Personal information

Sequence-defined molecules, Bio-inspired crystallization, Soft Matter, Hierarchical self-assembly
United States

Biography

Dr. Chun-Long Chen is currently a senior research scientist at Pacific Northwest National Laboratory (PNNL). His research focuses on developing sequence-defined synthetic polymers to mimic natural proteins for bio-inspired crystallization and for hierarchical self-assembly of energy- and health-related biomimetic materials. He received his Ph.D. degree in physical inorganic chemistry from Sun Yat-Sen (Zhongshan) University in China. His doctoral research was focused on the design and assembly of metallo-supramolecules and the study of their formation mechanisms and structural dynamics. Since then, he has worked extensively on the applications of "bottom-up" assembly approaches, including the self-assembly of proteins, peptides and peptoids for bio-inspired crystallization, and the assembly of complex nanoparticle superstructures by combining peptide self-assembly and peptide-directed mineralization. Throughout his career Dr. Chen has built extensive experience in both synthetic chemistry and materials science, developing a highly interdisciplinary approach to achieve the rational design and assembly of biomimetic materials. Dr. Chen has published more than 60 papers with three US patents.

Activities

Employment (1)

Pacific Northwest National Laboratory: Richland, WA, US

2013 to present | Senior Research Scientist (Physical Science Division)
Employment
Source: Self-asserted source
Chun-Long Chen

Education and qualifications (1)

Sun Yat-Sen University: Guangzhou, Guangdong, CN

2000-09 to 2005-12 | Ph.D. (school of chemistry and chemcial engineering)
Education
Source: Self-asserted source
Chun-Long Chen

Works (45)

Toward Computation-Guided Design of Tunable Organic–Inorganic CdS Quantum Dot Binary Superlattices

Nano Letters
2025-02-25 | Journal article
Contributors: Xin Qi; Sarah Helland; Christopher D. Lowe; Helen Larson; Jianming Cui; Renyu Zheng; Madison Monahan; Chun-Long Chen; James De Yoreo; Jim Pfaendtner et al.
Source: check_circle
Crossref

Silica–Biomacromolecule Interactions: Toward a Mechanistic Understanding of Silicification

Biomacromolecules
2025-01-13 | Journal article
Contributors: Christina A. McCutchin; Kevin J. Edgar; Chun-Long Chen; Patricia M. Dove
Source: check_circle
Crossref

CeO2 Nanoparticle Doping as a Probe of Active Site Speciation in the Catalytic Hydrolysis of Organophosphates

ACS Applied Nano Materials
2024-07-12 | Journal article
Contributors: Emily Miura-Stempel; Ashley G. Oregon; Samantha M. Harvey; James J. De Yoreo; Chun-Long Chen; Brandi M. Cossairt
Source: check_circle
Crossref

Hierarchical Self‐Assembly of Multidimensional Functional Materials from Sequence‐Defined Peptoids

Angewandte Chemie
2024-06-10 | Journal article
Contributors: Li Shao; Dehong Hu; Shao‐Liang Zheng; Thi Kim Hoang Trinh; Wenhao Zhou; Haoyu Wang; Yanxu Zong; Changning Li; Chun‐Long Chen
Source: check_circle
Crossref

Hierarchical Self‐Assembly of Multidimensional Functional Materials from Sequence‐Defined Peptoids

Angewandte Chemie International Edition
2024-06-10 | Journal article
Contributors: Li Shao; Dehong Hu; Shao‐Liang Zheng; Thi Kim Hoang Trinh; Wenhao Zhou; Haoyu Wang; Yanxu Zong; Changning Li; Chun‐Long Chen
Source: check_circle
Crossref

Assembly of short amphiphilic peptoids into nanohelices with controllable supramolecular chirality

Nature Communications
2024-04-16 | Journal article
Contributors: Renyu Zheng; Mingfei Zhao; Jingshan S. Du; Tarunya Rao Sudarshan; Yicheng Zhou; Anant K. Paravastu; James J. De Yoreo; Andrew L. Ferguson; Chun-Long Chen
Source: check_circle
Crossref

Access to Advanced Functional Materials through Postmodification of Biomimetic Assemblies via Click Chemistry

Biomacromolecules
2024-03-11 | Journal article
Contributors: Annie Y. Heble; Chun-Long Chen
Source: check_circle
Crossref

Rational Design of Novel Biomimetic Sequence-Defined Polymers for Mineralization Applications

Chemistry of Materials
2024-01-23 | Journal article
Contributors: Kaylyn Torkelson; Nada Y. Naser; Xin Qi; Zhiliang Li; Wenchao Yang; Karthik Pushpavanam; Chun-Long Chen; François Baneyx; Jim Pfaendtner
Source: check_circle
Crossref

