Personal information

PBPK, Long-acting, Nanoformulation, HIV, Antiretroviral
India

Activities

Employment (2)

University of Liverpool: Liverpool, GB

2016-03-01 to present | Research Fellow (Pharmacology & Therapeutics)
Employment
Source: check_circle
University of Liverpool via ORCID Member Portal

University of Liverpool: Liverpool, GB

2016-03-01 to 2020-11-02 | Research Associate (Molecular and Clinical Pharmacology)
Employment
Source: Self-asserted source
Rajith Kumar Reddy Rajoli

Education and qualifications (3)

University of Liverpool: Liverpool, GB

2013-01 to 2016-01 | Doctor of Philosophy
Education
Source: Self-asserted source
Rajith Kumar Reddy Rajoli

University College London: London, GB

2010 to 2011 | MSc Drug Delivery (School of Pharmacy)
Education
Source: Self-asserted source
Rajith Kumar Reddy Rajoli

Birla Institute of Technology and Science, Pilani: Pilani, Rajasthan, IN

2005-08-01 to 2009-05-31 | Bachelor of Pharmacy (Hons.)
Education
Source: Self-asserted source
Rajith Kumar Reddy Rajoli

Works (38)

Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters

Viruses
2024-11 | Journal article | Author
Contributors: Megan Neary; Eduardo Gallardo-Toledo; Joanne Sharp; Joanne Herriott; Edyta Kijak; Chloe Bramwell; Helen Cox; Lee Tatham; Helen Box; Paul Curley et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Physiologically Based Pharmacokinetic Modelling of Cabotegravir Microarray Patches in Rats and Humans

Pharmaceutics
2023-11-30 | Journal article
Contributors: Hannah Kinvig; Rajith K. R. Rajoli; Henry Pertinez; Lalitkumar K. Vora; Fabiana Volpe-Zanutto; Ryan F. Donnelly; Steve Rannard; Charles Flexner; Marco Siccardi; Andrew Owen
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters

Viruses
2023-10-27 | Journal article
Contributors: Eduardo Gallardo-Toledo; Megan Neary; Joanne Sharp; Joanne Herriott; Edyta Kijak; Chloe Bramwell; Paul Curley; Usman Arshad; Henry Pertinez; Rajith K. R. Rajoli et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells

Viruses
2022-02 | Journal article | Author
Contributors: Carolina Sacramento; Fintelman-Rodrigues, N; Suelen da Silva Gomes Dias; Temerozo, JR; Aline de Paula D. Da Silva; Carine S. da Silva; Camilla Blanco; André C. Ferreira; Mayara Mattos; Vinicius Cardoso et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research

BioRxiv
2021 | Journal article
Contributors: Neary, M.; Arshad, U.; Tatham, L.; Pertinez, H.; Box, H.; Rajoli, R. K.; Valentijn, A.; Sharp, J.; Rannard, S. P.; Biagini, G. A. et al.
Source: check_circle
Web of Science Researcher Profile Sync

Pharmacokinetic modelling to estimate intracellular favipiravir ribofuranosyl-5′-triphosphate exposure to support posology for SARS-CoV-2

Journal of Antimicrobial Chemotherapy
2021-07-15 | Journal article
Contributors: Henry Pertinez; Rajith K R Rajoli; Saye H Khoo; Andrew Owen
Source: check_circle
Crossref

Dose prediction for repurposing nitazoxanide in SARS‐CoV‐2 treatment or chemoprophylaxis

British Journal of Clinical Pharmacology
2021-04 | Journal article
Contributors: Rajith K. R. Rajoli; Henry Pertinez; Usman Arshad; Helen Box; Lee Tatham; Paul Curley; Megan Neary; Joanne Sharp; Neill J. Liptrott; Anthony Valentijn et al.
Source: check_circle
Crossref

Development of a highly sensitive bioanalytical assay for the quantification of favipiravir

2021-02 | Preprint
OTHER-ID:

PPR278759

Contributors: Curley P; Neary M; Arshad U; Tatham L; Pertinez H; Box H; Rajoli RK; Valentijn A; Sharp J; Rannard SP et al.
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central
grade
Preferred source (of 2)‎

Optimisation and validation of a sensitive bioanalytical method for niclosamide

2021-01 | Preprint
OTHER-ID:

PPR265508

Contributors: Arshad U; Pertinez H; Box H; Tatham L; Rajoli RK; Neary M; Sharp J; Valentijn A; Hobson J; Unsworth C et al.
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Pharmacokinetic modelling to estimate intracellular favipiravir ribofuranosyl-5’-triphosphate exposure to support posology for SARS-CoV-2

2021-01 | Preprint
OTHER-ID:

PPR261960

Contributors: Pertinez H; Rajoli RK; Khoo SH; Owen A
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central
grade
Preferred source (of 2)‎

Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

2021-01 | Preprint
OTHER-ID:

PPR275627

Contributors: Hobson J; Savage A; Dwyer A; Unsworth C; Arshad U; Pertinez H; box h; Tatham L; Rajoli RKR; Neary M et al.
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?

