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Keywords

Metabolic Engineering, Yeast, Sugar Transport, Protein Engineering

Countries

Germany

Activities

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Employment (2)

Goethe-Universität Frankfurt am Main: Frankfurt am Main, Hessen, DE

2010-10-01 to present | Group leader (Institute of Molecular Biosciences)
Employment
Source: Self-asserted source
Mislav Oreb

Technische Universität München: Munchen, Bayern, DE

2009-03-15 to 2010-09-31 | Postdoctoral Fellow (Institute of Biophysics)
Employment
Source: Self-asserted source
Mislav Oreb

Education and qualifications (3)

Goethe-Universität Frankfurt am Main: Frankfurt am Main, Hessen, DE

2006-11-01 to 2009-03-06 | PhD (Biology Department, Schleiff Group)
Education
Source: Self-asserted source
Mislav Oreb

Ludwig-Maximilians-Universitat Munchen: Munchen, Bayern, DE

2004-01-01 to 2006-09-31 | Start of the PhD thesis (Biology Department, Schleiff Group)
Education
Source: Self-asserted source
Mislav Oreb

Technische Universität Carolo Wilhelmina zu Braunschweig: Braunschweig, Niedersachsen, DE

1996-10-01 to 2002-04-16 | Diploma (equivalent to Master of Science) in Biology (Biology Department)
Education
Source: Self-asserted source
Mislav Oreb

Funding (3)

PRO-SUGAR: Pilze als Produktionssysteme zur Nutzung von Pektin-haltigen Reststoffen für die Herstellung von Polyhydroxysäuren

2017-08 to 2020-07 | Grant
Bundesministerium für Bildung und Forschung (Berlin, DE)
GRANT_NUMBER:

031B0342B
Source: Self-asserted source
Mislav Oreb

Ligand specificity in human glucose transporters GLUT1-5 and GLUT9

2017-04-01 to 2021-03-31 | Grant
National Institute of General Medical Sciences (n/a, US)
URL: https://grants.uberresearch.com/100000057/R01GM123103/Ligand-specificity-in-human-glucose-transporters-GLUT1-5-and-GLUT9
GRANT_NUMBER: R01GM123103
Source: Self-asserted source
Mislav Oreb via DimensionsWizard

Model-Based Construction And Optimisation Of Versatile Chassis Yeast Strains For Production Of Valuable Lipid And Aromatic Compounds

Source: Self-asserted source
Mislav Oreb via DimensionsWizard

Works (44)

A yeast-based in vivo assay system for analyzing efflux of sugars mediated by glucose and xylose transporters

FEMS Yeast Research
2022-09-24 | Journal article
DOI: 10.1093/femsyr/foac038
Contributors: Sebastian A Tamayo Rojas; Eckhard Boles; Mislav Oreb
Source: check_circle
Crossref

Maßgeschneiderte Hefezellen für biotechnologische Anwendungen

BIOspektrum
2022-02 | Journal article
DOI: 10.1007/s12268-022-1704-y
Contributors: Mislav Oreb; Joanna Tripp
Source: check_circle
Crossref

Identification of a glucose-insensitive variant of Gal2 from Saccharomyces cerevisiae exhibiting a high pentose transport capacity

Scientific Reports
2021-12-22 | Journal article
DOI: 10.1038/s41598-021-03822-7
Contributors: Sebastian A. Tamayo Rojas; Virginia Schadeweg; Ferdinand Kirchner; Eckhard Boles; Mislav Oreb
Source: check_circle
Crossref

Subcellular Localization of Fad1p in Saccharomyces cerevisiae: A Choice at Post-Transcriptional Level?

Life
2021-09-14 | Journal article
DOI: 10.3390/life11090967
Contributors: Francesco Bruni; Teresa Anna Giancaspero; Mislav Oreb; Maria Tolomeo; Piero Leone; Eckhard Boles; Marina Roberti; Michele Caselle; Maria Barile
Source: check_circle
Crossref
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Preferred source (of 2)‎

Production of octanoic acid in Saccharomyces cerevisiae: Investigation of new precursor supply engineering strategies and intrinsic limitations

Biotechnology and Bioengineering
2021-08 | Journal article
DOI: 10.1002/bit.27814
Contributors: Florian Wernig; Leonie Baumann; Eckhard Boles; Mislav Oreb
Source: check_circle
Crossref

