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Employment (2)

UCL Biomedical Research Centre: London, GB

Honorary Associate Professor (Institute of Women's Health)
Employment
Source: Self-asserted source
Sophie A Clarke

UCLH: London, GB

2021-12-20 to present | Consultant Reproductive Endocrinologist (Endocrinology/Women's Health)
Employment
Source: Self-asserted source
Sophie A Clarke

Funding (2)

NIHR BRC funding

2024-03 to 2027-03 | Salary award
NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust and (London, GB)
Source: Self-asserted source
Sophie A Clarke

NIHR Clinical Lectureship

2018-08 to 2021-08 | Salary award
NIHR BioResource (London, GB)
Source: Self-asserted source
Sophie A Clarke

Works (48)

Current Challenges and Future Directions in the Assessment of Glucocorticoid Status.

Endocrine reviews
2024-11 | Journal article
DOI: 10.1210/endrev/bnae016
PMID: 38795365
PMC: PMC11581704
Contributors: Clarke SA; Eng PC; Comninos AN; Lazarus K; Choudhury S; Tsang C; Meeran K; Tan TM; Dhillo WS; Abbara A
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Biomarkers to inform the management of polycystic ovary syndrome: A review of systematic reviews.

Clinical endocrinology
2024-08 | Journal article
DOI: 10.1111/cen.15101
PMID: 39155620
Contributors: Walford H; Tyler B; Abbara A; Clarke S; Talaulikar V; Wattar BA
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Fertility and pregnancy outcomes in women with Turner syndrome: A single centre experience.

Clinical endocrinology
2024-05 | Journal article
DOI: 10.1111/cen.15078
PMID: 38798185
Contributors: Burt E; Davies MC; Yasmin E; Cameron-Pimblett A; Talaulikar V; La Rosa C; Clarke SA; Conway GS
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Healthcare and research priorities for women with polycystic ovary syndrome in the UK National Health Service: A modified Delphi method.

Clinical endocrinology
2024-02 | Journal article
DOI: 10.1111/cen.15038
PMID: 38420872
Contributors: Al Wattar BH; Teh JJ; Clarke S; Abbara A; Morman R; Wilcox A; Talaulikar V
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death.

EBioMedicine
2023-09 | Journal article
DOI: 10.1016/j.ebiom.2023.104784
PMID: 37713808
PMC: PMC10507138
Contributors: Sauve F; Nampoothiri S; Clarke SA; Fernandois D; Ferreira Coêlho CF; Dewisme J; Mills EG; Ternier G; Cotellessa L; Iglesias-Garcia C et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Endocrine Responses to Triptorelin in Healthy Women, Women With Polycystic Ovary Syndrome, and Women With Hypothalamic Amenorrhea.

The Journal of clinical endocrinology and metabolism
2023-06 | Journal article
DOI: 10.1210/clinem/dgad026
PMID: 36653328
PMC: PMC10271229
Contributors: Abbara A; Phylactou M; Eng PC; Clarke SA; Pham TD; Ho TM; Ng KY; Mills EG; Purugganan K; Hunjan T et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Derivation and comparison of formulae for the adjustment of total calcium.

Frontiers in endocrinology
2023-05 | Journal article
DOI: 10.3389/fendo.2023.1070443
PMID: 37251673
PMC: PMC10213740
Contributors: Phylactou M; Comninos AN; Salih A; Labib M; Eng PC; Clarke SA; Moore P; Tan T; Cegla J; Dhillo WS et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

The effects of kisspeptin on food intake in women with overweight or obesity.

Diabetes, obesity & metabolism
2023-04 | Journal article
DOI: 10.1111/dom.15086
PMID: 37039248
PMC: PMC10946989
Contributors: Izzi-Engbeaya C; Choudhury MM; Patel B; Muzi B; Qayuum A; Mills EG; Ahsan M; Phylactou M; Clarke SA; Aslett L et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Screening for Adverse Metabolic Consequences in Women With Idiopathic Hirsutism-Is it Relevant?

The Journal of clinical endocrinology and metabolism
2023-02 | Journal article
DOI: 10.1210/clinem/dgac652
PMID: 36357007
Contributors: Dimakopoulou A; Clarke SA; Jayasena CN
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men.

Frontiers in endocrinology
2022-11 | Journal article
DOI: 10.3389/fendo.2022.1076984
PMID: 36523592
PMC: PMC9745113
Contributors: Abbara A; Koysombat K; Phylactou M; Eng PC; Clarke S; Comninos AN; Yang L; Izzi-Engbeaya C; Hanassab S; Smith N et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Letter to the editor of clinical endocrinology: Assessment of adrenal function in patients who survive COVID-19.

