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Employment (1)

Temple University: Philadelphia, PA, US

2014-06-01 to present | Assistant Professor (Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Oscar Perez-Leal

Education and qualifications (3)

Temple University Fox School of Business and Management: Philadelphia, PA, US

2013-08 to 2015-05 | MS Innovation Management & Entrepreneurship
Education
Source: Self-asserted source
Oscar Perez-Leal

Temple University: Philadelphia, PA, US

2005-11-20 to 2009-11-20 | Postdoctoral training in Biochemistry (Biochemistry)
Education
Source: Self-asserted source
Oscar Perez-Leal

Universidad del Norte: Barranquilla, Atlantico, CO

1996-01-15 to 2002-12-22 | Medical Doctor
Education
Source: Self-asserted source
Oscar Perez-Leal

Funding (1)

Turning on Nrf2 translation for chronic liver disease

2015-08-01 to 2018-07-31 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
URL: https://grants.uberresearch.com/100000062/R03DK105267/Turning-on-Nrf2-translation-for-chronic-liver-disease
GRANT_NUMBER: 5R03DK105267-02
Source: Self-asserted source
Oscar Perez-Leal via DimensionsWizard

Works (29)

Secreted folate receptor γ drives fibrogenesis in metabolic dysfunction–associated steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

Science Translational Medicine
2023-09-27 | Journal article
DOI: 10.1126/scitranslmed.ade2966
Contributors: Connor Quinn; Mario C. Rico; Carmen Merali; Carlos A. Barrero; Oscar Perez-Leal; Victoria Mischley; John Karanicolas; Scott L. Friedman; Salim Merali
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Extracellular Acetylated Histone 3.3 Induces Inflammation and Lung Tissue Damage

Biomolecules
2023-08-31 | Journal article
DOI: 10.3390/biom13091334
Contributors: Mario C. Rico; Oscar Perez-Leal; Mary F. Barbe; Mamta Amin; Dennis J. Colussi; Magda L. Florez; Victor Olusajo; Dennise S. Rios; Carlos A. Barrero
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CRISPR/Cas9-Based Screening of FDA-Approved Drugs for NRF2 Activation: A Novel Approach to Discover Therapeutics for Non-Alcoholic Fatty Liver Disease

Antioxidants
2023-06-29 | Journal article
DOI: 10.3390/antiox12071363
Contributors: James Li; Sandra Arest; Bartlomiej Olszowy; John Gordon; Carlos A. Barrero; Oscar Perez-Leal
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CRISPR-Based Screening of FDA-Approved Drugs for NRF2 Activation: A Novel Approach to Discover Therapeutics for Non-Alcoholic Fatty Liver Disease

2023-06-06 | Preprint
DOI: 10.20944/preprints202306.0423.v1
Contributors: James Li; Sandra Arest; Bartlomiej Olszowy; John Gordon; Carlos A Barrero; Oscar Perez-Leal
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Extracellular Histone 3.3 and Its Hyper-acetylated Isoform In-duce an Inflammatory Response and Damage Lung Tissue

2023-05-17 | Preprint
DOI: 10.20944/preprints202305.1200.v1
Contributors: Mario C. Rico; Oscar Perez-Leal; Mary F. Barbe; Mamta Amin; Dennis J. Colussi; Magda L. Florez; Victor Olusajo; Carlos A. Barrero
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Identification of Inhibitors of Tubulin Polymerization Using a CRISPR-Edited Cell Line with Endogenous Fluorescent Tagging of β-Tubulin and Histone H1

Biomolecules
2023-01-29 | Journal article
DOI: 10.3390/biom13020249
Contributors: Harutyun Khachatryan; Bartlomiej Olszowy; Carlos A. Barrero; John Gordon; Oscar Perez-Leal
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Identification of tubulin polymerization inhibitors with a CRISPR-edited cell line with endogenous fluorescent tagging of β-tubulin and Histone 1

2022-09-14 | Preprint
DOI: 10.1101/2022.09.14.507662
Contributors: Harutyun Khachatryan; Carlos A. Barrero; John Gordon; Bartlomiej Olszowy; Oscar Perez-Leal
Source: check_circle
Crossref