High-Throughput Screening of an Octanoic Acid Producer Strain Library Enables Detection of New Targets for Increasing Titers in Saccharomyces cerevisiae

ACS Synthetic Biology
2021-05-21 | Journal article
DOI: 10.1021/acssynbio.0c00600
Contributors: Leonie Baumann; Stefan Bruder; Johannes Kabisch; Eckhard Boles; Mislav Oreb
Source: check_circle
Crossref

Glucose-induced internalization of the S. cerevisiae galactose permease Gal2 is dependent on phosphorylation and ubiquitination of its aminoterminal cytoplasmic tail

FEMS Yeast Research
2021-04-07 | Journal article
DOI: 10.1093/femsyr/foab019
Contributors: Sebastian A Tamayo Rojas; Sina Schmidl; Eckhard Boles; Mislav Oreb
Source: check_circle
Crossref

Transcriptomic response of Saccharomyces cerevisiae to octanoic acid production

FEMS Yeast Research
2021-03-18 | Journal article
DOI: 10.1093/femsyr/foab011
Contributors: Leonie Baumann; Tyler Doughty; Verena Siewers; Jens Nielsen; Eckhard Boles; Mislav Oreb
Source: check_circle
Crossref

Crystal structures of non-oxidative decarboxylases reveal a new mechanism of action with a catalytic dyad and structural twists.

Scientific reports
2021-02 | Journal article
DOI: 10.1038/s41598-021-82660-z
PMID: 33542397
PMC: PMC7862292
Contributors: Zeug M; Markovic N; Iancu CV; Tripp J; Oreb M; Choe JY
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

A label-free real-time method for measuring glucose uptake kinetics in yeast

FEMS Yeast Research
2021-01-16 | Journal article
DOI: 10.1093/femsyr/foaa069
Contributors: Sina Schmidl; Cristina V Iancu; Mara Reifenrath; Jun-yong Choe; Mislav Oreb
Source: check_circle
Crossref

Artificial ER-Derived Vesicles as Synthetic Organelles for in Vivo Compartmentalization of Biochemical Pathways

ACS Synthetic Biology
2020-11-20 | Journal article
DOI: 10.1021/acssynbio.0c00241
Contributors: Mara Reifenrath; Mislav Oreb; Eckhard Boles; Joanna Tripp
Source: check_circle
Crossref

Engineering cofactor supply and NADH-dependent d-galacturonic acid reductases for redox-balanced production of l-galactonate in Saccharomyces cerevisiae

Scientific Reports
2020-11-04 | Journal article
DOI: 10.1038/s41598-020-75926-5
Contributors: Simon Harth; Jacqueline Wagner; Tamina Sens; Jun-yong Choe; J. Philipp Benz; Dirk Weuster-Botz; Mislav Oreb
Source: check_circle
Crossref

De novo biosynthesis of 8-hydroxyoctanoic acid via a medium-chain length specific fatty acid synthase and cytochrome P450 in Saccharomyces cerevisiae

Metabolic Engineering Communications
2020-06 | Journal article
DOI: 10.1016/j.mec.2019.e00111
Part of ISSN: 2214-0301
Source: Self-asserted source
Mislav Oreb

Fusing α and β subunits of the fungal fatty acid synthase leads to improved production of fatty acids

Scientific Reports
2020-06-17 | Journal article
DOI: 10.1038/s41598-020-66629-y
Contributors: Florian Wernig; Sandra Born; Eckhard Boles; Martin Grininger; Mislav Oreb
Source: check_circle
Crossref

Construction of artificial membrane transport metabolons – an emerging strategy in metabolic engineering

FEMS Microbiology Letters
2020-01-01 | Journal article
DOI: 10.1093/femsle/fnaa027
Contributors: Mislav Oreb
Source: check_circle
Crossref

A Growth-Based Screening System for Hexose Transporters in Yeast.

Methods in molecular biology (Clifton, N.J.)
2018 | Journal article
DOI: 10.1007/978-1-4939-7507-5_10
PMID: 29218522
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Bacterial bifunctional chorismate mutase-prephenate dehydratase PheA increases flux into the yeast phenylalanine pathway and improves mandelic acid production

Metabolic Engineering Communications
2018-12 | Journal article
DOI: 10.1016/j.mec.2018.e00079
Contributors: Mara Reifenrath; Maren Bauer; Mislav Oreb; Eckhard Boles
Source: check_circle
Crossref

A Yeast-Based Biosensor for Screening of Short- and Medium-Chain Fatty Acid Production.

