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Scopus Author ID: 55818311600
SciProfiles: 1497114

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IRCCS Humanitas Research Hospital: Rozzano, IT

Employment
Source: Self-asserted source
Antonietta Franco

Works (25)

Sensory-Motor Neuropathy in Mfn2 T105M Knock-in Mice and Its Reversal by a Novel Piperine-Derived Mitofusin Activator

The Journal of pharmacology and experimental therapeutics
2024 | Journal article
DOI: 10.1124/jpet.124.002258
EID:

2-s2.0-85206960087

Part of ISSN: 15210103
Contributors: Weigele, J.; Zhang, L.; Franco, A.; Cartier, E.; Dorn, G.W.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

A human mitofusin 2 mutation can cause mitophagic cardiomyopathy

eLife
2023 | Journal article
DOI: 10.7554/eLife.84235
EID:

2-s2.0-85175770339

Part of ISSN: 2050084X
Contributors: Franco, A.; Li, J.; Kelly, D.P.; Hershberger, R.E.; Marian, A.J.; Lewis, R.M.; Song, M.; Dang, X.; Schmidt, A.D.; Mathyer, M.E. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier
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Activating mitofusins interrupts mitochondrial degeneration and delays disease progression in SOD1 mutant amyotrophic lateral sclerosis

Human Molecular Genetics
2023 | Journal article
DOI: 10.1093/hmg/ddac287
EID:

2-s2.0-85150665771

Part of ISSN: 14602083 09646906
Contributors: Dang, X.; Zhang, L.; Franco, A.; Dorn, G.W.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

A human mitofusin 2 mutation causes mitophagic cardiomyopathy

bioRxiv
2022 | Other
DOI: 10.1101/2022.11.22.517462
EID:

2-s2.0-85146940566

Part of ISSN: 26928205
Contributors: Franco, A.; Li, J.; Kelly, D.P.; Hershberger, R.E.; Marian, A.J.; Lewis, R.M.; Song, M.; Dang, X.; Schmidt, A.D.; Mathyer, M.E. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier
grade
Preferred source (of 2)‎

Mitochondria Clumping vs. Mitochondria Fusion in CMT2A Diseases

Life
2022 | Journal article
DOI: 10.3390/life12122110
EID:

2-s2.0-85144848870

Part of ISSN: 20751729
Contributors: Franco, A.; Walton, C.E.; Dang, X.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier
grade
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Mitochondrial Dysfunction and Pharmacodynamics of Mitofusin Activation in Murine Charcot-Marie-Tooth Disease Type 2A

Journal of Pharmacology and Experimental Therapeutics
2022 | Journal article
DOI: 10.1124/jpet.122.001332
EID:

2-s2.0-85143972810

Part of ISSN: 15210103 00223565
Contributors: Franco, A.; Dang, X.; Zhang, L.; Molinoff, P.B.; Dorn, G.W.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Piperine Derivatives Enhance Fusion and Axonal Transport of Mitochondria by Activating Mitofusins

Chemistry (Switzerland)
2022 | Journal article
DOI: 10.3390/chemistry4030047
EID:

2-s2.0-85133128546

Part of ISSN: 26248549
Contributors: Zhang, L.; Dang, X.; Franco, A.; Zhao, H.; Dorn, G.W.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier
grade
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Reciprocal Regulation of Mitofusin 2-Mediated Mitophagy and Mitochondrial Fusion by Different PINK1 Phosphorylation Events

Frontiers in Cell and Developmental Biology
2022 | Journal article
DOI: 10.3389/fcell.2022.868465
EID:

2-s2.0-85131333321

Part of ISSN: 2296634X
Contributors: Li, J.; Dang, X.; Franco, A.; Dorn, G.W.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Erratum: Restoring mitofusin balance prevents axonal degeneration in a Charcot-marie-tooth type 2A model (The Journal of Clinical Investigation (2019) 129:4 (1756–1771) DOI: 10.1172/JCI124194)

