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Astrocytic FABP5 mediates retrograde endocannabinoid transport at central synapses

iScience
2025-05 | Journal article
Contributors: Saida Oubraim; Mohammad Fauzan; Keith Studholme; Chris Gordon; Sherrye T. Glaser; Roh-Yu Shen; Iwao Ojima; Martin Kaczocha; Samir Haj-Dahmane
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Crossref

Nonlinear recurrent inhibition through facilitating serotonin release in the raphe

Nature Neuroscience
2025-04-02 | Journal article
Contributors: Michael B. Lynn; Sean D. Geddes; Mohamad Chahrour; Sébastien Maillé; Léa Caya-Bissonnette; Emerson Harkin; Érik Harvey-Girard; Samir Haj-Dahmane; Richard Naud; Jean-Claude Béïque
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Crossref

Fatty acid binding proteins are novel modulators of synaptic epoxyeicosatrienoic acid signaling in the brain

Scientific Reports
2023 | Journal article
EID:

2-s2.0-85171331739

Part of ISSN: 20452322
Contributors: Glaser, S.T.; Jayanetti, K.; Oubraim, S.; Hillowe, A.; Frank, E.; Jong, J.; Wang, L.; Wang, H.; Ojima, I.; Haj-Dahmane, S. et al.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses

iScience
2023 | Journal article
EID:

2-s2.0-85153939508

Part of ISSN: 25890042
Contributors: Oubraim, S.; Shen, R.-Y.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier
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Oxytocin Excites Dorsal Raphe Serotonin Neurons and Bidirectionally Gates Their Glutamate Synapses

SSRN
2023 | Other
EID:

2-s2.0-85149792931

Part of ISSN: 15565068
Contributors: Oubraim, S.; Shen, R.-Y.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Prenatal ethanol exposure leads to persistent anxiety-like behavior during adulthood indicated by reduced horizontal and vertical exploratory behaviors

Frontiers in Neuroscience
2023 | Journal article
EID:

2-s2.0-85153495625

Part of ISSN: 1662453X 16624548
Contributors: Wang, A.-L.; Micov, V.B.; Kwarteng, F.; Wang, R.; Hausknecht, K.A.; Oubraim, S.; Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Adolescent chronic unpredictable stress leads to increased anxiety and attention deficit/hyperactivity-like symptoms in adulthood

Psychopharmacology
2022 | Journal article
EID:

2-s2.0-85141645566

Part of ISSN: 14322072 00333158
Contributors: Kwarteng, F.; Wang, R.; Micov, V.; Hausknecht, K.A.; Turk, M.; Ishiwari, K.; Oubraim, S.; Wang, A.-L.; Richards, J.B.; Haj-Dahmane, S. et al.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Fatty Acid-Binding Protein 5 Modulates Brain Endocannabinoid Tone and Retrograde Signaling in the Striatum

Frontiers in Cellular Neuroscience
2022 | Journal article
EID:

2-s2.0-85134565442

Part of ISSN: 16625102
Contributors: Fauzan, M.; Oubraim, S.; Yu, M.; Glaser, S.T.; Kaczocha, M.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Mechanisms of endocannabinoid transport in the brain

British Journal of Pharmacology
2022 | Journal article
EID:

2-s2.0-85106590385

Part of ISSN: 14765381 00071188
Contributors: Kaczocha, M.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Nonlinear computation by a habenula-driven recurrent inhibitory network in the raphe

bioRxiv
2022 | Other
EID:

2-s2.0-85200275006

Part of ISSN: 26928205
Contributors: Lynn, M.B.; Geddes, S.; Chahrour, M.; Maillé, S.; Caya-Bissonnette, L.; Harkin, E.; Harvey-Girard, É.; Haj-Dahmane, S.; Naud, R.; Béïque, J.-C.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier
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Prenatal ethanol exposure causes anxiety-like phenotype and alters synaptic nitric oxide and endocannabinoid signaling in dorsal raphe nucleus of adult male rats

Translational Psychiatry
2022 | Journal article
EID:

2-s2.0-85139517034

Part of ISSN: 21583188
Contributors: Oubraim, S.; Wang, R.; Hausknecht, K.; Kaczocha, M.; Shen, R.-Y.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier
grade
Preferred source (of 2)‎

Prenatal ethanol exposure impairs sensory processing and habituation to visual stimuli, effects normalized by enrichment of postnatal environmental

Alcoholism: Clinical and Experimental Research
2022 | Journal article
EID:

2-s2.0-85128271100

Part of ISSN: 15300277 01456008
Contributors: Wang, R.; Martin, C.D.; Lei, A.L.; Hausknecht, K.A.; Turk, M.; Micov, V.; Kwarteng, F.; Ishiwari, K.; Oubraim, S.; Wang, A.-L. et al.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Moderate prenatal ethanol exposure leads to attention deficits in both male and female rats

Alcoholism: Clinical and Experimental Research
2021 | Journal article
EID:

2-s2.0-85104326547

Part of ISSN: 15300277 01456008
Contributors: Wang, R.; Martin, C.D.; Lei, A.L.; Hausknecht, K.A.; Ishiwari, K.; Oubraim, S.; Wang, A.-L.; Richards, J.B.; Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Tonic Endocannabinoid Signaling Gates Synaptic Plasticity in Dorsal Raphe Nucleus Serotonin Neurons Through Peroxisome Proliferator-Activated Receptors

Frontiers in Pharmacology
2021 | Journal article
EID:

2-s2.0-85109906060

Part of ISSN: 16639812
Contributors: Oubraim, S.; Wang, R.; Hausknecht, K.A.; Shen, R.-Y.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Cellular effects of serotonin in the CNS

Handbook of Behavioral Neuroscience
2020 | Book chapter
EID:

2-s2.0-85078151901

Part of ISSN: 15697339
Contributors: Andrade, R.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Cocaine self-administration abolishes endocannabinoid-mediated long-term depression of glutamatergic synapses in the ventral tegmental area

European Journal of Neuroscience
2020 | Journal article
EID:

2-s2.0-85091729311

Part of ISSN: 14609568 0953816X
Contributors: Wang, R.; Hausknecht, K.A.; Gancarz-Kausch, A.M.; Oubraim, S.; Shen, R.-Y.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood

Alcoholism: Clinical and Experimental Research
2020 | Journal article
EID:

2-s2.0-85078662383

Part of ISSN: 15300277 01456008
Contributors: Aghaie, C.I.; Hausknecht, K.A.; Wang, R.; Dezfuli, P.H.; Haj-Dahmane, S.; Kane, C.J.M.; Sigurdson, W.J.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Prenatal Ethanol Exposure Leads to Attention Deficits in Both Male and Female Rats

Frontiers in Neuroscience
2020 | Journal article
EID:

2-s2.0-85079189066

Part of ISSN: 1662453X 16624548
Contributors: Wang, R.; Martin, C.D.; Lei, A.L.; Hausknecht, K.A.; Ishiwari, K.; Richards, J.B.; Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Chemogenetic activation of ventral tegmental area GABA neurons, but not mesoaccumbal GABA terminals, disrupts responding to reward-predictive cues

Neuropsychopharmacology
2019 | Journal article
EID:

2-s2.0-85048119892

Part of ISSN: 1740634X 0893133X
Contributors: Wakabayashi, K.T.; Feja, M.; Baindur, A.N.; Bruno, M.J.; Bhimani, R.V.; Park, J.; Hausknecht, K.; Shen, R.-Y.; Haj-Dahmane, S.; Bass, C.E.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Prenatal ethanol exposure increases risk of psychostimulant addiction

Behavioural Brain Research
2019 | Journal article
EID:

2-s2.0-85051812223

Part of ISSN: 18727549 01664328
Contributors: Wang, R.; Shen, Y.-L.; Hausknecht, K.A.; Chang, L.; Haj-Dahmane, S.; Vezina, P.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Decreased environmental complexity during development impairs habituation of reinforcer effectiveness of sensory stimuli

Behavioural Brain Research
2018 | Journal article
EID:

2-s2.0-85030477962

Part of ISSN: 18727549 01664328
Contributors: Wang, R.; Hausknecht, K.A.; Haj-Dahmane, S.; Shen, R.-Y.; Richards, J.B.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Environmental enrichment reverses increased addiction risk caused by prenatal ethanol exposure

Drug and Alcohol Dependence
2018 | Journal article
EID:

2-s2.0-85054059227

Part of ISSN: 18790046 03768716
Contributors: Wang, R.; Hausknecht, K.A.; Shen, Y.-L.; Haj-Dahmane, S.; Vezina, P.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Fatty acid binding protein deletion prevents stress-induced preference for cocaine and dampens stress-induced corticosterone levels

Synapse
2018 | Journal article
EID:

2-s2.0-85042154087

Part of ISSN: 10982396 08874476
Contributors: Hamilton, J.; Marion, M.; Figueiredo, A.; Clavin, B.H.; Deutsch, D.; Kaczocha, M.; Haj-Dahmane, S.; Thanos, P.K.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Fatty acid-binding proteins 5 and 7 gene deletion increases sucrose consumption and diminishes forced swim immobility time

