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Websites & social links

http://www.ibms.sinica.edu.tw/pi_webpage/blue_style2016/index.php?p_id=53&journal_info_sysid=128215

Other IDs

Scopus Author ID: 7102173206
ResearcherID: N-9512-2018

Keywords

DNA damage response, Cancer cell signaling, DNA repair

Countries

Taiwan

Activities

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Employment (2)

Academia Sinica: Taipei, TW

1999-09 to present | Research Fellow (Institute of Biomedical Sciences)
Employment
Source: Self-asserted source
Sheau-Yann Shieh

Columbia University/Carol Prives: New York, NY, US

1994-11 to 1999-08 | postdoctoral fellow (Biological Sciences)
Employment
Source: Self-asserted source
Sheau-Yann Shieh

Education and qualifications (1)

Baylor College of Medicine: Houston, TX, US

1988-09 to 1993-06 | PhD (Cell Biology)
Education
Source: Self-asserted source
Sheau-Yann Shieh

Works (37)

Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation.

Cell death & disease
2020-12-11 | Journal article
DOI: 10.1038/s41419-020-03248-5
PMID: 33311481
PMC: PMC7732837
Source: Self-asserted source
Sheau-Yann Shieh

Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
DOI: 10.1073/pnas.1719856115
WOSUID:

WOS:000432663000073
Contributors: Cheng, Yu-Che; Shieh, Sheau-Yann
Source: Self-asserted source
Sheau-Yann Shieh via ResearcherID

CHK2-mediated regulation of PARP1 in oxidative DNA damage response.

Oncogene
2018-09 | Journal article
DOI: 10.1038/s41388-018-0506-7
Source: Self-asserted source
Sheau-Yann Shieh

CK1 alpha ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
DOI: 10.1073/pnas.1702763114
WOSUID:

WOS:000411157100023
Contributors: Chang, Chung-Hsing; Kuo, Che-Jung; Ito, Takamichi; Su, Yu-Ya; Jiang, Si-Tse; Chiu, Min-Hsi; Lin, Yi-Hsiung; Nist, Andrea; Mernberger, Marco; Stiewe, Thorsten et al.
Source: Self-asserted source
Sheau-Yann Shieh via ResearcherID

Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT

Cell Death and Disease
2015 | Journal article
DOI: 10.1038/cddis.2014.550
EID:

2-s2.0-84927637895
Contributors: Cheng, Y.-C.; Chen, P.-H.; Chiang, H.-Y.; Suen, C.-S.; Hwang, M.-J.; Lin, T.-Y.; Yang, H.-C.; Lin, W.-C.; Lai, P.-L.; Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier
grade
Preferred source (of 2)‎

Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation

Nucleic Acids Research
2015-11-03 | Journal article
DOI: 10.1093/nar/gkv1173
Contributors: Zheng-Cheng Yu; Yi-Fu Huang; Sheau-Yann Shieh
Source: Self-asserted source
Sheau-Yann Shieh via Crossref Metadata Search
grade
Preferred source (of 2)‎

Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization

Journal of Biological Chemistry
2014 | Journal article
DOI: 10.1074/jbc.M114.552273
EID:

2-s2.0-84901712755
Contributors: Yeh, C.-W.; Yu, Z.-C.; Chen, P.-H.; Cheng, Y.-C.; Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the Checkpoint kinase CHK1

Proceedings of the National Academy of Sciences of the United States of America
2013 | Journal article
DOI: 10.1073/pnas.1220635110
EID:

2-s2.0-84876063227
Contributors: Cheng, Y.-C.; Lin, T.-Y.; Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16 INK4a signaling axis

Oncogene
2012 | Journal article
DOI: 10.1038/onc.2011.491
EID:

2-s2.0-84863718409
Contributors: Lin, T.-Y.; Cheng, Y.-C.; Yang, H.-C.; Lin, W.-C.; Wang, C.-C.; Lai, P.-L.; Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

The GAS41-PP2Cβ complex dephosphorylates p53 at serine 366 and regulates its stability

Journal of Biological Chemistry
2011 | Journal article
DOI: 10.1074/jbc.C110.210211
EID:

2-s2.0-79953180952
Contributors: Park, J.H.; Smith, R.J.; Shieh, S.-Y.; Roeder, R.G.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Dancing with p53: The role of p38MAPK in mitosis of p53-deficient tetraploid cells

Cell Cycle
2010 | Journal article
EID:

2-s2.0-77956848188
Contributors: Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

