Personal information

Other IDs

ResearcherID: F-6946-2013
Scopus Author ID: 7201511289

Countries

United States

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Employment (3)

West Virginia University: Morgantown, West Virginia, US

2018-01-07 to present | Assistant Professor (Biochemistry)
Employment
Source: Self-asserted source
Bradley Webb

University of California San Francisco School of Dentistry: San Francisco, CA, US

2008-01-07 to present | Postdoctoral Fellow and Research Specialist (Cell and Tissue Biology)
Employment
Source: Self-asserted source
Bradley Webb

Queen's University: Kingston, ON, CA

2006-10-01 to 2007-04-30 | Postdoctoral Scholar (Biochemistry)
Employment
Source: Self-asserted source
Bradley Webb

Education and qualifications (2)

Queen's University: Kingston, ON, CA

2000-01-07 to 2006-09-31 | PhD (Biochemistry)
Education
Source: Self-asserted source
Bradley Webb

Queen's University: Kingston, ON, CA

1996-09-01 to 1999-12-31 | BSc SSP (Biochemistry)
Education
Source: Self-asserted source
Bradley Webb

Funding (1)

pH-dependent Protein Activation by Growth Factors and Oncogenes

2009-06 to 2011-11 | Award
Canadian Institutes of Health Research (Ottawa, ON, CA)
GRANT_NUMBER:

193767
Source: Self-asserted source
Bradley Webb

Works (26)

The astrocytic zinc transporter ZIP12 is a synaptic protein that contributes to synaptic zinc levels in mouse auditory cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2025-01-14 | Journal article
DOI: 10.1523/jneurosci.2067-24.2025
PMID: 39809542
Contributors: Anderson CT; Manning A; Mendelson BZ; Bender PTR; Ruby R; Shifflett VR; Bainer K; Dariano D; Webb BA; Geldenhuys WJ
Source: Self-asserted source
Bradley Webb

Structural basis for allosteric regulation of human phosphofructokinase-1

Nature Communications
2024-08-25 | Journal article
DOI: 10.1038/s41467-024-51808-6
Contributors: Eric M. Lynch; Heather Hansen; Lauren Salay; Madison Cooper; Stepan Timr; Justin M. Kollman; Bradley A. Webb
Source: check_circle
Crossref

Mechanisms regulating the spatial and temporal control of glucose metabolism in cells

2023-09-27 | Data management plan
DOI: 10.48321/D1M076
Source: check_circle
California Digital Library DMP Tool

Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity

Biochemical Journal
2023-09-13 | Journal article
DOI: 10.1042/BCJ20230207
Contributors: Maria A. Voronkova; Heather L. Hansen; Madison P. Cooper; Jacob Miller; Narayanasami Sukumar; Werner J. Geldenhuys; Aaron R. Robart; Bradley A. Webb
Source: check_circle
Crossref

Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability

Journal of Biological Chemistry
2022-09 | Journal article
DOI: 10.1016/j.jbc.2022.102387
Contributors: Siyan Zhu; Jiancheng Huang; Rong Xu; Yekai Wang; Yiming Wan; Rachel McNeel; Edward Parker; Douglas Kolson; Michelle Yam; Bradley Webb et al.
Source: check_circle
Crossref

Filament assembly by the liver phosphofructokinase-1, the gatekeeper of glycolysis

The FASEB Journal
2020 | Journal article
DOI: 10.1096/FASEBJ.2020.34.S1.00227
WOSUID: WOS:000546023102185
Contributors: Webb, Bradley; Dosey, Anne; Wittmann, Torsten; Kollmann, Justin; Barber, Diane
Source: check_circle
Web of Science Researcher Profile Sync

Filament formation by metabolic enzymes-A new twist on regulation

Current Opinion in Cell Biology
2020 | Journal article
DOI: 10.1016/J.CEB.2020.04.006
WOSUID: WOS:000581664800004
Contributors: Lynch, Eric M.; Kollman, Justin M.; Webb, Bradley A.
Source: check_circle
Web of Science Researcher Profile Sync

The glycolytic enzyme phosphofructokinase-1 assembles into filaments

Journal of Cell Biology
2017-08-07 | Journal article
DOI: 10.1083/jcb.201701084
Contributors: Bradley A. Webb; Anne M. Dosey; Torsten Wittmann; Justin M. Kollman; Diane L. Barber
Source: check_circle
Crossref

A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity.

2016-11 | Journal article
DOI: 10.1074/jbc.m116.736215
PMID: 27650500
Contributors: Webb BA; White KA; Grillo-Hill BK; Schönichen A; Choi C; Barber DL
Source: Self-asserted source
Bradley Webb via Europe PubMed Central

Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.

