Personal information

stem cells, RNA methylation, skin, cancer
Germany

Biography

The Frye lab seeks to understand and exploit RNA modification pathways in regulating cell fate decisions in normal tissues and human diseases.

Activities

Employment (6)

Deutsches Krebsforschungszentrum: Heidelberg, Baden-Württemberg, DE

2019-02-01 to present | Professor (Mechanisms Regulating Gene Expression)
Employment
Source: Self-asserted source
Michaela Frye

University of Cambridge: Cambridge, Cambridgeshire, GB

2017-10-01 to 2019-01-31 | Reader (Genetics)
Employment
Source: Self-asserted source
Michaela Frye

University of Cambridge: Cambridge, Cambridgeshire, GB

2013-02-01 to 2019-01-31 | CR-UK Senior Fellow (WT-MRC Stem Cell Institute)
Employment
Source: Self-asserted source
Michaela Frye

University of Cambridge: Cambridge, Cambridgeshire, GB

2015-10-01 to 2017-09-31 | Lecturer (Genetics)
Employment
Source: Self-asserted source
Michaela Frye

University of Cambridge: Cambridge, Cambridgeshire, GB

2007-02-01 to 2013-01-31 | CR-UK Career Development Fellow (WT-MRC Stem Cell Intitute)
Employment
Source: Self-asserted source
Michaela Frye

Cancer Research UK: London, London, GB

2001-05-01 to 2006-12-31 | Postdoc (London Research Institute)
Employment
Source: Self-asserted source
Michaela Frye

Education and qualifications (2)

Goethe-Universität Frankfurt am Main: Frankfurt am Main, Hessen, DE

1995-06-13 to 2000-06-23 | PhD (Molecular Cell Biology and Human Genetics)
Education
Source: Self-asserted source
Michaela Frye

Goethe-Universität Frankfurt am Main: Frankfurt am Main, Hessen, DE

1994-06-13 to 1995-06-13 | Diploma (Ecology and Evolution)
Education
Source: Self-asserted source
Michaela Frye

Professional activities (4)

German Stem Cell Network: Berlin, DE

2021 to present | Extended Board Member
Service
Source: Self-asserted source
Michaela Frye

RNA Society: Bethesda, Maryland, US

2020 to present | Member
Membership
Source: Self-asserted source
Michaela Frye

EMBO: Heidelberg, DE

2018 to present | EMBO Member
Membership
Source: Self-asserted source
Michaela Frye

International Society for Stem Cell Research: Skokie, IL, US

2006 to present | Member
Service
Source: Self-asserted source
Michaela Frye

Funding (12)

Inhibition of mitochondrial translation to prevent metastasis

2021-01 to 2023-12 | Grant
Worldwide Cancer Research (Edinburgh, Worldwide, GB)
GRANT_NUMBER:

21-0223

Source: Self-asserted source
Michaela Frye

Regulating protein translation to protect from UV-induced damage

Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Manipulating protein synthesis as a strategy to control tumor growth

2015-01-01 to 2017-12-31 | Grant
Worldwide Cancer Research (St Andrews, GB)
GRANT_NUMBER:

WCR-15-0168

Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Cytosine-5 RNA methylation in normal and cancer stem cells

2013-10-01 to 2017-09-30 | Grant
Cancer Research UK (London, GB)
GRANT_NUMBER:

CRUK-A16134

Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Cytosine-5 RNA methylation in normal and cancer stem cells

2013-02-01 to 2019-01-31 | Grant
Cancer Research UK (London, GB)
GRANT_NUMBER:

CRUK-A15181

Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Cytosine-5 methylated RNAs as stem cell regulators in normal tissues and diseases

2013-02-01 to 2018-01-31 | Grant
European Research Council (Saint-Josse-ten-Noode, BE)
GRANT_NUMBER: 310360
Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Stem cells in skin - From morphogenesis to cancer development 31 August - 2 September 2010

Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Role of Misu (NSun2) in healthy tissues and tumourigenesis

Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Identification of Myc specific target genes in skin

2007-10-01 to 2011-09-30 | Grant
Cancer Research UK (London, GB)
GRANT_NUMBER:

CRUK-A7989

Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Functional analysis of the proto-oncogene Myc in adult epidermal stem cell self-renewal and differentiation

Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Functional analysis of the proto-oncogene Myc in adult epidermal stem cell self-renewal and differentiation

Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Signalling and regulation mechanisms of differentiation processes of mouse embryonic stem cells into epidermal cells

