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NMR, Chirality, Stereochemistry, Liquid crystals, 2H-RQC, Stable isotope
France

Biography

Philippe Lesot. Dr. Philippe Lesot, born in 1967, has been Research Director since 2007 at Institut de Chimie Moléculaire et des Materiaux d’Orsay (ICMMO) (France). He is affiliated to the french National Center for Scientific Research (CNRS). He received his Ph.D degree (cum laudae) at University of Paris-Sud (Orsay) in 1995 (supervisor: Prof. J. Courtieu), and then pursued his research activities at University of Southampton (UK) with Prof. J.W. Emsley, awarded by a grant from the Royal Society of London and the French Foreign Ministry (Lavoisier). After holding a temporary assistant professor position for one year, he joined the French National centre for the Scientific research (CNRS ) in 1997. He was a recipient of the 2001 Bronze Medal from CNRS for young scientists for his pioneering work on the NAD NMR in CLC. He has published over 130 publications (more 120 peer-reviewed paper) and given approx. 70 invited talks or seminars on the analytical and methodological developments in anisotropic NMR in collaboration with various chemists, biochemists as well as geochemists. One of his current research interests focus on the natural isotope fractionation of bioproducts by anisotropic NAD NMR and the fight against counterfeiting as well as the use of NAD NMR approach in the structural analysis.

Function : Director of Research at CNRS (ERMN Team leader)
Institution : Institut de Chimie Moléculaire et des Matériaux d’Orsay (UMR CNRS 8182)
Address : ICMMO, UMR CNRS 8182, Equipe RMN en Milieu Orienté
Bât. 410, Université de Paris Saclay, 91405 Orsay cedex, France

 Contact :
E-mail : philippe.lesot@u-psud.fr
Tel No. : +33 (0)1 69 15 47 59 / 70 17

 Personal data :
Date of Birth : 07th October 1967
Family : Wife, 1 child
Nationality : French

 Higher Education :
1992-95 : Ph.D of Organic Chemistry -NMR speciality- (University of Paris Sud, XI)
1991-92 : Under-officer in the french army
1990-91 : M.Sc. of Organic Chemistry (University of Paris Sud)
1989-90 : B.Sc. of Chemistry (University of Paris Sud)
1987-88 : Technological university diploma (University of Paris Sud)

 Academic positions held :
2007-16 : CNRS, Director of research (Univ. of Paris Sud)
2000-07 : CNRS, Scientist researcher (Univ. of Paris Sud)
1997-00 : CNRS, Junior research scientist (University of Paris Sud)
1996-97 : University Assistant reader (University of Paris Sud)
1995-96 : Post-doctoral research associate (University of Southampton, UK)

 Awards and Honours :
2011: Executive Chairman (programme) "SMASH conference 2011" (France)
2007 : Bronze medal of CNRS (Young Scientist Award of CNRS)
1996 : Scientific grant from the «ROYAL SOCIETY of London»
1996 : Scientific grant from the French Ministry of Foreign Affairs (Lavoisier grant)

 Membership of Professional bodies :
2015-19 : Member (elected) of Academic Council of Paris-Saclay University
2012-16 : Member (elected), National Committee of the National Institute of Chemistry of CNRS (INC, S-12)
2010-19 : Member (nominated), scientific experts for the research french Ministry
2008-12 : Member (elected), scientific board of the National Institute of Chemistry of CNRS (INC, S-12)
2007-15 : Member (elected or nominated), management board of ICMMO, Orsay, France
2011-17 : Member, National Magnetic Resonance Society, India
2007-17 : Member, SFIS (French Society of Stable Isotopes), France

 Invited scientist :
2017 : Karlsruhe, Institute of Technology, Germany
2010,11,12,14 : Indian Institute of Science, Bangalore, India
2010 : University of Padova, Italy
2007 : Weizmann Institute of Science, Israël
1999 : University of Southampton, UK