Directing polymorph specific calcium carbonate formation with de novo protein templates

Nature Communications
2023-12-14 | Journal article
Contributors: Fatima A. Davila-Hernandez; Biao Jin; Harley Pyles; Shuai Zhang; Zheming Wang; Timothy F. Huddy; Asim K. Bera; Alex Kang; Chun-Long Chen; James J. De Yoreo et al.
Source: check_circle
Crossref

Designed Metal-Containing Peptoid Membranes as Enzyme Mimetics for Catalytic Organophosphate Degradation

ACS Applied Materials & Interfaces
2023-11-08 | Journal article
Contributors: Thi Kim Hoang Trinh; Tengyue Jian; Biao Jin; Dan-Thien Nguyen; Ronald N. Zuckermann; Chun-Long Chen
Source: check_circle
Crossref

Insights into the Biomimetic Synthesis of 2D ZnO Nanomaterials through Peptoid Engineering

The Journal of Physical Chemistry Letters
2023-11-02 | Journal article
Contributors: Wenchao Yang; Bin Cai; Kacper J. Lachowski; Qiuxiang Yin; James J. De Yoreo; Lilo D. Pozzo; Chun-Long Chen
Source: check_circle
Crossref

Thermodynamic Basis for the Stabilization of Helical Peptoids by Chiral Sidechains

The Journal of Physical Chemistry B
2023-07-13 | Journal article
Contributors: Sarah Alamdari; Kaylyn Torkelson; Xiaoqian Wang; Chun-Long Chen; Andrew L. Ferguson; Jim Pfaendtner
Source: check_circle
Crossref

Computational and Experimental Determination of the Properties, Structure, and Stability of Peptoid Nanosheets and Nanotubes

Biomacromolecules
2023-06-12 | Journal article
Contributors: Mingfei Zhao; Shuai Zhang; Renyu Zheng; Sarah Alamdari; Christopher J. Mundy; Jim Pfaendtner; Lilo D. Pozzo; Chun-Long Chen; James J. De Yoreo; Andrew L. Ferguson
Source: check_circle
Crossref

Molecular Driving Force for Facet Selectivity of Sequence-Defined Amphiphilic Peptoids at Au–Water Interfaces

The Journal of Physical Chemistry B
2022-07-14 | Journal article
Contributors: Xin Qi; Biao Jin; Bin Cai; Feng Yan; James De Yoreo; Chun-Long Chen; Jim Pfaendtner
Source: check_circle
Crossref

Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

Nature Communications
2022-05-31 | Journal article
Contributors: Tengyue Jian; Yicheng Zhou; Peipei Wang; Wenchao Yang; Peng Mu; Xin Zhang; Xiao Zhang; Chun-Long Chen
Source: check_circle
Crossref

Impact of Nanoparticle Size and Surface Chemistry on Peptoid Self-Assembly

ACS Nano
2022-05-24 | Journal article
Contributors: Madison Monahan; Micaela Homer; Shuai Zhang; Renyu Zheng; Chun-Long Chen; James De Yoreo; Brandi M. Cossairt
Source: check_circle
Crossref

Hierarchical Self-Assembly Pathways of Peptoid Helices and Sheets

Biomacromolecules
2022-03-14 | Journal article
Contributors: Mingfei Zhao; Kacper J. Lachowski; Shuai Zhang; Sarah Alamdari; Janani Sampath; Peng Mu; Christopher J. Mundy; Jim Pfaendtner; James J. De Yoreo; Chun-Long Chen et al.
Source: check_circle
Crossref

Amphiphilic Peptoid‐Directed Assembly of Oligoanilines into Highly Crystalline Conducting Nanotubes

Macromolecular Rapid Communications
2022-02 | Journal article
Contributors: Zhiliang Li; Duyen K. Tran; Mary Nguyen; Tengyue Jian; Feng Yan; Samson A. Jenekhe; Chun‐Long Chen
Source: check_circle
Crossref

Peptoid-directed assembly of CdSe nanoparticles

Nanoscale
2021 | Journal article
Contributors: Madison Monahan; Bin Cai; Tengyue Jian; Shuai Zhang; Guomin Zhu; Chun-Long Chen; James J. De Yoreo; Brandi M. Cossairt
Source: check_circle
Crossref

Transfer learning of memory kernels for transferable coarse-graining of polymer dynamics

Soft Matter
2021 | Journal article
Contributors: Zhan Ma; Shu Wang; Minhee Kim; Kaibo Liu; Chun-Long Chen; Wenxiao Pan
Source: check_circle
Crossref

Hierarchical Nanomaterials Assembled from Peptoids and Other Sequence-Defined Synthetic Polymers

Chemical Reviews
2021-11-24 | Journal article
Contributors: Zhiliang Li; Bin Cai; Wenchao Yang; Chun-Long Chen
Source: check_circle
Crossref

