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Employment (1)

Montreal Neurological Institute and Hospital: Montreal, QC, CA

1999-07-01 to present | Professor (Neurology and Neurosurgery, McGill University)
Employment
Source: Self-asserted source
Edward A. Fon

Works (22)

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.

Molecular neurodegeneration
2024-11-25 | Journal article | Author
DOI: 10.1186/s13024-024-00779-9
PMID: 39587654
PMC: PMC11587650
Contributors: Jones-Tabah J; He K; Karpilovsky N; Senkevich K; Deyab G; Pietrantonio I; Goiran T; Cousineau Y; Nikanorova D; Goldsmith T et al.
Source: Self-asserted source
Edward A. Fon

Modeling Parkinson's disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines.

Nature neuroscience
2024-10-08 | Journal article | Author
DOI: 10.1038/s41593-024-01775-4
PMID: 39379564
Contributors: Armin Bayati; Ayoubi R; Adriana Aguila; Cornelia Zorca; Deyab G; Han C; Sherilyn Junelle Recinto; Nguyen-Renou E; Rocha C; Gilles Maussion et al.
Source: Self-asserted source
Edward A. Fon

Activation of parkin by a molecular glue.

Nature communications
2024-09-19 | Journal article | Author
DOI: 10.1038/s41467-024-51889-3
PMID: 39300082
PMC: PMC11412986
Contributors: Veronique Sauve; Stefan E; Croteau N; Goiran T; Fakih R; Bansal N; Hadzipasic A; Fang J; Murugan P; Chen S et al.
Source: Self-asserted source
Edward A. Fon

CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids.

iScience
2024-07-30 | Journal article
DOI: 10.1016/j.isci.2024.110613
PMID: 39224516
PMC: PMC11367488
Contributors: Rhalena A. Thomas; Sirois J; Li S; Gestin A; Deyab G; Piscopo VEC; Lépine P; Mathur M; Chen CX; Soubannier V et al.
Source: Self-asserted source
Edward A. Fon

Machine learning nominates the inositol pathway and novel genes in Parkinson's disease.

Brain : a journal of neurology
2024-03-01 | Journal article | Author
DOI: 10.1093/brain/awad345
PMID: 37804111
PMC: PMC10907089
Contributors: Yu E; Larivière R; Thomas RA; Liu L; Senkevich K; Shady Rahayel; Trempe JF; Edward A. Fon; Ziv Gan-Or
Source: Self-asserted source
Edward A. Fon

Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress.

Proceedings of the National Academy of Sciences of the United States of America
2024-02-28 | Journal article | Author
DOI: 10.1073/pnas.2313540121
PMID: 38416681
PMC: PMC10927582
Contributors: Mohamed A. Eldeeb; Andrew N. Bayne; Armaan Fallahi; Goiran T; MacDougall EJ; Andrea Soumbasis; Zorca CE; Jones-Tabah J; Rhalena A. Thomas; Karpilovsky N et al.
Source: Self-asserted source
Edward A. Fon

GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease.

Brain : a journal of neurology
2023-05-01 | Journal article | Author
DOI: 10.1093/brain/awac413
PMID: 36370000
PMC: PMC10151180
Contributors: Konstantin Senkevich; Zorca CE; Dworkind A; Rudakou U; Emma N. Somerville; Yu E; Ermolaev A; Nikanorova D; Ahmad J; Ruskey JA et al.
Source: Self-asserted source
Edward A. Fon

Hallmarks and Molecular Tools for the Study of Mitophagy in Parkinson’s Disease

Cells
2022-07 | Journal article | Author
DOI: 10.3390/cells11132097
Contributors: thomas goiran; Mohamed A. Eldeeb; Cornelia Zorca; Edward A. Fon
Source: check_circle
Multidisciplinary Digital Publishing Institute

Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex.

Molecular cell
2021-12-06 | Journal article
DOI: 10.1016/j.molcel.2021.11.012
PMID: 34875213
Contributors: Shafqat Rasool; Simon Veyron; Naoto Soya; Eldeeb MA; Lukacs GL; Fon EA; Trempe JF
Source: Self-asserted source
Edward A. Fon

Proteomic Profiling of Mitochondrial-Derived Vesicles in Brain Reveals Enrichment of Respiratory Complex Sub-assemblies and Small TIM Chaperones.

Journal of proteome research
2020-11-26 | Journal article | Author
DOI: 10.1021/acs.jproteome.0c00506
PMID: 33242952
Contributors: Rosalind F Roberts; Bayne AN; Goiran T; Lévesque D; Boisvert FM; Trempe JF; Edward A. Fon
Source: Self-asserted source
Edward A. Fon

Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies.