Multiplex Gene Tagging with CRISPR-Cas9 for Live-Cell Microscopy and Application to Study the Role of SARS-CoV-2 Proteins in Autophagy, Mitochondrial Dynamics, and Cell Growth

The CRISPR Journal
2021-11 | Journal article
DOI: 10.1089/crispr.2021.0041
Part of ISSN: 2573-1599
Contributors: Oscar Perez-Leal; Jonathon Nixon-Abell; Carlos A. Barrero; John C. Gordon; James Oesterling; Mario C. Rico
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

A Versatile Vector System for the Fast Generation of Knock-in Cell Lines with CRISPR

2020-02-06 | Preprint
DOI: 10.1101/2020.02.06.927384
Contributors: Oscar Perez-Leal; Jonathon Nixon-Abell; Carlos A. Barrero; John Gordon; Mario C. Rico
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Crossref

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

Cell
2018 | Journal article
DOI: 10.1016/j.cell.2018.09.051
Source: Self-asserted source
Oscar Perez-Leal

Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses

Journal of Biological Chemistry
2017-08-25 | Journal article
DOI: 10.1074/jbc.M116.770925
Contributors: Oscar Perez-Leal; Carlos Alberto Barrero; Salim Merali
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Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors

Bioorganic & Medicinal Chemistry Letters
2017-07 | Journal article
DOI: 10.1016/j.bmcl.2017.05.044
Contributors: Aisha A.K. Al-Ashmawy; Fatma A. Ragab; Khaled M. Elokely; Manal M. Anwar; Oscar Perez-Leal; Mario C. Rico; John Gordon; Eugeney Bichenkov; George Mateo; Emad M.M. Kassem et al.
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

A Novel Assay Platform for the Detection of Translation Modulators of Spermidine/ Spermine Acetyltransferase

CPD
2014-01 | Journal article
DOI:

10.2174/13816128113199990035
Contributors: Oscar Perez-Leal; Magid Abou-Gharbia; John Gordon; Wayne Childers; Salim Merali
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Histone 3.3 Participates in a Self-Sustaining Cascade of Apoptosis That Contributes to the Progression of Chronic Obstructive Pulmonary Disease

Am J Respir Crit Care Med
2013-09 | Journal article
DOI:

10.1164/rccm.201302-0342oc
Contributors: Carlos A. Barrero; Oscar Perez-Leal; Mark Aksoy; Camilo Moncada; Rong Ji; Yolanda Lopez; Karthik Mallilankaraman; Muniswamy Madesh; Gerard J. Criner; Steven G. Kelsen et al.
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Modulation of polyamine metabolic flux in adipose tissue alters the accumulation of body fat by affecting glucose homeostasis

Amino Acids
2013-07 | Journal article
DOI:

10.1007/s00726-013-1548-3
Contributors: Chunli Liu; Oscar Perez-Leal; Carlos Barrero; Kamyar Zahedi; Manoocher Soleimani; Carl Porter; Salim Merali
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Translational control of Nrf2 within the open reading frame

Biochemical and Biophysical Research Communications
2013-07 | Journal article
DOI:

10.1016/j.bbrc.2013.06.052
Contributors: Oscar Perez-Leal; Carlos A. Barrero; Salim Merali
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Polyamine-Regulated Translation of Spermidine/Spermine-N1-Acetyltransferase

Molecular and Cellular Biology
2012-02 | Journal article
DOI:

10.1128/mcb.06444-11
Contributors: O. Perez-Leal; C. A. Barrero; A. B. Clarkson; R. A. Casero; S. Merali
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Pneumocystis S-Adenosylmethionine Transport

Am J Respir Cell Mol Biol
2011 | Journal article
DOI:

10.1165/rcmb.2011-0009oc
Contributors: Oscar Perez-Leal; Camilo Moncada; Allen B. Clarkson; Salim Merali
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Regulation of polyamine metabolism by translational control