Early-Stage Aggregation and Crystalline Interactions of Peptoid Nanomembranes

The Journal of Physical Chemistry Letters
2021-07-08 | Journal article
Contributors: Joshua A. Hammons; Marcel D. Baer; Tengyue Jian; Jonathan R. I. Lee; Thomas M. Weiss; James J. De Yoreo; Aleksandr Noy; Chun-Long Chen; Anthony Van Buuren
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Crossref

Programmable two-dimensional nanocrystals assembled from POSS-containing peptoids as efficient artificial light-harvesting systems

Science Advances
2021-05-14 | Journal article
Contributors: Mingming Wang; Yang Song; Shuai Zhang; Xin Zhang; Xiaoli Cai; Yuehe Lin; James J. De Yoreo; Chun-Long Chen
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Crossref

Designing Sequence-Defined Peptoids for Biomimetic Control over Inorganic Crystallization

Chemistry of Materials
2021-05-11 | Journal article
Contributors: Wenchao Yang; Qiuxiang Yin; Chun-Long Chen
Source: check_circle
Crossref

Nanoparticle-Mediated Assembly of Peptoid Nanosheets Functionalized with Solid-Binding Proteins: Designing Heterostructures for Hierarchy

Nano Letters
2021-02-24 | Journal article
Contributors: Jinrong Ma; Bin Cai; Shuai Zhang; Tengyue Jian; James J. De Yoreo; Chun-Long Chen; François Baneyx
Source: check_circle
Crossref

Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

Research
2021-01 | Journal article
Contributors: Xiaoli Cai; Mingming Wang; Peng Mu; Tengyue Jian; Dong Liu; Shichao Ding; Yanan Luo; Dan Du; Yang Song; Chun-Long Chen et al.
Source: check_circle
Crossref

Programming Amphiphilic Peptoid Oligomers for Hierarchical Assembly and Inorganic Crystallization

Accounts of Chemical Research
2021-01-05 | Journal article
Contributors: Bin Cai; Zhiliang Li; Chun-Long Chen
Source: check_circle
Crossref

Peptoid-Based Programmable 2D Nanomaterial Sensor for Selective and Sensitive Detection of H2S in Live Cells

ACS Applied Bio Materials
2020-09-21 | Journal article
Contributors: Mingming Wang; Yang Song; Peng Mu; Xiaoli Cai; Yuehe Lin; Chun-Long Chen
Source: check_circle
Crossref

MARTINI-Compatible Coarse-Grained Model for the Mesoscale Simulation of Peptoids

The Journal of Physical Chemistry B
2020-09-10 | Journal article
Contributors: Mingfei Zhao; Janani Sampath; Sarah Alamdari; Gillian Shen; Chun-Long Chen; Christopher J. Mundy; Jim Pfaendtner; Andrew L. Ferguson
Source: check_circle
Crossref

In Liquid Infrared Scattering Scanning Near-Field Optical Microscopy for Chemical and Biological Nanoimaging

Nano Letters
2020-06-10 | Journal article
Contributors: Brian T. O’Callahan; Kyoung-Duck Park; Irina V. Novikova; Tengyue Jian; Chun-Long Chen; Eric A. Muller; Patrick Z. El-Khoury; Markus B. Raschke; A. Scott Lea
Source: check_circle
Crossref

Solid‐phase synthesis of three‐armed star‐shaped peptoids and their hierarchical self‐assembly

Biopolymers
2019-04 | Journal article
Contributors: Haibao Jin; Tengyue Jian; Yan‐Huai Ding; Yulin Chen; Peng Mu; Lei Wang; Chun‐Long Chen
Source: check_circle
Crossref

Tunable assembly of biomimetic peptoids as templates to control nanostructure catalytic activity

Nanoscale
2018 | Journal article
Contributors: Nicholas A. Merrill; Feng Yan; Haibao Jin; Peng Mu; Chun-Long Chen; Marc R. Knecht
Source: check_circle
Crossref

2D nanomaterials assembled from sequence-defined molecules

Nano-Structures & Nano-Objects
2018-07 | Journal article
Part of ISSN: 2352-507X
Contributors: Peng Mu; Guangwen Zhou; Chun-Long Chen
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids

Nature Communications
2018-01 | Journal article
Part of ISSN: 2041-1723
Contributors: Haibao Jin; Yan-Huai Ding; Mingming Wang; Yang Song; Zhihao Liao; Christina J. Newcomb; Xuepeng Wu; Xian-Qiong Tang; Zheng Li; Yuehe Lin et al.
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Using Biomimetic Polymers in Place of Noncollagenous Proteins to Achieve Functional Remineralization of Dentin Tissues

