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Genetics, Molecular epidemiology, Nucleolar biology, Epigenetics, Transcriptomics, Mendelian randomization, Reproductive health, Translational research, Trans-omics, Rare diseases, Aging, Cardiovascular disease, Precision medicine, Statistical genetics

Biography

I am an applied statistical geneticist and biostatistician specializing in multi-omics integration for precision
medicine. Currently, I am the Statistical Geneticist and Lead Biostatistician in Cardiovascular Medicine at
Beth Israel Deaconess Medical Center (BIDMC), a Harvard Medical School teaching hospital.

I earned a PhD in Public Health Genetics from the University of Washington, followed by postdoctoral
training at Harvard (machine learning and bioinformatics), the University of Bristol (Mendelian
randomization), and City of Hope (breast and ovarian cancer research). My expertise spans causal inference,
statistical genetics, and large-scale multi-omics research, with a focus on pipeline development and
translating genetic discoveries.

Beyond academia, I was a Principal Scientist at Teal Omics, an aging research biotech startup, where I
guided R&D and applied advanced statistical and computational methods to multi-omics datasets. I also hold
a unique triplet of master’s degrees in applied linguistics (MA), humanist chaplaincy (MTS), and genetic
epidemiology (MPH).

Activities

Employment (1)

Harvard University: Cambridge, Massachusetts, US

2020-04 to present
Employment
Source: Self-asserted source
Charleen Adams

Education and qualifications (4)

University of Washington: Seattle, WA, US

2013 to 2016 | PhD (Public Health Genetics)
Education
Source: Self-asserted source
Charleen Adams

Johns Hopkins University: Baltimore, Maryland, US

2012 | MPH (Johns Hopkins Bloomberg School of Public Health)
Education
Source: Self-asserted source
Charleen Adams

Trinity Lutheran Seminary: Columbus, Ohio, US

2002-07-01 to 2010-03-01 | Master of Theology (Divinity)
Education
Source: Self-asserted source
Charleen Adams

Northern Arizona University: Flagstaff, Arizona, US

2000-09-01 to 2002-05-01 | MA-TESL/Applied Linguistics (English)
Education
Source: Self-asserted source
Charleen Adams

Works (39)

Mendelian randomization reveals apolipoprotein B shortens healthspan and possibly increases risk for Alzheimer’s disease

Communications Biology
2024-02-24 | Journal article | Author
Part of ISSN: 2399-3642
Contributors: Leah Martin; Brian B. Boutwell; Carmen Messerlian; Charleen Adams
Source: Self-asserted source
Charleen Adams

Profiling the Somatic Mutational Landscape of Breast Tumors from Hispanic/Latina Women Reveals Conserved and Unique Characteristics.

Cancer research
2023-08-01 | Journal article | Author
Contributors: YUAN DING; Hanbing Song; Aaron Adamson; Daniel Schmolze; Donglei Hu; Scott Huntsman; Linda Steele; Carmina Patrick; Shu Tao; Natalie Hernandez et al.
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Trauma and female reproductive health across the lifecourse: motivating a research agenda for the future of women's health.

Human reproduction (Oxford, England)
2023-08-01 | Journal article
Contributors: Hillcoat A; Jaya Prakash; Martin L; Zhang Y; Rosa G; Henning Tiemeier; Torres N; Vicente Mustieles; Adams CD; Carmen Messerlian
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Profile of the somatic mutational landscape in breast tumors from Hispanic/Latina women

bioRxiv
2022 | Other
EID:

2-s2.0-85140754134

Part of ISSN: 26928205
Contributors: Ding, Y.C.; Song, H.; Adamson, A.; Schmolze, D.; Hu, D.; Huntsman, S.; Steele, L.; Patrick, C.; Hernandez, N.; Adams, C.D. et al.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

Lifestyle interventions to reduce endocrine-disrupting phthalate and phenol exposures among reproductive age men and women: A review and future steps.

Environment international
2022-10-14 | Journal article
Contributors: Martin L; Zhang Y; Olivia First; Vicente Mustieles; Dodson R; Rosa G; Coburn-Sanderson A; Adams CD; Carmen Messerlian
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Shared genomic architectures of COVID-19 and antisocial behavior.

Translational Psychiatry
2022-05 | Journal article
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 4)‎

A research note on Mendelian randomization and causal inference in criminology: promises and considerations

Journal of Experimental Criminology
2022-03 | Journal article
Part of ISSN: 1573-3750
Part of ISSN: 1572-8315
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Shared Genomic Architectures of COVID-19 and Antisocial Behavior

medRxiv
2021 | Other
EID:

2-s2.0-85129779052

Contributors: Adams, C.D.; Tielbeek, J.J.; Boutwell, B.B.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

What multiple mendelian randomization approaches reveal about obesity and gout

medRxiv
2021 | Other
EID:

2-s2.0-85105421687

Contributors: Adams, C.D.; Boutwell, B.B.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

Using multiple Mendelian randomization approaches and genetic correlations to understand obesity, urate, and gout

Scientific Reports
2021-12 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Molecular Psychiatry
2021-06 | Journal article
Part of ISSN: 1359-4184
Part of ISSN: 1476-5578
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 4)‎

A Preliminary Report on Alcohol-Associated DNA Methylation Changes and Suicidal Behavior: Evidence Using Mendelian Randomization

Illness, Crisis and Loss
2021-06-19 | Journal article
Part of ISSN: 1054-1373
Part of ISSN: 1552-6968
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

A Mendelian randomization study of telomere length and blood-cell traits

medRxiv
2020 | Other
EID:

2-s2.0-85099240091

Contributors: Adams, C.D.; Boutwell, B.B.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