Behavioural Pharmacology
2018 | Journal article
EID:

2-s2.0-85051268623

Part of ISSN: 14735849 09558810
Contributors: Hamilton, J.; Koumas, C.; Clavin, B.H.; Marion, M.; Figueiredo, A.; Gonzalez, S.; O'Rourke, J.R.; Deutsch, D.; Kaczocha, M.; Haj-Dahmane, S. et al.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
EID:

2-s2.0-85044510227

Part of ISSN: 10916490 00278424
Contributors: Haj-Dahmane, S.; Shen, R.-Y.; Elmes, M.W.; Studholme, K.; Kanjiya, M.P.; Bogdan, D.; Thanos, P.K.; Miyauchi, J.T.; Tsirka, S.E.; Deutsch, D.G. et al.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Potentiation of glutamatergic synaptic transmission onto dorsal raphe serotonergic neurons in the valproic acid model of autism

Frontiers in Pharmacology
2018 | Journal article
EID:

2-s2.0-85055279217

Part of ISSN: 16639812
Contributors: Wang, R.; Hausknecht, K.; Shen, R.-Y.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Glua2-lacking AMPA receptors and nitric oxide signaling gate spike-timing–dependent potentiation of glutamate synapses in the dorsal raphe nucleus

eNeuro
2017 | Journal article
EID:

2-s2.0-85032164042

Part of ISSN: 23732822
Contributors: Haj-Dahmane, S.; Béïque, J.C.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier
grade
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Prenatal ethanol exposure persistently alters endocannabinoid signaling and endocannabinoid-mediated excitatory synaptic plasticity in ventral tegmental area dopamine neurons

Journal of Neuroscience
2017 | Journal article
EID:

2-s2.0-85020489671

Part of ISSN: 15292401 02706474
Contributors: Hausknecht, K.; Shen, Y.-L.; Wang, R.-X.; Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier
grade
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Slack K<sub>Na</sub> channels influence dorsal horn synapses and nociceptive behavior

Molecular Pain
2017 | Journal article
EID:

2-s2.0-85038952363

Part of ISSN: 17448069
Contributors: Evely, K.M.; Pryce, K.D.; Bausch, A.; Lukowski, R.; Ruth, P.; Haj-Dahmane, S.; Bhattacharjee, A.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Examination of the addictive and behavioral properties of fatty acid-binding protein inhibitor SBFI26

Frontiers in Psychiatry
2016 | Journal article
EID:

2-s2.0-84975260019

Part of ISSN: 16640640
Contributors: Thanos, P.K.; Clavin, B.H.; Hamilton, J.; O'Rourke, J.R.; Maher, T.; Koumas, C.; Miao, E.; Lankop, J.; Elhage, A.; Haj-Dahmane, S. et al.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Melatonin receptor activation increases glutamatergic synaptic transmission in the rat medial lateral habenula

Synapse
2016 | Journal article
EID:

2-s2.0-84961202813

Part of ISSN: 10982396 08874476
Contributors: Evely, K.M.; Hudson, R.L.; Dubocovich, M.L.; Haj-dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Target-specific modulation of the descending prefrontal cortex inputs to the dorsal raphe nucleus by cannabinoids

Proceedings of the National Academy of Sciences of the United States of America
2016 | Journal article
EID:

2-s2.0-84966318753

Part of ISSN: 10916490 00278424
Contributors: Geddes, S.D.; Assadzada, S.; Lemelin, D.; Sokolovski, A.; Bergeron, R.; Haj-Dahmane, S.; Béïque, J.-C.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Excitatory synaptic function and plasticity is persistently altered in ventral tegmental area dopamine neurons after prenatal ethanol exposure

Neuropsychopharmacology
2015 | Journal article
EID:

2-s2.0-84925488329

Part of ISSN: 1740634X 0893133X
Contributors: Hausknecht, K.; Haj-Dahmane, S.; Shen, Y.-L.; Vezina, P.; Dlugos, C.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Time-dependent modulation of glutamate synapses onto 5-HT neurons by antidepressant treatment

Neuropharmacology
2015 | Journal article
EID:

2-s2.0-84925449953

Part of ISSN: 18737064 00283908
Contributors: Geddes, S.D.; Assadzada, S.; Sokolovski, A.; Bergeron, R.; Haj-Dahmane, S.; Béïque, J.-C.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Chronic stress impairs α<sub>1</sub>-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus

Journal of Neuroscience
2014 | Journal article
EID:

2-s2.0-84908341518

Part of ISSN: 15292401 02706474
Contributors: Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Endocannabinoid signaling and the regulation of the serotonin system

Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders
2013 | Book chapter
EID:

2-s2.0-84929593584

Contributors: Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Prenatal stress exposure increases the excitation of dopamine neurons in the ventral tegmental area and alters their reponses to psychostimulants

Neuropsychopharmacology
2013 | Journal article
EID:

2-s2.0-84871421690

Part of ISSN: 0893133X 1740634X
Contributors: Hausknecht, K.; Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Serotonin neuron diversity in the dorsal raphe

ACS Chemical Neuroscience
2013 | Journal article
EID:

2-s2.0-84872520941

Part of ISSN: 19487193
Contributors: Andrade, R.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Endocannabinoids mediate the glucocorticoid-induced inhibition of excitatory synaptic transmission to dorsal raphe serotonin neurons

Journal of Physiology
2012 | Journal article
EID:

2-s2.0-84869805161

Part of ISSN: 00223751 14697793
Contributors: Wang, J.; Shen, R.-Y.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters - A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs

PLoS ONE
2012 | Journal article
EID:

2-s2.0-84870938235

Part of ISSN: 19326203
Contributors: Berger, W.T.; Ralph, B.P.; Kaczocha, M.; Sun, J.; Balius, T.E.; Rizzo, R.C.; Haj-Dahmane, S.; Ojima, I.; Deutsch, D.G.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Modulation of the serotonin system by endocannabinoid signaling

Neuropharmacology
2011 | Journal article
EID:

2-s2.0-79958148796

Part of ISSN: 00283908 18737064
Contributors: Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Regulation of plasticity of glutamate synapses by endocannabinoids and the cyclic-AMP/protein kinase A pathway in midbrain dopamine neurons

Journal of Physiology
2010 | Journal article
EID:

2-s2.0-77954730199

Part of ISSN: 00223751 14697793
Contributors: Haj-Dahmane, S.; Shen, R.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Endocannabinoids suppress excitatory synaptic transmission to dorsal raphe serotonin neurons through the activation of presynaptic CB<sub>1</sub> receptors

Journal of Pharmacology and Experimental Therapeutics
2009 | Journal article
EID:

2-s2.0-70349311447

Part of ISSN: 00223565 15210103
Contributors: Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

D<sub>2</sub>-like dopamine receptors depolarize dorsal raphe serotonin neurons through the activation of nonselective cationic conductance

Journal of Pharmacology and Experimental Therapeutics
2007 | Journal article
EID:

2-s2.0-33845907429

Part of ISSN: 00223565 15210103
Contributors: Aman, T.K.; Shen, R.-Y.; Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Effects of prenatal ethanol exposure on the excitability of ventral tegmental area dopamine neurons in vitro

Journal of Pharmacology and Experimental Therapeutics
2006 | Journal article
EID:

2-s2.0-33751197515

Part of ISSN: 00223565 15210103
Contributors: Wang, J.; Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling

Journal of Neuroscience
2005 | Journal article
EID:

2-s2.0-12844284453

Part of ISSN: 02706474
Contributors: Haj-Dahmane, S.; Shen, R.-Y.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

The 5-HT<sub>4</sub> receptor-induced depolarization in rat hippocampal neurons is mediated by cAMP but is independent of I<sub>h</sub>

Neuroscience Letters
2002 | Journal article
EID:

2-s2.0-0037052728

Part of ISSN: 03043940
Contributors: Chapin, E.M.; Haj-Dahmane, S.; Andrade, R.; Torres, G.; Andrade, R.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

D<sub>2</sub>-like dopamine receptor activation excites rat dorsal raphe 5-HT neurons in vitro

European Journal of Neuroscience
2001 | Journal article
EID:

2-s2.0-0034742514

Part of ISSN: 0953816X
Contributors: Haj-Dahmane, S.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Muscarinic receptors regulate two different calcium-dependent non-selective cation currents in rat prefrontal cortex

European Journal of Neuroscience
1999 | Journal article
EID:

2-s2.0-0033005499

Part of ISSN: 0953816X
Contributors: Haj-Dahmane, S.; Andrade, R.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier

Ionic mechanism of the slow afterdepolarization induced by muscarinic receptor activation in rat prefrontal cortex

Journal of Neurophysiology
1998 | Journal article
EID:

2-s2.0-0031761727

Part of ISSN: 00223077
Contributors: Haj-dahmane, S.; Andrade, R.
Source: Self-asserted source
Samir Haj-Dahmane via Scopus - Elsevier
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Peer review (4 reviews for 2 publications/grants)

Review activity for iScience. (3)
Review activity for Molecular and cellular neurosciences. (1)