ACS infectious diseases
2020-12 | Journal article
Contributors: Stachulski AV; Taujanskas J; Pate SL; Rajoli RKR; Aljayyoussi G; Pennington SH; Ward SA; Hong WD; Biagini GA; Owen A et al.
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

The Current Landscape of Novel Formulations and the Role of Mathematical Modeling in Their Development.

Journal of clinical pharmacology
2020-10 | Journal article
Contributors: Cottura N; Howarth A; Rajoli RKR; Siccardi M
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Physiologically-based Pharmacokinetic (PBPK) Modeling for Prediction of the Optimal Dose Regimens of Quinine and Phenobarbital Co-administration in Adult Patients with Cerebral Malaria and Seizures

2020-08 | Preprint
OTHER-ID:

PPR198175

Contributors: Saeheng T; Karbwang J; Rajoli RKR; Siccardi M; Na-Bangchang K
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Predicting Pharmacokinetics of a Tenofovir Alafenamide Subcutaneous Implant Using Physiologically Based Pharmacokinetic Modelling

Antimicrobial Agents and Chemotherapy
2020-07-22 | Journal article
Contributors: Rajith K. R. Rajoli; Zach R. Demkovich; Charles Flexner; Andrew Owen; Marco Siccardi
Source: check_circle
Crossref

Prioritization of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.

Clinical pharmacology and therapeutics
2020-06 | Journal article
Contributors: Arshad U; Pertinez H; Box H; Tatham L; Rajoli RKR; Curley P; Neary M; Sharp J; Liptrott NJ; Valentijn A et al.
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

The in vitro antiviral activity of the anti-hepatitis C virus (HCV) drugs daclatasvir and sofosbuvir against SARS-CoV-2

2020-06 | Preprint
OTHER-ID:

PPR176779

Contributors: Sacramento CQ; Fintelman-Rodrigues N; Temerozo JR; de Paula Dias Da Silva A; da Silva Gomes Dias S; dos Santos da Silva C; Ferreira AC; Mattos M; Souza TML
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis

2020-05-06 | Other
Contributors: Rajith KR Rajoli; Henry Pertinez; Usman Arshad; Helen Box; Lee Tatham; Paul Curley; Megan Neary; Joanne Sharp; Neill J Liptrott; Anthony Valentijn et al.
Source: check_circle
Crossref

Modelling of Systemic versus Pulmonary Chloroquine Exposure in Man for COVID-19 Dose Selection

2020-04-30 | Other
Contributors: Ghaith Aljayyoussi; Rajith KR Rajoli; Henry Pertinez; Shaun H Pennington; W. David Hong; Paul M. O’Neill; Andrew Owen; Steve A Ward; Giancarlo A Biagini
Source: check_circle
Crossref

Prioritisation of potential anti-SARS-CoV-2 drug repurposing opportunities based on ability to achieve adequate plasma and target site concentrations derived from their established human pharmacokinetics

2020-04-22 | Other
Contributors: Usman Arshad; Henry Pertinez; Helen Box; Lee Tatham; Rajith KR Rajoli; Paul Curley; Megan Neary; Joanne Sharp; Neill J Liptrott; Anthony Valentijn et al.
Source: check_circle
Crossref

Prediction of dolutegravir pharmacokinetics and dose optimization in neonates via physiologically based pharmacokinetic (PBPK) modelling

Journal of Antimicrobial Chemotherapy
2020-03-01 | Journal article
Contributors: Fazila Bunglawala; Rajith K R Rajoli; Mark Mirochnick; Andrew Owen; Marco Siccardi
Source: check_circle
Crossref

Physiologically-Based Pharmacokinetic Modeling for Optimal Dosage Prediction of Quinine Coadministered With Ritonavir-Boosted Lopinavir.

Clinical pharmacology and therapeutics
2019-11-13 | Journal article
Source: Self-asserted source
Rajith Kumar Reddy Rajoli

Modelling the intradermal delivery of microneedle array patches for long-acting antiretrovirals using PBPK.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
2019-09-13 | Journal article
Source: Self-asserted source
Rajith Kumar Reddy Rajoli

Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies.