 Scientific expertises :
- Expert for ANR (National agency for Reseach)
- Expert for various international peer-review journals (92 articles reviewed)
- Expert for the german research foundation -DFG- (Germany)
- Expert for french evaluation agency for research and higher education -AERES-
- Expert for national CNRS contests (Researchers and ingeniors)
- Expert for university Professor recruitment
- Expert for university Professor Assistant recruitment and university ingeniors
- Main referee or examinator of University Thesis
- Examinator for student training periods (Masters)

 Scientific production :
- Total of articles : 143
- Total of peer-reviewed articles : 120
- Other articles (broad audience) : 6
- Book Chapters : 10 (two reeditions paper / online)
- Proceedings : 2
- Review articles in peer-reviewed journal : 5
- Cover of journals : 15
- Oral communications and posters (author/co-author) : 108
- Invited conferences : 54 (20, out of France)
- Invited university seminars : 21 (10, out of France)
- Articles listed ISI of Knowledge WEB database (article/review): 120
- Articles listed in Science Finder : 120

 Scientific competences :
- NMR methodology in (chiral) oriented solvents
- 2H NMR and related experiments
- Isotopic fractionation analysis
- Stereochemistry/Structural analysis

Activities

Employment (5)

Université Paris-Saclay Faculté des Sciences d'Orsay: Orsay, Île-de-France, FR

2021-01-01 to present | Director of Research at CNRS (DR-1) (CNRS Chemistry Institute; CoNRS section 12 )
Employment
Source: Self-asserted source
Philippe Lesot

Université Paris-Saclay Faculté des Sciences d'Orsay: Orsay, Île-de-France, FR

2007-10-01 to 2020-12-31 | Director of Research at CNRS (DR-2) (CNRS Chemistry Institute; CoNRS section 12 )
Employment
Source: Self-asserted source
Philippe Lesot

Université Paris-Saclay Faculté des Sciences d'Orsay: Orsay, Île-de-France, FR

1997-10-01 to 2007-10-01 | Scientific Researcher at CNRS (CNRS Chemistry Institute; CoNRS section 12 )
Employment
Source: Self-asserted source
Philippe Lesot

Université Paris-Sud: Orsay, Île-de-France, FR

1996-10-01 to 1997-10-01 | Assistant reader
Employment
Source: Self-asserted source
Philippe Lesot

University of Southampton: Southampton, Southampton, GB

1995-10-01 to 1996-10-01 | Post-doctoral researcher
Employment
Source: Self-asserted source
Philippe Lesot

Education and qualifications (3)

Université Paris-Sud: Orsay, Île-de-France, FR

1995-10-01 to 1997-10-01 | Ph.D
Education
Source: Self-asserted source
Philippe Lesot

Université Paris-Sud: Orsay, Île-de-France, FR

1994-10-01 to 1995-07-01 | Master 2 of Organic Chemistry, Option : analytical techniques (Department of chemistry)
Education
Source: Self-asserted source
Philippe Lesot

Université Paris-Sud: Orsay, Île-de-France, FR

1993-10-01 to 1994-07-01 | Bachelor of Organic Chemistry (Department of chemistry)
Education
Source: Self-asserted source
Philippe Lesot

Funding (4)

Recurrent funding for research from French CNRS

1997-10 to 2017-10 | Contract
National Center for Scientific Research (CNRS) (Paris, FR)
Source: Self-asserted source
Philippe Lesot

Recurrent funding for research from the University of Paris Sud

1997-10 to 2017-10 | Contract
Recurrent funding for research from the University of Paris Sud (Agency, FR)
Source: Self-asserted source
Philippe Lesot

Lavoisier grant

1995-10 to 1996-10 | Grant
French ministry of research (Paris, FR)
Source: Self-asserted source
Philippe Lesot

Royal Society of London

1995-10 to 1996-10 | Grant
Royal Society of London (London, Great Britain, GB)
Source: Self-asserted source
Philippe Lesot

Works (50 of 139)

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Development of deep learning software to improve HPLC and GC predictions using a new crown-ether based mesogenic stationary phase and beyond