Adventurousness cuts both ways: A Mendelian randomization of adventurousness on 10 cognitive and behavioral traits

medRxiv
2020 | Other
EID:

2-s2.0-85098930985

Contributors: Adams, C.D.; Boutwell, B.B.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

Can increasing years of schooling reduce type 2 diabetes (T2D)?—Evidence from a Mendelian randomization of T2D and 10 of its risk factors

medRxiv
2020 | Other
EID:

2-s2.0-85098930697

Contributors: Adams, C.D.; Boutwell, B.B.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

A Mendelian randomization study of telomere length and blood-cell traits

Scientific Reports
2020-12 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

A multivariable Mendelian randomization to appraise the pleiotropy between intelligence, education, and bipolar disorder in relation to schizophrenia

Scientific Reports
2020-12 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Can increasing years of schooling reduce type 2 diabetes (T2D)?: Evidence from a Mendelian randomization of T2D and 10 of its risk factors

Scientific Reports
2020-12 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

A Mendelian randomization study of circulating glutamine and red blood cell traits

Pediatric Blood & Cancer
2020-09 | Journal article
Part of ISSN: 1545-5009
Part of ISSN: 1545-5017
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Circulating sphingomyelins on estrogen receptor-positive and estrogen receptor-negative breast cancer-specific survival

Breast Cancer Management
2020-09-01 | Journal article
Part of ISSN: 1758-1923
Part of ISSN: 1758-1931
Source: Self-asserted source
Charleen Adams

Circulating Glutamine and Alzheimer’s Disease: A Mendelian Randomization Study

Clinical Interventions in Aging
2020-02 | Journal article
Part of ISSN: 1178-1998
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

A multivariable Mendelian randomization to appraise the pleiotropy between intelligence, education, and bipolar disorder in relation to schizophrenia

medRxiv
2019 | Other
EID:

2-s2.0-85098929712

Contributors: Adams, C.D.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

A preliminary report on alcohol-associated DNA methylation and suicidal behavior: Evidence using Mendelian randomization

medRxiv
2019 | Other
EID:

2-s2.0-85098931037

Contributors: Adams, C.D.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

Bi-directional Mendelian randomization of epithelial ovarian cancer and schizophrenia and uni-directional Mendelian randomization of schizophrenia on circulating glycerophosphocholine metabolites

bioRxiv
2019 | Other
EID:

2-s2.0-85095509463

Part of ISSN: 26928205
Contributors: Adams, C.D.; Neuhausen, S.L.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

Circulating glutamine and Alzheimer's disease: A Mendelian randomization study

bioRxiv
2019 | Other
EID:

2-s2.0-85095643151

Part of ISSN: 26928205
Contributors: Adams, C.D.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

Mendelian randomization analysis of smoking behavior and cognitive ability on the Big Five

medRxiv
2019 | Other
EID:

2-s2.0-85098930274

Contributors: Adams, C.D.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

Null effect of circulating sphingomyelins on risk for breast cancer: A Mendelian randomization report using Breast Cancer Association Consortium (BCAC) data.

medRxiv
2019 | Other
EID:

2-s2.0-85098930024

Contributors: Adams, C.D.
Source: Self-asserted source
Charleen Adams via Scopus - Elsevier
grade
Preferred source (of 2)‎

Bi-directional Mendelian randomization of epithelial ovarian cancer and schizophrenia and uni-directional Mendelian randomization of schizophrenia on circulating 1- or 2-glycerophosphocholine metabolites

Molecular Genetics and Metabolism Reports
2019-12 | Journal article
Part of ISSN: 2214-4269
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Null effect of circulating sphingomyelins on risk for breast cancer: a Mendelian randomization report using Breast Cancer Association Consortium (BCAC) data [version 1; peer review: 2 approved with reservations]

F1000Research
2019-12-18 | Journal article
Part of ISSN: 2046-1402
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 2)‎

Evaluating causal associations between chronotype and fatty acids and between fatty acids and type 2 diabetes: A Mendelian randomization study

Nutrition, Metabolism and Cardiovascular Diseases
2019-11 | Journal article
Part of ISSN: 0939-4753
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 4)‎

A brief tour of epidemiologic epigenetics and mental health

Current Opinion in Psychology
2019-06 | Journal article
Part of ISSN: 2352-250X
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial

International Journal of Cancer
2019-04-15 | Journal article
Part of ISSN: 0020-7136
Part of ISSN: 1097-0215
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 4)‎

The Precautionary Principle for Shift-Work Research and Decision-Making

Public Health Ethics
2019-04-01 | Journal article
Part of ISSN: 1754-9981
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

Cancer Epidemiology Biomarkers & Prevention
2019-01 | Journal article
Part of ISSN: 1055-9965
Part of ISSN: 1538-7755
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 4)‎

Circadian biology for public health

Nature
2017-11 | Journal article
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Nightshift work, chronotype, and genome-wide DNA methylation in blood

Epigenetics
2017-10-03 | Journal article
Part of ISSN: 1559-2294
Part of ISSN: 1559-2308
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Otologic manifestations of Fanconi anemia and other inherited bone marrow failure syndromes

Pediatric Blood & Cancer
2016-12 | Journal article
Part of ISSN: 1545-5009
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Prospectively Identified Incident Testicular Cancer Risk in a Familial Testicular Cancer Cohort

Cancer Epidemiology Biomarkers & Prevention
2015-10 | Journal article
Part of ISSN: 1055-9965
Part of ISSN: 1538-7755
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎

Response to “Civil time ≠ biological time: Recent options for empirically testing possible effects of chronodisruption”

Chronobiology International
2015-05-28 | Journal article
Part of ISSN: 0742-0528
Part of ISSN: 1525-6073
Source: Self-asserted source
Charleen Adams
grade
Preferred source (of 3)‎