4-year follow-up of the PEPaNIC randomized controlled trial.

Critical care (London, England)
2022-05 | Journal article
DOI: 10.1186/s13054-022-04010-3
PMID: 35549984
PMC: PMC9097055
Contributors: Vanhorebeek I; Jacobs A; Mebis L; Dulfer K; Eveleens R; Van Cleemput H; Wouters PJ; Verlinden I; Joosten K; Verbruggen S et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Impact of duration of critical illness and level of systemic glucocorticoid availability on tissue-specific glucocorticoid receptor expression and actions: A prospective, observational, cross-sectional human and two translational mouse studies.

EBioMedicine
2022-05 | Journal article
DOI: 10.1016/j.ebiom.2022.104057
PMID: 35584557
PMC: PMC9117556
Contributors: Téblick A; Van Dyck L; Van Aerde N; Van der Perre S; Pauwels L; Derese I; Debaveye Y; Wouters PJ; Vanhorebeek I; Langouche L et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Physical, Emotional/Behavioral, and Neurocognitive Developmental Outcomes From 2 to 4 Years After PICU Admission: A Secondary Analysis of the Early Versus Late Parenteral Nutrition Randomized Controlled Trial Cohort.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2022-05 | Journal article
DOI: 10.1097/pcc.0000000000002971
PMID: 35522534
PMC: PMC9345517
Contributors: Verlinden I; Güiza F; Dulfer K; Van Cleemput H; Wouters PJ; Guerra GG; Joosten KF; Verbruggen SC; Vanhorebeek I; Van den Berghe G
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

C-reactive protein rise in response to macronutrient deficit early in critical illness: sign of inflammation or mediator of infection prevention and recovery

Intensive Care Medicine
2022-01 | Journal article
DOI: 10.1007/s00134-021-06565-1
Contributors: Catherine Ingels; Lies Langouche; Jasperina Dubois; Inge Derese; Sarah Vander Perre; Pieter J. Wouters; Jan Gunst; Michaël Casaer; Fabian Güiza; Ilse Vanhorebeek et al.
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Phasing out DEHP from plastic indwelling medical devices used for intensive care: Does it reduce the long-term attention deficit of critically ill children?

Environment International
2022-01 | Journal article
DOI: 10.1016/j.envint.2021.106962
Contributors: Ilse Vanhorebeek; Govindan Malarvannan; Fabian Güiza; Giulia Poma; Inge Derese; Pieter J. Wouters; Koen Joosten; Sascha Verbruggen; Philippe G. Jorens; Adrian Covaci et al.
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Differential DNA methylation by early versus late parenteral nutrition in the PICU: a biological basis for its impact on emotional and behavioral problems documented 4 years later

Clinical Epigenetics
2021-12 | Journal article
DOI: 10.1186/s13148-021-01124-3
Contributors: An Jacobs; Fabian Güiza; Ines Verlinden; Karolijn Dulfer; Gonzalo Garcia Guerra; Koen Joosten; Sascha C. Verbruggen; Ilse Vanhorebeek; Greet Van den Berghe
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Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness.

Critical care (London, England)
2021-12 | Journal article
DOI: 10.1186/s13054-021-03858-1
PMID: 34915907
PMC: PMC8675467
Contributors: Vanhorebeek I; Derese I; Gunst J; Wouters PJ; Hermans G; Van den Berghe G
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Postoperative Cerebral Oxygen Saturation in Children After Congenital Cardiac Surgery and Long-Term Total Intelligence Quotient: A Prospective Observational Study.

Critical care medicine
2021-06 | Journal article
DOI: 10.1097/ccm.0000000000004852
PMID: 33591016
PMC: PMC8132917
Contributors: Carra G; Flechet M; Jacobs A; Verstraete S; Vlasselaers D; Desmet L; Van Cleemput H; Wouters P; Vanhorebeek I; Van den Berghe G et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Achieving enteral nutrition during the acute phase in critically ill children: Associations with patient characteristics and clinical outcome

Clinical Nutrition
2021-04 | Journal article
DOI: 10.1016/j.clnu.2020.09.005
Contributors: R.D. Eveleens; J.M. Hulst; B.A.E. de Koning; J. van Brakel; D. Rizopoulos; G. Garcia Guerra; I. Vanhorebeek; G. Van den Berghe; K.F.M. Joosten; S.C.A.T. Verbruggen
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Supplementation of vitamins, trace elements and electrolytes in the PEPaNIC Randomised Controlled Trial: Composition and preparation of the prescription

