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Works (3)

Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides

Bioconjugate Chemistry
2022-08-17 | Journal article
DOI: 10.1021/acs.bioconjchem.2c00288
Contributors: Gemma E. Mudd; Steven J. Stanway; David R. Witty; Alex Thomas; Silvia Baldo; Andrew D. Bond; Paul Beswick; Adrian Highton
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Synthesis of Vixotrigine, a Use-Dependent Sodium Channel Blocker. Part 1: Development of Bulk Supply Routes to Enable Proof of Concept

Organic Process Research & Development
2020-12-18 | Journal article
DOI: 10.1021/acs.oprd.0c00382
Contributors: Gerard Giblin; Adrian Heseltine; William Kiesman; David MacPherson; James Ramsden; Ravi Vadali; Michael Williams; David Witty
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Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia

ACS Medicinal Chemistry Letters
2020-09-10 | Journal article
DOI: 10.1021/acsmedchemlett.0c00263
Contributors: David R. Witty; Giuseppe Alvaro; Dominique Derjean; Gerard M. P. Giblin; Kevin Gunn; Charles Large; David T. Macpherson; Valerie Morisset; Davina Owen; Joanne Palmer et al.
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Peer review (2 reviews for 2 publications/grants)

Review activity for ACS medicinal chemistry letters. (1)
Review activity for Journal of medicinal chemistry. (1)
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