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Washington University in Saint Louis School of Medicine: Saint Louis, MO, US

James S. McDonnell Professor and Head, Department of Genetics (Department of Genetics)
Employment
Source: Self-asserted source
Jeffrey Milbrandt

Works (50 of 258)

Items per page:
Page 1 of 6

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice

Journal of Experimental Medicine
2019 | Journal article
EID:

2-s2.0-85061111385

Contributors: Geisler, S.; Huang, S.X.; Strickland, A.; Doan, R.A.; Summers, D.W.; Mao, X.; Park, J.; DiAntonio, A.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

Science
2019 | Journal article
EID:

2-s2.0-85071375651

Contributors: Wan, L.; Essuman, K.; Anderson, R.G.; Sasaki, Y.; Monteiro, F.; Chung, E.-H.; Nishimura, E.O.; DiAntonio, A.; Milbrandt, J.; Dangl, J.L. et al.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program

JCI Insight
2019 | Journal article
EID:

2-s2.0-85072253312

Contributors: Geisler, S.; Doan, R.A.; Cheng, G.C.; Cetinkaya-Fisgin, A.; Huang, S.X.; Höke, A.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Abnormal microglia and enhanced inflammation-related gene transcription in mice with conditional deletion of Ctcf in Camk2a-Cre-expressing neurons

Journal of Neuroscience
2018 | Journal article
EID:

2-s2.0-85040053572

Contributors: McGill, B.E.; Barve, R.A.; Maloney, S.E.; Strickland, A.; Rensing, N.; Wang, P.L.; Wong, M.; Head, R.; Wozniak, D.F.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Dysregulation of NAD<sup>+</sup> metabolism induces a Schwann cell dedifferentiation program

Journal of Neuroscience
2018 | Journal article
EID:

2-s2.0-85051054251

Contributors: Sasaki, Y.; Hackett, A.R.; Kim, S.; Strickland, A.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

HSP90 is a chaperone for DLK and is required for axon injury signaling

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
EID:

2-s2.0-85054979702

Contributors: Karney-Grobe, S.; Russo, A.; Frey, E.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Palmitoylation enables MAPK-dependent proteostasis of axon survival factors

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
EID:

2-s2.0-85053040810

Contributors: Summers, D.W.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
EID:

2-s2.0-85051716647

Contributors: Kim, S.; Maynard, J.C.; Strickland, A.; Burlingame, A.L.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia

Cell Reports
2018 | Journal article
EID:

2-s2.0-85053319496

Contributors: Avey, D.; Sankararaman, S.; Yim, A.K.Y.; Barve, R.; Milbrandt, J.; Mitra, R.D.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

TIR Domain Proteins Are an Ancient Family of NAD<sup>+</sup>-Consuming Enzymes

Current Biology
2018 | Journal article
EID:

2-s2.0-85041563247

Contributors: Essuman, K.; Summers, D.W.; Sasaki, Y.; Mao, X.; Yim, A.K.Y.; DiAntonio, A.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

TRPV1 agonist, capsaicin, induces axon outgrowth after injury via Ca<sup>2+</sup>/PKA signaling

eNeuro
2018 | Journal article
EID:

2-s2.0-85048473988

Contributors: Frey, E.; Karney-Grobe, S.; Krolak, T.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

eLife
2017 | Journal article
EID:

2-s2.0-85010637423

Contributors: Walker, L.J.; Summers, D.W.; Sasaki, Y.; Brace, E.J.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

MTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
EID:

2-s2.0-85019585929

Contributors: Beirowski, B.; Wong, K.M.; Babetto, E.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia

Annals of Clinical and Translational Neurology
2017 | Journal article
EID:

2-s2.0-85028566903

Contributors: Galindo, R.; Banks Greenberg, M.; Araki, T.; Sasaki, Y.; Mehta, N.; Milbrandt, J.; Holtzman, D.M.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD<sup>+</sup> Cleavage Activity that Promotes Pathological Axonal Degeneration

Neuron
2017 | Journal article
EID:

2-s2.0-85016048059

Contributors: Essuman, K.; Summers, D.W.; Sasaki, Y.; Mao, X.; DiAntonio, A.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

An NAD<sup>+</sup>-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma

Proceedings of the National Academy of Sciences of the United States of America
2016 | Journal article
EID:

2-s2.0-85006380765

Contributors: Gujar, A.D.; Le, S.; Mao, D.D.; Dadey, D.Y.A.; Turski, A.; Sasaki, Y.; Aum, D.; Luo, J.; Dahiya, S.; Yuan, L. et al.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

Neuron
2016 | Journal article
EID:

2-s2.0-84959314882

Contributors: Gerdts, J.; Summers, D.W.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

PLoS ONE
2016 | Journal article
EID:

2-s2.0-84979236345

Contributors: Ippolito, J.E.; Brandenburg, M.W.; Ge, X.; Crowley, J.R.; Kirmess, K.M.; Som, A.; D'Avignon, D.A.; Arbeit, J.M.; Achilefu, S.; Yarasheski, K.E. et al.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Is Axonal Degeneration a Key Early Event in Parkinson's Disease?