Source: Self-asserted source
Michaela Frye via DimensionsWizard
grade
Preferred source (of 2)‎

Works (50 of 55)

Items per page:
Page 1 of 2

Localization-dictated function for METTL3

Nature Cell Biology
2022-08 | Journal article
Part of ISSN: 1465-7392
Part of ISSN: 1476-4679
Contributors: Michaela Frye
Source: Self-asserted source
Michaela Frye

Mitochondrial RNA modifications shape metabolic plasticity in metastasis

Nature
2022-07-21 | Journal article
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Michaela Frye
Source: Self-asserted source
Michaela Frye

RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin

Nature Communications
2021-12 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Michaela Frye

Noncanonical functions of the serine‐arginine‐rich splicing factor (SR) family of proteins in development and disease

BioEssays
2021-04 | Journal article
Part of ISSN: 0265-9247
Part of ISSN: 1521-1878
Source: Self-asserted source
Michaela Frye

Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6

Nucleic Acids Research
2020-12-16 | Journal article
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
Michaela Frye

CONCUR: quick and robust calculation of codon usage from ribosome profiling data

Bioinformatics
2020-08-31 | Journal article
Part of ISSN: 1367-4803
Part of ISSN: 1460-2059
Source: Self-asserted source
Michaela Frye

Codon usage optimization in pluripotent embryonic stem cells

Genome Biology
2019-12 | Journal article
Part of ISSN: 1474-760X
Source: Self-asserted source
Michaela Frye

Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation

Nature Communications
2019-12 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Michaela Frye

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

Nucleic Acids Research
2019-09-19 | Journal article
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
Michaela Frye

Cytosine-5 RNA methylation links protein synthesis to cell metabolism

PLOS Biology
2019-06-14 | Journal article
Part of ISSN: 1545-7885
Source: Self-asserted source
Michaela Frye

RNA modifications regulating cell fate in cancer

Nature Cell Biology
2019-05 | Journal article
Part of ISSN: 1465-7392
Part of ISSN: 1476-4679
Source: Self-asserted source
Michaela Frye

Considerations for skin carcinogenesis experiments using inducible transgenic mouse models

BMC Research Notes
2018-12 | Journal article
Part of ISSN: 1756-0500
Source: Self-asserted source
Michaela Frye

RNA modifications modulate gene expression during development

Science
2018-09-28 | Journal article
Part of ISSN: 0036-8075
Part of ISSN: 1095-9203
Source: Self-asserted source
Michaela Frye

Positioning Europe for the EPITRANSCRIPTOMICS challenge

RNA Biology
2018-05-09 | Journal article
Part of ISSN: 1547-6286
Part of ISSN: 1555-8584
Source: Self-asserted source
Michaela Frye

Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility

Stem Cell Reports
2017 | Journal article
EID:

2-s2.0-85009100579

Contributors: Flores, J.V.; Cordero-Espinoza, L.; Oeztuerk-Winder, F.; Andersson-Rolf, A.; Selmi, T.; Blanco, S.; Tailor, J.; Dietmann, S.; Frye, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Deficient methylation and formylation of mt-tRNA<sup>Met</sup> wobble cytosine in a patient carrying mutations in NSUN3

Nature Communications
2016 | Journal article
EID:

2-s2.0-84977138242

Contributors: Van Haute, L.; Dietmann, S.; Kremer, L.; Hussain, S.; Pearce, S.F.; Powell, C.A.; Rorbach, J.; Lantaff, R.; Blanco, S.; Sauer, S. et al.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Post-transcriptional modifications in development and stem cells

Development (Cambridge)
2016 | Journal article
EID:

2-s2.0-84994236488

Contributors: Frye, M.; Blanco, S.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Posttranscriptional methylation of transfer and ribosomal RNA in stress response pathways, cell differentiation, and cancer

Current Opinion in Oncology
2016 | Journal article
EID:

2-s2.0-84951569387

Contributors: Popis, M.C.; Blanco, S.; Frye, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

RNA modifications: What have we learned and where are we headed?

