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Biography

My research focuses on psychopharmacology, employing experimental studies to investigate the impact of various drugs on cognition, subjective experiences, and driving performance. I've explored the effects of medicinal drugs such as antihistamines and antidepressants, as well as illicit substances, with a focus on (synthetic) cannabis and novel psychoactive substances (NPS).

Activities

Employment (2)

Maastricht University: Maastricht, Limburg, NL

2007 to present | Assistant professor (Neuropsychology and psychopharmacology)
Employment
Source: Self-asserted source
Eef Theunissen

Maastricht University: Maastricht, Limburg, NL

2005 to 2007 | Post doc (Neuropsychology and psychopharmacology)
Employment
Source: Self-asserted source
Eef Theunissen

Works (50 of 112)

Items per page:
Page 1 of 3

Use patterns of classic, novel, and herbal opioids

Emerging Trends in Drugs, Addictions, and Health
2025-12-01 | Journal article | Author
SOURCE-WORK-ID:

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EID:

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Contributors: Elisabeth Prevete; N.L. Mason; Kim P. C. Kuypers; Eef Theunissen; Pablo Mallaroni; Massimo Pasquini; Johannes Ramaekers
Source: check_circle
Maastricht University

A Preliminary Inventory of Kratom (Mitragyna Speciosa) Products and Vendors on the Darknet and Cryptomarkets

Journal of Psychoactive Drugs
2024 | Journal article | Author
SOURCE-WORK-ID:

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EID:

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Contributors: Elisabeth Prevete; Valeria Catalani; Darshan Singh; Kim P. C. Kuypers; Eef Theunissen; Honor D. Townshend; Hani Banayoti; Johannes Ramaekers; Massimo Pasquini; Ornella Corazza
Source: check_circle
Maastricht University

An exploratory study of the safety profile and neurocognitive function after single doses of mitragynine in humans

Psychopharmacology
2024-12-26 | Journal article | Author
SOURCE-WORK-ID:

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EID:

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Contributors: Elisabeth Prevete; Eef Theunissen; Kim P. C. Kuypers; Riccardo Paci; Johannes Reckweg; Mauro Cavarra; Stefan W. Toennes; Sabrina Ritscher; Giuseppe Bersani; Ornella Corazza et al.
Source: check_circle
Maastricht University

Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC)

Neuropsychopharmacology
2024-12-24 | Journal article | Author
SOURCE-WORK-ID:

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EID:

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Contributors: Johannes Ramaekers; Johannes Reckweg; N.L. Mason; Kim P. C. Kuypers; Stefan W. Toennes; Eef Theunissen
Source: check_circle
Maastricht University

Inter-individual variability in neural response to low doses of LSD

Translational Psychiatry
2024-07-15 | Journal article | Author
SOURCE-WORK-ID:

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WOSUID:

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EID:

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Contributors: Nadia Hutten; Conny W.E.M. Quaedflieg; N.L. Mason; Eef Theunissen; Matthias E. Liechti; Urs Duthaler; Kim P. C. Kuypers; Valerie Bonnelle; Amanda Feilding; Johannes Ramaekers
Source: check_circle
Maastricht University

The prevalence, risks, and detection of driving under the influence of nitrous oxide

Wiley Interdisciplinary Reviews: Forensic Science
2024-03 | Review | Author
SOURCE-WORK-ID:

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Contributors: Frederick Vinckenbosch; Dinesh Duran Jimenez; Hendrik Helmerhorst; Albert Dahan; Leon Aarts; Floris Bikker; Eef Theunissen; Johannes Ramaekers
Source: check_circle
Maastricht University

Recreational Nitrous Oxide Dosing and Administration and Its Use in Traffic

Journal of Drug Issues
2024-02-01 | Journal article | Author
SOURCE-WORK-ID:

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EID:

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Contributors: Frederick Vinckenbosch; Eef Theunissen; Agnieszka Stelling; Charles Goldenbeld; Johannes Ramaekers
Source: check_circle
Maastricht University

Assessment of the Acute Effects of 2C-B vs. Psilocybin on Subjective Experience, Mood, and Cognition

Clinical Pharmacology & Therapeutics
2023-08 | Journal article | Author
SOURCE-WORK-ID:

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EID:

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Contributors: Pablo Mallaroni; N.L. Mason; Johannes Reckweg; Riccardo Paci; Sabrina Ritscher; Stefan W Toennes; Eef Theunissen; Kim P. C. Kuypers; Johannes Ramaekers
Source: check_circle
Maastricht University

A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression

Frontiers in Psychiatry
2023-06-20 | Journal article | Author
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EID:

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Contributors: Johannes Reckweg; Cees van Leeuwen; Cécile Henquet; Therese van Amelsvoort; Eef Theunissen; N.L. Mason; Riccardo Paci; Theis H. Terwey; Johannes Ramaekers
Source: check_circle
Maastricht University

Clinical Implications of Kratom (Mitragyna speciosa) Use

Current Addiction Reports
2023-06-01 | Review | Author
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EID:

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Contributors: Elisabeth Prevete; Kim P. C. Kuypers; Eef Theunissen; Gianluca Esposito; Johannes Ramaekers; Massimo Pasquini; Ornella Corazza
Source: check_circle
Maastricht University

Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis

Psychopharmacology
2022-11 | Journal article | Author
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EID:

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Contributors: Nadia Hutten; T. R. Arkell; Frederick Vinckenbosch; jan schepers; R. C. Kevin; Eef Theunissen; Kim P. C. Kuypers; I. S. McGregor; Johannes Ramaekers
Source: check_circle
Maastricht University

Psychotomimetic symptoms after a moderate dose of a synthetic cannabinoid (JWH-018)

Psychopharmacology
2022-05 | Journal article | Author
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Contributors: Eef Theunissen; Johannes Reckweg; Nadia Hutten; Kim P. C. Kuypers; Stefan W. Toennes; Merja A. Neukamm; Sebastian Halter; Johannes Ramaekers
Source: check_circle
Maastricht University

A Comparison of Acute Neurocognitive and Psychotomimetic Effects of a Synthetic Cannabinoid and Natural Cannabis at Psychotropic Dose Equivalence

Frontiers in Psychiatry
2022-05-19 | Journal article | Author
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Contributors: Eef Theunissen; Kim P. C. Kuypers; N.L. Mason; Johannes Ramaekers
Source: check_circle
Maastricht University

Cannabis Use and Neuroadaptation

Frontiers in Psychiatry
2022-04-14 | Journal article | Author
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EID:

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Contributors: Johannes Ramaekers; Eef Theunissen; Peter van Ruitenbeek; N.L. Mason
Source: check_circle
Maastricht University

Sex differences in acute cannabis effects revisited

Addiction Biology
2022-03 | Journal article | Author
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EID:

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Contributors: Thomas Arkell; R.C. Kevin; Frederick Vinckenbosch; N. Lintzeris; Eef Theunissen; Johannes Ramaekers; I.S. McGregor
Source: check_circle
Maastricht University

Functional brain connectomes reflect acute and chronic cannabis use

Scientific Reports
2022-02-14 | Journal article | Author
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Contributors: Johannes Ramaekers; N.L. Mason; S. W. Toennes; Eef Theunissen; E. Amico
Source: check_circle
Maastricht University

A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans

Human psychopharmacology
2022-01 | Review | Author
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EID:

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Contributors: Elisabeth Prevete; Kim P. C. Kuypers; Eef Theunissen; Ornella Corazza; Giuseppe Bersani; Johannes Ramaekers
Source: check_circle
Maastricht University

Driving Aptitude and Fitness to Drive

Handbook of Forensic Medicine, Second Edition: Volume 1-3
2022-01-01 | Book chapter | Author
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EID:

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Part of ISBN: 9781119648628
Part of ISBN: 9781119648550
Contributors: Frederick Vinckenbosch; Annemiek Vermeeren; Eef Theunissen; Johannes Ramaekers
Source: check_circle
Maastricht University

Effects of Medicinal Drugs on Fitness to Drive

Handbook of Forensic Medicine, Second Edition: Volume 1-3
2022-01-01 | Book chapter | Author
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EID:

