Personal information

United States

Activities

Employment (1)

University of California San Francisco: San Francisco, CA, US

2019-02-04 to present | Postdoctoral Scholar (Biochemistry and Biophysics)
Employment
Source: Self-asserted source
Un Seng Chio

Education and qualifications (2)

California Institute of Technology: Pasadena, CA, US

2012-10-01 to 2019-01-31 | PhD (Chemistry)
Education
Source: Self-asserted source
Un Seng Chio

Cornell University: Ithaca, NY, US

2008-08-28 to 2012-05-27 | BA (Chemistry, Biology)
Education
Source: Self-asserted source
Un Seng Chio

Funding (1)

Molecular mechanisms of the ACF chromatin remodeling complex

2020-04-01 to 2023-03-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: F32GM137463
Source: Self-asserted source
Un Seng Chio via DimensionsWizard

Works (15)

Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking

Nature Communications
2024-03-12 | Journal article
Contributors: Un Seng Chio; Eugene Palovcak; Anton A. A. Smith; Henriette Autzen; Elise N. Muñoz; Zanlin Yu; Feng Wang; David A. Agard; Jean-Paul Armache; Geeta J. Narlikar et al.
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Crossref

Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler

Nature Structural & Molecular Biology
2023-10 | Journal article
Contributors: Nour J. Abdulhay; Laura J. Hsieh; Colin P. McNally; Megan S. Ostrowski; Camille M. Moore; Mythili Ketavarapu; Sivakanthan Kasinathan; Arjun S. Nanda; Ke Wu; Un Seng Chio et al.
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Crossref

Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility

Science
2023-07-21 | Journal article
Contributors: Hao Wu; Elise N. Muñoz; Laura J. Hsieh; Un Seng Chio; Muryam A. Gourdet; Geeta J. Narlikar; Yifan Cheng
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Crossref

Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking

2023-06-20 | Preprint
Contributors: Un Seng Chio; Eugene Palovcak; Anton A. A. Autzen; Henriette E. Autzen; Elise N. Muñoz; Zanlin Yu; Feng Wang; David A. Agard; Jean-Paul Armache; Geeta J. Narlikar et al.
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Crossref

Dodecamer assembly of a metazoan AAA + chaperone couples substrate extraction to refolding

Science Advances
2023-05-12 | Journal article
Contributors: Arpit Gupta; Alfred M. Lentzsch; Alex Siegel; Zanlin Yu; Un Seng Chio; Yifan Cheng; Shu-ou Shan
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Crossref

Cryo-EM structure of the human Sirtuin 6–nucleosome complex

Science Advances
2023-04-14 | Journal article
Contributors: Un Seng Chio; Othman Rechiche; Alysia R. Bryll; Jiang Zhu; Erik M. Leith; Jessica L. Feldman; Craig L. Peterson; Song Tan; Jean-Paul Armache
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Crossref

Cryo-EM structure of the human Sirtuin 6-nucleosome complex

2023-03-18 | Preprint
Contributors: Un Seng Chio; Othman Rechiche; Alysia R. Bryll; Jiang Zhu; Jessica L. Feldman; Craig L. Peterson; Song Tan; Jean-Paul Armache
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Crossref

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

2022-08-10 | Preprint
Contributors: Soumya G. Remesh; Gregory E. Merz; Axel F. Brilot; Un Seng Chio; Alexandrea N. Rizo; Thomas H. Pospiech, Jr.; Irene Lui; Mathew T. Laurie; Jeff Glasgow; Chau Q. Le et al.
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Crossref

Subunit cooperation in the Get1/2 receptor promotes tail-anchored membrane protein insertion

Journal of Cell Biology
2021-11-01 | Journal article
Contributors: Un Seng Chio; Yumeng Liu; SangYoon Chung; Woo Jun Shim; Sowmya Chandrasekar; Shimon Weiss; Shu-ou Shan
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Crossref

A Chaperone Lid Ensures Efficient and Privileged Client Transfer during Tail-Anchored Protein Targeting

Cell Reports
2019-01 | Journal article
Part of ISSN: 2211-1247
Contributors: Un Seng Chio; SangYoon Chung; Shimon Weiss; Shu-ou Shan
Source: Self-asserted source
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In vitro Assays for Targeting and Insertion of Tail-Anchored Proteins Into the ER Membrane

Current Protocols in Cell Biology
2018-09 | Journal article
Part of ISSN: 1934-2500
Contributors: Hyunju Cho; Un Seng Chio; Shu-ou Shan
Source: Self-asserted source
Un Seng Chio via Crossref Metadata Search

Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion

Annual Review of Cell and Developmental Biology
2017-10-06 | Journal article
Part of ISSN: 1081-0706
Contributors: Un Seng Chio; Hyunju Cho; Shu-ou Shan
Source: Self-asserted source
Un Seng Chio via Crossref Metadata Search

A protean clamp guides membrane targeting of tail-anchored proteins

Proceedings of the National Academy of Sciences
2017-09 | Journal article
Part of ISSN: 0027-8424
Contributors: Un Seng Chio; SangYoon Chung; Shimon Weiss; Shu-ou Shan
Source: Self-asserted source
Un Seng Chio via Crossref Metadata Search

Multiple selection filters ensure accurate tail-anchored membrane protein targeting

eLife
2016 | Journal article
Part of ISSN: 2050-084X
Contributors: Meera Rao; Voytek Okreglak; Un Seng Chio; Hyunju Cho; Peter Walter; Shu-ou Shan
Source: Self-asserted source
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Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway

Proceedings of the National Academy of Sciences
2014-11-03 | Journal article
Part of ISSN: 0027-8424
Contributors: Michael E. Rome; Un Seng Chio; Meera Rao; Harry Gristick; Shu-ou Shan
Source: Self-asserted source
Un Seng Chio via Crossref Metadata Search