Journal of Clinical Investigation
2021 | Journal article
DOI: 10.1172/JCI147307
EID:

2-s2.0-85100005444

Part of ISSN: 15588238 00219738
Contributors: Zhou, Y.; Carmona, S.; Muhammad, A.K.M.G.; Bell, S.; Landeros, J.; Vazquez, M.; Ho, R.; Franco, A.; Lu, B.; Dorn, G.W. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity

Journal of Medicinal Chemistry
2021 | Journal article
DOI: 10.1021/acs.jmedchem.1c00163
EID:

2-s2.0-85114446366

Part of ISSN: 15204804 00222623
Contributors: Dang, X.; Williams, S.B.; Devanathan, S.; Franco, A.; Fu, L.; Bernstein, P.R.; Walters, D.; Dorn, G.W.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Burst mitofusin activation reverses neuromuscular dysfunction in murine cmt2a

eLife
2020 | Journal article
DOI: 10.7554/eLife.61119
EID:

2-s2.0-85095714027

Part of ISSN: 2050084X
Contributors: Franco, A.; Dang, X.; Walton, E.K.; Ho, J.N.; Zablocka, B.; Ly, C.; Miller, T.M.; Baloh, R.H.; Shy, M.E.; Yoo, A.S. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier
grade
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Correction: Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases (Journal of Medicinal Chemistry (2020) 63:13 (7033−7051) DOI: 10.1021/acs.jmedchem.0c00366)

Journal of Medicinal Chemistry
2020 | Journal article
DOI: 10.1021/acs.jmedchem.0c01267
EID:

2-s2.0-85090870580

Part of ISSN: 15204804 00222623
Contributors: Dang, X.; Zhang, L.; Franco, A.; Li, J.; Rocha, A.G.; Devanathan, S.; Dolle, R.E.; Bernstein, P.R.; Dorn, G.W.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases

Journal of Medicinal Chemistry
2020 | Journal article
DOI: 10.1021/acs.jmedchem.0c00366
EID:

2-s2.0-85088208295

Part of ISSN: 15204804 00222623
Contributors: Dang, X.; Zhang, L.; Franco, A.; Li, J.; Rocha, A.G.; Devanathan, S.; Dolle, R.E.; Bernstein, P.R.; Dorn, G.W.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure

ESC Heart Failure
2020 | Journal article
DOI: 10.1002/ehf2.12706
EID:

2-s2.0-85084219028

Part of ISSN: 20555822
Contributors: Ciccarelli, M.; Sorriento, D.; Fiordelisi, A.; Gambardella, J.; Franco, A.; del Giudice, C.; Sala, M.; Monti, M.G.; Bertamino, A.; Campiglia, P. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier
grade
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The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca<sup>2+</sup>–NFATc1 axis

Journal of Biological Chemistry
2020 | Journal article
DOI: 10.1074/jbc.RA119.012023
EID:

2-s2.0-85083963595

Part of ISSN: 1083351X 00219258
Contributors: Ballard, A.; Zeng, R.; Zarei, A.; Shao, C.; Cox, L.; Yan, H.; Franco, A.; Dorn, G.W.; Faccio, R.; Veis, D.J.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier
grade
Preferred source (of 2)‎

Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model

Journal of Clinical Investigation
2019 | Journal article
DOI: 10.1172/JCI124194
EID:

2-s2.0-85063286946

Part of ISSN: 15588238 00219738
Contributors: Zhou, Y.; Carmona, S.; Muhammad, A.K.M.G.; Bell, S.; Landeros, J.; Vazquez, M.; Ho, R.; Franco, A.; Lu, B.; Dorn, G.W. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts

Journal of Molecular and Cellular Cardiology
2018 | Journal article
DOI: 10.1016/j.yjmcc.2018.06.009
EID:

2-s2.0-85049487923

Part of ISSN: 10958584 00222828
Contributors: Franco, A.; Zhang, L.; Matkovich, S.J.; Kovacs, A.; Dorn, G.W.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

GRK2 moderates the acute mitochondrial damage to ionizing radiation exposure by promoting mitochondrial fission/fusion

Cell Death Discovery
2018 | Journal article
DOI: 10.1038/s41420-018-0028-7
EID:

2-s2.0-85048040755

Part of ISSN: 20587716
Contributors: Franco, A.; Sorriento, D.; Gambardella, J.; Pacelli, R.; Prevete, N.; Procaccini, C.; Matarese, G.; Trimarco, B.; Iaccarino, G.; Ciccarelli, M.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

Science
2018 | Journal article
DOI: 10.1126/science.aao1785
EID:

2-s2.0-85045684908

Part of ISSN: 10959203 00368075
Contributors: Rocha, A.G.; Franco, A.; Krezel, A.M.; Rumsey, J.M.; Alberti, J.M.; Knight, W.C.; Biris, N.; Zacharioudakis, E.; Janetka, J.W.; Baloh, R.H. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier
grade
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Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence

Cell Metabolism
2017 | Journal article
DOI: 10.1016/j.cmet.2017.09.023
EID:

2-s2.0-85032571207

Part of ISSN: 19327420 15504131
Contributors: Song, M.; Franco, A.; Fleischer, J.A.; Zhang, L.; Dorn, G.W.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Correcting mitochondrial fusion by manipulating mitofusin conformations

Nature
2016 | Journal article
DOI: 10.1038/nature20156
EID:

2-s2.0-85000868491

Part of ISSN: 14764687 00280836
Contributors: Franco, A.; Kitsis, R.N.; Fleischer, J.A.; Gavathiotis, E.; Kornfeld, O.S.; Gong, G.; Biris, N.; Benz, A.; Qvit, N.; Donnelly, S.K. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Good at heart: Preserving cardiac metabolism during aging

Current Diabetes Reviews
2016 | Journal article
DOI: 10.2174/1573399811666150722124958
EID:

2-s2.0-84959498822

Part of ISSN: 18756417 15733998
Contributors: Sorriento, D.; Franco, A.; Rusciano, M.R.; Maione, A.S.; Soprano, M.; Illario, M.; Iaccarino, G.; Ciccarelli, M.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy

Journal of Cardiovascular Translational Research
2015 | Journal article
DOI: 10.1007/s12265-015-9646-0
EID:

2-s2.0-84947493668

Part of ISSN: 19375395 19375387
Contributors: Sorriento, D.; Santulli, G.; Franco, A.; Cipolletta, E.; Napolitano, L.; Gambardella, J.; Gomez-Monterrey, I.; Campiglia, P.; Trimarco, B.; Iaccarino, G. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Targeting the CaMKII/ERK interaction in the heart prevents cardiac hypertrophy

PLoS ONE
2015 | Journal article
DOI: 10.1371/journal.pone.0130477
EID:

2-s2.0-84938632136

Part of ISSN: 19326203
Contributors: Cipolletta, E.; Rusciano, M.R.; Maione, A.S.; Santulli, G.; Sorriento, D.; Del Giudice, C.; Ciccarelli, M.; Franco, A.; Crola, C.; Campiglia, P. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier

Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species

Arteriosclerosis, Thrombosis, and Vascular Biology
2013 | Journal article
DOI: 10.1161/ATVBAHA.113.302262
EID:

2-s2.0-84885034477

Part of ISSN: 10795642 15244636
Contributors: Ciccarelli, M.; Sorriento, D.; Franco, A.; Fusco, A.; Del Giudice, C.; Annunziata, R.; Cipolletta, E.; Monti, M.G.; Dorn, G.W.; Trimarco, B. et al.
Source: Self-asserted source
Antonietta Franco via Scopus - Elsevier
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