Clinical endocrinology
2022-08 | Journal article
DOI: 10.1111/cen.14816
PMID: 35986449
PMC: PMC9538615
Contributors: Clarke SA; Phylactou M; Patel B; Mills EG; Muzi B; Izzi-Engbeaya C; Choudhury S; Khoo B; Meeran K; Comninos AN et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications.

The Journal of clinical endocrinology and metabolism
2022-01 | Journal article
DOI: 10.1210/clinem/dgab617
PMID: 34427658
PMC: PMC8684464
Contributors: Abbara A; Al-Memar M; Phylactou M; Daniels E; Patel B; Eng PC; Nadir R; Izzi-Engbeaya C; Clarke SA; Mills EG et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Impact of COVID-19 on the Endocrine System: A Mini-review.

Endocrinology
2022-01 | Journal article
DOI: 10.1210/endocr/bqab203
PMID: 34543404
PMC: PMC8500009
Contributors: Clarke SA; Abbara A; Dhillo WS
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Preserved C-peptide in survivors of COVID-19: Post hoc analysis.

Diabetes, obesity & metabolism
2021-12 | Journal article
DOI: 10.1111/dom.14608
PMID: 34850532
Contributors: Clarke SA; Phylactou M; Patel B; Mills EG; Muzi B; Izzi-Engbeaya C; Khoo B; Meeran K; Comninos AN; Abbara A et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Normal Adrenal and Thyroid Function in Patients Who Survive COVID-19 Infection.

The Journal of clinical endocrinology and metabolism
2021-07 | Journal article
DOI: 10.1210/clinem/dgab349
PMID: 34008009
PMC: PMC8194556
Contributors: Clarke SA; Phylactou M; Patel B; Mills EG; Muzi B; Izzi-Engbeaya C; Choudhury S; Khoo B; Meeran K; Comninos AN et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Clinical Potential of Kisspeptin in Reproductive Health.

Trends in molecular medicine
2021-06 | Journal article
DOI: 10.1016/j.molmed.2021.05.008
PMID: 34210598
Contributors: Abbara A; Clarke SA; Dhillo WS
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester.

Fertility and sterility
2021-05 | Journal article
DOI: 10.1016/j.fertnstert.2021.04.031
PMID: 34053677
PMC: PMC8445632
Contributors: Abbara A; Al-Memar M; Phylactou M; Kyriacou C; Eng PC; Nadir R; Izzi-Engbeaya C; Clarke SA; Mills EG; Daniels E et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Clinical and biochemical discriminants between functional hypothalamic amenorrhoea (FHA) and polycystic ovary syndrome (PCOS).

Clinical endocrinology
2021-01 | Journal article
DOI: 10.1111/cen.14402
PMID: 33354766
PMC: PMC11497304
Contributors: Phylactou M; Clarke SA; Patel B; Baggaley C; Jayasena CN; Kelsey TW; Comninos AN; Dhillo WS; Abbara A
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Thyroid Function Before, During and After COVID-19

Journal of the Endocrine Society
2021-01 | Journal article
PMC: PMC8135571
Contributors: Eu Khoo B; Tan T; Mills E; Clarke S; Patel B; Modi M; Phylactou M; Eng P; Thurston L; Alexander E et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Thyroid Function Before, During, and After COVID-19.

The Journal of clinical endocrinology and metabolism
2021-01 | Journal article
DOI: 10.1210/clinem/dgaa830
PMID: 33180932
PMC: PMC7823247
Contributors: Khoo B; Tan T; Clarke SA; Mills EG; Patel B; Modi M; Phylactou M; Eng PC; Thurston L; Alexander EC et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Kisspeptin-54 Accurately Identifies Hypothalamic Gonadotropin-Releasing Hormone Neuronal Dysfunction in Men with Congenital Hypogonadotropic Hypogonadism.

Neuroendocrinology
2020-11 | Journal article
DOI: 10.1159/000513248
PMID: 33227799
Contributors: Abbara A; Eng PC; Phylactou M; Clarke SA; Mills E; Chia G; Yang L; Izzi-Engbeaya C; Smith N; Jayasena CN et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders

Journal of Clinical Investigation
2020-11-16 | Journal article
DOI: 10.1172/JCI139681
Contributors: Ali Abbara; Pei Chia Eng; Maria Phylactou; Sophie A. Clarke; Rachel Richardson; Charlene M. Sykes; Chayarndorn Phumsatitpong; Edouard Mills; Manish Modi; Chioma Izzi-Engbeaya et al.
Source: check_circle
Crossref

Endocrine Requirements for Oocyte Maturation Following hCG, GnRH Agonist, and Kisspeptin During IVF Treatment.