ACS Biomaterials Science & Engineering
2017-11 | Journal article
Part of ISSN: 2373-9878
Contributors: Yung-Ching Chien; Jinhui Tao; Kuniko Saeki; Alexander F. Chin; Jolene L. Lau; Chun-Long Chen; Ronald N. Zuckermann; Sally J. Marshall; Grayson W. Marshall; James J. De Yoreo
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Tuning crystallization pathways through sequence engineering of biomimetic polymers

Nature Materials
2017-04 | Journal article
Part of ISSN: 1476-1122
Contributors: Xiang Ma; Shuai Zhang; Fang Jiao; Christina J. Newcomb; Yuliang Zhang; Arushi Prakash; Zhihao Liao; Marcel D. Baer; Christopher J. Mundy; James Pfaendtner et al.
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Self-Repair and Patterning of 2D Membrane-Like Peptoid Materials

Advanced Functional Materials
2016-08 | Journal article
Part of ISSN: 1616-301X
Contributors: Fang Jiao; Yulin Chen; Haibao Jin; Pingang He; Chun-Long Chen; James J. De Yoreo
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids

Nature Communications
2016-07 | Journal article
Part of ISSN: 2041-1723
Contributors: Haibao Jin; Fang Jiao; Michael D. Daily; Yulin Chen; Feng Yan; Yan-Huai Ding; Xin Zhang; Ellen J. Robertson; Marcel D. Baer; Chun-Long Chen
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Surface-Directed Assembly of Sequence-Defined Synthetic Polymers into Networks of Hexagonally Patterned Nanoribbons with Controlled Functionalities

ACS Nano
2016-05-09 | Journal article
Part of ISSN: 1936-0851
Contributors: Chun-Long Chen; Ronald N. Zuckermann; James J. DeYoreo
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Amyloid-like ribbons of amelogenins in enamel mineralization

Scientific Reports
2016-03 | Journal article
Part of ISSN: 2045-2322
Contributors: Karina M. M. Carneiro; Halei Zhai; Li Zhu; Jeremy A. Horst; Melody Sitlin; Mychi Nguyen; Martin Wagner; Cheryl Simpliciano; Melissa Milder; Chun-Long Chen et al.
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Tuning calcite morphology and growth acceleration by a rational design of highly stable protein-mimetics

Scientific Reports
2014-09-05 | Journal article
Part of ISSN: 2045-2322
Contributors: Chun-Long Chen; Jiahui Qi; Jinhui Tao; Ronald N. Zuckermann; James J. DeYoreo
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

In situ AFM Study of Amelogenin Assembly and Disassembly Dynamics on Charged Surfaces Provides Insights on Matrix Protein Self-Assembly

Journal of the American Chemical Society
2011-11-02 | Journal article
Part of ISSN: 0002-7863
Contributors: Chun-Long Chen; Keith M. Bromley; Janet Moradian-Oldak; James J. DeYoreo
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Engineered Biomimetic Polymers as Tunable Agents for Controlling CaCO3Mineralization

Journal of the American Chemical Society
2011-04 | Journal article
Part of ISSN: 0002-7863
Contributors: Chun-Long Chen; Jiahui Qi; Ronald N. Zuckermann; James J. DeYoreo
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Preparation of Unique 1-D Nanoparticle Superstructures and Tailoring their Structural Features

Journal of the American Chemical Society
2010-05 | Journal article
Part of ISSN: 0002-7863
Contributors: Chun-Long Chen; Nathaniel L. Rosi
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Peptide-Based Methods for the Preparation of Nanostructured Inorganic Materials

Angewandte Chemie International Edition
2010-02 | Journal article
Part of ISSN: 1433-7851
Contributors: Chun-Long Chen; Nathaniel L. Rosi
Source: Self-asserted source
Chun-Long Chen via Crossref Metadata Search

Peer review (42 reviews for 21 publications/grants)

Review activity for Accounts of chemical research. (2)
Review activity for ACS applied bio materials. (1)
Review activity for ACS applied materials & interfaces. (4)
Review activity for ACS nano. (1)
Review activity for ACS omega. (1)
Review activity for Advanced intelligent systems. (1)
Review activity for Advanced materials. (1)
Review activity for Advanced sustainable systems. (1)
Review activity for Angewandte Chemie. (4)
Review activity for Biomacromolecules. (2)
Review activity for ChemMedChem. (1)
Review activity for Crystal growth & design. (3)
Review activity for Journal of chemical theory and computation : (1)
Review activity for Journal of the American Chemical Society. (2)
Review activity for Langmuir : (8)
Review activity for Macromolecules. (3)
Review activity for Nano letters. (1)
Review activity for Nature communications (2)
Review activity for Small methods (1)
Review activity for Small. (1)
Review activity for The journal of physical chemistry letters. (1)