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Part of ISBN: 9781119648628
Part of ISBN: 9781119648550
Contributors: Eef Theunissen; Kim P. C. Kuypers; Annemiek Vermeeren; Frederick Vinckenbosch; Johannes Ramaekers
Source: check_circle
Maastricht University

P824. Creative Processes Under the Influence of a Low Dose of LSD

Neuropsychopharmacology
2021-12-01 | Conference abstract | Author
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Contributors: Kim P. C. Kuypers; Nadia Hutten; N.L. Mason; P. Dolder; Eef Theunissen; F. Holze; M. Liechti; A. Feilding; Johannes Ramaekers
Source: check_circle
Maastricht University

Reply to

Nature Reviews Neuroscience
2021-09 | Journal article | Author
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Contributors: Johannes Ramaekers; N.L. Mason; Lilian Kloft; Eef Theunissen
Source: check_circle
Maastricht University

The why behind the high

Nature Reviews Neuroscience
2021-07 | Review | Author
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Contributors: Johannes Ramaekers; N.L. Mason; Lilian Kloft; Eef Theunissen
Source: check_circle
Maastricht University

Phase 1 clinical trials in psychopharmacology

Modern CNS Drug Discovery: Reinventing the Treatment of Psychiatric and Neurological Disorders
2021-06-17 | Book chapter | Author
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Part of ISBN: 9783030623517
Part of ISBN: 9783030623500
Contributors: Eef Theunissen
Source: check_circle
Maastricht University

A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers

Journal of Psychopharmacology
2021-04 | Journal article | Author
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Contributors: Johannes Ramaekers; Nadia Hutten; N.L. Mason; Patrick Dolder; Eef Theunissen; Friederike Holze; Matthias E Liechti; Amanda Feilding; Kim P. C. Kuypers
Source: check_circle
Maastricht University

Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

ACS Pharmacology & Translational Science
2021-04-09 | Journal article | Author
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Contributors: Nadia Hutten; N.L. Mason; Patrick C. Dolder; Eef Theunissen; Friederike Holze; Matthias E Liechti; Nimmy Varghese; Anne Eckert; Amanda Feilding; Johannes Ramaekers et al.
Source: check_circle
Maastricht University

Intoxication by a synthetic cannabinoid (JWH-018) causes cognitive and psychomotor impairment in recreational cannabis users

Pharmacology, Biochemistry and Behavior
2021-03 | Journal article | Author
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Contributors: Eef Theunissen; Johannes Reckweg; Nadia Hutten; Kim P. C. Kuypers; Stefan W Toennes; Merja A Neukamm; Sebastian Halter; Johannes Ramaekers
Source: check_circle
Maastricht University

P.329 State anxiety induced by THC and CBD does not change after correcting for baseline anxiety levels

European Neuropsychopharmacology
2021-03 | Conference abstract | Author
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Contributors: Nadia Hutten; Thomas Arkell; Frederick Vinckenbosch; Eef Theunissen; Kim P. C. Kuypers; I. McGregor; Johannes Ramaekers
Source: check_circle
Maastricht University

Pharmacokinetics and pharmacodynamics of lysergic acid diethylamide microdoses in healthy participants

Clinical Pharmacology & Therapeutics
2021-03 | Journal article | Author
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Contributors: Friederike Holze; Matthias E Liechti; Nadia Hutten; N.L. Mason; Patrick C. Dolder; Eef Theunissen; Urs Duthaler; Amanda Feilding; Johannes Ramaekers; Kim P. C. Kuypers
Source: check_circle
Maastricht University

Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users

Addiction Biology
2021-01 | Journal article | Author
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Contributors: N.L. Mason; Eef Theunissen; Nadia Hutten; Desmond H. Y. Tse; Stefan W. Toennes; Jacobus F.A. Jansen; Peter Stiers; Johannes Ramaekers
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Maastricht University

Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

Neuropsychopharmacology
2020-12 | Conference abstract | Author
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Contributors: Nadia Hutten; N.L. Mason; Patrick Dolder; Eef Theunissen; Friederike Holze; Matthias Liechti; Nimmy Varghese; Anne Eckert; Amanda Fielding; Johannes Ramaekers et al.
Source: check_circle
Maastricht University