Frontiers in endocrinology
2020-10 | Journal article
DOI: 10.3389/fendo.2020.537205
PMID: 33123084
PMC: PMC7573298
Contributors: Abbara A; Hunjan T; Ho VNA; Clarke SA; Comninos AN; Izzi-Engbeaya C; Ho TM; Trew GH; Hramyka A; Kelsey T et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

OR20-06 Kisspeptin as a Biomarker for Pregnancy Complications

Journal of the Endocrine Society
2020-05 | Journal article
PMC: PMC7207859
Contributors: Phylactou M; Abbara A; Al-Memar M; Eng P; Comninos A; Izzi-Engbeaya C; Clarke S; Mills E; Nadir R; Sykes M et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Pharmacodynamic Response to Anti-thyroid Drugs in Graves' Hyperthyroidism.

Frontiers in endocrinology
2020-05 | Journal article
DOI: 10.3389/fendo.2020.00286
PMID: 32477269
PMC: PMC7236601
Contributors: Abbara A; Clarke SA; Brewster R; Simonnard A; Eng PC; Phylactou M; Papadopoulou D; Izzi-Engbeaya C; Sam AH; Wernig F et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer.

Cell death & disease
2020-02 | Journal article
DOI: 10.1038/s41419-020-2305-7
PMID: 32034133
PMC: PMC7005685
Contributors: Dragan M; Nguyen MU; Guzman S; Goertzen C; Brackstone M; Dhillo WS; Bech PR; Clarke S; Abbara A; Tuck AB et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Anti-Müllerian hormone (AMH) in the Diagnosis of Menstrual Disturbance Due to Polycystic Ovarian Syndrome.

Frontiers in endocrinology
2019-09 | Journal article
DOI: 10.3389/fendo.2019.00656
PMID: 31616381
PMC: PMC6775233
Contributors: Abbara A; Eng PC; Phylactou M; Clarke SA; Hunjan T; Roberts R; Vimalesvaran S; Christopoulos G; Islam R; Purugganan K et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling.

The Journal of clinical endocrinology and metabolism
2019-09 | Journal article
DOI: 10.1210/jc.2018-02797
PMID: 30985867
PMC: PMC6637789
Contributors: Prague JK; Voliotis M; Clarke S; Comninos AN; Abbara A; Jayasena CN; Roberts RE; Yang L; Veldhuis JD; Tsaneva-Atanasova K et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation.

Frontiers in endocrinology
2019-08 | Journal article
DOI: 10.3389/fendo.2019.00579
PMID: 31507532
PMC: PMC6718557
Contributors: Abbara A; Patel A; Hunjan T; Clarke SA; Chia G; Eng PC; Phylactou M; Comninos AN; Lavery S; Trew GH et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Phoenixin and Its Role in Reproductive Hormone Release.

Seminars in reproductive medicine
2019-07 | Journal article
DOI: 10.1055/s-0039-3400964
PMID: 31972864
Contributors: Clarke SA; Dhillo WS
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

OR11-4 Determining the Relationship between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modelling

Journal of the Endocrine Society
2019-04 | Journal article
PMC: PMC6555028
Contributors: Dhillo W; Prague J; Voliotis M; Clarke S; Comninos A; Abbara A; Jayasena C; Roberts R; Yang L; Veldhuis J et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

OR32-3 Kisspeptin- a Novel Clinical Test of Hypothalamic Function in Men with Hypogonadotrophic Hypogonadism

Journal of the Endocrine Society
2019-04 | Journal article
PMC: PMC6554783
Contributors: Phylactou M; Abbara A; Eng P; Clarke S; Mills E; Koteshwara M; Chia G; Yang L; Machenahalli P; Papadopoulou D et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

OR33-4 A Single Subcutaneous Injection Of The Kisspeptin Analogue, MVT-602, Induces A More Prolonged LH Surge Compared With Kisspeptin-54 In Healthy Women

Journal of the Endocrine Society
2019-04 | Journal article
PMC: PMC6555007
Contributors: Clarke S; Abbara A; Eng P; Phylactou M; Chia G; Yang L; Prague J; Muralidhara K; Papadopoulou D; Mills E et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

SAT-211 Gonadotrophin Rise Following Kisspeptin Analogue (MVT-602) Is Increased In Women With Hypothalamic Amenorrhoea Compared To Healthy Women

Journal of the Endocrine Society
2019-04 | Journal article
PMC: PMC6551662
Contributors: Eng P; Abbara A; Phylactou M; Clarke S; Yang L; Mills E; Modi M; Papadopoulou D; Plumptre I; Tia H et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions.

JCI insight
2018-10 | Journal article
DOI: 10.1172/jci.insight.121958
PMID: 30333302
PMC: PMC6237465
Contributors: Comninos AN; Demetriou L; Wall MB; Shah AJ; Clarke SA; Narayanaswamy S; Nesbitt A; Izzi-Engbeaya C; Prague JK; Abbara A et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment.

Endocrine reviews
2018-10 | Journal article
DOI: 10.1210/er.2017-00236
PMID: 29982525
PMC: PMC6173475
Contributors: Abbara A; Clarke SA; Dhillo WS
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Clinical and biochemical characteristics of patients presenting with pituitary apoplexy.