DDX3 regulates cell growth through translational control of cyclin E1

Molecular and Cellular Biology
2010 | Journal article
DOI: 10.1128/MCB.00560-10
EID:

2-s2.0-78649532406
Contributors: Lai, M.-C.; Chang, W.-C.; Shieh, S.-Y.; Tarn, W.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

P53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control

Oncogene
2010 | Journal article
DOI: 10.1038/onc.2010.40
EID:

2-s2.0-77952430886
Contributors: Hsu, F.-F.; Lin, T.-Y.; Chen, J.-Y.; Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Dancing with p53: The role of p38MAPK in mitosis of p53-deficient tetraploid cells

Cell Cycle
2010-07 | Journal article
DOI: 10.4161/cc.9.14.12594
Contributors: Sheau-Yann Shieh
Source: Self-asserted source
Sheau-Yann Shieh via Crossref Metadata Search

Breast cancer amplified sequence 2, a novel negative regulator of the p53 tumor suppressor

Cancer Research
2009 | Journal article
DOI: 10.1158/0008-5472.CAN-09-2023
EID:

2-s2.0-71549159140
Contributors: Kuo, P.-C.; Tsao, Y.-P.; Chang, H.-W.; Chen, P.-H.; Huang, C.-W.; Lin, S.-T.; Weng, Y.-T.; Tsai, T.-C.; Shieh, S.-Y.; Chen, S.-L.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress

Oncogene
2009 | Journal article
DOI: 10.1038/onc.2009.58
EID:

2-s2.0-66149104550
Contributors: Sun, T.-P.; Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1

Oncogene
2009 | Journal article
DOI: 10.1038/onc.2008.477
EID:

2-s2.0-62249140224
Contributors: Yeh, Y.-H.; Huang, Y.-F.; Lin, T.-Y.; Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18

Molecular and Cellular Biology
2009 | Journal article
DOI: 10.1128/MCB.01837-08
EID:

2-s2.0-66349136840
Contributors: Huang, Y.-F.; Chang, M.D.-T.; Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair

The EMBO Journal
2008-10 | Journal article
DOI: 10.1038/emboj.2008.229
Contributors: Wen-Cheng Chou; Hui-Chun Wang; Fen-Hwa Wong; Shian-ling Ding; Pei-Ei Wu; Sheau-Yann Shieh; Chen-Yang Shen
Source: Self-asserted source
Sheau-Yann Shieh via Crossref Metadata Search
grade
Preferred source (of 2)‎

The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1

The EMBO Journal
2007-08-09 | Journal article
DOI: 10.1038/sj.emboj.7601825
Contributors: Yi-Hung Ou; Pei-Han Chung; Fu-Fei Hsu; Te-Ping Sun; Wen-Ying Chang; Sheau-Yann Shieh
Source: Self-asserted source
Sheau-Yann Shieh via Crossref Metadata Search
grade
Preferred source (of 2)‎

Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining

Cancer Research
2006 | Journal article
DOI: 10.1158/0008-5472.CAN-05-3270
EID:

2-s2.0-32944459979
Contributors: Wang, H.-C.; Chou, W.-C.; Shieh, S.-Y.; Shen, C.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation

Molecular Biology of the Cell
2005 | Journal article
DOI: 10.1091/mbc.E04-08-0689
EID:

2-s2.0-16344381702
Contributors: Ou, Y.-H.; Chung, P.-H.; Sun, T.-P.; Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68

Journal of Biological Chemistry
2005 | Journal article
DOI: 10.1074/jbc.M410152200
EID:

2-s2.0-14844333117
Contributors: Wei, J.-H.; Chou, Y.-F.; Ou, Y.-H.; Yeh, Y.-H.; Tyan, S.-W.; Sun, T.-P.; Shen, C.-Y.; Shieh, S.-Y.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

p53 accumulates but is functionlly impaired when DNA sysnthesis is blocked

Proceedings of the National Academy of Sciences of the United States of America
2001 | Journal article
DOI: 10.1073/pnas.021282898
EID:

2-s2.0-0035969988
Contributors: Gottifredi, V.; Shieh, S.-Y.; Taya, Y.; Prives, C.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

p53 down-regulates CHK1 through p21 and the retinoblastoma protein

Molecular and Cellular Biology
2001 | Journal article
DOI: 10.1128/MCB.21.4.1066-1076.2001
EID:

2-s2.0-0035142822
Contributors: Gottifredi, V.; Karni-Schmidt, O.; Shieh, S.-Y.; Prives, C.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Regulation of p53 after different forms of stress and at different cell cycle stages

Cold Spring Harbor Symposia on Quantitative Biology
2000 | Book
EID:

2-s2.0-0034437338
Contributors: Gottifredi, V.; Shieh, S.Y.; Prives, C.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate, p53 at multiple DNA damage-inducible sites

Genes and Development
2000 | Journal article
EID:

2-s2.0-0034142034
Contributors: Shieh, S.-Y.; Ahn, J.; Tamai, K.; Taya, Y.; Prives, C.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

A role for ATR in the DNA damage-induced phosphorylation of p53

Genes and Development
1999 | Journal article
EID:

2-s2.0-0033555260
Contributors: Tibbetts, R.S.; Brumbaugh, K.M.; Williams, J.M.; Sarkaria, J.N.; Cliby, W.A.; Shieh, S.-Y.; Taya, Y.; Prives, C.; Abraham, R.T.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

EMBO Journal
1999 | Journal article
EID:

2-s2.0-0033118933
Contributors: Shieh, S.-Y.; Taya, Y.; Prives, C.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

E1A signaling to p53 involves the p19(ARF) tumor suppressor

Genes and Development
1998 | Journal article
EID:

2-s2.0-0032146795
Contributors: De Stanchina, E.; McCurrach, M.E.; Zindy, F.; Shieh, S.-Y.; Ferbeyre, G.; Samuelson, A.V.; Prives, C.; Roussel, M.F.; Sherr, C.J.; Lowe, S.W.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Enhanced phosphorylation of p53 by ATM in response to DNA damage

Science
1998 | Journal article
DOI: 10.1126/science.281.5383.1674
EID:

2-s2.0-0032508504
Contributors: Banin, S.; Moyal, L.; Shieh, S.-Y.; Taya, Y.; Anderson, C.W.; Chessa, L.; Smorodinsky, N.I.; Prives, C.; Reiss, Y.; Shiloh, Y. et al.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

p53 is phosphorylated by CDK7-cyclin H in a p36(MAT1)-dependent manner

Molecular and Cellular Biology
1997 | Journal article
EID:

2-s2.0-0030724673
Contributors: Ko, L.J.; Shieh, S.-Y.; Chen, X.; Jayaraman, L.; Tamai, K.; Taya, Y.; Prives, C.; Pan, Z.-Q.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Signalling to the C-terminus of p53

Oncogenes as Transcriptional Regulators
1997 | Other
DOI: 10.1007/978-3-0348-8934-6_2
Contributors: Christine Cain; Sheau-Yann Shieh; Carol Prives
Source: Self-asserted source
Sheau-Yann Shieh via Crossref Metadata Search

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

Cell
1997-10 | Journal article
DOI: 10.1016/s0092-8674(00)80416-x
Contributors: Sheau-Yann Shieh; Masako Ikeda; Yoichi Taya; Carol Prives
Source: Self-asserted source
Sheau-Yann Shieh via Crossref Metadata Search
grade
Preferred source (of 2)‎

Molecular characterization of the rat insulin enhancer-binding complex 3b2: Cloning of a binding factor with putative helicase motifs

Journal of Biological Chemistry
1995 | Journal article
EID:

2-s2.0-0029128355
Contributors: Shieh, S.-Y.; Stellrecht, C.M.M.; Tsai, M.-J.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription

Journal of Biological Chemistry
1994 | Journal article
EID:

2-s2.0-0028136103
Contributors: Robinson, G.L.W.G.; Peshavaria, M.; Henderson, E.; Shieh, S.-Y.; Tsai, M.-J.; Teitelman, G.; Stein, R.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene

Journal of Biological Chemistry
1991 | Journal article
EID:

2-s2.0-0025994835
Contributors: Shieh, S.-Y.; Tsai, M.-J.
Source: Self-asserted source
Sheau-Yann Shieh via Scopus - Elsevier

Peer review (21 reviews for 10 publications/grants)

Review activity for BMC biology. (1)
Review activity for Cell death and disease. (3)
Review activity for Cell reports. (2)
Review activity for International journal of radiation oncology, biology, physics. (1)
Review activity for Journal of biomedical science (9)
Review activity for Nature communications (1)
Review activity for Oncogene. (1)
Review activity for Oncogenesis. (1)
Review activity for PLOS genetics. (1)
Review activity for PloS one. (1)
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