Mood and cognition after administration of low LSD doses in healthy volunteers

European Neuropsychopharmacology
2020-12 | Journal article | Author
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Contributors: Nadia Hutten; N.L. Mason; Patrick C. Dolder; Eef Theunissen; Friederike Holze; Matthias E. Liechti; Amanda Feilding; Johannes Ramaekers; Kim P. C. Kuypers
Source: check_circle
Maastricht University

Effect of Cannabidiol and Δ9-Tetrahydrocannabinol on Driving Performance

JAMA-Journal of the American Medical Association
2020-12-01 | Journal article | Author
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Contributors: Thomas Arkell; Frederick Vinckenbosch; Richard C Kevin; Eef Theunissen; Iain S McGregor; Johannes Ramaekers
Source: check_circle
Maastricht University

Analysis of 4-fluoroamphetamine in cerumen after controlled oral application

Drug Testing and Analysis
2020-07 | Journal article | Author
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Contributors: Sylvia I Meier; Silvana Petzel-Witt; Manfred Schubert-Zsilavecz; Elizabeth de Sousa Fernandes Perna; Eef Theunissen; Johannes Ramaekers; Stefan W Toennes
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Maastricht University

Blunted highs

European Neuropsychopharmacology
2020-07 | Journal article | Author
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Contributors: Johannes Ramaekers; N.L. Mason; Eef Theunissen
Source: check_circle
Maastricht University

Semiquantitative Activity-Based Detection of JWH-018, a Synthetic Cannabinoid Receptor Agonist, in Oral Fluid after Vaping

Analytical Chemistry
2020-04-21 | Journal article | Author
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Contributors: Annelies Cannaert; Maria del Mar Ramirez Fernandez; Eef Theunissen; Johannes Ramaekers; Sarah M. R. Wille; Christophe P. Stove
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Maastricht University

P.323 Cognitive and subjective effects of different low ‘micro’ doses of LSD in a placebo-controlled study

European Neuropsychopharmacology
2020-02 | Conference abstract | Author
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Contributors: Nadia Hutten; N.L. Mason; P. Dolder; Eef Theunissen; M. Liechti; A. Feilding; Johannes Ramaekers; Kim P. C. Kuypers
Source: check_circle
Maastricht University

Excretion of 4-fluoroamphetamine and three metabolites in urine after controlled oral ingestion

Journal of Pharmaceutical and Biomedical Analysis
2020-02-03 | Journal article | Author
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Contributors: Stefan W. Toennes; David Schneider; Werner Pogoda; Alexander Paulke; Cora Wunder; Eef Theunissen; Elizabeth de Sousa Fernandes Perna; Johannes Ramaekers
Source: check_circle
Maastricht University

Mephedrone and Alcohol Interactions in Humans

Frontiers in Pharmacology
2020-01-28 | Journal article | Author
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Contributors: Esther Papaseit; Clara Pérez-Mañá; Elizabeth de Sousa Fernandes Perna; Eulalia Olesti; Julian Mateus; Kim P. C. Kuypers; Eef Theunissen; Francina Fonseca; Marta Torrens; Johannes Ramaekers et al.
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Maastricht University

The novel psychoactive phenetylamine 4-fluoroamphetamine produces a mild psychedelic state without affecting creative thinking

European Neuropsychopharmacology
2019 | Conference abstract | Author
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Contributors: Kim P. C. Kuypers; Elizabeth de Sousa Fernandes Perna; Eef Theunissen; S. W. Toennes; N.L. Mason; Nadia Hutten; Johannes Ramaekers
Source: check_circle
Maastricht University

Cannabis induced increase in striatal glutamate associated with loss of functional corticostriatal connectivity

European Neuropsychopharmacology
2019-12 | Journal article | Author
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Contributors: N.L. Mason; Eef Theunissen; Nadia Hutten; Desmond H. Y. Tse; Stefan W. Toennes; Peter Stiers; Johannes Ramaekers
Source: check_circle
Maastricht University

Cocaine enhances figural, but impairs verbal 'flexible' divergent thinking

European Neuropsychopharmacology
2019-07 | Journal article | Author
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Contributors: Nadia Hutten; Laura Steenbergen; Lorenza S Colzato; Bernard Hommel; Eef Theunissen; Johannes Ramaekers; Kim P. C. Kuypers
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Maastricht University