Journal of Chromatography A
2025-01 | Journal article
Contributors: Warda Fella Belaid; Azeddine Dekhira; Philippe Lesot; Ouassila Ferroukhi
Source: check_circle
Crossref

Potential and performance of anisotropic 19F NMR for the enantiomeric analysis of fluorinated chiral active pharmaceutical ingredients

The Analyst
2024 | Journal article
Contributors: Boris Gouilleux; François-Marie Moussallieh; Philippe Lesot
Source: check_circle
Crossref

Spatially Resolved Anisotropic Natural Abundance Deuterium 2D-NMR Spectroscopy Using Bimesophasic Lyotropic Chiral Systems

The Journal of Physical Chemistry Letters
2024-02-22 | Journal article
Contributors: Thomas Julien; Boris Gouilleux; Bernard Rousseau; Stefan Immel; Michael Reggelin; Philippe Lesot
Source: check_circle
Crossref

Combining Fast 2D NMR Methods and Oriented Media

2023-05-17 | Book chapter
Contributors: Philippe Lesot; Olivier Lafon
Source: check_circle
Crossref

Anisotropic 1H STD‐NMR Spectroscopy: Exploration of Enantiomer‐Polypeptide Interactions in Chiral Oriented Environments

ChemPhysChem
2023-02-14 | Journal article
Contributors: Boris Gouilleux; François‐Marie Moussallieh; Philippe Lesot
Source: check_circle
Crossref

Anisotropic 1H STD‐NMR Spectroscopy: Exploration of Enantiomer‐Polypeptide Interactions in Chiral Oriented Environments

ChemPhysChem
2023-02-14 | Journal article
Contributors: Boris Gouilleux; Francois‐Marie Moussallieh; Philippe Lesot
Source: check_circle
Crossref

Front Cover: Anisotropic 1H STD‐NMR Spectroscopy: Exploration of Enantiomer‐Polypeptide Interactions in Chiral Oriented Environments (ChemPhysChem 4/2023)

ChemPhysChem
2023-02-14 | Journal article
Contributors: Boris Gouilleux; Francois‐Marie Moussallieh; Philippe Lesot
Source: check_circle
Crossref

Study and quantification of the enantiodiscrimination power of four polymeric chiral LLCs using NAD 2D-NMR

Physical Chemistry Chemical Physics
2022 | Journal article
Contributors: Philippe Berdagué; Boris Gouilleux; Markus Noll; Stefan Immel; Michael Reggelin; Philippe Lesot
Source: check_circle
Crossref

Molecular enantiodiscrimination by NMR spectroscopy in chiral oriented systems: Concept, tools, and applications

Chirality
2022-02 | Journal article
Contributors: Christie Aroulanda; Philippe Lesot
Source: check_circle
Crossref

Exploring the enantiomeric 13C position-specific isotope fractionation: challenges and anisotropic NMR-based analytical strategy

Analytical and Bioanalytical Chemistry
2021-10-09 | Journal article
Contributors: Philippe Lesot; Philippe Berdagué; Virginie Silvestre; Gérald Remaud
Source: check_circle
Crossref

Chemical Synthesis of [2H]-Ethyl Tosylate and Exploration of Its Crypto-optically Active Character Combining Complementary Spectroscopic Tools

Organic Letters
2020-11-20 | Journal article
Contributors: Timothée Naret; Philippe Lesot; Andrew R. Puente; Prasad L. Polavarapu; David-Alexandre Buisson; Jeanne Crassous; Grégory Pieters; Sophie Feuillastre
Source: check_circle
Crossref

Tuning the Reactivity of a Heterogeneous Catalyst using N‐Heterocyclic Carbene Ligands for C−H Activation Reactions

Angewandte Chemie International Edition
2020-11-16 | Journal article
Contributors: Alberto Palazzolo; Timothée Naret; Marion Daniel‐Bertrand; David‐Alexandre Buisson; Simon Tricard; Philippe Lesot; Yannick Coppel; Bruno Chaudret; Sophie Feuillastre; Grégory Pieters
Source: check_circle
Crossref

