Personal information

Biostatistics, Randomization, Optimal Design, Clinical trials, Small population group trials, rare d
Germany

Activities

Employment (2)

RWTH Aachen University: Aachen, Nordrhein-Westfalen, DE

Employment
Source: check_circle
RWTH Aachen University

RWTH Aachen University: Aachen, Germany, DE

2001-10-01 to present | Department Chair (Medical Statistics)
Employment
Source: Self-asserted source
Ralf-Dieter Hilgers

Works (50 of 179)

Items per page:
Page 1 of 4

Methodological approaches for generating robust evidence from trials in rare diseases

Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen
2024 | Journal article
Contributors: Ralf-Dieter Hilgers
Source: Self-asserted source
Ralf-Dieter Hilgers

Methodological insights from the EPISTOP trial to designing clinical trials in rare diseases—A secondary analysis of a randomized clinical trial

PLOS ONE
2024-12-03 | Journal article
Contributors: Stephanie Wied; Dragan Hrncic; Ralf-Dieter Hilgers; Nicole Heussen; Katarzyna Kotulska; Maya Dirani; Mathieu Kuchenbuch; Sergiusz Jozwiak; Rima Nabbout
Source: check_circle
Crossref

Which Randomization Methods Are Used Most Frequently in Clinical Trials? Results of a Survey by the Randomization Working Group

Statistics in Biopharmaceutical Research
2024-10 | Journal article
Contributors: Oleksandr Sverdlov; Kerstine Carter; Ralf-Dieter Hilgers; Colin C. Everett; Vance W. Berger; Yuqun Abigail Luo; Jonathan J. Chipman; Yevgen Ryeznik; Jennifer Ross; Ruth Knight et al.
Source: check_circle
Crossref

Innovative methodologies for rare diseases clinical trials

Orphanet Journal of Rare Diseases
2024-05-07 | Journal article
Contributors: Rima Nabbout; Ralf-Dieter Hilgers
Source: check_circle
Crossref

Istore: a project on innovative statistical methodologies to improve rare diseases clinical trials in limited populations

Orphanet Journal of Rare Diseases
2024-03-02 | Journal article
Contributors: Stefanie Schoenen; Johan Verbeeck; Lukas Koletzko; Isabella Brambilla; Mathieu Kuchenbuch; Maya Dirani; Georg Zimmermann; Holger Dette; Ralf-Dieter Hilgers; Geert Molenberghs et al.
Source: check_circle
Crossref

Confidence interval comparison: Precision of maximum likelihood estimates in LLOQ affected data

PLOS ONE
2023-11-02 | Journal article
Contributors: Tanja Bülow; Harald Heinzl; Ralf-Dieter Hilgers; Nicole Heussen
Source: check_circle
Crossref

No difference in outcomes between large- and small-pore meshes in a prospective, randomized, multicenter trial investigating open retromuscular meshplasty for incisional hernia repair

Langenbeck's Archives of Surgery
2023-01-13 | Journal article
Contributors: Andreas Kroh; Markus Zufacher; Roman Eickhoff; Daniel Heise; Marius Helmedag; Florian Ulmer; Ulf P. Neumann; Joachim Conze; Ralf-Dieter Hilgers; Marcel Binnebösel
Source: check_circle
Crossref

Multimodal Treatment of Nasopharyngeal Carcinoma in Children, Adolescents and Young Adults-Extended Follow-Up of the NPC-2003-GPOH Study Cohort and Patients of the Interim Cohort

Cancers
2022-02 | Journal article | Author
Contributors: Tristan Römer; Sabrina Franzen; Hanna Kravets; Ahmed Farrag; Anna Makowska; Hans Christiansen; Michael J. Eble; Beate Timmermann; Gundula; Felix Mottaghy et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

A roadmap to using randomization in clinical trials

BMC Medical Research Methodology
2021-12 | Journal article
Contributors: Vance W. Berger; Louis Joseph Bour; Kerstine Carter; Jonathan J. Chipman; Colin C. Everett; Nicole Heussen; Catherine Hewitt; Ralf-Dieter Hilgers; Yuqun Abigail Luo; Jone Renteria et al.
Source: check_circle
Crossref

Design and analysis of stratified clinical trials in the presence of bias

Statistical Methods in Medical Research
2020-06 | Journal article
Contributors: Ralf-Dieter Hilgers; Martin Manolov; Nicole Heussen; William F Rosenberger
Source: check_circle
Crossref

CTLA-4 Polymorphisms in Patients with IgA Nephropathy Correlate with Proteinuria

Kidney & Blood Pressure Research
2018 | Journal article
WOSUID:

WOS:000434716500006

Contributors: Jacob, Marius; Ohl, Kim; Goodarzi, Tannaz; Harendza, Sigrid; Eggermann, Thomas; Fitzner, Christina; Hilgers, Ralf-Dieter; Bolte, Anna; Floege, Juergen; Rauen, Thomas et al.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