ACS synthetic biology
2018-10 | Journal article
DOI: 10.1021/acssynbio.8b00309
PMID: 30338986
Contributors: Baumann L; Rajkumar AS; Morrissey JP; Boles E; Oreb M
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae

Biotechnology for Biofuels
2018-06-01 | Journal article
DOI: 10.1186/s13068-018-1149-1
Part of ISSN: 1754-6834
Contributors: Sandra Henritzi; Manuel Fischer; Martin Grininger; Mislav Oreb; Eckhard Boles
Source: Self-asserted source
Mislav Oreb via Crossref Metadata Search

Ligand Screening Systems for Human Glucose Transporters as Tools in Drug Discovery

Frontiers in Chemistry
2018-05 | Journal article
DOI: 10.3389/fchem.2018.00183
Part of ISSN: 2296-2646
Contributors: Sina Schmidl; Cristina V. Iancu; Jun-yong Choe; Mislav Oreb
Source: Self-asserted source
Mislav Oreb via Crossref Metadata Search

An expanded enzyme toolbox for production of cis, cis-muconic acid and other shikimate pathway derivatives in Saccharomyces cerevisiae.

FEMS yeast research
2018-02 | Journal article
DOI: 10.1093/femsyr/foy017
PMID: 29462295
Contributors: Brückner C; Oreb M; Kunze G; Boles E; Tripp J
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Optimisation of trans-cinnamic acid and hydrocinnamyl alcohol production with recombinant Saccharomyces cerevisiae and identification of cinnamyl methyl ketone as a by-product.

FEMS yeast research
2017-11 | Journal article
DOI: 10.1093/femsyr/fox091
PMID: 29186481
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

An artificial transport metabolon facilitates improved substrate utilization in yeast.

Nature chemical biology
2017-09 | Journal article
DOI: 10.1038/nchembio.2457
PMID: 28869594
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Establishing a yeast-based screening system for discovery of human GLUT5 inhibitors and activators.

Scientific reports
2017-07 | Journal article
DOI: 10.1038/s41598-017-06262-4
PMID: 28740135
PMC: PMC5524692
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

De novo biosynthesis of trans-cinnamic acid derivatives in Saccharomyces cerevisiae

Applied Microbiology and Biotechnology
2017-06-29 | Journal article
DOI: 10.1007/s00253-017-8220-x
Contributors: Manuela Gottardi; Jan Dines Knudsen; Lydie Prado; Mislav Oreb; Paola Branduardi; Eckhard Boles
Source: check_circle
Crossref

Polymorphisms in the LAC12 gene explain lactose utilisation variability in Kluyveromyces marxianus strains.

2017-05 | Journal article
DOI: 10.1093/femsyr/fox021
PMID: 28444380
Contributors: Varela JA; Montini N; Scully D; Van der Ploeg R; Oreb M; Boles E; Hirota J; Akada R; Hoshida H; Morrissey JP
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Requirement of a Functional Flavin Mononucleotide Prenyltransferase for the Activity of a Bacterial Decarboxylase in a Heterologous Muconic Acid Pathway in Saccharomyces cerevisiae.

2017-05 | Journal article
DOI: 10.1128/aem.03472-16
PMID: 28283523
Contributors: Weber HE; Gottardi M; Brückner C; Oreb M; Boles E; Tripp J
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Secretion of 2,3-dihydroxyisovalerate as a limiting factor for isobutanol production in Saccharomyces cerevisiae.

2017-05 | Journal article
DOI: 10.1093/femsyr/fox029
PMID: 28505306
Contributors: Generoso WC; Brinek M; Dietz H; Oreb M; Boles E
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters.

2016 | Journal article
DOI: 10.1038/srep23502
PMID: 26996892
PMC: PMC4800717
Contributors: Jordan P; Choe JY; Boles E; Oreb M
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Simplified CRISPR-Cas genome editing for Saccharomyces cerevisiae.

2016-08 | Journal article
DOI: 10.1016/j.mimet.2016.06.020
PMID: 27327211
Contributors: Generoso WC; Gottardi M; Oreb M; Boles E
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Metabolic engineering of Saccharomyces cerevisiae for production of butanol isomers.