Clinical Nutrition ESPEN
2021-04 | Journal article
DOI: 10.1016/j.clnesp.2021.01.028
Contributors: Renate D. Eveleens; Bregje C.M. Witjes; Michael P. Casaer; Ilse Vanhorebeek; Gonzalo Garcia Guerra; Karlien Veldscholte; Lidwien M. Hanff; Katrien Cosaert; Lars Desmet; Dirk Vlasselaers et al.
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Role of age of critically ill children at time of exposure to early or late parenteral nutrition in determining the impact hereof on long-term neurocognitive development: A secondary analysis of the PEPaNIC-RCT

Clinical Nutrition
2021-03 | Journal article
DOI: 10.1016/j.clnu.2020.07.004
Contributors: Ines Verlinden; Karolijn Dulfer; Ilse Vanhorebeek; Fabian Güiza; José A. Hordijk; Pieter J. Wouters; Gonzalo Garcia Guerra; Koen F. Joosten; Sascha C. Verbruggen; Greet Van den Berghe
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>.

Autophagy
2021-01 | Journal article
DOI: 10.1080/15548627.2020.1797280
PMID: 33634751
PMC: PMC7996087
Contributors: Klionsky DJ; Abdel-Aziz AK; Abdelfatah S; Abdellatif M; Abdoli A; Abel S; Abeliovich H; Abildgaard MH; Abudu YP; Acevedo-Arozena A et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU

Clinical Epigenetics
2020-12 | Journal article
DOI: 10.1186/s13148-020-00947-w
Contributors: Ines Verlinden; Fabian Güiza; Inge Derese; Pieter J. Wouters; Koen Joosten; Sascha C. Verbruggen; Greet Van den Berghe; Ilse Vanhorebeek
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Early neuromuscular electrical stimulation reduces the loss of muscle mass in critically ill patients - A within subject randomized controlled trial.

Journal of critical care
2020-11 | Journal article
DOI: 10.1016/j.jcrc.2020.11.018
PMID: 33285371
Contributors: Segers J; Vanhorebeek I; Langer D; Charususin N; Wei W; Frickx B; Demeyere I; Clerckx B; Casaer M; Derese I et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

The clinical potential of GDF15 as a "ready-to-feed indicator" for critically ill adults.

Critical care (London, England)
2020-09 | Journal article
DOI: 10.1186/s13054-020-03254-1
PMID: 32928255
PMC: PMC7488998
Contributors: Van Dyck L; Gunst J; Casaer MP; Peeters B; Derese I; Wouters PJ; de Zegher F; Vanhorebeek I; Van den Berghe G
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Long-term developmental effect of withholding parenteral nutrition in paediatric intensive care units: a 4-year follow-up of the PEPaNIC randomised controlled trial.

The Lancet. Child & adolescent health
2020-07 | Journal article
DOI: 10.1016/s2352-4642(20)30104-8
PMID: 32562632
Contributors: Jacobs A; Dulfer K; Eveleens RD; Hordijk J; Van Cleemput H; Verlinden I; Wouters PJ; Mebis L; Guerra GG; Joosten K et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Health-related quality of life of children and their parents 2 years after critical illness: pre-planned follow-up of the PEPaNIC international, randomized, controlled trial.

Critical care (London, England)
2020-06 | Journal article
DOI: 10.1186/s13054-020-03059-2
PMID: 32546247
PMC: PMC7296688
Contributors: Hordijk J; Verbruggen S; Vanhorebeek I; Güiza F; Wouters P; Van den Berghe G; Joosten K; Dulfer K
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver.

Molecular systems biology
2020-05 | Journal article
DOI: 10.15252/msb.20199156
PMID: 32407006
PMC: PMC7224309
Contributors: Dubois V; Gheeraert C; Vankrunkelsven W; Dubois-Chevalier J; Dehondt H; Bobowski-Gerard M; Vinod M; Zummo FP; Güiza F; Ploton M et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

MON-LB012 Long-Term Developmental Impact of Withholding Parenteral Nutrition in Pediatric-ICU: A 4-Year Follow-Up of the Pepanic Randomized Controlled Trial

Journal of the Endocrine Society
2020-05 | Journal article
PMC: PMC7209307
Contributors: Jacobs A; Dulfer K; Eveleens R; Hordijk J; Cleemput H; Verlinden I; Wouters P; Mebis L; Guerra G; Joosten K et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

SAT-724 Endocrine Disruption by Phthalate Exposure in the Pediatric Intensive Care Unit

Journal of the Endocrine Society
2020-05 | Journal article
PMC: PMC7208930
Contributors: Jacobs A; Covaci A; Malarvannan G; Poma G; Derese I; Wouters P; Verbruggen S; Guerra G; Jorens P; Joosten K et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

SUN-072 Age of Critically Ill Children at Time of Exposure to Early Parenteral Nutrition Determines Its Impact on Long-Term Physical and Cognitive Development

Journal of the Endocrine Society
2020-05 | Journal article
PMC: PMC7208736
Contributors: Verlinden I; Dulfer K; Güiza F; Hordijk J; Vanhorebeek I; Guerra G; Joosten K; Verbruggen S; Van den Berghe G
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study.