Tuning the Reactivity of a Heterogeneous Catalyst using N‐Heterocyclic Carbene Ligands for C−H Activation Reactions

Angewandte Chemie
2020-11-16 | Journal article
Contributors: Alberto Palazzolo; Timothée Naret; Marion Daniel‐Bertrand; David‐Alexandre Buisson; Simon Tricard; Philippe Lesot; Yannick Coppel; Bruno Chaudret; Sophie Feuillastre; Grégory Pieters
Source: check_circle
Crossref

Deuterium Residual Quadrupolar Couplings: Crossing the Current Frontiers in the Relative Configuration Analysis of Natural Products

Journal of Natural Products
2020-10-23 | Journal article
Contributors: Philippe Lesot; Roberto R. Gil; Philippe Berdagué; Armando Navarro-Vázquez
Source: check_circle
Crossref

Determination of the natural deuterium distribution of fatty acids by application of 2H 2D-NMR in liquid crystals: fundamentals, advances, around and beyond

Liquid Crystals
2020-10-20 | Journal article
Contributors: Philippe Lesot
Source: check_circle
Crossref

2H QUOSY 2D‐NMR Experiments in Weakly Aligning Systems: From the Conventional to the Ultrafast Approach

ChemPhysChem
2020-07-17 | Journal article
Contributors: Boris Gouilleux; Abdelkrim Meddour; Philippe Lesot
Source: check_circle
Crossref

Designing and building a low-cost portable FT-NMR spectrometer in 2019: A modern challenge

Comptes Rendus Chimie
2019-09 | Journal article
Contributors: Alain Louis-Joseph; Philippe Lesot
Source: check_circle
Crossref

2H and 13C NMR‐Based Enantiodetection Using Polyacetylene versus Polypeptide Aligning Media: Versatile and Complementary Tools for Chemists

ChemPlusChem
2019-02 | Journal article
Contributors: Philippe Lesot; Philippe Berdagué; Abdelkrim Meddour; Alexander Kreiter; Markus Noll; Michael Reggelin
Source: check_circle
Crossref

2H and 13C NMR‐Based Enantiodetection Using Polyacetylene versus Polypeptide Aligning Media: Versatile and Complementary Tools for Chemists

ChemPlusChem
2019-02 | Journal article
Contributors: Philippe Lesot; Philippe Berdagué; Abdelkrim Meddour; Alexander Kreiter; Markus Noll; Michael Reggelin
Source: check_circle
Crossref

Front Cover: 2H and 13C NMR‐Based Enantiodetection Using Polyacetylene versus Polypeptide Aligning Media: Versatile and Complementary Tools for Chemists (ChemPlusChem 2/2019)

ChemPlusChem
2019-02 | Journal article
Contributors: Philippe Lesot; Philippe Berdagué; Abdelkrim Meddour; Alexander Kreiter; Markus Noll; Michael Reggelin
Source: check_circle
Crossref

Analytical contribution of deuterium 2D‐NMR in oriented media to 2H/1H isotopic characterization: the case of vanillin

Flavour and Fragrance Journal
2018-05 | Journal article
Contributors: Tristan Texier–Bonniot; Philippe Berdagué; Richard J. Robins; Gérald Remaud; Philippe Lesot
Source: check_circle
Crossref

Article : Integrated Computational Protocol for Analyzing Quadrupolar Splittings from Natural Abundance Deuterium NMR Spectra In (Chiral) Oriented Media

ChemPhysChem., 18(10), 1252-1266, (2017).
2017-06-02 | Journal article
Source: Self-asserted source
Philippe Lesot

Cover profile, Integrated Computational Protocol for Analyzing Quadrupolar Splittings from Natural Abundance Deuterium NMR Spectra In (Chiral) Oriented Media

ChemPhysChem., 18(10), 1210-1210, (2017).
2017-06-01 | Journal article
Source: Self-asserted source
Philippe Lesot
grade
Preferred source (of 2)‎