Annals of neurology
2019-11-18 | Journal article
DOI: 10.1002/ana.25629
PMID: 31658403
Contributors: Lynne Krohn; Tugba Ozturk; Benoît Vanderperre; Bouchra Ouled Amar Bencheikh; Ruskey JA; Laurent SB; dan spiegelman; Postuma RB; Isabelle Arnulf; Michele Hu et al.
Source: Self-asserted source
Edward A. Fon

The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson's disease.

Human molecular genetics
2019-09-01 | Journal article
DOI: 10.1093/hmg/ddz080
PMID: 30994895
PMC: PMC6736174
Contributors: Yi W; MacDougall EJ; Tang MY; Andrea Isabel Krahn; Gan-Or Z; Trempe JF; Fon EA
Source: Self-asserted source
Edward A. Fon

Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson's disease.

Proceedings of the National Academy of Sciences of the United States of America
2019-07-15 | Journal article
DOI: 10.1073/pnas.1901805116
PMID: 31308240
PMC: PMC6681704
Contributors: Fava, V. M.; Xu YZ; Lettre G; Van Thuc N; Marianna Orlova; Thai VH; Tao S; Croteau N; Eldeeb MA; MacDougall EJ et al.
Source: Self-asserted source
Edward A. Fon

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.

eLife
2018-04-20 | Journal article | Author
DOI: 10.7554/elife.32866
PMID: 29676259
PMC: PMC5927771
Contributors: Gian-Luca McLelland; thomas goiran; Yi W; Dorval G; Chen CX; Lauinger ND; Andrea Isabel Krahn; Valimehr S; Rakovic A; isabelle rouiller et al.
Source: Self-asserted source
Edward A. Fon

Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.

Nature communications
2017-03-09 | Journal article
DOI: 10.1038/ncomms14697
PMID: 28276439
PMC: PMC5347139
Contributors: Tang MY; Marta Vranas; Marta Vranas; Andrea Isabel Krahn; Pundlik S; Trempe JF; Fon EA
Source: Self-asserted source
Edward A. Fon

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.

The Journal of cell biology
2016-07-25 | Journal article | Author
DOI: 10.1083/jcb.201603105
PMID: 27458136
PMC: PMC4970327
Contributors: Gian-Luca McLelland; Lee Sydney ; Heidi McBride; Edward A. Fon
Source: Self-asserted source
Edward A. Fon

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.

The EMBO journal
2014-09-12 | Journal article
DOI: 10.15252/embj.201489729
PMID: 25216678
PMC: PMC4283406
Contributors: Durcan TM; Tang MY; Pérusse JR; Dashti EA; Aguileta MA; Gian-Luca McLelland; Priti Gros; Shaler TA; Faubert D; Coulombe B et al.
Source: Self-asserted source
Edward A. Fon

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles.

The EMBO journal
2014-08-08 | Journal article
DOI: 10.15252/embj.201488104
PMID: 25107473
PMC: PMC4282503
Contributors: Ayumu Sugiura; Gian-Luca McLelland; Fon EA; Heidi McBride
Source: Self-asserted source
Edward A. Fon

Ubiquitin is phosphorylated by PINK1 to activate parkin.

Nature
2014-06-04 | Journal article
DOI: 10.1038/nature13392
PMID: 24784582
Contributors: Koyano F; Kei Okatsu; Kosako H; Yasushi Tamura; Go E; Kimura M; Kimura Y; Tsuchiya H; Yoshihara H; Hirokawa T et al.
Source: Self-asserted source
Edward A. Fon

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.

The EMBO journal
2014-01-20 | Journal article
DOI: 10.1002/embj.201385902
PMID: 24446486
PMC: PMC3989637
Contributors: Gian-Luca McLelland; Soubannier V; Chen CX; Heidi McBride; Fon EA
Source: Self-asserted source
Edward A. Fon

Structure of parkin reveals mechanisms for ubiquitin ligase activation.

Science (New York, N.Y.)
2013-05-09 | Journal article
DOI: 10.1126/science.1237908
PMID: 23661642
Contributors: Trempe JF; Sauvé V; Grenier K; Seirafi M; Tang MY; Ménade M; M. Sameer Al-Abdul-Wahid; Jonathan D. Krett; Wong K; Kozlov G et al.
Source: Self-asserted source
Edward A. Fon

SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination.

Molecular cell
2009-12-01 | Journal article
DOI: 10.1016/j.molcel.2009.11.021
PMID: 20064468
Contributors: Trempe JF; Chen CX; Grenier K; Camacho EM; Kozlov G; McPherson PS; Kalle Gehring; Fon EA
Source: Self-asserted source
Edward A. Fon

Peer review (7 reviews for 6 publications/grants)

Review activity for Communications biology. (1)
Review activity for Life science alliance. (1)
Review activity for Nature (1)
Review activity for Nature cell biology (1)
Review activity for Nature genetics. (1)
Review activity for NPJ Parkinson's disease. (2)
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