European Journal of Pharmaceutical Sciences
2019-09-10 | Journal article
Source: Self-asserted source
Rajith Kumar Reddy Rajoli

Predicting Drug–Drug Interactions Between Rifampicin and Long-Acting Cabotegravir and Rilpivirine Using Physiologically Based Pharmacokinetic Modeling

The Journal of Infectious Diseases
2019-05-05 | Journal article
Contributors: Rajith K R Rajoli; Paul Curley; Justin Chiong; David Back; Charles Flexner; Andrew Owen; Marco Siccardi
Source: check_circle
Crossref

Modelling the long-acting administration of anti-tuberculosis agents using PBPK: a proof of concept study.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
2018-08 | Journal article
Contributors: Rajoli RKR; Podany AT; Moss DM; Swindells S; Flexner C; Owen A; Siccardi M
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Physiologically-based pharmacokinetic modelling of infant exposure to efavirenz through breastfeeding [version 1; referees: awaiting peer review]

2018-05-14 | Journal article
Part of ISSN: 2515-9321
Contributors: Adeniyi Olagunju; Rajith K. R. Rajoli; Shakir A. Atoyebi; Saye Khoo; Andrew Owen; Marco Siccardi
Source: check_circle
African Academy of Sciences (AAS) - Open Research
grade
Preferred source (of 2)‎

Physiologically based pharmacokinetic modelling prediction of the effects of dose adjustment in drug-drug interactions between levonorgestrel contraceptive implants and efavirenz-based ART.

The Journal of antimicrobial chemotherapy
2018-04 | Journal article
Contributors: Roberts O; Rajoli RKR; Back DJ; Owen A; Darin KM; Fletcher CV; Lamorde M; Scarsi KK; Siccardi M
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach.

Drug metabolism and pharmacokinetics
2018-03 | Journal article
Contributors: Chan CYS; Roberts O; Rajoli RKR; Liptrott NJ; Siccardi M; Almond L; Owen A
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate.

Antimicrobial agents and chemotherapy
2017-07 | Journal article
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

In Silico Dose Prediction for Long-Acting Rilpivirine and Cabotegravir Administration to Children and Adolescents.

Clinical pharmacokinetics
2017-05 | Journal article
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation.

2017-01 | Journal article
Contributors: Curley P; Rajoli RK; Moss DM; Liptrott NJ; Letendre S; Owen A; Siccardi M
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

A physiologically based pharmacokinetic model to predict the superparamagnetic iron oxide nanoparticles (SPIONs) accumulation in vivo

European Journal of Nanomedicine
2017-01-01 | Journal article
Contributors: Adny Henrique Silva; Enio Lima Jr; Marcelo Vasquez Mansilla; Roberto Daniel Zysler; Mary Luz Mojica Pisciotti; Claudriana Locatelli; Rajith Kumar Reddy Rajoli; Andrew Owen; Tânia Beatriz Creczynski-Pasa; Marco Siccardi
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Crossref Metadata Search

Use of a physiologically based pharmacokinetic model to simulate drug-drug interactions between antineoplastic and antiretroviral drugs.

2016-12 | Journal article
Contributors: Moltó J; Rajoli R; Back D; Valle M; Miranda C; Owen A; Clotet B; Siccardi M
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions with Efavirenz Involving Simultaneous Inducing and Inhibitory Effects on Cytochromes.

2016-09 | Journal article
Contributors: Marzolini C; Rajoli R; Battegay M; Elzi L; Back D; Siccardi M
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies.

2015 | Journal article
Contributors: Moss DM; Marzolini C; Rajoli RK; Siccardi M
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV.

2015-06 | Journal article
Contributors: Rajoli RK; Back DJ; Rannard S; Freel Meyers CL; Flexner C; Owen A; Siccardi M
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Europe PubMed Central

Physiologically based pharmacokinetic models for the optimization of antiretroviral therapy: recent progress and future perspective

Future Virology
2013-09 | Journal article
Contributors: Marco Siccardi; Rajith Kumar Reddy Rajoli; Paul Curley; Adeniyi Olagunju; Darren Moss; Andrew Owen
Source: Self-asserted source
Rajith Kumar Reddy Rajoli via Crossref Metadata Search

Peer review (10 reviews for 6 publications/grants)

Review activity for Drug design, development and therapy (1)
Review activity for International journal of medical sciences[electronic resource]. (3)
Review activity for International journal of nanomedicine. (2)
Review activity for Journal of clinical medicine. (2)
Review activity for Molecules. (1)
Review activity for Scientific reports. (1)