Nature Reviews Genetics
2016 | Journal article
EID:

2-s2.0-84965028802

Contributors: Frye, M.; Jaffrey, S.R.; Pan, T.; Rechavi, G.; Suzuki, T.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Stem cell function and stress response are controlled by protein synthesis

Nature
2016 | Journal article
EID:

2-s2.0-84976334228

Contributors: Blanco, S.; Bandiera, R.; Popis, M.; Hussain, S.; Lombard, P.; Aleksic, J.; Sajini, A.; Tanna, H.; Cortés-Garrido, R.; Gkatza, N. et al.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Genetically induced cell death in bulge stem cells reveals their redundancy for hair and epidermal regeneration

Stem Cells
2015 | Journal article
EID:

2-s2.0-84923239987

Contributors: Driskell, I.; Oeztuerk-Winder, F.; Humphreys, P.; Frye, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

EMBO Journal
2014 | Journal article
EID:

2-s2.0-84908153517

Contributors: Blanco, S.; Dietmann, S.; Flores, J.V.; Hussain, S.; Kutter, C.; Humphreys, P.; Lukk, M.; Lombard, P.; Treps, L.; Popis, M. et al.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Role of RNA methyltransferases in tissue renewal and pathology

Current Opinion in Cell Biology
2014 | Journal article
EID:

2-s2.0-84904412679

Contributors: Blanco, S.; Frye, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Characterizing 5-methylcytosine in the mammalian epitranscriptome

Genome Biology
2013 | Journal article
EID:

2-s2.0-84888791449

Contributors: Hussain, S.; Aleksic, J.; Blanco, S.; Dietmann, S.; Frye, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs

Cell Reports
2013 | Journal article
EID:

2-s2.0-84880791572

Contributors: Hussain, S.; Sajini, A.A.; Blanco, S.; Dietmann, S.; Lombard, P.; Sugimoto, Y.; Paramor, M.; Gleeson, J.G.; Odom, D.T.; Ule, J. et al.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation

Molecular and Cellular Biology
2013 | Journal article
EID:

2-s2.0-84876304441

Contributors: Hussain, S.; Tuorto, F.; Menon, S.; Blanco, S.; Cox, C.; Flores, J.V.; Watt, S.; Kudo, N.R.; Lyko, F.; Frye, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions

Genome biology
2012 | Journal article
EID:

2-s2.0-84936744064

Contributors: Sugimoto, Y.; König, J.; Hussain, S.; Zupan, B.; Curk, T.; Frye, M.; Ule, J.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Chromatin regulators in mammalian epidermis

Seminars in Cell and Developmental Biology
2012 | Journal article
EID:

2-s2.0-84868457573

Contributors: Frye, M.; Benitah, S.A.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability

American Journal of Human Genetics
2012 | Journal article
EID:

2-s2.0-84860760092

Contributors: Khan, M.A.; Rafiq, M.A.; Noor, A.; Hussain, S.; Flores, J.V.; Rupp, V.; Vincent, A.K.; Malli, R.; Ali, G.; Khan, F.S. et al.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

Nature Structural and Molecular Biology
2012 | Journal article
EID:

2-s2.0-84866074106

Contributors: Tuorto, F.; Liebers, R.; Musch, T.; Schaefer, M.; Hofmann, S.; Kellner, S.; Frye, M.; Helm, M.; Stoecklin, G.; Lyko, F.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Stem cells in ectodermal development

Journal of Molecular Medicine
2012 | Journal article
EID:

2-s2.0-84865111694

Contributors: Benitah, S.A.; Frye, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin

EMBO Journal
2012 | Journal article
EID:

2-s2.0-84856449868

Contributors: Driskell, I.; Oda, H.; Blanco, S.; Nascimento, E.; Humphreys, P.; Frye, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome

Journal of Medical Genetics
2012 | Journal article
EID:

2-s2.0-84864110032

Contributors: Martinez, F.J.; Lee, J.H.; Lee, J.E.; Blanco, S.; Nickerson, E.; Gabrie, S.; Frye, M.; Al-Gazali, L.; Gleeson, J.G.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Erratum: Regulation of human epidermal stem cell proliferation and senescence requires polycomb-dependent and -independent functions of Cbx4 (Cell Stem Cell (2011) 9 (233-246))

Cell Stem Cell
2011 | Journal article
EID:

2-s2.0-80755141304

Contributors: Luis, N.M.; Morey, L.; Mejetta, S.; Pascual, G.; Janich, P.; Kuebler, B.; Cozutto, L.; Roma, G.; Nascimento, E.; Frye, M. et al.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Regulation of human epidermal stem cell proliferation and senescence requires polycomb-dependent and independent functions of cbx4

Cell Stem Cell
2011 | Journal article
EID:

2-s2.0-80052300618

Contributors: Luis, N.M.; Morey, L.; Mejetta, S.; Pascual, G.; Janich, P.; Kuebler, B.; Roma, G.; Nascimento, E.; Frye, M.; Di Croce, L. et al.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis

Nature Cell Biology
2011 | Journal article
EID:

2-s2.0-84856161647

Contributors: Nascimento, E.M.; Cox, C.L.; MacArthur, S.; Hussain, S.; Trotter, M.; Blanco, S.; Suraj, M.; Nichols, J.; Kübler, B.; Benitah, S.A. et al.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

The RNA-methyltransferase misu (NSun2) poises epidermal stem cells to differentiate

PLoS Genetics
2011 | Journal article
EID:

2-s2.0-84855261134

Contributors: Blanco, S.; Kurowski, A.; Nichols, J.; Watt, F.M.; Benitah, S.A.; Frye, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer

Cancer Letters
2010 | Journal article
EID:

2-s2.0-75949095935

Contributors: Frye, M.; Dragoni, I.; Chin, S.-F.; Spiteri, I.; Kurowski, A.; Provenzano, E.; Green, A.; Ellis, I.O.; Grimmer, D.; Teschendorff, A. et al.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

Cell Stem Cell
2009 | Journal article
EID:

2-s2.0-65349166258

Contributors: Jensen, K.B.; Collins, C.A.; Nascimento, E.; Tan, D.W.; Frye, M.; Itami, S.; Watt, F.M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability

Journal of Cell Biology
2009 | Journal article
EID:

2-s2.0-67650487255

Contributors: Hussain, S.; Benavente, S.B.; Nascimento, E.; Dragoni, I.; Kurowski, A.; Gillich, A.; Humphreys, P.; Frye, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and β-catenin

Stem Cells
2008 | Journal article
EID:

2-s2.0-47949125557

Contributors: Celso, C.L.; Berta, M.A.; Braun, K.M.; Frye, M.; Lyle, S.; Zouboulis, C.C.; Watt, F.M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

MYC in mammalian epidermis: How can an oncogene stimulate differentiation?

Nature Reviews Cancer
2008 | Journal article
EID:

2-s2.0-39749124274

Contributors: Watt, F.M.; Frye, M.; Benitah, S.A.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

MYC in mammalian epidermis: How can an oncogene stimulate differentiation? (Erratum) (Nature Reviews Cancer (2008) 8, (234-242))

Nature Reviews Cancer
2008 | Journal article
EID:

2-s2.0-41149125469

Contributors: Watt, F.M.; Frye, M.; Benitah, S.A.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation

PLoS ONE
2007 | Journal article
EID:

2-s2.0-34848864644

Contributors: Frye, M.; Fisher, A.G.; Watt, F.M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

The RNA Methyltransferase Misu (NSun2) Mediates Myc-Induced Proliferation and Is Upregulated in Tumors (DOI:10.1016/j.cub.2006.04.027)

Current Biology
2007 | Journal article
EID:

2-s2.0-36049013661

Contributors: Frye, M.; Watt, F.M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

Journal of Cell Biology
2006 | Journal article
EID:

2-s2.0-29944444852

Contributors: Gebhardt, A.; Frye, M.; Herold, S.; Benitah, S.A.; Braun, K.; Samans, B.; Watt, F.M.; Elsässer, H.-P.; Eilers, M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

The RNA Methyltransferase Misu (NSun2) Mediates Myc-Induced Proliferation and Is Upregulated in Tumors

Current Biology
2006 | Journal article
EID:

2-s2.0-33646552414

Contributors: Frye, M.; Watt, F.M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Developmental biology: Stem cell depletion through epidermal deletion of Rac1

Science
2005 | Journal article
EID:

2-s2.0-23244452354

Contributors: Benitah, S.A.; Frye, M.; Glogauer, M.; Watt, F.M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Mitochondrial haplotypes and the New Zealand origin of clonal European Potamopyrgus, an invasive aquatic snail

Molecular Ecology
2005 | Journal article
EID:

2-s2.0-21244458072

Contributors: Städler, T.; Frye, M.; Neiman, M.; Lively, C.M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

Development
2003 | Journal article
EID:

2-s2.0-0042913170

Contributors: Frye, M.; Gardner, C.; Li, E.R.; Arnold, I.; Watt, F.M.
Source: Self-asserted source
Michaela Frye via Scopus - Elsevier
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