2015-07 | Journal article
DOI: 10.1038/nature14405
PMID: 25985179
PMC: PMC4510984
Contributors: Webb BA; Forouhar F; Szu FE; Seetharaman J; Tong L; Barber DL
Source: Self-asserted source
Bradley Webb via Europe PubMed Central
grade
Preferred source (of 2)‎

Ratiometric Imaging of pH Probes

Methods in Cell Biology
2014 | Book
DOI: 10.1016/B978-0-12-420138-5.00023-9
EID:

2-s2.0-84902964284
Contributors: Grillo-Hill, B.K.; Webb, B.A.; Barber, D.L.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Considering protonation as a posttranslational modification regulating protein structure and function

Annual Review of Biophysics
2013 | Book
DOI: 10.1146/annurev-biophys-050511-102349
EID:

2-s2.0-84877731906
Contributors: Schönichen, A.; Webb, B.A.; Jacobson, M.P.; Barber, D.L.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Ph sensing by FAK-His58 regulates focal adhesion remodeling

Journal of Cell Biology
2013 | Journal article
DOI: 10.1083/jcb.20130213
EID:

2-s2.0-84884385851
Contributors: Choi, C.-H.; Webb, B.A.; Chimenti, M.S.; Jacobson, M.P.; Barber, D.L.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Dysregulated pH: A perfect storm for cancer progression

Nature Reviews Cancer
2011 | Journal article
DOI: 10.1038/nrc3110
EID:

2-s2.0-81155159685
Contributors: Webb, B.A.; Chimenti, M.; Jacobson, M.P.; Barber, D.L.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

The sodium-hydrogen exchanger NHE1 is an akt substrate necessary for actin filament reorganization by growth factors

Journal of Biological Chemistry
2009 | Journal article
DOI: 10.1074/jbc.M109.019448
EID:

2-s2.0-70350389830
Contributors: Meima, M.E.; Webb, B.A.; Witkowska, H.E.; Barber, D.L.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Dissecting the functional domain requirements of cortactin in invadopodia formation

European Journal of Cell Biology
2007 | Journal article
DOI: 10.1016/j.ejcb.2007.01.003
EID:

2-s2.0-33947140891
Contributors: Webb, B.A.; Jia, L.; Eves, R.; Mak, A.S.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Caldesmon is an integral component of podosomes in smooth muscle cells

Journal of Cell Science
2006 | Journal article
DOI: 10.1242/jcs.02881
EID:

2-s2.0-33744507187
Contributors: Eves, R.; Webb, B.A.; Zhou, S.; Mak, A.S.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Cortactin regulates podosome formation: Roles of the protein interaction domains

Experimental Cell Research
2006 | Journal article
DOI: 10.1016/j.yexcr.2005.11.032
EID:

2-s2.0-33644882476
Contributors: Webb, B.A.; Eves, R.; Mak, A.S.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells

American Journal of Physiology - Cell Physiology
2006 | Journal article
DOI: 10.1152/ajpcell.00350.2005
EID:

2-s2.0-33644860573
Contributors: Zhou, S.; Webb, B.A.; Eves, R.; Mak, A.S.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Phosphorylation of cortactin by p21-activated kinase

Archives of Biochemistry and Biophysics
2006 | Journal article
DOI: 10.1016/j.abb.2006.06.011
EID:

2-s2.0-33845303985
Contributors: Webb, B.A.; Zhou, S.; Eves, R.; Shen, L.; Jia, L.; Mak, A.S.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

PAK1 induces podosome formation in A7r5 vascular smooth muscle cells in a PAK-interacting exchange factor-dependent manner

American Journal of Physiology - Cell Physiology
2005 | Journal article
DOI: 10.1152/ajpcell.00095.2005
EID:

2-s2.0-25444450611
Contributors: Webb, B.A.; Eves, R.; Crawley, S.W.; Zhou, S.; Côté, G.P.; Mak, A.S.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Structural and thermodynamical characterization of the complete p21 gene product of Max

Biochemistry
2005 | Journal article
DOI: 10.1021/bi0500729
EID:

2-s2.0-25444455861
Contributors: Naud, J.-F.; McDuff, F.-O.; Sauvé, S.; Montagne, M.; Webb, B.A.; Smith, S.P.; Chabot, B.; Lavigne, P.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Structural characterization of type II dockerin module from the cellulosome of Clostridium thermocellum: Calcium-induced effects on conformation and target recognition

Biochemistry
2005 | Journal article
DOI: 10.1021/bi048039u
EID:

2-s2.0-13544258645
Contributors: Adams, J.J.; Webb, B.A.; Spencer, H.L.; Smith, S.P.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

A ligand-induced conformational change in apolipoprotein(a) enhances covalent Lp(a) formation

Journal of Biological Chemistry
2003 | Journal article
DOI: 10.1074/jbc.M212855200
EID:

2-s2.0-0038529734
Contributors: Becker, L.; Webb, B.A.; Chitayat, S.; Nesheim, M.E.; Koschinsky, M.L.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

G2/M arrest caused by actin disruption is a manifestation of the cell size checkpoint in fission yeast

Molecular Biology of the Cell
2001 | Journal article
EID:

2-s2.0-0035661649
Contributors: Rupeš, I.; Webb, B.A.; Mak, A.; Young, P.G.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

A role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex

Journal of Cell Biology
2000 | Journal article
DOI: 10.1083/jcb.148.2.353
EID:

2-s2.0-0034707598
Contributors: Evangelista, M.; Klebl, B.M.; Tong, A.H.Y.; Webb, B.A.; Leeuw, T.; Leberer, E.; Whiteway, M.; Thomas, D.Y.; Boone, C.
Source: Self-asserted source
Bradley Webb via Scopus - Elsevier

Peer review (6 reviews for 6 publications/grants)

Review activity for ACS omega. (1)
Review activity for Biochemical journal. (1)
Review activity for Journal of chemotherapy (1)
Review activity for Journal of enzyme inhibition and medicinal chemistry. (1)
Review activity for Nature communications (1)
Review activity for Nature metabolism. (1)
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