CTLA-4 Polymorphisms in Patients with IgA Nephropathy Correlate with Proteinuria

2018 | Journal article
Source: Self-asserted source
Ralf-Dieter Hilgers

Effects of Two Immunosuppressive Treatment Protocols for IgA Nephropathy

Journal of the American Society of Nephrology
2018 | Journal article
WOSUID:

WOS:000419070800031

Contributors: Rauen, Thomas; Fitzner, Christina; Eitner, Frank; Sommerer, Claudia; Zeier, Martin; Otte, Britta; Panzer, Ulf; Peters, Harm; Benck, Urs; Mertens, Peter R. et al.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Preterm Pulmonary Hemorrhage Is Associated with Multiple Births but Not with Intracytoplasmic Sperm Injection: A Cohort Study on Medical Records.

American journal of perinatology
2018 | Journal article
WOSUID:

MEDLINE:29635656

Contributors: Stierling, Stefanie; Hilgers, Ralf-Dieter; Trepels-Kottek, Sonja; Heimann, Konrad; Orlikowsky, Thorsten; Schoberer, Mark
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

randomizeR: An R Package for the Assessment and Implementation of Randomization in Clinical Trials

Journal of Statistical Software
2018 | Journal article
WOSUID:

WOS:000435611700001

Contributors: Uschner, Diane; Hilgers, Ralf-Dieter; Schindler, David; Heussen, Nicole
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

The impact of selection bias in randomized multi-arm parallel group clinical trials

Plos One
2018 | Journal article
WOSUID:

WOS:000423668400074

Contributors: Uschner, Diane; Hilgers, Ralf-Dieter; Heussen, Nicole
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Lessons learned from IDeAl — 33 recommendations from the IDeAl-net about design and analysis of small population clinical trials

Orphanet Journal of Rare Diseases
2018-12 | Journal article
Contributors: Ralf-Dieter Hilgers; Malgorzata Bogdan; Carl-Fredrik Burman; Holger Dette; Mats Karlsson; Franz König; Christoph Male; France Mentré; Geert Molenberghs; Stephen Senn
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Crossref
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Additional file 1: of Telemedical support for prehospital Emergency Medical Service (TEMS trial): study protocol for a randomized controlled trial

2017 | Report
Source: Self-asserted source
Ralf-Dieter Hilgers

Additional file 1: of Telemedical support for prehospital Emergency Medical Service (TEMS trial): study protocol for a randomized controlled trial

2017 | Report
Source: Self-asserted source
Ralf-Dieter Hilgers

Additional file 2: of Telemedical support for prehospital Emergency Medical Service (TEMS trial): study protocol for a randomized controlled trial

2017 | Report
Source: Self-asserted source
Ralf-Dieter Hilgers

Additional file 2: of Telemedical support for prehospital Emergency Medical Service (TEMS trial): study protocol for a randomized controlled trial

2017 | Report
Source: Self-asserted source
Ralf-Dieter Hilgers

Assessing the impact of selection bias on test decisions in trials with a time-to-event outcome

Statistics in Medicine
2017 | Journal article
WOSUID:

WOS:000404905200002

Contributors: Ruckbeil, Marcia Viviane; Hilgers, Ralf-Dieter; Heussen, Nicole
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Incidence of adult respiratory distress syndrome in trauma patients: A systematic review and meta-analysis over a period of three decades

Journal of Trauma and Acute Care Surgery
2017 | Journal article
WOSUID:

WOS:000408575700022

Contributors: Pfeifer, Roman; Heussen, Nicole; Michalewicz, Emilia; Hilgers, Ralf-Dieter; Pape, Hans-Christoph
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Maxillary advancement versus mandibular setback in class III dentofacial deformity: are there any differences in aesthetic outcomes?

International Journal of Oral and Maxillofacial Surgery
2017 | Journal article
WOSUID:

WOS:000398009500012

Contributors: Ghassemi, M.; Hilgers, R. -D.; Fritz, U.; Modabber, A.; Ghassemi, A.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Telemedical support for prehospital Emergency Medical Service (TEMS trial): study protocol for a randomized controlled trial

2017 | Other
Source: Self-asserted source
Ralf-Dieter Hilgers

Telemedical support for prehospital Emergency Medical Service (TEMS trial): study protocol for a randomized controlled trial

2017 | Other
Source: Self-asserted source
Ralf-Dieter Hilgers

Telemedical support for prehospital Emergency Medical Service (TEMS trial): study protocol for a randomized controlled trial

Trials
2017 | Journal article
WOSUID:

WOS:000392760300002

Contributors: Stevanovic, Ana; Beckers, Stefan Kurt; Czaplik, Michael; Bergrath, Sebastian; Coburn, Mark; Brokmann, Joerg Christian; Hilgers, Ralf-Dieter; Rossaint, Rolf; TEMS Collaboration Grp
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Testing the clinical value of multifocal electroretinography and microperimetry and the effects of intravitreal therapy with ranibizumab on macular function in the course of wet age- related macular degeneration: a 1-year prospective study

Clinical Ophthalmology
2017 | Journal article
WOSUID:

WOS:000398772800001

Contributors: Reinsberg, Mihaela; Hilgers, Ralf-Dieter; Luedeke, Inger; Nassar, Khaled; Grisanti, Swaantje; Grisanti, Salvatore; Lueke, Julia; Lueke, Matthias
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

The randomized shortened dental arch study: influence of two different treatments on interdental spacing over 5 years

Clinical Oral Investigations
2017 | Journal article
WOSUID:

WOS:000403936900004

Contributors: Kern, Jaana-Sophia; Wolfart, Stefan; Hilgers, Ralf-Dieter; Marre, Birgit; Scheller, Herbert; Strub, Joerg; Boening, Klaus; Hannak, Wolfgang; Luthardt, Ralph G.; Heydecke, Guido et al.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects

European Journal of Nutrition
2017 | Journal article
WOSUID:

WOS:000396039300010

Contributors: Rosenkranz, Eva; Hilgers, Ralf-Dieter; Uciechowski, Peter; Petersen, Arnd; Plumaekers, Birgit; Rink, Lothar
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

ERDO - a framework to select an appropriate randomization procedure for clinical trials

BMC Medical Research Methodology
2017-12 | Journal article
Contributors: Ralf-Dieter Hilgers; Diane Uschner; William F. Rosenberger; Nicole Heussen
Source: check_circle
Crossref
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Comparison of two different concepts of mesh and fixation technique in laparoscopic ventral hernia repair: a randomized controlled trial

Surgical Endoscopy and Other Interventional Techniques
2016 | Journal article
WOSUID:

WOS:000373021700049

Contributors: Pawlak, Maciej; Hilgers, Ralf-Dieter; Bury, Kamil; Lehmann, Andrzej; Owczuk, Radoslaw; Smietanski, Maciej
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Data Integration for Integrated Research and Care

Methods of Information in Medicine
2016 | Journal article
WOSUID:

WOS:000381446600011

Contributors: Winter, Alfred; Hilgers, Ralf-Dieter; Hofestaedt, Ralf; Knaup-Gregori, Petra; Ose, Claudia; Timmer, Antje
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Disinfection of gloves: feasible, but pay attention to the disinfectant/glove combination

Journal of Hospital Infection
2016 | Journal article
WOSUID:

WOS:000388542500014

Contributors: Scheithauer, S.; Hafner, H.; Seef, R.; Seef, S.; Hilgers, R. D.; Lemmen, S.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Effects of Smoking Cessation on Presynaptic Dopamine Function of Addicted Male Smokers

Biological Psychiatry
2016 | Journal article
WOSUID:

WOS:000379689200008

Contributors: Rademacher, Lena; Prinz, Susanne; Winz, Oliver; Henkel, Karsten; Dietrich, Claudia A.; Schmaljohann, Joern; Shali, Siamak Mohammadkhani; Schabram, Ina; Stoppe, Christian; Cumming, Paul et al.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Estimating the reliability of repeatedly measured endpoints based on linear mixed-effects models. A tutorial

Pharmaceutical Statistics
2016 | Journal article
WOSUID:

WOS:000388565400004

Contributors: Van der Elst, Wim; Molenberghs, Geert; Hilgers, Ralf-Dieter; Verbeke, Geert; Heussen, Nicole
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Hedgehog Blockade for Basal Cell Carcinoma Coming at a (Secondary Neoplastic) Price

Jama Dermatology
2016 | Journal article
WOSUID:

WOS:000375795400006

Contributors: Ruebben, Albert; Hilgers, Ralf-Dieter; Leverkus, Martin
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Induction of regulatory T cells in Th1-/Th17-driven experimental autoimmune encephalomyelitis by zinc administration

Journal of Nutritional Biochemistry
2016 | Journal article
WOSUID:

WOS:000371653100014

Contributors: Rosenkranz, Eva; Maywald, Martina; Hilgers, Ralf-Dieter; Brieger, Anne; Clarner, Tim; Kipp, Markus; Pluemaekers, Birgit; Meyer, Soeren; Schwerdtle, Tanja; Rink, Lothar
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Making sense of big data in health research: Towards an EU action plan

Genome Medicine
2016 | Journal article
WOSUID:

WOS:000378592900001

Contributors: Auffray, Charles; Balling, Rudi; Barroso, Ines; Bencze, Laszlo; Benson, Mikael; Bergeron, Jay; Bernal-Delgado, Enrique; Blomberg, Niklas; Bock, Christoph; Conesa, Ana et al.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Making sense of big data in health research: towards an EU action plan (vol 8, pg 71, 2016)