2015-06 | Journal article
DOI: 10.1016/j.copbio.2014.09.004
PMID: 25286420
Contributors: Generoso WC; Schadeweg V; Oreb M; Boles E
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

On the role of GAPDH isoenzymes during pentose fermentation in engineered Saccharomyces cerevisiae.

2014-05 | Journal article
DOI: 10.1111/1567-1364.12137
PMID: 24456572
Contributors: Linck A; Vu XK; Essl C; Hiesl C; Boles E; Oreb M
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Engineering of yeast hexose transporters to transport D-xylose without inhibition by D-glucose.

2014-04 | Journal article
DOI: 10.1073/pnas.1323464111
PMID: 24706835
PMC: PMC3986176
Contributors: Farwick A; Bruder S; Schadeweg V; Oreb M; Boles E
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Nucleotides and substrates trigger the dynamics of the Toc34 GTPase homodimer involved in chloroplast preprotein translocation.

2014-04 | Journal article
DOI: 10.1016/j.str.2014.02.004
PMID: 24631462
Contributors: Lumme C; Altan-Martin H; Dastvan R; Sommer MS; Oreb M; Schuetz D; Hellenkamp B; Mirus O; Kretschmer J; Lyubenova S et al.
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Novel strategies to improve co-fermentation of pentoses with D-glucose by recombinant yeast strains in lignocellulosic hydrolysates.

2012 | Journal article
DOI: 10.4161/bioe.21444
PMID: 22892590
PMC: PMC3489712
Contributors: Oreb M; Dietz H; Farwick A; Boles E
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33.

2011-06 | Journal article
DOI: 10.1042/BJ20110246
PMID: 21434866
PMC: PMC4086448
Contributors: Oreb M; Höfle A; Koenig P; Sommer MS; Sinning I; Wang F; Tews I; Schnell DJ; Schleiff E
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Phosphorylation regulates the assembly of chloroplast import machinery.

2008 | Journal article
DOI: 10.1093/jxb/ern095
PMID: 18487635
PMC: PMC2423650
Contributors: Oreb M; Höfle A; Mirus O; Schleiff E
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

pH sensitivity of the GTPase Toc33 as a regulatory circuit for protein translocation into chloroplasts.

2008-12 | Journal article
DOI: 10.1093/pcp/pcn171
PMID: 19001421
Contributors: Bionda T; Koenig P; Oreb M; Tews I; Schleiff E
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

On the significance of Toc-GTPase homodimers.

2008-08 | Journal article
DOI: 10.1074/jbc.M710576200
PMID: 18541539
Contributors: Koenig P; Oreb M; Rippe K; Muhle-Goll C; Sinning I; Schleiff E; Tews I
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures.

2008-04 | Journal article
DOI: 10.1016/j.str.2008.01.008
PMID: 18400179
Contributors: Koenig P; Oreb M; Höfle A; Kaltofen S; Rippe K; Sinning I; Schleiff E; Tews I
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Policing Tic 'n' Toc, the doorway to chloroplasts.

2008-01 | Journal article
DOI: 10.1016/j.tcb.2007.10.002
PMID: 18068366
Contributors: Oreb M; Tews I; Schleiff E
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Phospho-mimicry mutant of atToc33 affects early development of Arabidopsis thaliana.

2007-12 | Journal article
DOI: 10.1016/j.febslet.2007.11.071
PMID: 18054337
Contributors: Oreb M; Zoryan M; Vojta A; Maier UG; Eichacker LA; Schleiff E
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Chloroplast Protein Import: Reverse Genetic Approaches

CG
2006-06-01 | Journal article
DOI: 10.2174/138920206778427004
Contributors: Mislav Oreb; Katharina Reger; Enrico Schleiff
Source: Self-asserted source
Mislav Oreb via Crossref Metadata Search

ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana.

2001-11 | Journal article
DOI: 10.1074/jbc.C100472200
PMID: 11553608
Contributors: Bittner F; Oreb M; Mendel RR
Source: Self-asserted source
Mislav Oreb via Europe PubMed Central

Peer review (8 reviews for 4 publications/grants)

Review activity for ACS synthetic biology. (4)
Review activity for Metabolic engineering. (2)
Review activity for Nature chemical biology. (1)
Review activity for Nature communications (1)
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