Endocrine connections
2018-08 | Journal article
DOI: 10.1530/ec-18-0255
PMID: 30139818
PMC: PMC6198188
Contributors: Abbara A; Clarke S; Eng PC; Milburn J; Joshi D; Comninos AN; Ramli R; Mehta A; Jones B; Wernig F et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Neurokinin 3 receptor antagonism rapidly improves vasomotor symptoms with sustained duration of action.

Menopause (New York, N.Y.)
2018-08 | Journal article
DOI: 10.1097/gme.0000000000001090
PMID: 29533369
PMC: PMC6092106
Contributors: Prague JK; Roberts RE; Comninos AN; Clarke S; Jayasena CN; Mohideen P; Lin VH; Stern TP; Panay N; Hunter MS et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.

Diabetes, obesity & metabolism
2018-08 | Journal article
DOI: 10.1111/dom.13460
PMID: 29974637
PMC: PMC6282711
Contributors: Izzi-Engbeaya C; Comninos AN; Clarke SA; Jomard A; Yang L; Jones S; Abbara A; Narayanaswamy S; Eng PC; Papadopoulou D et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Follicle Size on Day of Trigger Most Likely to Yield a Mature Oocyte.

Frontiers in endocrinology
2018-04 | Journal article
DOI: 10.3389/fendo.2018.00193
PMID: 29743877
PMC: PMC5930292
Contributors: Abbara A; Vuong LN; Ho VNA; Clarke SA; Jeffers L; Comninos AN; Salim R; Ho TM; Kelsey TW; Trew GH et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Interpretation of Serum Gonadotropin Levels in Hyperprolactinaemia.

Neuroendocrinology
2018-04 | Journal article
DOI: 10.1159/000489264
PMID: 29660734
Contributors: Abbara A; Clarke SA; Nesbitt A; Ali S; Comninos AN; Hatfield E; Martin NM; Sam AH; Meeran K; Dhillo WS
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Hypothalamic Response to Kisspeptin-54 and Pituitary Response to Gonadotropin-Releasing Hormone Are Preserved in Healthy Older Men.

Neuroendocrinology
2018-03 | Journal article
DOI: 10.1159/000488452
PMID: 29544222
PMC: PMC6008875
Contributors: Abbara A; Narayanaswamy S; Izzi-Engbeaya C; Comninos AN; Clarke SA; Malik Z; Papadopoulou D; Clobentz A; Sarang Z; Bassett P et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Reply: Clinical trial registry alone is not adequate: on the perception of possible endpoint switching and P-hacking.

Human reproduction (Oxford, England)
2018-02 | Journal article
DOI: 10.1093/humrep/dex360
PMID: 29194495
Contributors: Abbara A; Clarke S; Islam R; Prague JK; Comninos A; Narayanaswamy S; Papadopoulou DA; Roberts RE; Izzi-Engbeaya CN; Ratnasabapathy R et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

The use of hormonal strategies to improve the safety of in vitro fertilisation

2018-01 | Dissertation or Thesis
DOI: 10.25560/78820
OTHER-ID:

806466
Contributors: Clarke S
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial.

Human reproduction (Oxford, England)
2017-09 | Journal article
DOI: 10.1093/humrep/dex253
PMID: 28854728
PMC: PMC5850304
Contributors: Abbara A; Clarke S; Islam R; Prague JK; Comninos AN; Narayanaswamy S; Papadopoulou D; Roberts R; Izzi-Engbeaya C; Ratnasabapathy R et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial.

Lancet (London, England)
2017-04 | Journal article
DOI: 10.1016/s0140-6736(17)30823-1
PMID: 28385352
PMC: PMC5439024
Contributors: Prague JK; Roberts RE; Comninos AN; Clarke S; Jayasena CN; Nash Z; Doyle C; Papadopoulou DA; Bloom SR; Mohideen P et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Kisspeptin modulates sexual and emotional brain processing in humans.

The Journal of clinical investigation
2017-01 | Journal article
DOI: 10.1172/jci89519
PMID: 28112678
PMC: PMC5272173
Contributors: Comninos AN; Wall MB; Demetriou L; Shah AJ; Clarke SA; Narayanaswamy S; Nesbitt A; Izzi-Engbeaya C; Prague JK; Abbara A et al.
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Kisspeptin across the human lifespan:evidence from animal studies and beyond.

The Journal of endocrinology
2016-06 | Journal article
DOI: 10.1530/joe-15-0538
PMID: 27340201
Contributors: Clarke SA; Dhillo WS
Source: Self-asserted source
Sophie A Clarke via Europe PubMed Central

Peer review (1 review for 1 publication/grant)

Review activity for The journal of clinical endocrinology and metabolism. (1)
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