Isotope Ratio Monitoring by NMR. Part 1 : Recent Advances

Modern Magnetic Resonance, 2nd Ed., pp 1-25, Ed. G. Webb, Springer Int. Publishing (2017).
2017-04-03 | Book chapter
Source: Self-asserted source
Philippe Lesot

Isotope Ratio Monitoring by NMR. Part 2: New Applications in the Field of Defining Biosynthesis

Modern Magnetic Resonance, 2nd Ed., pp. 1-26, Ed. G. Webb, Springer Int. Publishing (2017).
2017-04-02 | Book chapter
Source: Self-asserted source
Philippe Lesot

Natural Abundance 2H NMR Spectroscopy

Encyclopedia of Spectroscopy and Spectrometry, 3rd Edition, Vol. 3, pp. 1-14 (2017). Eds. Lindon, Tranter and Kopenaal, Elsevier.
2017-03-01 | Book chapter
Source: Self-asserted source
Philippe Lesot

Investigation of Solute-Fiber Affinity and Orientational Ordering of Norbornadiene Interacting with Two-polypeptide Chiral Liquid Crystalline Solvents by NAD NMR

J. Phys. Chem. A, 120, 6076-6088, (2016).
2016-09-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Detection of Quadrupolar Nuclei by Ultrafast 2D-NMR: Exploring the Case of Deuterated Analytes Aligned in Chiral Oriented Solvents

Chem. Commun., 52, 2122-2125, (2016).
2016-05-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Contribution of NAD 2D-NMR in Liquid Crystals to the Determination of Hydrogen isotope Profile of Methyl Groups in Miliacin

Geochim. Cosmochim. Acta, 173, 337-351, (2016).
2016-03-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Chronique Littéraire: « NMR Spectroscopy in Liquid and Solids » de V. I. Bakhmutov

Spectra Analyse, 306, 16-16, (2015).
2015-10-01 | Book review
Source: Self-asserted source
Philippe Lesot

Multi-nuclear NMR of Axially Chiral Biaryls in Polypeptide Orienting Solvents: Spectral Discriminations and Enantiorecognition Mechanisms

New J. Chem., 39, 9504-9517, (2015)
2015-07-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Critical book review: « NMR Spectroscopy in Liquid and Solids » by V. I. Bakhmutov

Anal. Bioanal. Chem., 407, 8625-8626, (2015).
2015-05-01 | Book review
Source: Self-asserted source
Philippe Lesot

Fast Acquisition of Multidimensional NMR Spectra of Solids and Mesophases using Alternative Sampling Methods

Magn. Reson. in Chem., 53, 927-939, (2015).
2015-04-01 | Journal issue or edition
Source: Self-asserted source
Philippe Lesot

Enantiotopic Discrimination in the NMR Spectrum of Prochiral Solutes in Chiral Liquid Crystals

Chem. Soc. Rev., 44, 230-275, (2015).
2015-03-01 | Journal article
Source: Self-asserted source
Philippe Lesot
grade
Preferred source (of 2)‎

Rapport de Conjoncture du CoNRS 2014 (INC / Section 12)

Chap. 12, 255-274, CoNRS-CNRS, CNRS Editions, Paris, France (2014). ISBN: 978-2-271-08746-1
2014-09-01 | Standards or policy
Source: Self-asserted source
Philippe Lesot

RMN 2D DAN dans les CLC: de Nouveaux Outils pour l’Etude du Fractionnement Isotopique Naturel (2H/1H) d’Acides Gras et de Triglycérides

Spectra Analyse, 299, 62-72, (2014).
2014-07-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Correlation 2D-NMR Experiments Involving both 13C and 2H Isotopes in Oriented Media: Methodological Developments and Analytical Applications

Magn. Reson. Chem., 52, 595-613, (2014).
2014-06-08 | Journal issue or edition
Source: Self-asserted source
Philippe Lesot

RMN 2D DAN dans les CLC: de Nouveaux Outils pour l’Etude du Fractionnement Isotopique Naturel (2H/1H) d’Acides Gras et de Triglycérides

