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Platelets, Flow cytometry, Cell signalling, Bioenergetics
United Kingdom

Biography

Dr. Hindle is a senior lecturer at Leeds Beckett University within the Centre for Biomedical Science Research, School of Health. They are developing a translational and collaborative research portfolio with a core theme of platelet biology. Through a range of molecular and cell biology experimental approaches the impact of both platelets on disease, and disease on platelets, are being explored and characterised.

Activities

Employment (2)

Leeds Beckett University: Leeds, GB

2023-08-02 to present | Senior Lecturer (Centre for Biomedical Research, School of Health)
Employment
Source: Self-asserted source
Matthew S Hindle

University of Leeds: Leeds, GB

2019-11-01 to 2023-07-31 | Postdoctoral Research Fellow (DTSD, Leeds Institute of Cardiovascular and Metabolic Medicine)
Employment
Source: Self-asserted source
Matthew S Hindle

Education and qualifications (3)

University of Leeds: Leeds, GB

2016-09-30 to 2019-11-01 | PhD Medical Sciences
Education
Source: Self-asserted source
Matthew S Hindle

University of Glasgow: Glasgow, GB

2015-09-30 to 2016-08-31 | MSc Infection Biology (spec. virology)
Education
Source: Self-asserted source
Matthew S Hindle

Nottingham Trent University: Nottingham, GB

2010-09-30 to 2013-07-31 | BSc (Hons) Biomedical Science
Education
Source: Self-asserted source
Matthew S Hindle

Professional activities (3)

Fund for the Replacement of Animals in Medical Experiments: Nottingham, GB

2024-06-13 to present | Scientific Advisory Panel Member
Service
Source: Self-asserted source
Matthew S Hindle

Royal Society of Biology: London, GB

2024-04-08 to present | MRSB
Membership
Source: Self-asserted source
Matthew S Hindle

The Platelet Society: London, GB

2018-07-12 to present | Ordinary Member
Membership
Source: Self-asserted source
Matthew S Hindle

Works (10)

α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly

Cells
2024-12-17 | Journal article
Contributors: Christopher Sennett; Wanzhu Jia; Jawad S. Khalil; Matthew S. Hindle; Charlie Coupland; Simon D. J. Calaminus; Julian D. Langer; Sean Frost; Khalid M. Naseem; Francisco Rivero et al.
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Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer

Blood Advances
2024-08-13 | Journal article
Contributors: Rui-Gang Xu; Christian Tiede; Antonio N. Calabrese; Lih T. Cheah; Thomas L. Adams; Julia S. Gauer; Matthew S. Hindle; Beth A. Webb; Daisie M. Yates; Alexandre Slater et al.
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Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner

Cells
2024-06-26 | Journal article
Contributors: Jawad S. Khalil; Robert Law; Zaher Raslan; Lih T. Cheah; Matthew S. Hindle; Ahmed A. Aburima; Mark T. Kearney; Khalid M. Naseem
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Crossref
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Platelets from patients with chronic inflammation have a phenotype of chronic IL-1beta release.

Research and Practice in Thrombosis and Haemostasis
2023-11-14 | Journal article
Part of ISSN: 2475-0379
Contributors: M. Berger; H. Maqua; K. Lysaja; S.F. Mause; M.S. Hindle; K.M. Naseem; E. Dahl; T. Speer; N. Marx; K. Schuett
Source: Self-asserted source
Matthew S Hindle

Pre-analytical conditions for multiparameter platelet flow cytometry.

Research and Practice in Thrombosis and Haemostasis
2023-09-20 | Journal article
Part of ISSN: 2475-0379
Contributors: Matthew S. Hindle; Lih T. Cheah; Daisie M. Yates; Khalid M. Naseem
Source: Self-asserted source
Matthew S Hindle

Ticagrelor inverse agonist activity at the P2Y12 receptor is non‐reversible versus its endogenous agonist ADP.

British Journal of Pharmacology
2023-08-02 | Journal article
Part of ISSN: 0007-1188
Part of ISSN: 1476-5381
Contributors: Jawad Khalil; Tudor Dimofte; Timothy Roberts; Michael Keith; Kumuthu Amaradasa; Matthew S. Hindle; Sukhinder Bancroft; James L. Hutchinson; Khalid Naseem; Thomas Johnson et al.
Source: Self-asserted source
Matthew S Hindle

Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis

eLife
2021-10-11 | Journal article
Part of ISSN: 2050-084X
Contributors: Helen R McPherson; Cedric Duval; Stephen R Baker; Matthew S Hindle; Lih T Cheah; Nathan L Asquith; Marco M Domingues; Victoria C Ridger; Simon DA Connell; Khalid M Naseem et al.
Source: Self-asserted source
Matthew S Hindle

Multidimensional flow cytometry reveals novel platelet subpopulations in response to prostacyclin

Journal of Thrombosis and Haemostasis
2021-07 | Journal article
Part of ISSN: 1538-7836
Contributors: Matthew S. Hindle; Benjamin E.J. Spurgeon; Lih T. Cheah; Beth A. Webb; Khalid M. Naseem
Source: Self-asserted source
Matthew S Hindle

Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin: the role of phosphodiesterase 3A

Haematologica
2020-03 | Journal article
Part of ISSN: 0390-6078
Part of ISSN: 1592-8721
Contributors: Martin Berger; Zaher Raslan; Ahmed Aburima; Simbarashe Magwenzi; Katie S. Wraith; Benjamin E.J. Spurgeon; Matthew S. Hindle; Robert Law; Maria Febbraio; Khalid M. Naseem
Source: Self-asserted source
Matthew S Hindle

Dyslipidemia-associated atherogenic oxidized lipids induce platelet hyperactivity through phospholipase Cγ2-dependent reactive oxygen species generation

Platelets
2019-05-19 | Journal article
Part of ISSN: 0953-7104
Part of ISSN: 1369-1635
Contributors: Martin Berger; Katie Wraith; Casey Woodward; Ahmed Aburima; Zaher Raslan; Matthew S. Hindle; Julia Moellmann; Maria Febbraio; Khalid M. Naseem
Source: Self-asserted source
Matthew S Hindle