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Other IDs

ResearcherID: O-9370-2015

Keywords

Mechanistic Modeling, Drug Sensitivity, Parameter Estimation, Cancer, Targeted Therapies, Kinetic Models, Optimization, Systems Biology, Systems Medicine, Systems Pharmacology

Countries

Germany, United States

Activities

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Employment (4)

The Francis Crick Institute: London, GB

2023-03-20 to present | Group Leader (Dynamics of Living Systems Laboratory)
Employment
Source: Self-asserted source
Fabian Fröhlich

Universitätsklinikum Heidelberg: Heidelberg, DE

2022-07-01 to 2023-03-19 | Postdoctoral Fellow (Institute of Computational Biomedicine)
Employment
Source: Self-asserted source
Fabian Fröhlich

Harvard Medical School: Boston, MA, US

2018-07-15 to 2022-06-30 | Postdoctoral Research Fellow (Department of Systems Biology)
Employment
Source: Self-asserted source
Fabian Fröhlich

Helmholtz Zentrum München Deutsches Forschungszentrum für Umwelt und Gesundheit: Neuherberg, Bavaria, DE

2013-10-01 to 2018-05-31 | PhD Student (Institute of Computational Biology)
Employment
Source: Self-asserted source
Fabian Fröhlich

Education and qualifications (3)

Technical University of Munich: Munich, DE

B. Sc. (Mathematics)
Education
Source: Self-asserted source
Fabian Fröhlich

Technical University of Munich: Munich, DE

M. Sc. (Mathematics)
Education
Source: Self-asserted source
Fabian Fröhlich

Technical University of Munich: Munich, DE

2013-10-01 to 2018-03-31 | Dr. rer. nat. (Mathematics)
Education
Source: Self-asserted source
Fabian Fröhlich

Professional activities (1)

MTZ Stiftung: Erkrath, DE

2021-05-10 | MTZ-Awards for Medical Systems Biology 2020
Distinction
Source: Self-asserted source
Fabian Fröhlich

Funding (2)

Unraveling melanoma adaptive resistance through kinetic and statistical modeling

2019-06 to 2022-03 | Grant
Human Frontier Science Program (Strasbourg, FR)
GRANT_NUMBER: LT000259/2019-L
Source: Self-asserted source
Fabian Fröhlich

GSC 1006:  Graduate School of Quantitative Biosciences Munich (QBM)

Source: Self-asserted source
Fabian Fröhlich via DimensionsWizard

Works (28)

pyPESTO: A modular and scalable tool for parameter estimation for dynamic models

arXiv
2023 | Preprint
DOI: 10.48550/ARXIV.2305.01821
Contributors: Yannik Schälte; Fabian Fröhlich; Paul J. Jost; Jakob Vanhoefer; Dilan Pathirana; Paul Stapor; Polina Lakrisenko; Dantong Wang; Elba Raimúndez; Simon Merkt et al.
Source: Self-asserted source
Fabian Fröhlich

Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction

Cell Reports
2023-03 | Journal article
DOI: 10.1016/j.celrep.2023.112252
Part of ISSN: 2211-1247
Contributors: Jia-Yun Chen; Clemens Hug; José Reyes; Chengzhe Tian; Luca Gerosa; Fabian Fröhlich; Bas Ponsioen; Hugo J.G. Snippert; Sabrina L. Spencer; Ashwini Jambhekar et al.
Source: Self-asserted source
Fabian Fröhlich

Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance

Molecular Systems Biology
2023-02-10 | Journal article
DOI: 10.15252/msb.202210988
Contributors: Fabian Fröhlich; Luca Gerosa; Jeremy Muhlich; Peter K Sorger
Source: check_circle
Crossref

Efficient computation of adjoint sensitivities at steady-state in ODE models of biochemical reaction networks