Journal of Parkinson's Disease
2016 | Journal article
EID:

2-s2.0-84994113011

Contributors: Kurowska, Z.; Kordower, J.H.; Stoessl, A.J.; Burke, R.E.; Brundin, P.; Yue, Z.; Brady, S.T.; Milbrandt, J.; Trapp, B.D.; Sherer, T.B. et al.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD<sup>+</sup>depletion

eLife
2016 | Journal article
EID:

2-s2.0-84991628947

Contributors: Sasaki, Y.; Nakagawa, T.; Mao, X.; DiAntonio, A.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy

Annals of Clinical and Translational Neurology
2016 | Journal article
EID:

2-s2.0-85018525462

Contributors: Musiek, E.S.; Xiong, D.D.; Patel, T.; Sasaki, Y.; Wang, Y.; Bauer, A.Q.; Singh, R.; Finn, S.L.; Culver, J.P.; Milbrandt, J. et al.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice

Brain
2016 | Journal article
EID:

2-s2.0-85010655795

Contributors: Geisler, S.; Doan, R.A.; Strickland, A.; Huang, X.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

SARM1-specific motifs in the TIR domain enable NAD<sup>+</sup> loss and regulate injury-induced SARM1 activation

Proceedings of the National Academy of Sciences of the United States of America
2016 | Journal article
EID:

2-s2.0-84991447123

Contributors: Summers, D.W.; Gibson, D.A.; DiAntonio, A.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Schwann cell O-GlcNAc glycosylation is required for myelin maintenance and axon integrity

Journal of Neuroscience
2016 | Journal article
EID:

2-s2.0-84987850225

Contributors: Kim, S.; Maynard, J.C.; Sasaki, Y.; Strickland, A.; Sherman, D.L.; Brophy, P.J.; Burlingame, A.L.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

TMEM184b promotes axon degeneration and neuromuscular junction maintenance

Journal of Neuroscience
2016 | Journal article
EID:

2-s2.0-84966495184

Contributors: Bhattacharya, M.R.C.; Geisler, S.; Pittman, S.K.; Doan, R.A.; Weihl, C.C.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

An in vitro assay to study induction of the regenerative state in sensory neurons

Experimental Neurology
2015 | Journal article
EID:

2-s2.0-84909992188

Contributors: Frey, E.; Valakh, V.; Karney-Grobe, S.; Shi, Y.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Characterization of Leber congenital amaurosis-associated NMNAT1 mutants

Journal of Biological Chemistry
2015 | Journal article
EID:

2-s2.0-84940094594

Contributors: Sasaki, Y.; Margolin, Z.; Borgo, B.; Havranek, J.J.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders

Genome Research
2015 | Journal article
EID:

2-s2.0-84937037088

Contributors: Fairfield, H.; Srivastava, A.; Ananda, G.; Liu, R.; Kircher, M.; Lakshminarayana, A.; Harris, B.S.; Karst, S.Y.; Dionne, L.A.; Kane, C.C. et al.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Feeding the brain and nurturing the mind: Linking nutrition and the gut microbiota to brain development

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
EID:

2-s2.0-84947461438

Contributors: Goyal, M.S.; Venkatesh, S.; Milbrandt, J.; Gordon, J.I.; Raichle, M.E.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

SARM1 activation triggers axon degeneration locally via NAD<sup>+</sup> destruction

Science
2015 | Journal article
EID:

2-s2.0-84928411460

Contributors: Gerdts, J.; Brace, E.J.; Sasaki, Y.; DiAntonio, A.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance

Nature Neuroscience
2014 | Journal article
EID:

2-s2.0-84908127551

Contributors: Beirowski, B.; Babetto, E.; Golden, J.P.; Chen, Y.-J.; Yang, K.; Gross, R.W.; Patti, G.J.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons

Journal of Neuroscience
2014 | Journal article
EID:

2-s2.0-84903954827

Contributors: Summers, D.W.; DiAntonio, A.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Validation of a next-generation sequencing assay for clinical molecular oncology

Journal of Molecular Diagnostics
2014 | Journal article
EID:

2-s2.0-84890421610

Contributors: Cottrell, C.E.; Al-Kateb, H.; Bredemeyer, A.J.; Duncavage, E.J.; Spencer, D.H.; Abel, H.J.; Lockwood, C.M.; Hagemann, I.S.; O'Guin, S.M.; Burcea, L.C. et al.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Aberrant schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy

Neuron
2013 | Journal article
EID:

2-s2.0-84876428871

Contributors: Viader, A.; Sasaki, Y.; Kim, S.; Strickland, A.; Workman, C.S.; Yang, K.; Gross, R.W.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury.