Critical care (London, England)
2020-05 | Journal article
DOI: 10.1186/s13054-020-02987-3
PMID: 32448392
PMC: PMC7245817
Contributors: Van Dyck L; Vanhorebeek I; Wilmer A; Schrijvers A; Derese I; Mebis L; Wouters PJ; Van den Berghe G; Gunst J; Casaer MP
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

ICU-acquired weakness

Intensive Care Medicine
2020-04-19 | Journal article
DOI: 10.1007/s00134-020-05944-4
Contributors: Ilse Vanhorebeek; Nicola Latronico; Greet Van den Berghe
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Effect of Intravenous 25OHD Supplementation on Bone Turnover and Inflammation in Prolonged Critically Ill Patients.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
2020-03 | Journal article
DOI: 10.1055/a-1114-6072
PMID: 32215888
Contributors: Ingels C; Vanhorebeek I; Van Cromphaut S; Wouters PJ; Derese I; Dehouwer A; Møller HJ; Hansen TK; Billen J; Mathieu C et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Effect of early parenteral nutrition during paediatric critical illness on DNA methylation as a potential mediator of impaired neurocognitive development: a pre-planned secondary analysis of the PEPaNIC international randomised controlled trial.

The Lancet. Respiratory medicine
2020-02 | Journal article
DOI: 10.1016/s2213-2600(20)30046-1
PMID: 32085844
Contributors: Güiza F; Vanhorebeek I; Verstraete S; Verlinden I; Derese I; Ingels C; Dulfer K; Verbruggen SC; Garcia Guerra G; Joosten KF et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Dynamics and prognostic value of the hypothalamus–pituitary–adrenal axis responses to pediatric critical illness and association with corticosteroid treatment: a prospective observational study

Intensive Care Medicine
2020-01-11 | Journal article
DOI: 10.1007/s00134-019-05854-0
Contributors: An Jacobs; Inge Derese; Sarah Vander Perre; Pieter J. Wouters; Sascha Verbruggen; Jaak Billen; Pieter Vermeersch; Gonzalo Garcia Guerra; Koen Joosten; Ilse Vanhorebeek et al.
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Health-related quality of life of children and their parents 6 months after children's critical illness.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
2019-11 | Journal article
DOI: 10.1007/s11136-019-02347-x
PMID: 31691884
PMC: PMC6962289
Contributors: Hordijk J; Verbruggen S; Vanhorebeek I; Van den Berghe G; Utens E; Joosten K; Dulfer K
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

The GH Axis in Relation to Accepting an Early Macronutrient Deficit and Outcome of Critically Ill Patients

The Journal of Clinical Endocrinology & Metabolism
2019-11-01 | Journal article
DOI: 10.1210/jc.2019-00842
Contributors: Lisa Van Dyck; Inge Derese; Sarah Vander Perre; Pieter J Wouters; Michaël P Casaer; Greet Hermans; Greet Van den Berghe; Ilse Vanhorebeek
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Critical Roles of Endogenous Glucocorticoids for Disease Tolerance in Malaria.

Trends in parasitology
2019-10 | Journal article
DOI: 10.1016/j.pt.2019.08.007
PMID: 31606404
Contributors: Vandermosten L; Vanhorebeek I; De Bosscher K; Opdenakker G; Van den Steen PE
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Nonthyroidal illness in critically ill children.

Current opinion in endocrinology, diabetes, and obesity
2019-10 | Journal article
DOI: 10.1097/med.0000000000000494
PMID: 31343421
Contributors: Jacobs A; Vanhorebeek I; Van den Berghe G
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

The soluble mannose receptor (sMR/sCD206) in critically ill patients with invasive fungal infections, bacterial infections or non-infectious inflammation: a secondary analysis of the EPaNIC RCT.

Critical care (London, England)
2019-08 | Journal article
DOI: 10.1186/s13054-019-2549-8
PMID: 31375142
PMC: PMC6679534
Contributors: De Vlieger G; Vanhorebeek I; Wouters PJ; Derese I; Casaer MP; Debaveye Y; Hermans G; Meersseman P; Møller HJ; Van den Berghe G et al.
Source: Self-asserted source
Ilse Vanhorebeek via Europe PubMed Central

Early Supplemental Parenteral Nutrition in Critically Ill Children: An Update

Journal of Clinical Medicine
2019-06-11 | Journal article
DOI: 10.3390/jcm8060830
Contributors: An Jacobs; Ines Verlinden; Ilse Vanhorebeek; Greet Van den Berghe
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