Spectra Analyse, 299, 62-72, (2014).
2014-06-02 | Journal article
Source: Self-asserted source
Philippe Lesot

NMR Discrimination in Non-Rigid Prochiral Solutes Dissolved in Chiral Liquid Crystal Solvents: Symmetry Considerations

Magn. Reson. Chem., 52, 581-594, (2014).
2014-05-01 | Journal issue or edition
Source: Self-asserted source
Philippe Lesot

Criteria for Sensitivity Enhancement by Compressed Sensing: Practical Application to Anisotropic NAD 2D NMR Spectroscopy

Analyst, 139(11), 2702-2713, (2014).
2014-03-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Synthesis of enones, Pyrazolines and Pyrrolines with gem-difluoroalkyl Side Chains

Beilstein J. Org. Chem., 9, 1943–1948, (2013).
2013-09-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Deuterium NMR of Liquid-crystalline Samples at Natural Abundance

Encyclopedia of Magnetic Resonance (eMagRes), 2 (3), 315-334, (2013). J. Wiley: Chichester, Ed. R.K. Harris
2013-08-01 | Encyclopedia entry
Source: Self-asserted source
Philippe Lesot

Mesogenic Ionic Liquid Electrolytes with Strong Anisotropic Behavior: An Innovative Material for the Next Generation of Lithium-Polymer Batteries?

RSC Advance, 3, 16604-16611, (2013).
2013-08-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Synthesis of a Mycobacterium tuberculosis Tetra-Acylated Sulfolipid Analogue and Characterization of the Chiral Acyl Chains Using Anisotropic NAD 2D-NMR Spectroscopy

J. Org. Chem., 78, 7648−7657, (2013).
2013-07-01 | Journal article
Source: Self-asserted source
Philippe Lesot

On-the-fly’ Kinetics of Enzymatic Racemization using Deuterium NMR in DNA-based, Oriented Chiral Solvents

Anal. Chem., 85, 4694-4697, (2013).
2013-06-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Chiral Solutes Can Seed the Formation of Enantiomorphic Domains in a Twist-bend Nematic Liquid Crystal

Phys. Rev. E, 87, 040501-1/4(R), (2013).
2013-04-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Chiral Discrimination using Chiral Ordering Agents

AROULANDA Encyclopedia of Magnetic Resonance, 2nd Edition, Vol. 1, 578-586, (2012).
2012-08-01 | Journal article
Source: Self-asserted source
Philippe Lesot

Methodological Study of the Peptide Coupling of the N-desactivated Stable Proline Surrogate CF3-pseudoproline

Journal of Pept. Sci., 18, S1, S183-S183, (2012).
2012-07-19 | Conference paper
Source: Self-asserted source
Philippe Lesot

Détection d’Isotopomères 2H-13C en Abondance Naturelle par RMN 2D Isotrope et Anisotrope, ou Comment Distinguer Expérimentalement une Molécule parmi 600 000?

Spectra Analyse, 287, 24-30, (2012).
2012-07-07 | Magazine article
Source: Self-asserted source
Philippe Lesot

La RMN en Chimie Organique

L’actualité Chimique, 364-365, 30-41, (2012).
2012-07-01 | Journal issue or edition
Source: Self-asserted source
Philippe Lesot
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Peer review (40 reviews for 13 publications/grants)

Review activity for Analytical chemistry. (14)
Review activity for Angewandte Chemie. (4)
Review activity for Chemistry. (2)
Review activity for ChemistryOpen (1)
Review activity for ChemPhysChem. (2)
Review activity for ChemPlusChem. (1)
Review activity for Journal of chemical theory and computation : (2)
Review activity for Journal of natural products. (3)
Review activity for Journal of physical chemistry. (1)
Review activity for Journal of the American Chemical Society. (3)
Review activity for Nature (1)
Review activity for The journal of physical chemistry letters. (1)
Review activity for The journal of physical chemistry. (5)