BMC genomics
2013 | Other
EID:

2-s2.0-84873258821

Contributors: Chang, L.W.; Viader, A.; Varghese, N.; Payton, J.E.; Milbrandt, J.; Nagarajan, R.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1

Investigative Ophthalmology and Visual Science
2013 | Journal article
EID:

2-s2.0-84872004802

Contributors: Zhu, Y.; Zhang, L.; Sasaki, Y.; Milbrandt, J.; Gidday, J.M.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Role of oxygen consumption in hypoxia protection by translation factor depletion

Journal of Experimental Biology
2013 | Journal article
EID:

2-s2.0-84878583122

Contributors: Scott, B.; Sun, C.-L.; Mao, X.; Yu, C.; Vohra, B.P.S.; Milbrandt, J.; Crowder, C.M.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Sarm1-mediated axon degeneration requires both SAM and TIR interactions

Journal of Neuroscience
2013 | Journal article
EID:

2-s2.0-84881495428

Contributors: Gerdts, J.; Summers, D.W.; Sasaki, Y.; DiAntonio, A.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

Cell Reports
2013 | Journal article
EID:

2-s2.0-84878586685

Contributors: Babetto, E.; Beirowski, B.; Russler, E.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration

Journal of Neuroscience
2012 | Journal article
EID:

2-s2.0-84859544784

Contributors: Bhattacharya, M.R.C.; Gerdts, J.; Naylor, S.A.; Royse, E.X.; Ebstein, S.Y.; Sasaki, Y.; Milbrandt, J.; Diantonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Assembly and Maintenance of Nodes of Ranvier Rely on Distinct Sources of Proteins and Targeting Mechanisms

Neuron
2012 | Journal article
EID:

2-s2.0-84862908261

Contributors: Zhang, Y.; Bekku, Y.; Dzhashiashvili, Y.; Armenti, S.; Meng, X.; Sasaki, Y.; Milbrandt, J.; Salzer, J.L.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems

Science Signaling
2012 | Journal article
EID:

2-s2.0-84864554059

Contributors: Patel, A.; Harker, N.; Moreira-Santos, L.; Ferreira, M.; Alden, K.; Timmis, J.; Foster, K.; Garefalaki, A.; Pachnis, P.; Andrews, P. et al.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration

Neuron
2012 | Journal article
EID:

2-s2.0-84862687092

Contributors: Shin, J.E.; Cho, Y.; Beirowski, B.; Milbrandt, J.; Cavalli, V.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration

Journal of Neuroscience
2012 | Journal article
EID:

2-s2.0-84858397292

Contributors: Misko, A.L.; Sasaki, Y.; Tuck, E.; Milbrandt, J.; Baloh, R.H.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

SCG10 is a JNK target in the axonal degeneration pathway

Proceedings of the National Academy of Sciences of the United States of America
2012 | Journal article
EID:

2-s2.0-84871834042

Contributors: Shin, J.E.; Miller, B.R.; Babetto, E.; Cho, Y.; Sasaki, Y.; Qayum, S.; Russler, E.V.; Cavalli, V.; Milbrandt, J.; DiAntonio, A.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

The AMPK ß2 Subunit Is Required for Energy Homeostasis during Metabolic Stress

Molecular and Cellular Biology
2012 | Journal article
EID:

2-s2.0-84864001222

Contributors: Dasgupta, B.; Ju, J.S.; Sasaki, Y.; Liu, X.; Jung, S.-R.; Higashida, K.; Lindquist, D.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction

PLoS ONE
2011 | Journal article
EID:

2-s2.0-81155137294

Contributors: Viader, A.; Wright-Jin, E.C.; Vohra, B.P.S.; Heuckeroth, R.O.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Image-based screening identifies novel roles for IκB kinase and glycogen synthase kinase 3 in axonal degeneration

Journal of Biological Chemistry
2011 | Journal article
EID:

2-s2.0-80051519518

Contributors: Gerdts, J.; Sasaki, Y.; Vohra, B.; Marasa, J.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

MicroRNAs modulate schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes

Journal of Neuroscience
2011 | Journal article
EID:

2-s2.0-82555200943

Contributors: Viader, A.; Chang, L.-W.; Fahrner, T.; Nagarajan, R.; Milbrandt, J.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier

Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

Proceedings of the National Academy of Sciences of the United States of America
2011 | Journal article
EID:

2-s2.0-82755168795

Contributors: Verghese, P.B.; Sasaki, Y.; Yang, D.; Stewart, F.; Sabar, F.; Finn, M.B.; Wroge, C.M.; Mennerick, S.; Neil, J.J.; Milbrandt, J. et al.
Source: Self-asserted source
Jeffrey Milbrandt via Scopus - Elsevier
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