PLOS Computational Biology
2023-01-03 | Journal article
DOI: 10.1371/journal.pcbi.1010783
Contributors: Polina Lakrisenko; Attila Csikász-Nagy; Paul Stapor; Stephan Grein; Łukasz Paszkowski; Dilan Pathirana; Fabian Fröhlich; Glenn Terje Lines; Daniel Weindl; Jan Hasenauer
Source: check_circle
Crossref

Fides: Reliable trust-region optimization for parameter estimation of ordinary differential equation models

PLOS Computational Biology
2022-07-13 | Journal article
DOI: 10.1371/journal.pcbi.1010322
Contributors: Fabian Fröhlich; Hugues Berry; Peter K. Sorger
Source: check_circle
Crossref

BioSimulators: a central registry of simulation engines and services for recommending specific tools

Nucleic Acids Research
2022-07-05 | Journal article | Author
DOI: 10.1093/nar/gkac331
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Bilal Shaikh; Lucian Smith; Dan Vasilescu; Gnaneswara Marupilla; Michael Wilson; Eran Agmon; Henry Agnew; Steven Andrews; Azraf Anwar; Moritz Emanuel Beber et al.
Source: Self-asserted source
Fabian Fröhlich

A protocol for dynamic model calibration

Briefings in Bioinformatics
2022-01-17 | Journal article
DOI: 10.1093/bib/bbab387
Part of ISSN: 1467-5463
Part of ISSN: 1477-4054
Source: Self-asserted source
Fabian Fröhlich

Combination treatment optimization using a pan-cancer pathway model

PLOS Computational Biology
2021-12-28 | Journal article
DOI: 10.1371/journal.pcbi.1009689
Part of ISSN: 1553-7358
Source: Self-asserted source
Fabian Fröhlich

AMICI: high-performance sensitivity analysis for large ordinary differential equation models

Bioinformatics
2021-10-25 | Journal article
DOI: 10.1093/bioinformatics/btab227
Part of ISSN: 1367-4803
Part of ISSN: 1460-2059
Source: Self-asserted source
Fabian Fröhlich

PEtab—Interoperable specification of parameter estimation problems in systems biology

PLOS Computational Biology
2021-01-26 | Journal article
DOI: 10.1371/journal.pcbi.1008646
Part of ISSN: 1553-7358
Source: Self-asserted source
Fabian Fröhlich

Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

Cell Systems
2020-11 | Journal article
DOI: 10.1016/j.cels.2020.10.002
Part of ISSN: 2405-4712
Source: Self-asserted source
Fabian Fröhlich

Scalable Inference of Ordinary Differential Equation Models of Biochemical Processes

Methods in Molecular Biology
2019 | Book chapter
DOI: 10.1007/978-1-4939-8882-2_16
Part of ISBN: 9781493988815
Part of ISBN: 9781493988822
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Fabian Fröhlich

Efficient parameterization of large-scale dynamic models based on relative measurements

Bioinformatics
2019-07-26 | Journal article
DOI: 10.1093/bioinformatics/btz581
Part of ISSN: 1367-4803
Part of ISSN: 1460-2059
Source: Self-asserted source
Fabian Fröhlich

Benchmarking optimization methods for parameter estimation in large kinetic models

Bioinformatics
2019-03-01 | Journal article
DOI: 10.1093/bioinformatics/bty736
Part of ISSN: 1367-4803
Part of ISSN: 1460-2059
Source: Self-asserted source
Fabian Fröhlich

Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model

Cell Systems
2018-12 | Journal article
DOI: 10.1016/j.cels.2018.10.013
Part of ISSN: 2405-4712
Source: Self-asserted source
Fabian Fröhlich

Multi-experiment nonlinear mixed effect modeling of single-cell translation kinetics after transfection

npj Systems Biology and Applications
2018-12-10 | Journal article
DOI: 10.1038/s41540-018-0079-7
Contributors: Fabian Fröhlich; Anita Reiser; Laura Fink; Daniel Woschée; Thomas Ligon; Fabian Joachim Theis; Joachim Oskar Rädler; Jan Hasenauer
Source: check_circle
Crossref