Pharmacokinetic properties of 4-fluoroamphetamine in serum and oral fluid after oral ingestion

Drug Testing and Analysis
2019-07 | Journal article | Author
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Contributors: Stefan W Toennes; David Schneider; Werner Pogoda; Alexander Paulke; Cora Wunder; Eef Theunissen; Kim P. C. Kuypers; Elizabeth de Sousa Fernandes Perna; Johannes Ramaekers
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Maastricht University

A First-in-Man Study with 4-Fluoroamphetamine Demonstrates it Produces a Mild Psychedelic State

Journal of Psychoactive Drugs
2019-05-27 | Journal article | Author
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Contributors: Kim P. C. Kuypers; Elizabeth de Sousa Fernandes Perna; Eef Theunissen; S W Toennes; N.L. Mason; Nadia Hutten; Johannes Ramaekers
Source: check_circle
Maastricht University

Neurocognition and subjective experience following acute doses of the synthetic cannabinoid JWH-018

Cannabis and cannabinoid research
2019-03 | Journal article | Author
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EID:

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Contributors: Eef Theunissen; Nadia Hutten; N.L. Mason; Stefan W Toennes; Kim P. C. Kuypers; Johannes Ramaekers
Source: check_circle
Maastricht University

Independent elevation of peripheral oxytocin concentrations and reduction in cognitive empathy during 4-fluoroamphetamine intoxication

Human Psychopharmacology-Clinical and Experimental
2018-11 | Journal article | Author
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Contributors: Patrick Dolder; Elizabeth de Sousa Fernandes Perna; N.L. Mason; Nadia Hutten; Stefan W Toennes; Eef Theunissen; Johannes Ramaekers; Kim P. C. Kuypers
Source: check_circle
Maastricht University

A single dose of cocaine enhances prospective memory performance

Journal of Psychopharmacology
2018-08 | Journal article | Author
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Contributors: Nadia Hutten; Kim P. C. Kuypers; Janelle HP van Wel; Eef Theunissen; Stefan W Toennes; Robbert-Jan Verkes; Johannes Ramaekers
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Maastricht University

Drug liking and wanting, not impulsive action or reflection is increased by 4-fluoroamphetamine

Psychopharmacology
2018-08 | Journal article | Author
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Contributors: Kim P. C. Kuypers; Elizabeth de Sousa Fernandes Perna; Patrick Dolder; S W Toennes; Eef Theunissen; N.L. Mason; Nadia Hutten; Johannes Ramaekers
Source: check_circle
Maastricht University

Safety Profile and Neurocognitive Function Following Acute 4-Fluoroamphetamine (4-FA) Administration in Humans

Frontiers in Pharmacology
2018-07-06 | Journal article | Author
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EID:

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Contributors: Elizabeth de Sousa Fernandes Perna; Eef Theunissen; Patrick Dolder; N.L. Mason; Nadia Hutten; Stefan W. Toennes; Kim P. C. Kuypers; Johannes Ramaekers
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Maastricht University

Pharmacokinetic properties of the synthetic cannabinoid JWH-018 in oral fluid after inhalation

Drug Testing and Analysis
2018-04 | Journal article | Author
SOURCE-WORK-ID:

9870a56b-ac0c-4752-ae80-3f766e5a9af2

EID:

2-s2.0-85034747322

WOSUID:

000430284700003

Contributors: Stefan W. Toennes; Anna Geraths; Werner Pogoda; Alexander Paulke; Cora Wunder; Eef Theunissen; Johannes Ramaekers
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Maastricht University

Excretion of metabolites of the synthetic cannabinoid JWH-018 in urine after controlled inhalation

Journal of Pharmaceutical and Biomedical Analysis
2018-02-20 | Journal article | Author
SOURCE-WORK-ID:

16277d42-59d4-47ac-a69c-0aea384ce3cd

EID:

2-s2.0-85037680020

WOSUID:

000423497000022

Contributors: Stefan W Toennes; Anna Geraths; Werner Pogoda; Alexander Paulke; Cora Wunder; Eef Theunissen; Johannes Ramaekers
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Maastricht University
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