Amino Acids
2011-08-03 | Journal article
DOI:

10.1007/s00726-011-1036-6
Contributors: Oscar Perez-Leal; Salim Merali
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice

Peptides
2009-02 | Journal article
DOI:

10.1016/j.peptides.2008.10.022
Contributors: Paola A. Martínez; Nubia Yandar; Liliana P. Lesmes; Martha Forero; Oscar Pérez-Leal; Manuel Elkin Patarroyo; José Manuel Lozano
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

Diabetes
2008-06 | Journal article
DOI:

10.2337/db08-0604
Contributors: G. Boden; X. Duan; C. Homko; E. J. Molina; W. Song; O. Perez; P. Cheung; S. Merali
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Cigarette Smoke Induces an Unfolded Protein Response in the Human Lung

Am J Respir Cell Mol Biol
2008-05 | Journal article
DOI:

10.1165/rcmb.2007-0221oc
Contributors: Steven G. Kelsen; Xunbao Duan; Rong Ji; Oscar Perez; Chunli Liu; Salim Merali
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Mechanism and Tissue Specificity of Nicotine-mediated Lung S-Adenosylmethionine Reduction

Journal of Biological Chemistry
2008-01-07 | Journal article
DOI:

10.1074/jbc.m709399200
Contributors: C. A. Moncada; A. Clarkson; O. Perez-leal; S. Merali
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue

Biochemical and Biophysical Research Communications
2007-07 | Journal article
DOI:

10.1016/j.bbrc.2007.05.015
Contributors: Alvaro Mongui; Oscar Perez-Leal; Jose Rojas-Caraballo; Diana I. Angel; Jimena Cortes; Manuel A. Patarroyo
Source: Self-asserted source
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Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

Biochemical and Biophysical Research Communications
2006 | Journal article
DOI:

10.1016/j.bbrc.2006.10.082
Contributors: Alvaro Mongui; Oscar Perez-Leal; Sara C. Soto; Jimena Cortes; Manuel A. Patarroyo
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

The Plasmodium vivax rhoptry-associated protein 1

Biochemical and Biophysical Research Communications
2006-03 | Journal article
DOI:

10.1016/j.bbrc.2006.01.061
Contributors: Oscar Perez-Leal; Alvaro Mongui; Jimena Cortes; Gloria Yepes; Jesus Leiton; Manuel A. Patarroyo
Source: Self-asserted source
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Identification and characterisation of the Plasmodium vivax rhoptry-associated protein 2

Biochemical and Biophysical Research Communications
2005-11 | Journal article
DOI:

10.1016/j.bbrc.2005.09.120
Contributors: Manuel A. Patarroyo; Oscar Perez-Leal; Yolanda Lopez; Jimena Cortes; Jose Rojas-Caraballo; Andromeda Gomez; Camilo Moncada; Jaiver Rosas; Manuel E. Patarroyo
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Identifying and characterising the Plasmodium falciparum merozoite surface protein 10 Plasmodium vivax homologue

Biochemical and Biophysical Research Communications
2005-06 | Journal article
DOI:

10.1016/j.bbrc.2005.04.031
Contributors: Oscar Perez-Leal; Adriana Y. Sierra; Carlos A. Barrero; Camilo Moncada; Pilar Martinez; Jimena Cortes; Yolanda Lopez; Luz M. Salazar; Johan Hoebeke; Manuel A. Patarroyo
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Plasmodium vivax merozoite surface protein 8 cloning, expression, and characterisation

Biochemical and Biophysical Research Communications
2004-11 | Journal article
DOI:

10.1016/j.bbrc.2004.09.202
Contributors: Oscar Perez-Leal; Adriana Y. Sierra; Carlos A. Barrero; Camilo Moncada; Pilar Martinez; Jimena Cortes; Yolanda Lopez; Elizabeth Torres; Luz M. Salazar; Manuel A. Patarroyo
Source: Self-asserted source
Oscar Perez-Leal via Crossref Metadata Search

Peer review (2 reviews for 1 publication/grant)

Review activity for Molecular metabolism. (2)
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