Genome Medicine
2016 | Journal article
WOSUID:

WOS:000387621900001

Contributors: Auffray, Charles; Balling, Rudi; Barroso, Ines; Bencze, Laszlo; Benson, Mikael; Bergeron, Jay; Bernal-Delgado, Enrique; Blomberg, Niklas; Bock, Christoph; Conesa, Ana et al.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Primary vitrectomy for rhegmatogenous retinal detachment in pseudophakic eyes: 20-gauge versus 25-gauge vitrectomy

Acta Ophthalmologica
2016 | Journal article
WOSUID:

WOS:000388576400048

Contributors: Suesskind, Daniela; Neuhann, Irmingard; Hilgers, Ralf-Dieter; Hagemann, Ulrike; Szurman, Peter; Bartz-Schmidt, Karl Ulrich; Aisenbrey, Sabine
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Progression characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS): a 2 year cohort study

Lancet Neurology
2016 | Journal article
WOSUID:

WOS:000387529800020

Contributors: Reetz, Kathrin; Dogan, Imis; Hilgers, Ralf-Dieter; Giunti, Paola; Mariotti, Caterina; Durr, Alexandra; Boesch, Sylvia; Klopstock, Thomas; Javier Rodriguez de Rivera, Francisco; Schols, Ludger et al.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Significant Reduction of External Ventricular Drainage-Associated Meningoventriculitis by Chlorhexidine-Containing Dressings: A Before-After Trial

Clinical Infectious Diseases
2016 | Journal article
WOSUID:

WOS:000370205600029

Contributors: Scheithauer, Simone; Schulze-Steinen, Henna; Hoellig, Anja; Lopez-Gonzalez, Luis; Hilgers, Ralf-Dieter; Reinges, Marcus H. T.; Marx, Gernot; Lemmen, Sebastian
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Subtarsal Versus Transconjunctival Approach-Esthetic and Functional Long-Term Experience

Journal of Oral and Maxillofacial Surgery
2016 | Journal article
WOSUID:

WOS:000389512200030

Contributors: Strobel, Lisa; Holzle, Frank; Riediger, Dieter; Hilgers, Ralf-Dieter; Modabber, Ali; Gerressen, Marcus
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures

Molecular Nutrition & Food Research
2016 | Journal article
WOSUID:

WOS:000372844200018

Contributors: Rosenkranz, Eva; Metz, Claudia H. D.; Maywald, Martina; Hilgers, Ralf-Dieter; Wessels, Inga; Senff, Tina; Haase, Hajo; Jaeger, Maximilian; Ott, Melanie; Aspinall, Richard et al.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Directions for new developments on statistical design and analysis of small population group trials

Orphanet Journal of Rare Diseases
2016-12 | Journal article
Contributors: Ralf-Dieter Hilgers; Kit Roes; Nigel Stallard
Source: check_circle
Crossref
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Preferred source (of 2)‎

Combined Tin-Containing Fluoride Solution and CO2 Laser Treatment Reduces Enamel Erosion in vitro

Caries Research
2015 | Journal article
WOSUID:

WOS:000368177600001

Contributors: Esteves-Oliveira, Marcella; Witulski, Nadine; Hilgers, Ralf-Dieter; Apel, Christian; Meyer-Lueckel, Hendrik; Eduardo, Carlos de Paula
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Effect of maxillary advancement on the change in the soft tissues after treatment of patients with class III malocclusion

British Journal of Oral & Maxillofacial Surgery
2015 | Journal article
WOSUID:

WOS:000361014100014

Contributors: Ghassemi, Mehrangiz; Hilgers, Ralf-Dieter; Jamilian, Abdolreza; Shokatbakhsh, Abdolrahman; Hoelzle, Frank; Fritz, Ulrike; Ghassemi, Alireza
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Good Medicine and Good Healthcare Demand Good Information (Systems)

Methods of Information in Medicine
2015 | Journal article
WOSUID:

WOS:000363599400001

Contributors: Winter, A.; Hilgers, R. -D.; Hofestaedt, R.; Huebnert, U.; Knaup-Gregori, P.; Ose, C.; Schmoor, C.; Timmer, A.; Wege, D.
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID

Inference for Blocked Randomization under a Selection Bias Model

Biometrics
2015 | Journal article
WOSUID:

WOS:000368187300014

Contributors: Kennes, Lieven N.; Rosenberger, William F.; Hilgers, Ralf-Dieter
Source: Self-asserted source
Ralf-Dieter Hilgers via ResearcherID
Items per page:
Page 1 of 4

Peer review (133 reviews for 3 publications/grants)

Review activity for Nature communications (2)
Review activity for Orphanet journal of rare diseases. (2)
Review activity for PloS one. (129)