Optimization and profile calculation of ODE models using second order adjoint sensitivity analysis

Bioinformatics
2018-07-01 | Journal article
DOI: 10.1093/bioinformatics/bty230
Part of ISSN: 1367-4803
Part of ISSN: 1460-2059
Source: Self-asserted source
Fabian Fröhlich

A Hierarchical, Data-Driven Approach to Modeling Single-Cell Populations Predicts Latent Causes of Cell-To-Cell Variability

Cell Systems
2018-05 | Journal article
DOI: 10.1016/j.cels.2018.04.008
Part of ISSN: 2405-4712
Source: Self-asserted source
Fabian Fröhlich

GenSSI 2.0: multi-experiment structural identifiability analysis of SBML models

Bioinformatics
2018-04-15 | Journal article
DOI: 10.1093/bioinformatics/btx735
Part of ISSN: 1367-4803
Part of ISSN: 1460-2059
Source: Self-asserted source
Fabian Fröhlich

PESTO: Parameter EStimation TOolbox

Bioinformatics
2018-02-15 | Journal article
DOI: 10.1093/bioinformatics/btx676
Part of ISSN: 1367-4803
Part of ISSN: 1460-2059
Source: Self-asserted source
Fabian Fröhlich

Parameter estimation for dynamical systems with discrete events and logical operations

Bioninformatics
2017 | Journal article
DOI: 10.1093/bioinformatics/btw764
Source: Self-asserted source
Fabian Fröhlich

Scalable Parameter Estimation for Genome-Scale Biochemical Reaction Networks

PLOS Computational Biology
2017-01-23 | Journal article
DOI: 10.1371/journal.pcbi.1005331
Contributors: Fabian Fröhlich; Jorg Stelling; Barbara Kaltenbacher; Fabian J. Theis; Jan Hasenauer
Source: check_circle
Crossref

CERENA: ChEmical REaction Network Analyzer--A toolbox for the simulation and analysis of stochastic chemical kinetics

PLoS One
2016 | Journal article
DOI: 10.1371/journal.pone.0146732
Source: Self-asserted source
Fabian Fröhlich

Inference for Stochastic Chemical Kinetics Using Moment Equations and System Size Expansion

PLOS Computational Biology
2016-07-22 | Journal article
DOI: 10.1371/journal.pcbi.1005030
Contributors: Fabian Fröhlich; Daniel A Beard; Philipp Thomas; Atefeh Kazeroonian; Fabian J. Theis; Ramon Grima; Jan Hasenauer
Source: check_circle
Crossref

Radial basis function approximation of Bayesian parameter posterior densities for uncertainty analysis

Proceedings of the 12th International Conference on Computational Methods in Systems Biology (CMSB 2014), Manchester, UK
2014 | Conference paper
DOI: 10.1007/978-3-319-12982-2_6
Source: Self-asserted source
Fabian Fröhlich

Sparse control of force field dynamics

2014 7th International Conference on NETwork Games, COntrol and OPtimization (NetGCoop)
2014 | Conference paper
Contributors: Bongini, Mattia; Fornasier, Massimo; Fabian Fröhlich; Haghverdi, Laleh
Source: Self-asserted source
Fabian Fröhlich

Uncertainty analysis for non-identifiable dynamical systems: Profile likelihoods, bootstrapping and more.

Proceedings of the 12th International Conference on Computational Methods in Systems Biology (CMSB 2014), Manchester, UK
2014 | Conference paper
DOI: 10.1007/978-3-319-12982-2_5
Source: Self-asserted source
Fabian Fröhlich

Design and Characterization of a Modular Membrane Protein Anchor to Functionalize the Moss Physcomitrella patens with Extracellular Catalytic and/or Binding Activities

ACS Synthetic Biology
2014-12 | Journal article
DOI: 10.1021/sb5000302
Source: Self-asserted source
Fabian Fröhlich

Peer review (2 reviews for 2 publications/grants)

Review activity for eLife (1)
Review activity for npj systems biology and applications. (1)
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