Luc P. Brion (0000-0002-6139-0132)

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Dr. Brion has published more than 150 original manuscripts and 12 chapters. During his training he participated and conducted studies on growth, nutrition and assessment of renal function in neonates and children. As Faculty at AECOM, he was funded for years by the NIH, American Heart Association, Genentech Foundation, and Pharmacia for basic sciences research in developmental nephrology, specifically renal acid secretion, carbonic anhydrase, pathophysiological effects of acidosis and growth. His academic focus later changed to clinical research assessing neonatal mortality and morbidity and evidence-based medicine. He is a member of the Neonatal Cochrane Collaboration Group. He has authored several Cochrane reviews and has participated in several multi-center studies and randomized controlled trials (RCTs) in preterm infants. Dr. Brion has served on the IRB at AECOM. Dr. Brion was Director of the Fellowship Training Program in Neonatal-Perinatal Medicine at AECOM for 10 years and at the UT Southwestern Medical Center for 12 years. He was the University of Texas Southwestern (UTSW) Alternate PI for the NICHD Eunice Kennedy Shriver Cooperative Multicenter Neonatal Research Network (NRN) from 2009 to 2023. Dr. Brion served on the subcommittee on protection of human subjects of the NRN. In January 2015, Dr. Brion obtained 2-year funding from Children’s Medical Center Foundation at Dallas and 3-year funding from the Gerber Foundation for studies aiming at analyzing the relationship between neonatal nutrition, growth, neurodevelopment and signs suggestive of metabolic syndrome in high-risk preterm infants. Dr. Brion is collaborating with several co-investigators (Chan CS, Kong JY, Babata K, Thai Yeo K, Mazarella K, Adhikari E, Hascoët JM) to analyze delivery room and breast milk practices designed to optimize mortality and morbidity in neonates exposed to SARS-Cov-2.

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The University of Texas Southwestern Medical Center: Dallas, Texas, US

2023-04-11 to present | Emeritus Professor (Pediatrics)

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Luc P. Brion

https://orcid.org/0000-0002-6139-0132

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Employment (1)

The University of Texas Southwestern Medical Center: Dallas, Texas, US

Education and qualifications (1)

Université Libre de Bruxelles: Brussels, BE

Works (46)

Multivariate Analysis of Factors Associated with Feeding Mother's Own Milk at Discharge in Preterm Infants: A Retrospective Cohort Study

Neonatal Feeding Practices and SARS-CoV-2 Transmission in Neonates with Perinatal SARS-CoV-2 Exposure: A Systematic Review and Meta-Analysis

Factors Associated with Need for Intravenous Glucose Infusion for the Treatment of Early Neonatal Hypoglycemia in Late Preterm and Term Neonates

Relationship between Ventricular Size on Latest Ultrasonogram and the Bayley Scores ≥ 18 Months in Extremely Low Gestational Age Neonates: A Retrospective Cohort Study

Development of a Prediction Model for Surgery or Early Mortality at the Time of Initial Assessment for Necrotizing Enterocolitis.

Maternal body mass index and necrotizing enterocolitis: A case-control study

Optimal Delivery Management for the Prevention of Early Neonatal SARS-CoV-2 Infection: Systematic review and Meta-analysis

Impact of fetal inflammatory response on the severity of necrotizing enterocolitis in preterm infants.

Follow-up of a randomized trial optimizing neonatal nutrition in preterm very low birthweight infants: growth, serum adipokines, renal function and blood pressure.

Neonatal Encephalopathy with Hiccups and an Updated Diagnostic Approach.

Impact of Size for Gestational Age on Multivariate Analysis of Factors Associated with Necrotizing Enterocolitis in Preterm Infants: Retrospective Cohort Study.

Antenatal Steroids, Prophylactic Indomethacin, and the Risk of Spontaneous Intestinal Perforation.

Hyperglycemia and prematurity: a narrative review.

Quality improvement project in a neonatal intensive care unit reduced the prevalence and duration of hypophosphatemia with significant and sustainable results.

Optimal Delivery Management for the Prevention of Early Neonatal SARS-CoV-2 Infection: Systematic review and Meta-analysis

Growth after implementing a donor breast milk program in neonates <33 weeks gestational age or birthweight <1500 grams: Retrospective cohort study.

Double-blinded randomized controlled trial of optimizing nutrition in preterm very low birth weight infants: Bayley scores at 18–38 months of age

Factors Associated with Need for Intravenous Glucose Infusion for the Treatment of Early Neonatal Hypoglycemia in Late Preterm and Term infants

Association of antenatal steroids with surfactant administration in moderate preterm infants born to women with diabetes mellitus and/or hypertension

Presumed Aspiration Pneumonia in a Term Newborn Infant.

Overview of the neonatal research network: History, contributions, challenges, and future.

Perinatal management: Lessons learned from the neonatal research network.

Decreasing delivery room CPAP-associated pneumothorax at ≥35-week gestational age.

Cuffed versus uncuffed endotracheal tubes for neonates.

Decreasing early hypoglycemia frequency in at-risk newborns after implementing a new hypoglycemia screening algorithm

Early Transient Hypoglycemia and Test Performance in At-Risk Newborns.

Association of antenatal steroids with neonatal mortality and morbidity in preterm infants born to mothers with diabetes mellitus and hypertension

Quality improvement project designed to reduce disproportionate growth in extremely low gestational age neonates: cognitive neurodevelopmental outcome at 18–41 months

Re: Zinc levels in neonatal life influence long-term neurodevelopment

Blood myo-inositol concentrations in preterm and term infants

Comment on evidence for and against vertical transmission of severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019)

Zinc deficiency limiting head growth to discharge in extremely low gestational age infants with insufficient linear growth: a cohort study

Role of zinc in neonatal growth and brain growth: review and scoping review.

Association of age of initiation and type of complementary foods with body mass index and weight-for-length at 12 months of age in preterm infants

Optimizing individual nutrition in preterm very low birth weight infants: double-blinded randomized controlled trial

Delivery Room Continuous Positive Airway Pressure and Pneumothorax.

Adjustable feedings plus accurate serial length measurements decrease discharge weight-length disproportion in very preterm infants: quality improvement project.

Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants <28 Weeks' Gestational Age: A Randomized Clinical Trial.

Valid serial length measurements in preterm infants permit characterization of growth patterns.

Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation.

Severe intraventricular hemorrhage and withdrawal of support in preterm infants.

The association of congenital heart disease with necrotizing enterocolitis in preterm infants: a birth cohort study.

Hypomagnesemia secondary to cerebrospinal fluid losses in a patient with congenital hydrocephalus.

Change in practice after the Surfactant, Positive Pressure and Oxygenation Randomised Trial.

Serum tocopherol levels in very preterm infants after a single dose of vitamin E at birth.

Perinatal acidosis and hypoxic-ischemic encephalopathy in preterm infants of 33 to 35 weeks' gestation.

Peer review (74 reviews for 6 publications/grants)